LOCUS X74322 2609 bp DNA linear HUM 14-NOV-2006
DEFINITION H.sapiens gap-I gene.
ACCESSION X74322
VERSION X74322.1
KEYWORDS gap-I gene; guanylate cyclase activator protein; guanylin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2609)
AUTHORS Hill O.
JOURNAL Submitted (22-JUL-1993) to the INSDC. O. Hill, Niedersaechsisches
Inst. f. Peptid-, Forschung, Feodor Lynen Strasse 31, 30625
Hannover, FRG
REMARK sequence revised by author (07-OCT-1993)
REFERENCE 2
AUTHORS Hill O., Kuhn M., Zucht HD., Cetin Y., Kulaksiz H., Adermann K.,
Klock G., Rechkemmer G., Forssmann W.G., Magert H.J.
TITLE Analysis of the human guanylin gene and the processing and cellular
localization of the peptide
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92(6), 2046-2050(1995).
PUBMED 7892222
FEATURES Location/Qualifiers
source 1..2609
/organism="Homo sapiens"
/mol_type="genomic DNA"
/clone_lib="946203"
/tissue_type="placenta"
/db_xref="taxon:9606"
regulatory 335..341
/gene="gap-I"
/note="putative"
/regulatory_class="TATA_box"
mRNA join(394..474,1502..1709,2142..2421)
/gene="gap-I"
exon 394..474
/gene="gap-I"
/number=1
CDS join(400..474,1502..1709,2142..2206)
/gene="gap-I"
/product="guanylate cyclase activating protein"
/db_xref="GOA:Q02747"
/db_xref="HGNC:HGNC:4682"
/db_xref="InterPro:IPR000879"
/db_xref="InterPro:IPR036382"
/db_xref="PDB:1GNA"
/db_xref="PDB:1GNB"
/db_xref="PDB:1O8R"
/db_xref="UniProtKB/Swiss-Prot:Q02747"
/protein_id="CAC22258.1"
/translation="MNAFLLFALCLLGAWAALAGGVTVQDGNFSFSLESVKKLKDLQE
PQEPRVGKLRNFAPIPGEPVVPILCSNPNFPEELKPLCKEPNAQEILQRLEEIAEDPG
TCEICAYAACTGC"
intron 475..1501
/gene="gap-I"
/number=1
exon 1502..1709
/gene="gap-I"
/number=2
intron 1710..2141
/gene="gap-I"
/number=2
exon 2142..2421
/gene="gap-I"
/number=3
BASE COUNT 515 a 780 c 738 g 576 t
ORIGIN
1 gagctcagcc cccagtgcag ccccgtcacc tcatcctaat caccccaccc taatcgcctt
61 gcgtttcact gtcgggctgg gcccccctcc tcaagggcag ggtctgccgg ccccacacag
121 cagcacaggg cagtcgtgag tgaatgtgcc ttgttggtga atgaatgcag gacccagccc
181 ggctgtgggt caaagtaggt gctcagggag gggccggggc cccccctgcc tggctcttat
241 ctcctagggc tgtctcgagc cttatctgat aaggcctgac aggtgagcag atgagactga
301 cagaggcttc caggttactc agtaacctgc cctctttaaa agtcccgccg cttccccctg
361 gcatccagaa cagccacccc tctctcgggc actgctgcca tgaatgcctt cctgctcttc
421 gcactgtgcc tccttggggc ctgggccgcc ttggcaggag gggtcaccgt gcaggtgagt
481 cctgtgtccc taccccggcc cagctggctc cctgccccta gtgcccaggt ctggtcccct
541 gagagagtac ctcctctttg gggctggatt gagggtgtgt gtcccaggct tggccttctt
601 cgaggagctc ctgctcagtc cagccacaca cacacctttc ccttcaactt tggaggagaa
661 agaaacccag tggagggaag aggaataacc atatggggaa ggcggggagt tggccaattt
721 actgagtgtc ctatgtgccg gctccttccc cagcccctca ctgtggctcc actatcaacc
781 tggaagaaag ggatcattag tcccatttta cagaggggaa aactgagcct cacaaaggtt
841 ctgtaacagg ccatgggcac atggctgtgg gaagtgcagg agctggattt aaatccagac
901 cttactcctc agtgggtccc aggaaccaca tggacaccct ggaggtcctg acagatgggt
961 atgcctacca gtgccaatgc tggcgacagg ccaagctggc acctagcggg ggccctgatc
1021 tctatcaaag ccagattccg ggaggccttt tattgcttct caaaccaaaa ccaggctgca
1081 ggctggagct gggggcccag taatcagccg caccgctctc aggcagggga aagacagcct
1141 gggcttggcc acgtggaact acgatgcctg ggtgctggtc ctttgcctct ccctaaaaat
1201 cagcacactg gctcctactc attaggcacc tatggtgttc ctggagcttc acacccattt
1261 tctccattcc ccatacaaca tgcagaattt gcgggttcca gagtgtccag catcacggag
1321 ccaagccagg acgtggggcc tgaactctgc ccctcacagt gccccactgt ggatcgcctg
1381 gctcccatat gccacgaaca ctgcctgtga gcaccactgg gctggaccgg ggccagcacg
1441 gggggcacag ccaggaagca ggctgcagcc tggcctcatg ctctgggctt ctctcttcca
1501 ggatggaaat ttctcctttt ctctggagtc agtgaagaag ctcaaagacc tccaggagcc
1561 ccaggagccc agggttggga aactcaggaa ctttgcaccc atccctggtg aacctgtggt
1621 tcccatcctc tgtagcaacc cgaactttcc agaagaactc aagcctctct gcaaggagcc
1681 caatgcccag gagatacttc agaggctggg tgagcagcct ccttcctctc tgattggtgg
1741 ggctcgggaa tactgtggtg gcacttgagg aagagatgtg ctctgattgg tgggatttgg
1801 aggaagggct cagctctgac tggtggaact agggagcttg gctctgattg gtgggtctgt
1861 tccatgccca cttcaattcc aagttgtaac tgctgaggtt tgggaactaa gaccattcat
1921 ctggtcttag tttcctctct ttctggtgga atctctgctt tgattggttg gtttgagtgg
1981 tctgtgtgcc ctggtttggg gcgaaaagcc cagtaggtca gagtacgggc ctgctgagat
2041 tctcctgggg ctgggtggtg acgtacaagc tctgggccaa gggcggcagg ggcctcgcga
2101 ggaaatgctg gttctcacga ggctccatct ctgttgtgca gaggaaatcg ctgaggaccc
2161 gggcacatgt gaaatctgtg cctacgctgc ctgtaccgga tgctaggggg gcttgcccac
2221 tgcctgcctc ccctccgcag cagggaagct cttttctcct gcagaaaggg ccacccatga
2281 tactccactc ccagcagctc aacctaccct ggtccagtcg ggaggagcag cccggggagg
2341 aactgggtga ctggaggcct cgccccaaca ctgtccttcc ctgccacttc aacccccagc
2401 taataaacca gattccagag tactctgggt gttgccttcc ttccttcctt catcccctag
2461 tctatcctgc cctggaagct cgggatgtaa tgtactaagc gaaggacccc actctccctg
2521 ctaagctgct cactgtccct ggggctgcca caacacagag gcgtggagag gatctggatc
2581 tccaaaccac caaggcagcg ggtggtggg
//