LOCUS X73424 1829 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens gene for propionyl-CoA carboxylase a subunit.
ACCESSION X73424
VERSION X73424.1
KEYWORDS biotin-dependent enzyme; mitochondrial matrix enzyme; PCCB gene;
propionyl-CoA carboxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Lamhonwah A.M., Leclerc D., Loyer M., Clarizio R., Gravel R.A.
TITLE Correction of the metabolic defect in propionic acidemia
fibroblasts by microinjection of a full-length cDNA or RNA
transcript encoding the propionyl-CoA carboxylase beta subunit
JOURNAL Genomics 19(3), 500-505(1994).
PUBMED 8188292
REFERENCE 2 (bases 1 to 1829)
AUTHORS Gravel R.A.
JOURNAL Submitted (11-JUN-1993) to the INSDC. R.A. Gravel, Mc Gill
University, Montreal Children's Hospital, Research Institute, 2300
Tupper Street, Montreal, Quebec, H3H 1P3, CANADA
COMMENT Related sequence: M13573
FEATURES Location/Qualifiers
source 1..1829
/db_xref="H-InvDB:HIT000323368"
/organism="Homo sapiens"
/chromosome="3"
/map="3q13-3q22"
/mol_type="mRNA"
/clone="pPCC41A2, pFLB2.15 & pTAHae"
/tissue_type="liver, kidney & fibroblasts"
/db_xref="taxon:9606"
CDS 71..1690
/gene="PCCB"
/product="propionyl-CoA carboxylase"
/EC_number="6.4.1.3"
/db_xref="GOA:P05166"
/db_xref="H-InvDB:HIT000323368.13"
/db_xref="HGNC:HGNC:8654"
/db_xref="InterPro:IPR011762"
/db_xref="InterPro:IPR011763"
/db_xref="InterPro:IPR029045"
/db_xref="InterPro:IPR034733"
/db_xref="UniProtKB/Swiss-Prot:P05166"
/protein_id="CAA51825.1"
/translation="MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRR
TALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAADKNKF
PGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLND
SGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVK
DTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFN
YLPLSSQDPASVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMP
NYAKNIIVGFARMNGRTVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFV
DVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGD
TNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQP
SSTRARICCDLDVLASKKVQRPWRKHANIPL"
regulatory 1817..1822
/regulatory_class="polyA_signal_sequence"
BASE COUNT 448 a 448 c 491 g 442 t
ORIGIN
1 agcgccgtac ccacgcttta gcacatgcgt actcaggtgc gccggtaggg gacgcgccgg
61 cacagcaaaa atggcggcgg cattacgggt ggcggcggtc ggggcaaggc tcagcgttct
121 ggcgagcggt ctccgcgccg cggtccgcag cctttgcagc caggccacct ctgttaacga
181 acgcatcgaa aacaagcgcc ggaccgcgct gctgggaggg ggccaacgcc gtattgacgc
241 gcagcacaag cgaggaaagc taacagccag ggagaggatc agtctcttgc tggaccctgg
301 cagctttgtt gagagcgaca tgtttgtgga acacagatgt gcagattttg gaatggctgc
361 tgacaagaat aagtttcctg gagacagcgt ggtcactgga cgaggccgaa tcaatggaag
421 attggtttat gtcttcagtc aggattttac agtttttgga ggcagtctgt caggagcaca
481 tgcccaaaag atctgcaaaa tcatggacca ggccataacg gtgggggctc cagtgattgg
541 gctgaatgac tctgggggag cacggatcca agaaggagtg gagtctttgg ctggctatgc
601 agacatcttt ctgaggaatg ttacggcatc cggagtcatc cctcagattt ctctgatcat
661 gggcccatgt gctggtgggg ccgtctactc cccagcccta acagacttca cgttcatggt
721 aaaggacacc tcctacctgt tcatcactgg ccctgatgtt gtgaagtctg tcaccaatga
781 ggatgttacc caggaggagc tcggtggtgc caagacccac accaccatgt caggtgtggc
841 ccacagagct tttgaaaatg atgttgatgc cttgtgtaat ctccgggatt tcttcaacta
901 cctgcccctg agcagtcagg acccggcttc cgtccgtgag tgccacgatc ccagtgaccg
961 tctggttcct gagcttgaca caattgtccc tttggaatca accaaagcct acaacatggt
1021 ggacatcata cactctgttg ttgatgagcg tgaatttttt gagatcatgc ccaattatgc
1081 caagaacatc attgttggtt ttgcaagaat gaatgggagg actgttggaa ttgttggcaa
1141 ccaacctaag gtggcctcag gatgcttgga tattaattca tctgtgaaag gggctcgttt
1201 tgtcagattc tgtgatgcat tcaatattcc actcatcact tttgttgatg tccctggctt
1261 tctacctggc acagcacagg aatacggggg catcatccgg catggtgcca agcttctcta
1321 cgcatttgct gaggcaactg tacccaaagt cacagtcatc accaggaagg cctatggagg
1381 tgcctatgat gtcatgagct ctaagcacct ttgtggtgat accaactatg cctggcccac
1441 cgcagagatt gcagtcatgg gagcaaaggg cgctgtggag atcatcttca aagggcatga
1501 gaatgtggaa gctgctcagg cagagtacat cgagaagttt gccaaccctt tccctgcagc
1561 agtgcgaggg tttgtggatg acatcatcca accttcttcc acacgtgccc gaatctgctg
1621 tgacctggat gtcttggcca gcaagaaggt acaacgtcct tggagaaaac atgcaaatat
1681 tccattgtaa acaaatcaaa ggaaaagaaa ccaagaactg aattactgtc tgcccattca
1741 catcccattc ctgccttttg caatcatgat acctggcaat ccaaataggt tggataagct
1801 tataataact gagtttatta aattctaga
//