LOCUS X73114 3778 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for slow MyBP-C.
ACCESSION X73114
VERSION X73114.1
KEYWORDS C protein; muscle isoform; myosin binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Weber F.E., Vaughan K.T., Reinach F.C., Fischman D.A.
TITLE Complete sequence of human fast-type and slow-type muscle
myosin-binding-protein C (MyBP-C). Differential expression,
conserved domain structure and chromosome assignment
JOURNAL Eur. J. Biochem. 216(2), 661-669(1993).
PUBMED 8375400
REFERENCE 2 (bases 1 to 3778)
AUTHORS Vaughan K.T.
JOURNAL Submitted (01-JUN-1993) to the INSDC. K.T. Vaughan, Worcester
Foundation for Exper. Biology, Cell Biology Group, 222 Maple
Avenue, Shrewsbury MA, 10545, USA
COMMENT Conflicts with x66276:
Weber et al. Furst et al.
length 3733 bp 3833 bp
length 1123 aa 1138 aa
DNA sequence differences
#/base #/base
1 C 16 T
7 G 23 T
340 - 355 T
345 A 360 -
360 A 375 -
369 A 383 -
370 G 385 -
730 G 742 A
732 G 744 C
770 G 782 -
785 - 796 A
795 C 807 G
812 T 824 G
813 G 825 C
814 C 826 A
815 G 827 T
837 A 849 C
863 C 875 T
937 T 949 A
955 A 967 C
985 C 997 G
989 - 1001 C
991 G 1003 -
1002 A 1014 C
1009 T 1021 A
1010 T 1022 A
1014 A 1026 G
1077 C 1089 T
1089 C 1101 A
1039 C 1113 A
1192 - 1208 C
1194 T 1210 -
1229 C 1241 -
1236 A 1247 -
1240 T 1249 -
1317 A 1326 T
1377 A 1386 T
1553 C 1562 A
1554 C 1563 T
1555 A 1564 C
2229 T 2238 C
2362 - 2372 to 2425
2544 T 2607 A
2546 G 2609 A
2549 - 2612 G
2556 A 2619 -
2571 C 2634 A
2581 A 2644 C
2586 T 2649 A
2592 A 2655 C
2593 G 2656 C
2594 C 2657 G
2600 A 2663 T
2604 G 2667 T
2610 A 2673 C
2806 C 2869 -
2809 - 2872 A
2872 A 2925 G
2873 G 2926 A
2874 A 2927 G
2964 T 3027 -
2967 - 3030 G
2980 T 3042 -
3000 C 3062 -
3002 T 3064 -
3193 - 3253 C
3207 T 3267 -
3215 A 3275 -
3217 - 3277 G
3323 A 3383 T
3346 C 3406 G
3360 C 3420 T
3462 - 3523 G
3540 C 3601 G
3541 A 3602 C
3769 A 3830 T
3770 A 3831 C
3771 A 3832 T
3772 A 3833 C
FEATURES Location/Qualifiers
source 1..3778
/db_xref="H-InvDB:HIT000323364"
/organism="Homo sapiens"
/chromosome="12"
/mol_type="mRNA"
/dev_stage="fetal"
/clone_lib="lambda gt10"
/clone="H8 and H8PPCR"
/tissue_type="skeletal muscle cell type"
/germline
/db_xref="taxon:9606"
CDS 82..3453
/product="slow MyBP-C"
/db_xref="GOA:Q00872"
/db_xref="H-InvDB:HIT000323364.14"
/db_xref="HGNC:HGNC:7549"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013098"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036116"
/db_xref="InterPro:IPR036179"
/db_xref="InterPro:IPR040849"
/db_xref="PDB:1X44"
/db_xref="PDB:2DAV"
/db_xref="PDB:2YUV"
/db_xref="PDB:2YUW"
/db_xref="PDB:2YUX"
/db_xref="PDB:2YUZ"
/db_xref="PDB:2YXM"
/db_xref="UniProtKB/Swiss-Prot:Q00872"
/protein_id="CAA51545.1"
/translation="MPEPTKKEENEVPAPAPPPEEPSKEKEAGTTPAKDWTLVETPPG
EEQAKQNANSQLSILFIEKPQGGTVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDL
ASKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVH
ESTGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPQVDVWELLKNAK
PSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGRVRFVVEL
ADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTE
LFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIR
VEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEI
CLKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAY
NVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAI
MEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPV
APTVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPK
KMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRP
PDHIGAAGLDGYVLEYCFEGTEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAA
GASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWK
KDGAEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRP
GPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSA
TITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPM
FTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEI
RKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIAQ"
3'UTR 3451..3778
regulatory 3748..3755
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1189 a 787 c 920 g 882 t
ORIGIN
1 cctctcgcct gcctgtgggg tttctgtcaa ctagtcgtgg agggaaggag actctttaaa
61 gaataacatc ttattgtggc catgccagaa cccactaaga aagaggaaaa tgaagtgcca
121 gccccagccc cacccccgga agaaccaagt aaagagaagg aggccggaac tacaccagca
181 aaagactgga cccttgtcga aactcctcct ggggaggaac aagccaagca gaatgccaac
241 tcccagctgt ccatcttgtt cattgaaaaa cctcaaggag gaacagtgaa agttggtgaa
301 gatatcacct tcatagccaa agtcaaggct gaagatcttc tgagaaaacc cactatcaaa
361 tggttcaaag gaaaatggat ggacctggcc agcaaagccg ggaagcacct tcagctgaag
421 gaaacctttg agaggcacag tcgggtgtac acatttgaga tgcagatcat caaggccaaa
481 gataactttg caggaaatta cagatgcgag gtcacctata aggataagtt tgacagctgt
541 tcatttgatc ttgaagtgca cgaatctact gggactactc caaacattga catcagatct
601 gctttcaaga gaagtggaga aggtcaagag gatgcaggag aacttgactt tagtggtctc
661 ctgaaacgta gggaggtgaa gcagcaggag gaagaacccc aggtggacgt atgggagttg
721 ctgaagaacg cgaaacccag tgagtacgag aagatcgcct tccagtatgg aatcaccgac
781 ctgcgcggca tgctcaagcg actcaagcgc atgcgcagag aggagaagaa gagcgcagct
841 tttgcaaaaa ttcttgatcc tgcatatcag gttgacaaag gaggcagagt gaggtttgtt
901 gtggagctgg cagatccaaa gttggaggtg aaatggtata aaaatggtca agaaattcga
961 cccagtacca aatacatctt tgaacacaaa ggatgccaga gaatcctgtt tatcaataac
1021 tgtcagatga cagatgattc agagtattat gtgacagccg gtgatgagaa atgttccact
1081 gagctcttcg taagagagcc tccaattatg gtgaccaaac agctggaaga tacaactgct
1141 tattgtgggg agagagtgga attagaatgt gaggtgtctg aagatgatgc caatgtaaaa
1201 tggtttaaga atggtgaaga gattatccct ggtccaaaat caagataccg aattagagtt
1261 gagggtaaaa aacacatctt gatcatagag ggagcaacaa aggctgatgc tgcagaatat
1321 tcagtaatga caacaggagg acaatcatct gctaaactta gtgttgactt gaaaccactg
1381 aagattttga cacctctgac tgatcagact gtaaatcttg gaaaagaaat ctgcctgaag
1441 tgtgaaatct ctgaaaacat accaggaaaa tggactaaaa atggcctacc tgttcaggag
1501 agtgaccgtc taaaggtggt tcacaaggga aggatccaca agttagtgat agccaatgcc
1561 ctcactgaag atgaaggtga ttatgtattt gcacctgatg cctacaatgt tactctgcct
1621 gccaaagttc atgttattga tcctcctaag atcatcctgg atggtcttga tgctgacaac
1681 acagtgacag tgattgcagg aaacaagctt cgtcttgaga tccccatcag cggagaacca
1741 cctcctaaag ccatgtggag ccggggagat aaggctatta tggaaggcag tggccggata
1801 agaacagaat cttaccctga tagcagcact ctggtcattg atatagctga aagagatgac
1861 tctggtgttt accacatcaa tctgaaaaac gaagctggag aggcacatgc aagcatcaag
1921 gttaaagttg tggacttccc tgatcctcca gtggcaccga ctgtgacaga ggtgggagat
1981 gactggtgta tcatgaactg ggagcctcct gcctacgacg gaggctctcc aatcctagga
2041 tattttattg agaggaagaa gaaacaaagc tccaggtgga tgaggctgaa ttttgatctc
2101 tgcaaagaaa caacttttga gcccaagaag atgattgaag gtgtggccta tgaggtccgc
2161 atctttgcag tcaatgccat tggcatctcc aagcccagta tgccctccag gccttttgtt
2221 cctttggctg taacaagccc tcctactctt ctgactgtgg actctgtcac tgacacgact
2281 gtcacgatga ggtggcgccc cccagaccac attggtgcag caggtttaga tggctatgtg
2341 ctagagtatt gctttgaagg aactgaggac tggatagttg caaacaaaga tctgattgac
2401 aagacgaagt tcaccatcac aggtctgcca acagatgcaa agatctttgt gcgtgtgaag
2461 gctgttaatg cagctggtgc cagcgagccc aagtactatt ctcagcccat tctcgtgaag
2521 gaaatcatag aacctccaaa gattcgcatc ccaagacacc tgaagcaaac ctatatccgc
2581 agagttggag aagctgtcaa tctggttata cctttccagg gaaaaccaag accagaatta
2641 acttggaaga aggatggtgc agaaattgat aagaatcaaa taaacattcg caactctgag
2701 actgatacaa tcatatttat tagaaaagca gagaggagcc actctgggaa atatgatctg
2761 caagtcaaag tggacaaatt cgtggagacc gcatcaattg acatccagat cattgaccgt
2821 ccaggtccac cccaaattgt gaagattgag gatgtctggg gagaaaatgt cgctctcaca
2881 tggactccac caaaggatga tggaaatgct gctatcacag gctataccat tcagaaggct
2941 gacaagaaga gcatggaatg gtttactgtc attgagcatt atcatcgaac cagtgccacc
3001 attactgaat tggtcatagg gaatgaatat tacttccggg tcttttctga aaacatgtgt
3061 ggcctcagtg aggatgccac catgactaaa gagagtgcag tgatcgccag ggatggtaaa
3121 atctacaaaa atccagtgta tgaagacttt gatttctcag aggcacccat gtttactcag
3181 cctttggtta acacctatgc catagctggt tacaatgcca ccctaaactg cagtgtgaga
3241 ggaaatccta agcctaaaat aacctggatg aaaaacaaag ttgctattgt ggatgatcca
3301 agatacagga tgttcagcaa ccagggagtc tgtaccctgg aaattcgcaa gcccagcccc
3361 tatgatggag gcacttactg ctgcaaagca gtcaatgacc ttgggacagt ggagattgaa
3421 tgcaaactgg aggtgaaagt cattgcacaa taaggatttt tgaatgtata atatcatcta
3481 aggtgggctc tccttctgca gactcctctt gcaaggcgta cctccaaaca taattgattc
3541 atatctgcga gacttacact caagcaatcc tgaggaatac tgagggaggg cctggctact
3601 gtctctctgc actctgctgc tttgaaatct ggttgaaatg agaaaaagca ttttctgttt
3661 tcccaccagg cccccaagtg tggtcttttt ctttcctcct aatgttgaag agaaaaaaaa
3721 aaaaaaaaaa gtttgcccag attgcttaat taaaaattgc aaacaaaaaa aaaaaaaa
//