LOCUS X70508 450 bp mRNA linear HUM 07-OCT-2008 DEFINITION Homo sapiens mRNA for insulinoma pre-proinsulin. ACCESSION X70508 VERSION X70508.1 KEYWORDS preproinsulin. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 450) AUTHORS Chekhranova M.K., Shubalova E.I., Kutin A.M., Betnev V.Y., Valentsova A.B., Il'ina E.N., Pankov Y.A. TITLE Cloning, primary structure determination and expression of preproinsulin cDNA from human insulinoma in Escherichia coli JOURNAL Mol. Biol. (Mosk.) 26(3), 596-600(1992). PUBMED 1406615 FEATURES Location/Qualifiers source 1..450 /db_xref="H-InvDB:HIT000323103" /organism="Homo sapiens" /mol_type="mRNA" /clone_lib="Human insulinoma cDNA library" /clone="pUEX1Ins12" /db_xref="taxon:9606" sig_peptide 45..80 CDS 45..377 /product="pre-proinsulin" /db_xref="GOA:P01308" /db_xref="H-InvDB:HIT000323103.12" /db_xref="HGNC:HGNC:6081" /db_xref="InterPro:IPR004825" /db_xref="InterPro:IPR016179" /db_xref="InterPro:IPR022352" /db_xref="InterPro:IPR022353" /db_xref="InterPro:IPR036438" /db_xref="PDB:1A7F" /db_xref="PDB:1AI0" /db_xref="PDB:1AIY" /db_xref="PDB:1B9E" /db_xref="PDB:1BEN" /db_xref="PDB:1EFE" /db_xref="PDB:1EV3" /db_xref="PDB:1EV6" /db_xref="PDB:1EVR" /db_xref="PDB:1FU2" /db_xref="PDB:1FUB" /db_xref="PDB:1G7A" /db_xref="PDB:1G7B" /db_xref="PDB:1GUJ" /db_xref="PDB:1HIQ" /db_xref="PDB:1HIS" /db_xref="PDB:1HIT" /db_xref="PDB:1HLS" /db_xref="PDB:1HTV" /db_xref="PDB:1HUI" /db_xref="PDB:1IOG" /db_xref="PDB:1IOH" /db_xref="PDB:1J73" /db_xref="PDB:1JCA" /db_xref="PDB:1JCO" /db_xref="PDB:1JK8" /db_xref="PDB:1K3M" /db_xref="PDB:1KMF" /db_xref="PDB:1LKQ" /db_xref="PDB:1LPH" /db_xref="PDB:1MHI" /db_xref="PDB:1MHJ" /db_xref="PDB:1MSO" /db_xref="PDB:1OS3" /db_xref="PDB:1OS4" /db_xref="PDB:1Q4V" /db_xref="PDB:1QIY" /db_xref="PDB:1QIZ" /db_xref="PDB:1QJ0" /db_xref="PDB:1RWE" /db_xref="PDB:1SF1" /db_xref="PDB:1SJT" /db_xref="PDB:1SJU" /db_xref="PDB:1T0C" /db_xref="PDB:1T1K" /db_xref="PDB:1T1P" /db_xref="PDB:1T1Q" /db_xref="PDB:1TRZ" /db_xref="PDB:1TYL" /db_xref="PDB:1TYM" /db_xref="PDB:1UZ9" /db_xref="PDB:1VKT" /db_xref="PDB:1W8P" /db_xref="PDB:1XDA" /db_xref="PDB:1XGL" /db_xref="PDB:1XW7" /db_xref="PDB:1ZEG" /db_xref="PDB:1ZEH" /db_xref="PDB:1ZNJ" /db_xref="PDB:2AIY" /db_xref="PDB:2C8Q" /db_xref="PDB:2C8R" /db_xref="PDB:2CEU" /db_xref="PDB:2G54" /db_xref="PDB:2G56" /db_xref="PDB:2H67" /db_xref="PDB:2HH4" /db_xref="PDB:2HHO" /db_xref="PDB:2HIU" /db_xref="PDB:2JMN" /db_xref="PDB:2JUM" /db_xref="PDB:2JUU" /db_xref="PDB:2JUV" /db_xref="PDB:2JV1" /db_xref="PDB:2JZQ" /db_xref="PDB:2K91" /db_xref="PDB:2K9R" /db_xref="PDB:2KJJ" /db_xref="PDB:2KJU" /db_xref="PDB:2KQP" /db_xref="PDB:2KQQ" /db_xref="PDB:2KXK" /db_xref="PDB:2L1Y" /db_xref="PDB:2L1Z" /db_xref="PDB:2LGB" /db_xref="PDB:2LWZ" /db_xref="PDB:2M1D" /db_xref="PDB:2M1E" /db_xref="PDB:2M2M" /db_xref="PDB:2M2N" /db_xref="PDB:2M2O" /db_xref="PDB:2M2P" /db_xref="PDB:2MLI" /db_xref="PDB:2MPG" /db_xref="PDB:2MPI" /db_xref="PDB:2MVC" /db_xref="PDB:2MVD" /db_xref="PDB:2N2V" /db_xref="PDB:2N2W" /db_xref="PDB:2N2X" /db_xref="PDB:2OLY" /db_xref="PDB:2OLZ" /db_xref="PDB:2OM0" /db_xref="PDB:2OM1" /db_xref="PDB:2OMG" /db_xref="PDB:2OMH" /db_xref="PDB:2OMI" /db_xref="PDB:2OMQ" /db_xref="PDB:2QIU" /db_xref="PDB:2R34" /db_xref="PDB:2R35" /db_xref="PDB:2R36" /db_xref="PDB:2RN5" /db_xref="PDB:2VJZ" /db_xref="PDB:2VK0" /db_xref="PDB:2W44" /db_xref="PDB:2WBY" /db_xref="PDB:2WC0" /db_xref="PDB:2WRU" /db_xref="PDB:2WRV" /db_xref="PDB:2WRW" /db_xref="PDB:2WRX" /db_xref="PDB:2WS0" /db_xref="PDB:2WS1" /db_xref="PDB:2WS4" /db_xref="PDB:2WS6" /db_xref="PDB:2WS7" /db_xref="PDB:3AIY" /db_xref="PDB:3BXQ" /db_xref="PDB:3E7Y" /db_xref="PDB:3E7Z" /db_xref="PDB:3EXX" /db_xref="PDB:3FQ9" /db_xref="PDB:3HYD" /db_xref="PDB:3I3Z" /db_xref="PDB:3I40" /db_xref="PDB:3ILG" /db_xref="PDB:3INC" /db_xref="PDB:3IR0" /db_xref="PDB:3JSD" /db_xref="PDB:3KQ6" /db_xref="PDB:3P2X" /db_xref="PDB:3P33" /db_xref="PDB:3Q6E" /db_xref="PDB:3ROV" /db_xref="PDB:3TT8" /db_xref="PDB:3U4N" /db_xref="PDB:3UTQ" /db_xref="PDB:3UTS" /db_xref="PDB:3UTT" /db_xref="PDB:3V19" /db_xref="PDB:3V1G" /db_xref="PDB:3W11" /db_xref="PDB:3W12" /db_xref="PDB:3W13" /db_xref="PDB:3W7Y" /db_xref="PDB:3W7Z" /db_xref="PDB:3W80" /db_xref="PDB:3ZI3" /db_xref="PDB:3ZQR" /db_xref="PDB:3ZS2" /db_xref="PDB:3ZU1" /db_xref="PDB:4AIY" /db_xref="PDB:4AJX" /db_xref="PDB:4AJZ" /db_xref="PDB:4AK0" /db_xref="PDB:4AKJ" /db_xref="PDB:4CXL" /db_xref="PDB:4CXN" /db_xref="PDB:4CY7" /db_xref="PDB:4EFX" /db_xref="PDB:4EWW" /db_xref="PDB:4EWX" /db_xref="PDB:4EWZ" /db_xref="PDB:4EX0" /db_xref="PDB:4EX1" /db_xref="PDB:4EXX" /db_xref="PDB:4EY1" /db_xref="PDB:4EY9" /db_xref="PDB:4EYD" /db_xref="PDB:4EYN" /db_xref="PDB:4EYP" /db_xref="PDB:4F0N" /db_xref="PDB:4F0O" /db_xref="PDB:4F1A" /db_xref="PDB:4F1B" /db_xref="PDB:4F1C" /db_xref="PDB:4F1D" /db_xref="PDB:4F1F" /db_xref="PDB:4F1G" /db_xref="PDB:4F4T" /db_xref="PDB:4F4V" /db_xref="PDB:4F51" /db_xref="PDB:4F8F" /db_xref="PDB:4FG3" /db_xref="PDB:4FKA" /db_xref="PDB:4GBC" /db_xref="PDB:4GBI" /db_xref="PDB:4GBK" /db_xref="PDB:4GBL" /db_xref="PDB:4GBN" /db_xref="PDB:4IUZ" /db_xref="PDB:4IYD" /db_xref="PDB:4IYF" /db_xref="PDB:4NIB" /db_xref="PDB:4OGA" /db_xref="PDB:4P65" /db_xref="PDB:4RXW" /db_xref="PDB:4UNE" /db_xref="PDB:4UNG" /db_xref="PDB:4UNH" /db_xref="PDB:4WDI" /db_xref="PDB:4XC4" /db_xref="PDB:4Y19" /db_xref="PDB:4Y1A" /db_xref="PDB:4Z76" /db_xref="PDB:4Z77" /db_xref="PDB:4Z78" /db_xref="PDB:5AIY" /db_xref="PDB:5BOQ" /db_xref="PDB:5BPO" /db_xref="PDB:5BQQ" /db_xref="PDB:5BTS" /db_xref="PDB:5C0D" /db_xref="PDB:5CJO" /db_xref="PDB:5CNY" /db_xref="PDB:5CO2" /db_xref="PDB:5CO6" /db_xref="PDB:5CO9" /db_xref="PDB:5E7W" /db_xref="PDB:5EMS" /db_xref="PDB:5EN9" /db_xref="PDB:5ENA" /db_xref="PDB:5HPR" /db_xref="PDB:5HPU" /db_xref="PDB:5HQI" /db_xref="PDB:5HRQ" /db_xref="PDB:5HYJ" /db_xref="PDB:5MAM" /db_xref="PDB:5MHD" /db_xref="PDB:5MT3" /db_xref="PDB:5MT9" /db_xref="PDB:5MWQ" /db_xref="PDB:5T7R" /db_xref="PDB:5UDP" /db_xref="PDB:5UOZ" /db_xref="PDB:5UQA" /db_xref="PDB:5URT" /db_xref="PDB:5URU" /db_xref="PDB:5USP" /db_xref="PDB:5USS" /db_xref="PDB:5USV" /db_xref="PDB:5UU2" /db_xref="PDB:5UU3" /db_xref="PDB:5UU4" /db_xref="PDB:5VIZ" /db_xref="PDB:5WBT" /db_xref="PDB:5WDM" /db_xref="PDB:5WOB" /db_xref="PDB:6B3Q" /db_xref="PDB:6B70" /db_xref="PDB:6BFC" /db_xref="PDB:6CE7" /db_xref="PDB:6CE9" /db_xref="PDB:6CEB" /db_xref="PDB:6CK2" /db_xref="PDB:6GNQ" /db_xref="PDB:6GV0" /db_xref="PDB:6HN5" /db_xref="PDB:6P4Z" /db_xref="PDB:6S34" /db_xref="UniProtKB/Swiss-Prot:P01308" /protein_id="CAA49913.1" /translation="MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCG ERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSL YQLENYCN" mat_peptide 80..374 /product="pre-proinsulin" BASE COUNT 86 a 152 c 136 g 76 t ORIGIN 1 gctgcatcag aagaggccat caagcacatc actgtccttc tgccatggcc ctgtggatgc 61 gcctcctgcc cctgctggcg ctgctggccc tctggggacc tgacccagcc gcagcctttg 121 tgaaccaaca cctgtgcggc tcacacctgg tggaagctct ctacctagtg tgcggggaac 181 gaggcttctt ctacacaccc aagacccgcc gggaggcaga ggacctgcag gtggggcagg 241 tggagctggg cgggggccct ggtgcaggca gcctgcagcc cttggccctg gaggggtccc 301 tgcagaagcg tggcattgtg gaacaatgct gtaccagcat ctgctccctc taccagctgg 361 agaactactg caactagacg cagcccgcag gcagcccccc acccgccgcc tcctgcaccg 421 agagagatgg aataaagccc ttgaaccagc //