LOCUS X70040 4541 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens RON mRNA for tyrosine kinase.
ACCESSION X70040
VERSION X70040.1
KEYWORDS met oncogene; receptor protein-tyrosine kinase; RON gene;
transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4541)
AUTHORS Breathnach R.
JOURNAL Submitted (08-JAN-1993) to the INSDC. R. Breathnach, Inserm U211,
Institut de Biologie CHR, 9 Quai Moncousu, 44035 Nantes, Cedex,
FRANCE
REFERENCE 2 (bases 1 to 4541)
AUTHORS Ronsin C., Muscatelli F., Mattei M.G., Breathnach R.
TITLE A novel putative receptor protein tyrosine kinase of the met family
JOURNAL Oncogene 8(5), 1195-1202(1993).
PUBMED 8386824
FEATURES Location/Qualifiers
source 1..4541
/db_xref="H-InvDB:HIT000323081"
/organism="Homo sapiens"
/chromosome="3"
/map="p21"
/mol_type="mRNA"
/cell_type="keratinocytes"
/tissue_type="foreskin"
/db_xref="taxon:9606"
CDS 29..4231
/gene="RON"
/product="tyrosine kinase"
/note="putative"
/db_xref="GOA:Q04912"
/db_xref="H-InvDB:HIT000323081.14"
/db_xref="HGNC:HGNC:7381"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR001627"
/db_xref="InterPro:IPR002909"
/db_xref="InterPro:IPR008266"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR014756"
/db_xref="InterPro:IPR015943"
/db_xref="InterPro:IPR016201"
/db_xref="InterPro:IPR016244"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR020635"
/db_xref="InterPro:IPR036352"
/db_xref="InterPro:IPR039413"
/db_xref="PDB:3PLS"
/db_xref="PDB:4FWW"
/db_xref="PDB:4QT8"
/db_xref="UniProtKB/Swiss-Prot:Q04912"
/protein_id="CAA49634.1"
/translation="MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKY
VVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQ
TCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAP
ACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAGSFSPRSVSI
RRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSAL
HTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLQVAHSAPVGAQLA
TELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHP
GLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTA
LYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDH
LLFASGDQVFQVPIRGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDH
CPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSS
KLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFM
EPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPP
GATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWH
LVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPG
FRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMV
VCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAAL
ATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLD
STTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVI
GKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLAL
IGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKF
VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY
RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM
QQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQP
QFSPMPGNVRRPRPLSEPPRPT"
BASE COUNT 862 a 1384 c 1309 g 986 t
ORIGIN
1 ggatcctcta gggtcccagc tcgcctcgat ggagctcctc ccgccgctgc ctcagtcctt
61 cctgttgctg ctgctgttgc ctgccaagcc cgcggcgggc gaggactggc agtgcccgcg
121 caccccctac gcggcctctc gcgactttga cgtgaagtac gtggtgccca gcttctccgc
181 cggaggcctg gtacaggcca tggtgaccta cgagggcgac agaaatgaga gtgctgtgtt
241 tgtagccata cgcaatcgcc tgcatgtgct tgggcctgac ctgaagtctg tccagagcct
301 ggccacgggc cctgctggag accctggctg ccagacgtgt gcagcctgtg gcccaggacc
361 ccacggccct cccggtgaca cagacacaaa ggtgctggtg ctggatcccg cgctgcctgc
421 gctggtcagt tgtggctcca gcctgcaggg ccgctgcttc ctgcatgacc tagagcccca
481 agggacagcc gtgcatctgg cagcgccagc ctgcctcttc tcagcccacc ataaccggcc
541 cgatgactgc cccgactgtg tggccagccc attgggcacc cgtgtaactg tggttgagca
601 aggccaggcc tcctatttct acgtggcatc ctcactggac gcagccgtgg ctggcagctt
661 cagcccacgc tcagtgtcta tcaggcgtct caaggctgac gcctcgggat tcgcaccggg
721 ctttgtggcg ttgtcagtgc tgcccaagca tcttgtctcc tacagtattg aatacgtgca
781 cagcttccac acgggagcct tcgtatactt cctgactgta cagccggcca gcgtgacaga
841 tgatcctagt gccctgcaca cacgcctggc acggcttagc gccactgagc cagagttggg
901 tgactatcgg gagctggtcc tcgactgcag atttgctcca aaacgcaggc gccggggggc
961 cccagaaggc ggacagccct accctgtgct gcaggtggcc cactccgctc cagtgggtgc
1021 ccaacttgcc actgagctga gcatcgccga gggccaggaa gtactatttg gggtctttgt
1081 gactggcaag gatggtggtc ctggcgtggg ccccaactct gtcgtctgtg ccttccccat
1141 tgacctgctg gacacactaa ttgatgaggg tgtggagcgc tgttgtgaat ccccagtcca
1201 tccaggcctc cggcgaggcc tcgacttctt ccagtcgccc agtttttgcc ccaacccgcc
1261 tggcctggaa gccctcagcc ccaacaccag ctgccgccac ttccctctgc tggtcagtag
1321 cagcttctca cgtgtggacc tattcaatgg gctgttggga ccagtacagg tcactgcatt
1381 gtatgtgaca cgccttgaca acgtcacagt ggcacacatg ggcacaatgg atgggcgtat
1441 cctgcaggtg gagctggtca ggtcactaaa ctacttgctg tatgtgtcca acttctcact
1501 gggtgacagt gggcagcccg tgcagcggga tgtcagtcgt cttggggacc acctactctt
1561 tgcctctggg gaccaggttt tccaggtacc tatccgaggc cctggctgcc gccacttcct
1621 gacctgtggg cgttgcctaa gggcatggca tttcatgggc tgtggctggt gtgggaacat
1681 gtgcggccag cagaaggagt gtcctggctc ctggcaacag gaccactgcc cacctaagct
1741 tactgagttc cacccccaca gtggacctct aaggggcagt acaaggctga ccctgtgtgg
1801 ctccaacttc taccttcacc cttctggtct ggtgcctgag ggaacccatc aggtcactgt
1861 gggccaaagt ccctgccggc cactgcccaa ggacagctca aaactcagac cagtgccccg
1921 gaaagacttt gtagaggagt ttgagtgtga actggagccc ttgggcaccc aggcagtggg
1981 gcctaccaac gtcagcctca ccgtgactaa catgccaccg ggcaagcact tccgggtaga
2041 cggcacctcc gtgctgagag gcttctcttt catggagcca gtgctgatag cagtgcaacc
2101 cctctttggc ccacgggcag gaggcacctg tctcactctt gaaggccaga gtctgtctgt
2161 aggcaccagc cgggctgtgc tggtcaatgg gactgagtgt ctgctagcac gggtcagtga
2221 ggggcagctt ttatgtgcca caccccctgg ggccacggtg gccagtgtcc cccttagcct
2281 gcaggtgggg ggtgcccagg tacctggttc ctggaccttc cagtacagag aagaccctgt
2341 cgtgctaagc atcagcccca actgtggcta catcaactcc cacatcacca tctgtggcca
2401 gcatctaact tcagcatggc acttagtgct gtcattccat gacgggctta gggcagtgga
2461 aagcaggtgt gagaggcagc ttccagagca gcagctgtgc cgccttcctg aatatgtggt
2521 ccgagacccc cagggatggg tggcagggaa tctgagtgcc cgaggggatg gagctgctgg
2581 ctttacactg cctggctttc gcttcctacc cccaccccat ccacccagtg ccaacctagt
2641 tccactgaag cctgaggagc atgccattaa gtttgagtat attgggctgg gcgctgtggc
2701 tgactgtgtg ggtatcaacg tgaccgtggg tggtgagagc tgccagcacg agttccgggg
2761 ggacatggtt gtctgccccc tgcccccatc cctgcagctt ggccaggatg gtgccccatt
2821 gcaggtctgc gtagatggtg aatgtcatat cctgggtaga gtggtgcggc cagggccaga
2881 tggggtccca cagagcacgc tccttggtat cctgctgcct ttgctgctgc ttgtggctgc
2941 actggcgact gcactggtct tcagctactg gtggcggagg aagcagctag ttcttcctcc
3001 caacctgaat gacctggcat ccctggacca gactgctgga gccacacccc tgcctattct
3061 gtactcgggc tctgactaca gaagtggcct tgcactccct gccattgatg gtctggattc
3121 caccacttgt gtccatggag catccttctc cgatagtgaa gatgaatcct gtgtgccact
3181 gctgcggaaa gagtccatcc agctaaggga cctggactct gcgctcttgg ctgaggtcaa
3241 ggatgtgctg attccccatg agcgggtggt cacccacagt gaccgagtca ttggcaaagg
3301 ccactttgga gttgtctacc acggagaata catagaccag gcccagaatc gaatccaatg
3361 tgccatcaag tcactaagtc gcatcacaga gatgcagcag gtggaggcct tcctgcgaga
3421 ggggctgctc atgcgtggcc tgaaccaccc gaatgtgctg gctctcattg gtatcatgtt
3481 gccacctgag ggcctgcccc atgtgctgct gccctatatg tgccacggtg acctgctcca
3541 gttcatccgc tcacctcagc ggaaccccac cgtgaaggac ctcatcagct ttggcctgca
3601 ggtagcccgc ggcatggagt acctggcaga gcagaagttt gtgcacaggg acctggctgc
3661 gcggaactgc atgctggacg agtcattcac agtcaaggtg gctgactttg gtttggcccg
3721 cgacatcctg gacagggagt actatagtgt tcaacagcat cgccacgctc gcctacctgt
3781 gaagtggatg gcgctggaga gcctgcagac ctatagattt accaccaagt ctgatgtgtg
3841 gtcatttggt gtgctgctgt gggaactgct gacacggggt gccccaccat accgccacat
3901 tgaccctttt gaccttaccc acttcctggc ccagggtcgg cgcctgcccc agcctgagta
3961 ttgccctgat tctctgtacc aagtgatgca gcaatgctgg gaggcagacc cagcagtgcg
4021 acccaccttc agagtactag tgggggaggt ggagcagata gtgtctgcac tgcttgggga
4081 ccattatgtg cagctgccag caacctacat gaacttgggc cccagcacct cgcatgagat
4141 gaatgtgcgt ccagaacagc cgcagttctc acccatgcca gggaatgtac gccggccccg
4201 gccactctca gagcctcctc ggcccacttg acttagttct tgggctggac ctgcttagct
4261 gccttgagct aaccccaagg ctgcctctgg gccatgccag gccagagcag tggccctcca
4321 ccttgttcct gccctttaac tttcagaggc aataggtaaa tgggcccatt aggtccctca
4381 ctccacagag tgagccagtg agggcagtcc tgcaacatgt atttatggag tgcctgctgt
4441 ggaccctgtc ttctgggcac agtggactca gcagtgacca caccaacact gacccttgaa
4501 ccaataaagg aacaaatgac tattaaagca caaaaaaaaa a
//