LOCUS       X69141                  2051 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  H.sapiens mRNA for squalene synthase.
ACCESSION   X69141
VERSION     X69141.1
KEYWORDS    farnesyl-diphosphate farnesyltransferase; squalene synthetase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Charles A.D.
  JOURNAL   Submitted (09-NOV-1992) to the INSDC. A.D. Charles, ICI
            Parmaceuticals, Biotechnology Dept, Alderley Park, NR Macclesfield,
            Cheshire SK10 4TG, UK
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Summers C., Karst F., Charles A.D.
  TITLE     Cloning, expression and characterisation of the cDNA encoding human
            hepatic squalene synthase, and its relationship to phytoene
            synthase
  JOURNAL   Gene 136(1-2Che), 185-192(1993).
   PUBMED   8294001
FEATURES             Location/Qualifiers
     source          1..2051
                     /db_xref="H-InvDB:HIT000322964"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /dev_stage="adult"
                     /clone_lib="lambda ZAPXR (stratagene)"
                     /tissue_type="liver"
                     /db_xref="taxon:9606"
     CDS             92..1345
                     /product="farnesyl-diphosphate farnesyltransferase"
                     /EC_number="2.5.1.21"
                     /note="squalene synthase"
                     /db_xref="GOA:P37268"
                     /db_xref="H-InvDB:HIT000322964.13"
                     /db_xref="HGNC:HGNC:3629"
                     /db_xref="InterPro:IPR002060"
                     /db_xref="InterPro:IPR006449"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR019845"
                     /db_xref="InterPro:IPR033904"
                     /db_xref="PDB:1EZF"
                     /db_xref="PDB:3ASX"
                     /db_xref="PDB:3LEE"
                     /db_xref="PDB:3Q2Z"
                     /db_xref="PDB:3Q30"
                     /db_xref="PDB:3V66"
                     /db_xref="PDB:3VJ8"
                     /db_xref="PDB:3VJ9"
                     /db_xref="PDB:3VJA"
                     /db_xref="PDB:3VJB"
                     /db_xref="PDB:3VJC"
                     /db_xref="PDB:3WC9"
                     /db_xref="PDB:3WCD"
                     /db_xref="PDB:3WCF"
                     /db_xref="PDB:3WCH"
                     /db_xref="PDB:3WCI"
                     /db_xref="PDB:3WCJ"
                     /db_xref="PDB:3WCL"
                     /db_xref="PDB:3WCM"
                     /db_xref="PDB:3WEF"
                     /db_xref="PDB:3WEG"
                     /db_xref="PDB:3WEH"
                     /db_xref="PDB:3WEI"
                     /db_xref="PDB:3WEJ"
                     /db_xref="PDB:3WEK"
                     /db_xref="PDB:3WSA"
                     /db_xref="UniProtKB/Swiss-Prot:P37268"
                     /protein_id="CAA48896.1"
                     /translation="MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCY
                     KYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
                     FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDK
                     HVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIR
                     DYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITY
                     LSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAV
                     KAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVML
                     LAALSWQYLATLSQVTEDYVQTGEH"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT          551 a          449 c          499 g          552 t
ORIGIN      
        1 cgagacctac tccacaggtc cagccggccg gtgagcgcct ggggaccgca gaggtgagag
       61 tcgcgcccgg gagtccgccg cctgcgccag gatggagttc gtgaaatgcc ttggccaccc
      121 cgaagagttc tacaacctgg tgcgcttccg gatcgggggc aagcggaagg tgatgcccaa
      181 gatggaccag gactcgctca gcagcagcct gaaaacttgc tacaagtatc tcaatcagac
      241 cagtcgcagt ttcgcagctg ttatccaggc gctggatggg gaaatgcgca acgcagtgtg
      301 catattttat ctggttctcc gagctctgga cacactggaa gatgacatga ccatcagtgt
      361 ggaaaagaag gtcccgctgt tacacaactt tcactctttc ctttaccaac cagactggcg
      421 gttcatggag agcaaggaga aggatcgcca ggtgctggag gacttcccaa cgatctccct
      481 tgagtttaga aatctggctg agaaatacca aacagtgatt gccgacattt gccggagaat
      541 gggcattggg atggcagagt ttttggataa gcatgtgacc tctgaacagg agtgggacaa
      601 gtactgccac tatgttgctg ggctggtcgg aattggcctt tcccgtcttt tctcagcctc
      661 agagtttgaa gaccccttag ttggtgaaga tacagaacgt gccaactcta tgggcctgtt
      721 tctgcagaaa acaaacatca tccgtgacta tctggaagac cagcaaggag gaagagagtt
      781 ctggcctcaa gaggtttgga gcaggtatgt taagaagtta ggggattttg ctaagccgga
      841 gaatattgac ttggccgtgc agtgcctgaa tgaacttata accaatgcac tgcaccacat
      901 cccagatgtc atcacctacc tttcgagact cagaaaccag agtgtgttta acttctgtgc
      961 tattccacag gtgatggcca ttgccacttt ggctgcctgt tataataacc agcaggtgtt
     1021 caaaggggca gtgaagattc ggaaagggca agcagtgacc ctgatgatgg atgccaccaa
     1081 tatgccagct gtcaaagcca tcatatatca gtatatggaa gagatttatc atagaatccc
     1141 cgactcagac ccatcttcta gcaaaacaag gcagatcatc tccaccatcc ggacgcagaa
     1201 tcttcccaac tgtcagctga tttcccgaag ccactactcc cccatctacc tgtcgtttgt
     1261 catgcttttg gctgccctga gctggcagta cctggccact ctctcccagg taacagaaga
     1321 ctatgttcag actggagaac actgatccca aatttgtcca tagctgaagt ccaccataaa
     1381 gtggatttac tttttttctt taaggatgga tgttgtgttc tctttatttt tttcctacta
     1441 ctttaatccc taaaagaacg ctgtgtggct gggaccttta ggaaagtgaa atgcaggtga
     1501 gaagaaccta aacatgaaag gaaagggtgc ctcatcccag caacctgtcc ttgtgggtga
     1561 tgatcactgt gctgcttgtg gctcatggca gagcattcag tgccacggtt taggtgaagt
     1621 cgctgcatat gtgactgtca tgagatccta cttagtatga tcctggctag aatgataatt
     1681 aaaagtattt aatttgaagc accatttgaa tgttcgtaat agtagaaaat gatgtgaatt
     1741 ttctttctgt tcggctccta tttttctcat cattttgttt tctttaattg ggttgaatgg
     1801 agtagataga aatatttatg gtttaggtaa cagttagatg tttcctaaga atgcaaactg
     1861 ccttttccac acaaaggctg ggaataaaat tctgggtatt ctcgtattct catttaaagg
     1921 agtttagctt tcagagagaa acagcaggat tgcttttgac cttttagaag attggtctcc
     1981 agtaaaggtg gacatttttg agatttttat aataaagaat ttaattgctc tgcaaaaaaa
     2041 aaaaaaaaaa a
//