LOCUS X69078 3228 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for S-adenosylmethionine synthetase.
ACCESSION X69078
VERSION X69078.1
KEYWORDS methionine adenosyltransferase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3228)
AUTHORS Mato J.M.
JOURNAL Submitted (02-NOV-1992) to the INSDC. J.M. Mato, Instituto de
Investigaciones Biomaicas, c/ Arturo Duperier No. 4, 28029 Madrid,
SPAIN
REFERENCE 2 (bases 1 to 3228)
AUTHORS Alvarez L., Corrales F., Martin-Duce A., Mato J.M.
TITLE Characterization of a full-length cDNA encoding
S-adenosylmethionine synthetase: tissue-specific gene expression
and mRNA levels in hepatopathies
JOURNAL Biochem. J. 293, 481-486(1993).
PUBMED 8393662
FEATURES Location/Qualifiers
source 1..3228
/db_xref="H-InvDB:HIT000322954"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="pSHL"
/cell_line="lambda gt11 cDNA"
/tissue_type="liver"
/db_xref="taxon:9606"
CDS 72..1259
/gene="SAM"
/product="methionine adenosyltransferase"
/EC_number="2.5.1.6"
/db_xref="GOA:Q00266"
/db_xref="H-InvDB:HIT000322954.14"
/db_xref="HGNC:HGNC:6903"
/db_xref="InterPro:IPR002133"
/db_xref="InterPro:IPR022628"
/db_xref="InterPro:IPR022629"
/db_xref="InterPro:IPR022630"
/db_xref="InterPro:IPR022631"
/db_xref="InterPro:IPR022636"
/db_xref="PDB:2OBV"
/db_xref="UniProtKB/Swiss-Prot:Q00266"
/protein_id="CAA48822.1"
/translation="MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDA
HLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFK
TCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKL
NARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEM
RRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGA
HGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFT
YGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRK
LVF"
BASE COUNT 728 a 866 c 904 g 730 t
ORIGIN
1 aaaaaactca ggcaaagtca cagcctcaaa attgttcact gaaagaacgc tgagtggaga
61 agtgtgagaa gatgaatgga ccggtggatg gcttgtgtga ccactctcta agtgaaggag
121 tcttcatgtt cacatcggag tctgtgggag agggacaccc ggataagatc tgtgaccaga
181 tcagtgatgc agtgctggat gcccatctca agcaagaccc caatgccaag gtggcctgtg
241 agacagtgtg caagaccggc atggtgctgc tgtgtggtga gatcacctca atggccatgg
301 tggactacca gcgggtggtg agggacacca tcaagcacat cggctacgat gactcagcca
361 agggctttga cttcaagact tgcaacgtgc tggtggcttt ggagcagcaa tccccagata
421 ttgcccagtg cgtccatctg gacagaaatg aggaggatgt gggggcagga gatcagggtt
481 tgatgttcgg ctatgctacc gacgagacag aggagtgcat gcccctcacc atcatccttg
541 ctcacaagct caacgcccgg atggcagacc tcaggcgctc cggcctcctc ccctggctgc
601 ggcctgactc taagactcag gtgacagttc agtacatgca ggacaatggc gcagtcatcc
661 ctgtgcgcat ccacaccatc gtcatctctg tgcagcacaa cgaagacatc acgctggagg
721 agatgcgcag ggccctgaag gagcaagtca tcagggccgt ggtgccggcc aagtacctgg
781 acgaagacac cgtctaccac ctgcagccca gtgggcggtt tgtcatcgga ggtccccagg
841 gggatgcggg tgtcactggc cgtaagatta ttgtggacac ctatggcggc tggggggctc
901 atggtggtgg ggccttctct gggaaggact acaccaaggt agaccgctca gctgcatatg
961 ctgcccgctg ggtggccaag tctctggtga aagcagggct ctgccggaga gtgcttgtcc
1021 aggtttccta tgccattggt gtggccgagc cgctgtccat ttccatcttc acctacggaa
1081 cctctcagaa gacagagcga gagctgctgg atgtggtgca taagaacttc gacctccggc
1141 cgggcgtcat tgtcagggat ttggacttga agaagcccat ctaccagaag acagcatgct
1201 acggccattt cggaagaagc gagttcccat gggaggttcc caggaagctt gtattttaga
1261 gccaggggga gctgggcctg gtctcaccct ggaggcacct ggtggccatg ctcctcttcc
1321 ccagacgcct ggctgctgat cgccttcccc acccaccaac cctcagggca aagccaggtc
1381 cctctcattt agcctgtcct gtcatcatca tggccagctg gaggcagggg cttcctggtg
1441 ctggaggttg gatcttgatg taaggatggg catggtgttc tcctgctgct ccctcagact
1501 ggggcaatgt taatttagtg gaaaaggcac ccccgtcaag agtgaattcc ctcactcgtc
1561 tcccccaaca gctggaccct gaccagctcc ccctccctcc ccttgcctgt gccaggtgag
1621 gtcagcacat ctcaacaggc ctcagggctc cttgtgggcc tgggctcctg gacccccctt
1681 tcacaggcag ccagtgccct gagccagggt ctccagaaag ccccacccag gccaggcatg
1741 tggcaggggt tagagcagga ctgatgtctc ctaagcacct gtaatgtgcg agggacccag
1801 ctaataactg atctcgtttt ttcttcactg caacatgatg aggtagtacc ttttatatcc
1861 catttataga tgggggaaag caaagcacag agagtctgga taacttccac agggtcccac
1921 agccacgtgt ttagacctag atgtataact aggagctttg actcaggagc ctgtgacata
1981 cccccttccc caccgttgtc tcatgccagt aacaggctca aacaatgaca aagcagattc
2041 agaaatgagg ccatggactc tgtcctgaag gcctgaggtt actggaaatt aggggattaa
2101 cccactagct cttgttgagc cgtgggcaat tgtctgaaaa gtgaagacag aaccacaggg
2161 ctattttgtt tgcttcatgt gtcccagaag atgactgagg gtgagttggc ttacctggcc
2221 catcagggta ggctggagtt agggactgac cagcagcttt agaatcccag ccccctgacc
2281 actcagagac atgcagagat tgggtttttg gacttctggg gtaagtggtc taagtccagt
2341 ccagtcctat gtgggcttcc tggagcagaa gcagcaactt gtcctagcac agatggccag
2401 ccccttagac agaggccctc aagtctttct ctttccctgg tcccttgtat cccctgcagg
2461 ctgagtgcat ttggagggag tgagtggccc tttcggatcc agggaggctg gtcctatggc
2521 ctcatgttaa ataggcgggg cttgccttct ggtgttggac aagcttctga gacgtcatga
2581 ggagattctg cctttgccag gtgactgtct ggggagcggg tctgctccca aggggcctga
2641 gcagtccttg gcctgctaag gtcttggaac ttgcctgcct ttccatccat ggccagcagc
2701 acctgcccta cctgccccac ttgtccttag cctggacctc tgacagcagc atctctacct
2761 tctccccagc tcccaggacc acaggctcag gcagggcctc catgggcccc aggggaacac
2821 tggggacttg gcctctctct agggtacatg gtgctgggag aggcagccca ggaagtctca
2881 tctggggagc aggcagccag catctgggcc ttggcctgga gcacaaagac cctggctttc
2941 attttctctc aggtgaaagg aaattaaggc aacaaaagaa gcccggctcc tggtcaccta
3001 ggaagcctca gattccttcc catggaggga gggagtggtt tgcaggtggc caagttcctc
3061 taacttggct cacactcgac atgaaaattc agaattttat actttcccta ccctctagag
3121 aaataagatc ttttttgtca gtttgtttgt atgaaactaa agctttattt gttaatagtt
3181 cctgctaaaa caatgaataa aaactcaagg agcaactaaa aaaaaaaa
//