LOCUS X68793 14206 bp DNA linear HUM 14-NOV-2006
DEFINITION H.sapiens gene for antithrombin III.
ACCESSION X68793 S52236 S52240
VERSION X68793.1
KEYWORDS antithrombin; antithrombin III gene; AT3 gene; plasma protein;
serine proteinase inhibitor; serpin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 14206)
AUTHORS Olds R.
JOURNAL Submitted (12-OCT-1992) to the INSDC. R. Olds, Institute of
Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK
REFERENCE 2 (bases 1 to 14206)
AUTHORS Olds R.J., Lane D.A., Chowdhury V., De Stefano V., Leone G.,
Thein S.L.
JOURNAL Biochemistry 0, 0(0).
REFERENCE 3
AUTHORS Bock S.C., Marrinan J.A., Radziejewska E.
TITLE Antithrombin III Utah: proline-407 to leucine mutation in a highly
conserved region near the inhibitor reactive site
JOURNAL Biochemistry 27(16), 6171-6178(1988).
PUBMED 3191114
REFERENCE 4
AUTHORS Olds R.J., Lane D.A., Ireland H., Leone G., De Stefano V.,
Wiesel M.L., Cazenave J.P., Thein S.L.
TITLE Novel point mutations leading to type 1 antithrombin deficiency and
thrombosis
JOURNAL Br. J. Haematol. 78(3), 408-413(1991).
PUBMED 1873223
COMMENT related sequences: M21636-M21645
FEATURES Location/Qualifiers
source 1..14206
/organism="Homo sapiens"
/chromosome="1"
/map="q23-25"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
variation 152..259
/note="polymorphism"
/citation=[3]
exon <605..645
/number=1
CDS join(605..645,2944..3310,5843..6058,6964..7101,7912..8302,
10336..10400,13775..13951)
/gene="AT3"
/product="antithrombin"
/db_xref="GOA:P01008"
/db_xref="HGNC:HGNC:775"
/db_xref="InterPro:IPR000215"
/db_xref="InterPro:IPR015555"
/db_xref="InterPro:IPR023795"
/db_xref="InterPro:IPR023796"
/db_xref="InterPro:IPR033829"
/db_xref="InterPro:IPR036186"
/db_xref="InterPro:IPR042178"
/db_xref="InterPro:IPR042185"
/db_xref="PDB:1ANT"
/db_xref="PDB:1ATH"
/db_xref="PDB:1AZX"
/db_xref="PDB:1BR8"
/db_xref="PDB:1DZG"
/db_xref="PDB:1DZH"
/db_xref="PDB:1E03"
/db_xref="PDB:1E04"
/db_xref="PDB:1E05"
/db_xref="PDB:1JVQ"
/db_xref="PDB:1LK6"
/db_xref="PDB:1NQ9"
/db_xref="PDB:1OYH"
/db_xref="PDB:1R1L"
/db_xref="PDB:1SR5"
/db_xref="PDB:1T1F"
/db_xref="PDB:1TB6"
/db_xref="PDB:2ANT"
/db_xref="PDB:2B4X"
/db_xref="PDB:2B5T"
/db_xref="PDB:2BEH"
/db_xref="PDB:2GD4"
/db_xref="PDB:2HIJ"
/db_xref="PDB:2ZNH"
/db_xref="PDB:3EVJ"
/db_xref="PDB:3KCG"
/db_xref="PDB:4EB1"
/db_xref="UniProtKB/Swiss-Prot:P01008"
/protein_id="CAA48690.1"
/translation="MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKP
RDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSK
NDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNC
RLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAI
NKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADG
ESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPE
VLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRD
DLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLN
TIIFMGRVANPCVK"
mRNA join(<605..645,2944..3310,5843..6058,6964..7101,
7912..8302,10336..10400,13775..>13951)
/gene="AT3"
intron 646..2943
/number=1
repeat_region complement(2193..2469)
/note="Alu repeat element"
exon 2944..3310
/number=2
intron 3311..5842
/number=2
repeat_region complement(3784..3965)
/partial
/note="Alu repeat element"
repeat_region complement(4007..4284)
/note="Alu repeat element"
exon 5843..6058
/number=3
/note="A"
intron 6059..6963
/number=3
/note="A"
exon 6964..7101
/number=3
/note="B"
intron 7102..7911
/number=3
/note="B"
repeat_region complement(7277..7558)
/note="Alu repeat element"
exon 7912..8302
/note="4"
variation 8131
/replace="a"
/note="polymorphism"
variation 8160
/replace="a"
/note="polymorphism"
/note="Pst1 site"
intron 8303..10335
/number=4
variation 8521
/replace="t"
/note="Nhe1 site"
/note="polymorphism"
repeat_region 8670..8687
/rpt_family="att"
repeat_region complement(8692..8951)
/note="Alu repeat element"
repeat_region 8994..9264
/note="Alu repeat element"
repeat_region complement(8994..9264)
/note="Alu repeat element"
repeat_region complement(9362..9633)
/note="Alu repeat element"
repeat_region 9823..9867
/rpt_family="att"
repeat_region complement(9871..10152)
/note="Alu repeat element"
exon 10336..10400
/number=5
intron 10401..13774
/number=5
variation 10427
/replace="c"
/note="Dde1 site"
/note="polymorphism"
repeat_region complement(10732..11011)
/note="Alu repeat element"
repeat_region complement(12124..12405)
/note="Alu repeat element"
exon 13775..13951
/number=6
BASE COUNT 3715 a 3338 c 3217 g 3936 t
ORIGIN
1 ccacaggtgt aacattgtgt tttccttgtc tgtgccaggg acaccttggc atcagatgcc
61 tgaaggtagc agcttgtccc tctttgcctt ctctaattag atatttctct ctctctctcc
121 ctctctccat aaagaaaact atgagagagg gaattacagg tagagggcta gaagtttttg
181 gacattaact atttctatct tctgatttag ttaacgagaa acaaaaaatc ctgcagacaa
241 gtttctcctc agtcaggtat ttcctaacca agtttgaggg tatgaacata ctctcctttt
301 ccttttctat aaagctgagg agaagagtga gggagtgtgg gcaagagagg tggctcaggc
361 tttccctggg cctgattgaa ctttaaaact tctctactaa ttaaacaaca ctgggctcta
421 cactttgctt aaccctggga actggtcatc agcctttgac ctcagttccc cctcctgacc
481 agctctctgc cccaccctgt cctctggaac ctctgcgaga tttagaggaa agaaccagtt
541 ttcaggcgga ttgcctcaga tcacactatc tccacttgcc cagccctgtg gaagattagc
601 ggccatgtat tccaatgtga taggaactgt aacctctgga aaaaggtaag aggggtgagc
661 tttccccttg cctgccccta ctgggttttg tgacctccaa aggactcaca ggaatgacct
721 ccaacacctt tgagaagacc aggccctctc cctggtagtt acagtcaaag acctgtttgg
781 aagacgtcat ttcaagtgct ctccctccca ccccacctct tggggtaagg cctttcctaa
841 gctacccctt gggtccctag cctaagaaac aagggggatg tcatccctgg tgtaaagatg
901 ctgtgcagga agtcagcact cacgggatcc aggggacgct ccaaggggaa tccccagggc
961 ctgccatcca tccgggaaga gagcaaatgc tacccatgag gacctcctca ctcccttttt
1021 gctctttctt ccactcagat ccaccccact ccacccccac ccaaatccca gtgacctttg
1081 actaaagggc caaaactgct tccttttctc acaatgagag ttgtccctcc ctcaatgcca
1141 cacacactcc cttcttcatc tgagttgtca caggaggcta gaaacggggt ggtggcacaa
1201 ctgtcttggt tttaatttgt gcttcatagc cctcccaggt cctctcagcc tcaaattgca
1261 tttccaaatg tagttgaagg gacagagtgg gcaaccgaag cagcagtgga gatgggaaga
1321 tgaatggcag ggtcctctcc tctctctctc tgcttcttca gcctgccttc cacatctccc
1381 ttggtgccgc tgcttctctc cggctttgca cctctgttct tgaaagggct gcagaactgg
1441 actcagacca cgcaagaagg caagtccccc tcagctgccc cagcttccag ccagccccag
1501 gcttgcccaa cggaccacgt ccgtgaatct gcactgggtg cctgtctttc tctcccagga
1561 gaagatggga agatccagta cccacacaca gacccccttg tgtacacgca ggaaccataa
1621 accagctgga ggcagcccct gccccaccct gtcttatcta caaaaaatat tacaagagac
1681 tttatctctt gatttgcttc atcgagtgtc ccaactacct cattttttta aaatgtgaaa
1741 ttagcttcat ttaccttcat tgaatccatg ttggcgacta ttaaaaattc caggcaataa
1801 aaagggatga gagcctgaac taaagcagtg gcaataactg gtgaaagagt aaaaaaacag
1861 aactgattga ctctggggtg aactgattga ctctggggtt tgactaaatg aggaggagag
1921 agggaggaat ccagggtgat tctcaggttt ctgtacggga ttcactgagc ccactcacag
1981 gagcaggcct gtgggggaga attaattacc agttcagttt ggtcctgttt ccctgaagaa
2041 cttgtaggag ttcctggtgg aactgtccag caaatagtca gtctggagct cagtggaagg
2101 gttagggctg gagctagaga tgtaggaatc ttcagcacac agatattgcc attgtttttg
2161 tttgtttgtt tgtttgttgt tgctgttttg aagacacagt ctcactttgt cacccaggtt
2221 ggaggtcagt ggcacaatct cagctcactg caaccttcgc ctcctgggtt caagtgattc
2281 ttctgcctca gcctccctag tagcttggga ctacagtgtg cgccaccaca cccagctaat
2341 ttttgtattt ttagtagaga cagggtttca ccatgttgtc caggctgatc tcgaacaccc
2401 aacctcaagt gatctgcatg cctcagcctc caaagtgctg ggattacagc gtgagccacg
2461 cacccggcca gatattgcct ttgctccatc catttcttct ttttctcttg tgttgctgaa
2521 atctctctgc ctgcatctat cagagtcctt ccccaaacag tttctgtaga tggctccccc
2581 taccaccctg actcttcact gggcactaaa gccgattttt taggcatgca cattccatgt
2641 cacaaacagg aagcttctca ttcttttttc tcccagcgtg gggaattgag cacataatac
2701 tccaaataac catcagatga ttctaattcc aacatgacca cgtccaggca actgaactgt
2761 cccctggcaa gaagtctagg actgaacctg tcccgggccc ctgtacttgg ttcaaaggat
2821 ttagcctttc tcttggccac accaggtggg ctggaatcct ctgctttact ggggcaaccc
2881 tgtggtgggc agtggggcta ggggttgcag cctagcttaa cttggcattt tgtctccttg
2941 caggaaggtt tatcttttgt ccttgctgct cattggcttc tgggactgcg tgacctgtca
3001 cgggagccct gtggacatct gcacagccaa gccgcgggac attcccatga atcccatgtg
3061 catttaccgc tccccggaga agaaggcaac tgaggatgag ggctcagaac agaagatccc
3121 ggaggccacc aaccggcgtg tctgggaact gtccaaggcc aattcccgct ttgctaccac
3181 tttctatcag cacctggcag attccaagaa tgacaatgat aacattttcc tgtcacccct
3241 gagtatctcc acggcttttg ctatgaccaa gctgggtgcc tgtaatgaca ccctccagca
3301 actgatggag gtacgaccaa aggtcttctg cccagccacc ttgttaggag cacctttggg
3361 cttccatagg cccaagtcca atgattcctc aaccaacact gcagccacta ggggcgctca
3421 ttatgcatta cgattccctt tgaacatcac tgtgttataa ttccctttga aaatcatttt
3481 ttaaaaaatt agccaaggaa tcttggctat ctacttttta aatcctggtt tcctcttttg
3541 agcaccttaa aatgggggaa ggcttgtatc ttctctcaac ttcttttcag taattctttc
3601 atctatatgt ttactcatta atttgatcat ttatttattt attcattcag cacttcctct
3661 gtgccaggca atgtgtagtg ccagtccctc ctctggtgga agaagagtag ctttaccata
3721 tggtgacatc aggcatatag gctctcgtgg aaaaaaattc taggatagta tttttttttt
3781 tttgagatgg aatctcgctc tattgcccag gctggagtgc agtggtgcag tctcggctca
3841 ctccaaactc tgcctcccag gttcaagcaa ttctcccacc tcagcctcct gagtagatgg
3901 gattacaggc acacgccatc acgcccagct aatttctata tttttagtag agatggggtt
3961 tcaccacgtg gccagactgg tctcaaactt tttttttttt ttttttgaga cggagtctcg
4021 ctctgtcatc caggctggag cgcagtgcac gatctcagct cactgcaacc tctacctccc
4081 gggttcaagc aattctcagc ctcagcctcc cgagtagctg ggattacagg cccccggcac
4141 catgcctggc taattttttt tcttcttagt agagatgggg tttcaccatg ttggccaggc
4201 tagtcttgaa ctcctgacct cgtgatccac ctgccttggc ctcccaaagt gctgtgatta
4261 caggcgtaac gaccgcgcct ggcctcaaac tcttgacttc aagggatcgg cctgacttgg
4321 cttcccaaag tgctgggatt acaagcatga gccactgcac ggggcctagg atggtatatt
4381 gagaccaggg gcccaggaaa gccaagagaa gcctcaagga cgtgagagtg tttctggctc
4441 tgggaagtat ggatcatttc agctcagtga cttagttccc acccccttcc ccccactgcc
4501 ttttgtggga gggaagtagg gcatgataag atgaaatgtc atagattgat tgatcactgt
4561 tggcctctgg ggctatgaca agtcatggat ggaaacacta gatctttaat ctgtccttgg
4621 cttggctgca tgacagtctt tcttcaagtt ggatcacact ttggaagcag agttcatcaa
4681 tagggaggca tgagtccctt caagatggta tacggtgctt atttgaaact tggacactaa
4741 agtctgtggg tcttaggagg gttccttcta ttctagtggt caatttccat ggaacttcat
4801 cacctttgct cagggctctg gggtgagtta acccaagtct tcactctttg aaagaaattg
4861 tagatttaaa aactctgaag acacataata ctgccttctc tgggcccttc agtcattttt
4921 gtatacattg gtactggtct caaagtactt ccatatcact catgtctctg tccccaggta
4981 agatcttaaa tgtaaccctt cctacaagaa gaacagaaca gaacactgct tccaaaccac
5041 acatgttcct ttggtcctcc cctctacaca aacgccatgt gttgggaaag cagggtgaga
5101 ctaaatctct ctggagaaaa gagaaattca gcaccaagct tttgatcaaa agcataatcc
5161 ccccctaaaa aaagtgccta ttggagcaaa atcaggaaaa ccaaaggcag agaacagata
5221 aaaccaaaag gccttttgta gcctgaggag agagcatgga aagggcagga ggggaacagc
5281 ctcacccatt ttgccttggg gatggtgaag gtgggcattg ggggattcca acttcaaagc
5341 atggatgact tctaagtcct tttcagccct gagctcttag attctgagcc tgtttaatcc
5401 cttgctgata gattcactct tcctttttca cccctaccac cagtatccca gagcctccat
5461 gagcagctgg ccccagtaga tgccacaaaa gtgtttgtta cgagaaggac accgtctgat
5521 tctcttctct gtccagaatc accaagagga cttttcccat tccagcaaga aaacgtctgt
5581 gtgttgatct agaggcgttt agagacttta ggtggcaacc tagtctctct ttttcccttt
5641 atccttccta cccttcattc ttcttttatc cttttattca tcagaacaca agagttgagc
5701 atttatgctg tcccaggtac tgtgcttgaa ggagttaaca actgaggtgg ctattagtca
5761 gagactgacc agcatgtgct caccacccat gttaactagg cagcccacca aacccaccac
5821 catttttttt tgacttctat aggtatttaa gtttgacacc atatctgaga aaacatctga
5881 tcagatccac ttcttctttg ccaaactgaa ctgccgactc tatcgaaaag ccaacaaatc
5941 ctccaagtta gtatcagcca atcgcctttt tggagacaaa tcccttacct tcaatgagac
6001 ctaccaggac atcagtgagt tggtatatgg agccaagctc cagcccctgg acttcaaggt
6061 gagttgcaga tgttacccct gacctccgag ttcttcctct ccactcagag attgaggagg
6121 tggagaaaca gcatccaaat tcacactgct ttgctgctga agactgctgg agggctgact
6181 aaaagttaga acccctgcaa tagttattct tacttgaaac ctgagaaatc aaaggtatcc
6241 atgcttggat tgtagtgact gcccagaaaa catgaattaa taatcaattc ttcattccat
6301 ccaccaactt caaatatata ccaaagggtg ttttgaagat gccagttcta caagatatct
6361 tacttaattt gaactgttat catggtcaaa taaagttggt acatgatgca tgttacattc
6421 tcctcttgga gattcatgaa gcacatgggc ctatgaaggt tctgagaaac tctgcaacaa
6481 agaaatctgt tggctttatt caatcggcat tcctcaaatg tatttgactg catgggcatt
6541 tctctcctcc atataacctg ccaaccccat ataacctgcc aaccccatat aacctgcaat
6601 cattcattgc ttcccctggc acatgccttg gaaattctac ttttgtgagt taaggttttc
6661 caaagtcaga gaaaataata ttttatcttc tttttcccag actattttcg ccttccttct
6721 tttcatttat ttcttcctat ttctttttgt ctttttcttc tgataatatt tattaactac
6781 aggaaagatt catggaacta tattagatat gtgaggcttc ccaatttggg ttagagcaat
6841 ggcttcttaa tcaaatggtg ggaaaggaca gagggatggt gagaaaaata aaatgctgcc
6901 tgggaaaatg gagaagccaa ttgaatagca caggtgagta ggtttatttt ctgttctcct
6961 caggaaaatg cagagcaatc cagagcggcc atcaacaaat gggtgtccaa taagaccgaa
7021 ggccgaatca ccgatgtcat tccctcggaa gccatcaatg agctcactgt tctggtgctg
7081 gttaacacca tttacttcaa ggtactcaga atggccctgg agagacccca gggacttcct
7141 cttgctcttc agcttacccc cttttttttt aaatggcgag accgaagccc tgagagggca
7201 aatggactgc cgaaagctac acaggtacag gtcagcaggg caggtcaatc tattatttat
7261 ttatttattt atttttgaca gagtctcgct ctgtcgccca ggctggagtg cagtggcgtg
7321 atctcggctc actgcaagct tcgcctcctg ggttctcggc attctcctgc ctcagcctcc
7381 caagtagctg ggaatacagg cacccaccac catgcctggc taattttttg gttttttttt
7441 agtaaagacg gggtttcacc gtgttagcca ggatagtctt gatctcctga cctcgtgatc
7501 tgcccacctc ggcctcccaa agtgctggga ttacaggcat gagccaccgc gcccggcaga
7561 ttggcttctt tcacctagta aaatgcattt actgttcctt tgtgttttcg tggctttgtc
7621 actcatttct tcttagcatg gaatagcatt acatttggtc tggatgtacc acagtctgtc
7681 tattcatcta ctgaaggaca ttttggctgc ttccaaggtt tgacagttat gaataaacct
7741 actcataatt ccatcattct gacacagcca ttgttaacct ttttgtgcat atcccgccag
7801 tcttttttcc gaataattat atattaatgt aacactataa tatggatatg tctgtgtcaa
7861 taactatcct cctatgaatg tttgtgttct tactttgtga ttctcttcca gggcctgtgg
7921 aagtcaaagt tcagccctga gaacacaagg aaggaactgt tctacaaggc tgatggagag
7981 tcgtgttcag catctatgat gtaccaggaa ggcaagttcc gttatcggcg cgtggctgaa
8041 ggcacccagg tgcttgagtt gcccttcaaa ggtgatgaca tcaccatggt cctcatcttg
8101 cccaagcctg agaagagcct ggccaaggtg gagaaggaac tcaccccaga ggtgctgcag
8161 gagtggctgg atgaattgga ggagatgatg ctggtggtcc acatgccccg cttccgcatt
8221 gaggacggct tcagtttgaa ggagcagctg caagacatgg gccttgtcga tctgttcagc
8281 cctgaaaagt ccaaactccc aggtttgtct aggaaggagt ttcctccctt ctccacccgc
8341 aaggtagtct gaccaaaagt ggaagagttg gagaaagaat agaaaggagc aacaagtcag
8401 gactcctgga tactgatcct agtttctact gctaatttgt ggaaatctct tttccttttg
8461 agacctcagt ttcctcttct gtaaaaggga agtttgttct tggatctcca tgggcccagc
8521 cagcactggt gccctgtgag tctgtatcag gtagaggaga tgggaccagg tggagaggaa
8581 tttgaaaggg cattggaatt cagagcaaag agacagatat taagagctgg ggaaatgtgg
8641 ttcccattac acaggcctca ctgacattta ttattattat tattattact tgagacagag
8701 tcttactctg ttgcccaggc tggagtgcag cggtgcgatc tcggctcact gcaacctctg
8761 cctcccgggt tcaagcgatt ctcatgcctc agcctcctga gtagctggga ttacaggcac
8821 acgtcaccat acctggtaat ttctgtattc ttagtagaga tgggtttcac catgttggcc
8881 aggatggtct tgaactcttg accttgtgat ccgcctgcct tggcttccca aagtgctggg
8941 attacaggcg tcacgaccgc acctggcaca ttaaaatatc ttttaaagaa gttggctggc
9001 cagggtggct cacgcctgta ataccagcac tttgggaggc tgaggtggga ggatcgtcta
9061 agcccatgag ttcgagacca gcctggacaa catagtgaga tggtctctac aaaaaataaa
9121 aaaaattagc caggcatggt gacgcacacc tgtagtccta gcttcttggg aggcagagct
9181 gggaggattg cctgagtccg ggaggtcaac gctgtggtgt actgtgatca caccactgca
9241 ctccagcctg agcaacagag tgaggtccta tcactaaata aataaataaa taataaaata
9301 gtttacgatg ttaagtaatt agatttatct ttattgacct tttttttttt tttttttttt
9361 tgagacgaag tcttgctctt gtcccccagg ctggagtgca gtggtgcaat cttggctcac
9421 tgcaacctcc accccccaga ttcaagtgat tctcctgcct cagcctccca aggagctagg
9481 attacaggcg cctgccacca cgcccggcta atttttgcat ttttagtaga aacggggttt
9541 cactatgttg gccaggctgg tcttgaactc ctgacctcag gcgatctacc tgccttggcc
9601 tcccaaagtg ctgggattac aggcgtgagc cactgtgcta ttgggctgtc tttaagctag
9661 ttttgaaaac taaaaatgtt gccagactgg aaagaaagat gttccttctg gatggagtga
9721 gttttttctg taagaacaga gtcttgccgt tctctctcca caaaaagctg aagcctgaga
9781 atgaattatc aggagccatg ctgaacaagc ccaaagtact ttattattat tattattatt
9841 attattatta ttattattat tattattttt gagatgcagt tttgctcttg ttgcccaggc
9901 tggagtgcag tggcgtgatc ttggctcact gcaacctcca cctcccgagt tcaagcgatc
9961 tcctgcctca gtcttccaag tagctgggat tacacgatgc gccaccacac ctggctaatt
10021 tttgtatttt cacgatagag acaaggtttc accatattag ttagagtgtc tccaactcct
10081 gacctcaggt gatctgtaca ccttggcctc ccgaagtgct gggattacag gtgtgagcca
10141 ctgcacccag cccccaaagt actttattat ttttaacaca tattcattgt gagagtatga
10201 ttaggtgaag atttaggatt tcttcttatg tttcaaaaag ccccaaagga tctcttaatc
10261 caaactgaat tcccatctgt ggattgaagc caactttctc ccatctcaca aagacttctc
10321 cggtcttcct tccaggtatt gttgcagaag gccgagatga cctctatgtc tcagatgcat
10381 tccataaggc atttcttgag gtgagtacac cttccccact ctcttagggt acagaaagga
10441 gatgcatgaa cagcaggaac acgtggaaaa ggcctgtttc cagtgttaag gcatgcaaaa
10501 ggcctccaca ggctgctata atacagccct ctccaaaacc ttcatggtgt gattgttctg
10561 ccttccctcc cactacctct tctgtagcag gtcaagcggg aacacaaaca tttagggagg
10621 gtgatatagg aaaagaagcc agcaaaggcc atcaagaaga aatttacagc atgaggagaa
10681 ccagaagagt atggggtcgc agaaacccag ggagaatttt tttttttttt tgagacagag
10741 cttcgttcgc tcgttgccca ggctagagtg caatggtgcg acctcactac aacttctgcc
10801 tcccgcgttc aagcgattct cctgcctcag cctcctgggt agctgggatg acaggcatgt
10861 gccatcacgc ccggctaatt tttgtatttt tagtagaaac agggtttctc catgttggtc
10921 aggcaggtct tgaactcccg atctcaggtg atccacctcc ttggctcccc caaagtgctg
10981 ggattacagg catgagccac tgcacccggc catacctagg gagaagtttt aagaaaatgg
11041 atagcatcta gtaagaagac tcctgggctg ggcatggtgg ttcacacctg taaccccagc
11101 accttgggag gctgagatgg aagatcactt tgagcccagg agtttgcaac cagccctgag
11161 caacatagtg agaccctgtc tctaccaaaa aaatcttaaa aaaaaaaaaa aaagtttgga
11221 gactgcccat agtttacctt tccctgagga cagaatagtg tggccacatg cctaattgta
11281 atggatgaag agcaaatgga aggtaagaaa gggaagctgg tgagtgtgca tcagtgtctt
11341 aaagtgtgct ccaactagag cactagacta cactggagga aacgaaaagg tggtcaaata
11401 aatgcatatc ctctcatggg agatgaacag tacacactga catgctgagg tctgacaagt
11461 cccacagtaa agaagacggt tgaatatcac ttaacgtgtt cccccaaatg agatgtgcat
11521 ggaaccctgt gttagagtaa tagcgtgtac agcctgtgga acttctggtt ctcaagtaaa
11581 cactaaacta tggaccaaca gcagtagtta tctggggagc tttatctttg gagattctgg
11641 atgggccctg agaatctctg tatgtactaa actcctcagg ggattcttat gcaaacaatg
11701 agatttggga accactggta tagactattt tttgcgggag ccaggctgtg agggatagga
11761 gattggacaa tggtagagat gttcctagaa tcaaagaaat cgaaaagaat gaaggttgta
11821 gtcaaagaga aaggtttcag aggatggtgc taagtaaata tagatccagg gatcaaactc
11881 agaggaaagt ggaattttaa cgggagcgag gaaatgtgat agcttgaaag aacccagtta
11941 taatctgaga aagatgctat taatataatt tcaaaggtag agtagttctg agatggcaag
12001 tccaaggtat agccatggac aggtttgctt aagtggaata aggcaatgct cattaggttt
12061 gatgaaagaa atgggagact agggtgttga acgggtctcc taatgagatt tttttttttc
12121 attgaaatgg agtcttgctc tctcgcctag gctggaatgc agtggtatga tctcagttca
12181 ctgcaacctc cgcctcctgg gttcaagcga tcctctcgcc tcagcctccc aagtagctgg
12241 gactacaggt gcccgccacc acgcccgact aaatttttgt atttttagta gagacggggt
12301 ttcaccatgt tggccaggct ggtctcaaac tcctgacctt aagtgatcca cctgactcgg
12361 cctcccaaag tgctgggatt acaggcatga gccacgtgcc cggcctactg agatattttt
12421 aattgcctca aatgatagca ggagttggag tggacagaaa ggctaagtgc aaaaatcatc
12481 agtgtgggga tataatctat aggacaatga atgtcaatga cctttaagac aatagcaaga
12541 gtagaggtat tgaggtcaga acaagggatt ttacaagagt gctgtattaa tggttttgga
12601 agttaagatg acactgctca caccctcttt cacatggatt tttggaagaa agaacactta
12661 ggaagactgc aagggaaatt gagtcctcag ggttttaact ctcattgaat atcctctggt
12721 aaggactcca gttagaagtg gtcaactcag acctccttga ggggtctgag ttactattag
12781 gaagaagcag aggtctggat tcattttatc cacctgagcc cagtacacaa tatgtaagat
12841 ttttccatgg ttcttacaac aaagccgttt tctttgaaaa ccttgggaat ccttaataaa
12901 caggacccca actaattgta gacctgagaa gccattaaaa accagaatct gatttgaata
12961 aaaggatcct ggtcatgcaa acactctagt ctgctaataa gctaataatt tagtgctgga
13021 atgagcatga aataggtaat atggggagat agcgggtaag gaagggagga acaaaggaag
13081 gggaaggaag agtgagaagg aaggagaaga catcatcaac cagctccaca aaacccaggg
13141 agccggttaa tcatgtgctt tcattaagag cagaaacaga gttttagtga tattctgggt
13201 cctgaggcaa aattttctga aggtgtttcc ctctagatcg ctatcagcca tgttcaaata
13261 ccattgtttc agtctattac tccaagaaaa tggcatctcg tccagccaga gaacccacct
13321 cttttcatag gccctaggtc ctgagtggct ctttggagta gctgtatctt ggatcttgat
13381 gctccaagag tgaaactgtt tctttcaact atggagttca gatcttgagc caaaaatctt
13441 tcagcggctg gtacaaaaaa aatccgctgt aaaaccattt acaatggtac cagccagaaa
13501 tgtgataacc tgtgtacatt cagatttctg ggttacctga atggaactct tacacttatt
13561 acctagcaca aggcttggac aaacacaagt accttacatt ctctgcatga aagaatgagt
13621 gaaagtagga ttctggaggg aatccaacct gacccaaatg tactttttac tggaaaacaa
13681 aagcatttga ggaattgctg tgtctgtgga tgatttacct gccaaaatga acggcagagt
13741 ggctaattta gttttattcc catgtgacct gcaggtaaat gaagaaggca gtgaagcagc
13801 tgcaagtacc gctgttgtga ttgctggccg ttcgctaaac cccaacaggg tgactttcaa
13861 ggccaacagg cctttcctgg tttttataag agaagttcct ctgaacacta ttatcttcat
13921 gggcagagta gccaaccctt gtgttaagta aaatgttctt attctttgca cctcttccta
13981 tttttggttt gtgaacagaa gtaaaaataa atacaaacta cttccatctc acattataaa
14041 tggactctgc atttgaaatg aagacaagga aaggggaaac atgctattgg ggcacatggt
14101 aaaatgatgc cttcaagttg ttctttaccc agtaaccaca tctggatcaa gaaaatgagg
14161 gagagagcga taaaagatgg tagacagcca gaaagggaag ggagag
//