LOCUS X68679 1269 bp mRNA linear HUM 18-APR-2005
DEFINITION H. sapiens mRNA for DOWN 16.
ACCESSION X68679 S54532
VERSION X68679.1
KEYWORDS complement factor H; DOWN 16 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1269)
AUTHORS Zipfel P.F.
JOURNAL Submitted (08-OCT-1992) to the INSDC. P.F. Zipfel, Bernhard Nocht
Institute for Tropical Medicine, Bernhard Nocht Str 74, 2000
Hamburg 36, FRG
REFERENCE 2
AUTHORS Skerka C., Kuhn S., Gunther K., Lingelbach K., Zipfel P.F.
TITLE A novel short consensus repeat-containing molecule is related to
human complement factor H
JOURNAL J Biol Chem 268(4), 2904-2908(1993).
PUBMED 8428964
COMMENT Related sequence: Y00716
Nomenclature: Zipfel P.F., Skerka C., Immunol. Today 15, 122-126,
1994
FEATURES Location/Qualifiers
source 1..1269
/db_xref="H-InvDB:HIT000322937"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="liver"
/db_xref="taxon:9606"
5'UTR 1..23
CDS 24..1019
/gene="DOWN 16"
/product="FHR-3; complement Factor H-related Protein 3"
/db_xref="GOA:Q02985"
/db_xref="H-InvDB:HIT000322937.13"
/db_xref="HGNC:HGNC:16980"
/db_xref="InterPro:IPR000436"
/db_xref="InterPro:IPR035976"
/db_xref="UniProtKB/Swiss-Prot:Q02985"
/protein_id="CAA48639.1"
/translation="MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFP
VAVGKYYSYYCDEHFETPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGR
KFVQGNSTEVACHPGYGLPKVRQTTVTCTENGWSPTPRCIRDRTCSKSDIEIENGFIS
ESSSIYILNKEIQYKCKPGYATADGNSSGSITCLRNGWSAQPICINSSEKCGPPPPIS
NGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSAPPRCIHPCIITEENM
NKNNIKLKGRSDRKYYAKTGDTIEFMCKLGYNANTSILSFQAVCREGIVEYPRCE"
regulatory 1231..1236
/regulatory_class="polyA_signal_sequence"
polyA_site 1248
BASE COUNT 450 a 224 c 221 g 374 t
ORIGIN
1 ggcacgagct gagaatatct aacatgttgt tactaatcaa tgtcattctg accttgtggg
61 tttcctgtgc taatggacaa gtgaaacctt gtgattttcc agacattaaa catggaggtc
121 tatttcatga gaatatgcgt agaccatact ttccagtagc tgtaggaaaa tattactcct
181 attactgtga tgaacatttt gagactccgt caggaagtta ctgggattac attcattgca
241 cacaaaatgg gtggtcacca gcagtaccat gtctcagaaa atgttatttt ccttatttgg
301 aaaatggata taatcaaaat tatggaagaa agtttgtaca gggtaactct acagaagttg
361 cctgccatcc tggctacggt cttccaaaag tccgtcagac cacagttaca tgtacggaga
421 atggctggtc tcctactccc agatgcatcc gagacagaac atgctcaaaa tcagatatag
481 aaattgaaaa tggattcatt tctgaatctt cctctattta tattttaaat aaagaaatac
541 aatataaatg taaaccagga tatgcaacag cagatggaaa ttcttcagga tcaattacat
601 gtttgcgaaa tggatggtca gcacaaccaa tttgcattaa ttcttcagaa aagtgtggac
661 ctcctccacc tattagcaat ggtgatacca cctcctttct actaaaagtg tatgtgccac
721 agtcaagagt cgagtaccaa tgccagtcct actatgaact tcagggttct aattatgtaa
781 catgtagtaa tggagagtgg tcggcaccac ctagatgcat acatccatgt ataataactg
841 aagaaaacat gaataaaaat aacataaagt taaaaggaag aagtgacaga aaatattatg
901 caaaaacagg ggataccatt gaatttatgt gtaaattggg atataatgca aatacatcaa
961 ttctatcatt tcaagcagtg tgtcgggaag ggatagtgga ataccccaga tgcgaataag
1021 gcagcattgt taccctaaat gtatgtccaa cttccacttt tccacttctc actcttatgg
1081 tctcaaagct tgcaaagata gcttctgata ttgttgtaat ttctacttta tttcaaagaa
1141 aattaatata atagtttcaa tttgcaactt aatatattct caaaaatata ttaaaacaaa
1201 ctaaattatt gcttatgctt gtactaaaat aataaaaact actcttataa aaaaaaaaaa
1261 aaaaaaaaa
//