LOCUS       X67301                  1453 bp    mRNA    linear   HUM 16-FEB-1995
DEFINITION  H.sapiens mRNA for IgM heavy chain constant region (Ab63).
ACCESSION   X67301 S50847
VERSION     X67301.1
KEYWORDS    Ig constant region; Ig heavy chain; IgM; immunoglobulin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Harindranath N., Donadel G., Sigounas G., Notkins A.L.
  TITLE     Comparison of complete nucleotide sequence of the human IgM heavy
            chain constant region of polyreactive and monoreactive antibodies
  JOURNAL   Mol. Immunol. 30(1), 111-112(1993).
   PUBMED   8417370
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Harindranath N.
  JOURNAL   Submitted (15-JUL-1992) to the INSDC. N. Harindranath, National
            Inst. of Dental Research, Laboratory of Oral Medicine, N.I.D.R.,
            N.I.H., Bldg. 30, RM121, Bethesda, MD-20892, USA
FEATURES             Location/Qualifiers
     source          1..1453
                     /db_xref="H-InvDB:HIT000322859"
                     /organism="Homo sapiens"
                     /chromosome="14q32"
                     /isolate="Rheumatoid arthritis patient (ML)"
                     /mol_type="mRNA"
                     /dev_stage="Adult"
                     /clone_lib="lambda gt11"
                     /clone="CH 123, CH4"
                     /cell_line="Ab 63"
                     /cell_type="B-cell heterohybridoma"
                     /db_xref="taxon:9606"
     CDS             <1..1362
                     /codon_start=1
                     /product="immunoglobulin M heavy chain"
                     /protein_id="CAA47714.1"
                     /translation="GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITFSWKY
                     KNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVP
                     LPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVT
                     TDQVQAEAKESGPTTYKVTSTLTIKESDWLSQSMFTCRVDHRGLTFQQNASSMCVPDQ
                     DTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISES
                     HPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLL
                     PPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRY
                     FAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAG
                     TCY"
     C_region        <1..312
                     /product="constant region of IgM heavy chain"
                     /note="CH1 domain"
     C_region        313..649
                     /product="constant region of IgM heavy chain"
                     /note="CH2 domain"
     C_region        650..967
                     /product="constant region of IgM heavy chain"
                     /note="CH3 domain"
     C_region        968..1298
                     /product="constant region of IgM heavy chain"
                     /note="CH4 domain"
     exon            1299..1359
                     /note="mS, secretory exon of IgM"
BASE COUNT          303 a          500 c          399 g          251 t
ORIGIN      
        1 gggagtgcat ccgccccaac ccttttcccc ctcgtctcct gtgagaattc cccgtcggat
       61 acgagcagcg tggccgttgg ctgcctcgca caggacttcc ttcccgactc catcactttc
      121 tcctggaaat acaagaacaa ctctgacatc agcagcaccc ggggcttccc atcagtcctg
      181 agagggggca agtacgcagc cacctcacag gtgctgctgc cttccaagga cgtcatgcag
      241 ggcacagacg aacacgtggt gtgcaaagtc cagcacccca acggcaacaa agaaaagaac
      301 gtgcctcttc cagtgattgc cgagctgcct cccaaagtga gcgtcttcgt cccaccccgc
      361 gacggcttct tcggcaaccc ccgcaagtcc aagctcatct gccaggccac gggtttcagt
      421 ccccggcaga ttcaggtgtc ctggctgcgc gaggggaagc aggtggggtc tggcgtcacc
      481 acggaccagg tgcaggctga ggccaaagag tctgggccca cgacctacaa ggtgaccagc
      541 acactgacca tcaaagagag cgactggctc agccagagca tgttcacctg ccgcgtggat
      601 cacaggggcc tgaccttcca gcagaatgcg tcctccatgt gtgtccccga tcaagacaca
      661 gccatccggg tcttcgccat ccccccatcc tttgccagca tcttcctcac caagtccacc
      721 aagttgacct gcctggtcac agacctgacc acctatgaca gcgtgaccat ctcctggacc
      781 cgccagaatg gcgaagctgt gaaaacccac accaacatct ccgagagcca ccccaatgcc
      841 actttcagcg ccgtgggtga ggccagcatc tgcgaggatg actggaattc cggggagagg
      901 ttcacgtgca ccgtgaccca cacagacctg ccctcgccac tgaagcagac catctcccgg
      961 cccaaggggg tggccctgca caggcccgat gtctacttgc tgccaccagc ccgggagcag
     1021 ctgaacctgc gggagtcggc caccatcacg tgcctggtga cgggcttctc tcccgcggac
     1081 gtcttcgtgc agtggatgca gagggggcag cccttgtccc cggagaagta tgtgaccagc
     1141 gccccaatgc ctgagcccca ggccccaggc cggtacttcg cccacagcat cctgaccgtg
     1201 tccgaagagg aatggaacac gggggagacc tacacctgcg tggtggccca tgaggccctg
     1261 cccaacaggg tcaccgagag gaccgtggac aagtccaccg gtaaacccac cctgtacaac
     1321 gtgtccctgg tcatgtccga cacagctggc acctgctact gaccctgctg gcctgcccac
     1381 aggctcgggg cggctggccg ctctgtgtgt gcatgcaaac taacccgtgt caacggggtg
     1441 agatgttgca tct
//