LOCUS X67301 1453 bp mRNA linear HUM 16-FEB-1995 DEFINITION H.sapiens mRNA for IgM heavy chain constant region (Ab63). ACCESSION X67301 S50847 VERSION X67301.1 KEYWORDS Ig constant region; Ig heavy chain; IgM; immunoglobulin. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1453) AUTHORS Harindranath N., Donadel G., Sigounas G., Notkins A.L. TITLE Comparison of complete nucleotide sequence of the human IgM heavy chain constant region of polyreactive and monoreactive antibodies JOURNAL Mol. Immunol. 30(1), 111-112(1993). PUBMED 8417370 REFERENCE 2 (bases 1 to 1453) AUTHORS Harindranath N. JOURNAL Submitted (15-JUL-1992) to the INSDC. N. Harindranath, National Inst. of Dental Research, Laboratory of Oral Medicine, N.I.D.R., N.I.H., Bldg. 30, RM121, Bethesda, MD-20892, USA FEATURES Location/Qualifiers source 1..1453 /db_xref="H-InvDB:HIT000322859" /organism="Homo sapiens" /chromosome="14q32" /isolate="Rheumatoid arthritis patient (ML)" /mol_type="mRNA" /dev_stage="Adult" /clone_lib="lambda gt11" /clone="CH 123, CH4" /cell_line="Ab 63" /cell_type="B-cell heterohybridoma" /db_xref="taxon:9606" CDS <1..1362 /codon_start=1 /product="immunoglobulin M heavy chain" /protein_id="CAA47714.1" /translation="GSASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITFSWKY KNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVP LPVIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLREGKQVGSGVT TDQVQAEAKESGPTTYKVTSTLTIKESDWLSQSMFTCRVDHRGLTFQQNASSMCVPDQ DTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISES HPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTISRPKGVALHRPDVYLL PPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPGRY FAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAG TCY" C_region <1..312 /product="constant region of IgM heavy chain" /note="CH1 domain" C_region 313..649 /product="constant region of IgM heavy chain" /note="CH2 domain" C_region 650..967 /product="constant region of IgM heavy chain" /note="CH3 domain" C_region 968..1298 /product="constant region of IgM heavy chain" /note="CH4 domain" exon 1299..1359 /note="mS, secretory exon of IgM" BASE COUNT 303 a 500 c 399 g 251 t ORIGIN 1 gggagtgcat ccgccccaac ccttttcccc ctcgtctcct gtgagaattc cccgtcggat 61 acgagcagcg tggccgttgg ctgcctcgca caggacttcc ttcccgactc catcactttc 121 tcctggaaat acaagaacaa ctctgacatc agcagcaccc ggggcttccc atcagtcctg 181 agagggggca agtacgcagc cacctcacag gtgctgctgc cttccaagga cgtcatgcag 241 ggcacagacg aacacgtggt gtgcaaagtc cagcacccca acggcaacaa agaaaagaac 301 gtgcctcttc cagtgattgc cgagctgcct cccaaagtga gcgtcttcgt cccaccccgc 361 gacggcttct tcggcaaccc ccgcaagtcc aagctcatct gccaggccac gggtttcagt 421 ccccggcaga ttcaggtgtc ctggctgcgc gaggggaagc aggtggggtc tggcgtcacc 481 acggaccagg tgcaggctga ggccaaagag tctgggccca cgacctacaa ggtgaccagc 541 acactgacca tcaaagagag cgactggctc agccagagca tgttcacctg ccgcgtggat 601 cacaggggcc tgaccttcca gcagaatgcg tcctccatgt gtgtccccga tcaagacaca 661 gccatccggg tcttcgccat ccccccatcc tttgccagca tcttcctcac caagtccacc 721 aagttgacct gcctggtcac agacctgacc acctatgaca gcgtgaccat ctcctggacc 781 cgccagaatg gcgaagctgt gaaaacccac accaacatct ccgagagcca ccccaatgcc 841 actttcagcg ccgtgggtga ggccagcatc tgcgaggatg actggaattc cggggagagg 901 ttcacgtgca ccgtgaccca cacagacctg ccctcgccac tgaagcagac catctcccgg 961 cccaaggggg tggccctgca caggcccgat gtctacttgc tgccaccagc ccgggagcag 1021 ctgaacctgc gggagtcggc caccatcacg tgcctggtga cgggcttctc tcccgcggac 1081 gtcttcgtgc agtggatgca gagggggcag cccttgtccc cggagaagta tgtgaccagc 1141 gccccaatgc ctgagcccca ggccccaggc cggtacttcg cccacagcat cctgaccgtg 1201 tccgaagagg aatggaacac gggggagacc tacacctgcg tggtggccca tgaggccctg 1261 cccaacaggg tcaccgagag gaccgtggac aagtccaccg gtaaacccac cctgtacaac 1321 gtgtccctgg tcatgtccga cacagctggc acctgctact gaccctgctg gcctgcccac 1381 aggctcgggg cggctggccg ctctgtgtgt gcatgcaaac taacccgtgt caacggggtg 1441 agatgttgca tct //