LOCUS X67001 2938 bp mRNA linear HUM 28-JUN-1995
DEFINITION H.sapiens HUMFLI-1 mRNA.
ACCESSION X67001 S44250
VERSION X67001.1
KEYWORDS FLI-1 gene homologue.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2938)
AUTHORS Delattre O.
JOURNAL Submitted (26-MAY-1992) to the INSDC. O. Delattre, Lab. de Genet.
des Tumeurs. Inst. Curie, 26 rue D'Ulm, 75231 Paris Cedex, FRANCE
REFERENCE 2
AUTHORS Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T.,
Peter M., Kovar H., Joubert I., de Jong P., Rouleau G., Aurias A.,
Thomas G.
TITLE Gene fusion with an ETS DNA-binding domain caused by chromosome
translocation in human tumours
JOURNAL Nature 359(6391), 162-165(1992).
PUBMED 1522903
FEATURES Location/Qualifiers
source 1..2938
/db_xref="H-InvDB:HIT000322852"
/organism="Homo sapiens"
/chromosome="11q24"
/mol_type="mRNA"
/dev_stage="adult"
/clone_lib="cDNA, Clontech HL1058"
/tissue_type="bone marrow"
/db_xref="taxon:9606"
CDS 143..1501
/gene="HUMFLI-1"
/product="homologue of the murine FLI-1 gene"
/db_xref="GOA:Q01543"
/db_xref="H-InvDB:HIT000322852.13"
/db_xref="HGNC:HGNC:3749"
/db_xref="InterPro:IPR000418"
/db_xref="InterPro:IPR003118"
/db_xref="InterPro:IPR013761"
/db_xref="InterPro:IPR035573"
/db_xref="InterPro:IPR035575"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:1FLI"
/db_xref="PDB:1X66"
/db_xref="PDB:2YTU"
/db_xref="PDB:5E8G"
/db_xref="PDB:5E8I"
/db_xref="PDB:5JVT"
/db_xref="UniProtKB/Swiss-Prot:Q01543"
/protein_id="CAA47399.1"
/translation="MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQ
PHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNY
NSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQ
NMDGKELCKMNKEDFLRATTLYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKE
DPSYDSVRRGAWGNNMNSGLNKSPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANP
GSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDK
LSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESSMYKYPSDISYMPSYH
AHQQKVNFVPPHPSSMPVTSSSFFGAASQYWTSPTGGIYPNPNVPRHPNTHVPSHLGS
YY"
misc_feature 971..1222
/note="ETS domain"
regulatory 2390..2395
/regulatory_class="polyA_signal_sequence"
regulatory 2411..2416
/regulatory_class="polyA_signal_sequence"
regulatory 2415..2420
/regulatory_class="polyA_signal_sequence"
regulatory 2908..2913
/experiment="experimental evidence, no additional details
recorded"
/regulatory_class="polyA_signal_sequence"
polyA_site 2927
BASE COUNT 847 a 692 c 675 g 724 t
ORIGIN
1 ggagggcgct cgcagggggc acgcagggag ggcccagggc gccagggagg ccgcgccggg
61 ctaatccgaa ggggctgcga ggtcaggctg taaccgggtc aatgtgtgga atattggggg
121 gctcggctgc agacttggcc aaatggacgg gactattaag gaggctctgt cggtggtgag
181 cgacgaccag tccctctttg actcagcgta cggagcggca gcccatctcc ccaaggccga
241 catgactgcc tcggggagtc ctgactacgg gcagccccac aagatcaacc ccctcccacc
301 acagcaggag tggatcaatc agccagtgag ggtcaacgtc aagcgggagt atgaccacat
361 gaatggatcc agggagtctc cggtggactg cagcgttagc aaatgcagca agctggtggg
421 cggaggcgag tccaacccca tgaactacaa cagctatatg gacgagaaga atggcccccc
481 tcctcccaac atgaccacca acgagaggag agtcatcgtc cccgcagacc ccacactgtg
541 gacacaggag catgtgaggc aatggctgga gtgggccata aaggagtata gcttgatgga
601 gatcgacaca tcctttttcc agaacatgga tggcaaggaa ctgtgtaaaa tgaacaagga
661 ggacttcctc cgcgccacca ccctctacaa cacggaagtg ctgttgtcac acctcagtta
721 cctcagggaa agttcactgc tggcctataa tacaacctcc cacaccgacc aatcctcacg
781 attgagtgtc aaagaagacc cttcttatga ctcagtcaga agaggagcat ggggcaataa
841 catgaattct ggcctcaaca aaagtcctcc ccttggaggg gcacaaacga tcagtaagaa
901 tacagagcaa cggccccagc cagatccgta tcagatcctg ggcccgacca gcagtcgcct
961 agccaaccct ggaagcgggc agatccagct gtggcaattc ctcctggagc tgctctccga
1021 cagcgccaac gccagctgta tcacctggga ggggaccaac ggggagttca aaatgacgga
1081 ccccgatgag gtggccaggc gctggggcga gcggaaaagc aagcccaaca tgaattacga
1141 caagctgagc cgggccctcc gttattacta tgataaaaac attatgacca aagtgcacgg
1201 caaaagatat gcttacaaat ttgacttcca cggcattgcc caggctctgc agccacatcc
1261 gaccgagtcg tccatgtaca agtacccttc tgacatctcc tacatgcctt cctaccatgc
1321 ccaccagcag aaggtgaact ttgtccctcc ccatccatcc tccatgcctg tcacttcctc
1381 cagcttcttt ggagccgcat cacaatactg gacctccccc acggggggaa tctaccccaa
1441 ccccaacgtc ccccgccatc ctaacaccca cgtgccttca cacttaggca gctactacta
1501 gaagcttact catcagtggc cttctagctg aagcccatcc tgcacactta ctggatgctt
1561 tggactcaac aggacatatg tggccttgaa gggaagacaa aactggatgt tctttcttgt
1621 tggatagaac ctttgtattt gttctttaaa aacatttttt ttaatgttgg taacttttgc
1681 ttcctctacc tgaacaaaga gatgaataat tccatgggcc agtatgccag tttgaattct
1741 cagtctccta gcatcttgtg agttgcatat taagattact ggaatggtta agtcatggtt
1801 ctgagaaaga agctgtacgt tttctttatg tttttatgac caaagcagtt tcttgtcaat
1861 acacggggtt cagtatgaca cagaatcatg gacttaaccc gtcatgttct ggtttgagat
1921 ttagtgacaa atagaggtgg gaagcttata atctaatttt aggaggacca aattcagtgg
1981 atggcaactg gaacattgat tgtaaggcca gtgaagtttt cacccaactg gaatttgatg
2041 gaaagaaggt ttgtgtgttt aagacgccaa gggcattgca gaatccctct cagtggacag
2101 tatgcactca gctgaccact ctctctagaa atagtcaaga tatgaactaa gaaattttaa
2161 tgcaaataca tacattcctg aaagacgggg aattaaatta ctaatttttt ttttttttta
2221 aatgatgaca gtggtcccag aacttggaaa agttgtaggg atttctaaac tcaagcagat
2281 tcgcaagtgc tgtgcgcttg tcagaccatc agaccagggc caaccaatca gaaggcaact
2341 tactgtataa attatgcaga gttattttcc tatatctcac agtattaaaa ataaataatt
2401 aaaaattaag aataaataaa cgagttgacc tcggtcacaa aagcagtttt actatcgaat
2461 caatcgctgt tatttttttt aatgtaattt gtacatcttt tttcaatctg tacatttggg
2521 ctgtctgtat gtttttatag ctggttttta aaaagcataa tatgcctata gctgaaaagg
2581 aaacagggct gtttaagtca ctgacttatg agaaagcaaa gcactggtac agttatttaa
2641 caggcataca caagcaggga aagataatcc atttagatct ttaatgcttt ggaaatgcgt
2701 gtaacagtac tgcaataatc acagctctgg gaaaaacaac gaaactttcc cttgtggaga
2761 ggagggattt tcctgctcta tataagcaac atatttttag acattaaaat atatataatt
2821 ttgcaggtaa ttgttgactt ttttaactat attaagcgtt aagctgacaa ctgtcaaaga
2881 agaccatgtt gtaaaataat ttgactaaat aaatggttcc ttctctcaaa aaaaaaaa
//