LOCUS X66957 2658 bp mRNA linear HUM 16-NOV-1993
DEFINITION H. sapiens hexokinase I (MK-16).
ACCESSION X66957 S40535
VERSION X66957.1
KEYWORDS hexokinase; hexokinase type I.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Magnani M., Bianchi M., Casabianca A., Stocchi V., Daniele A.,
Altruda F., Ferrone M., Silengo L.
TITLE A recombinant human 'mini'-hexokinase is catalytically active and
regulated by hexose 6-phosphates.
JOURNAL Biochem. J. 285, 193-199(1992).
PUBMED 1637300
REFERENCE 2 (bases 1 to 2658)
AUTHORS Magnani M.
JOURNAL Submitted (04-SEP-1992) to the INSDC. M. Magnani, Inst di Chimica
Biologica G Fornaini, Univ degli Sudi di Urbino, Via Saffi 2, 61029
Urbino, ITALY
FEATURES Location/Qualifiers
source 1..2658
/db_xref="H-InvDB:HIT000322850"
/organism="Homo sapiens"
/chromosome="10"
/mol_type="mRNA"
/clone_lib="cDNA from placenta"
/clone="HK-16"
/tissue_type="placenta"
/db_xref="taxon:9606"
CDS <1..1896
/codon_start=1
/product="hexokinase type 1"
/EC_number="2.7.1.1"
/db_xref="GOA:P19367"
/db_xref="H-InvDB:HIT000322850.13"
/db_xref="HGNC:HGNC:4922"
/db_xref="InterPro:IPR001312"
/db_xref="InterPro:IPR019807"
/db_xref="InterPro:IPR022672"
/db_xref="InterPro:IPR022673"
/db_xref="PDB:1CZA"
/db_xref="PDB:1DGK"
/db_xref="PDB:1HKB"
/db_xref="PDB:1HKC"
/db_xref="PDB:1QHA"
/db_xref="PDB:4F9O"
/db_xref="PDB:4FOE"
/db_xref="PDB:4FOI"
/db_xref="PDB:4FPA"
/db_xref="PDB:4FPB"
/db_xref="UniProtKB/Swiss-Prot:P19367"
/protein_id="CAA47379.1"
/translation="NPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLT
RGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAA
TLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSE
SGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTH
NNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAI
PIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT
KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV
GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVNEYSLNA
GKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETMKTRGIFETKFLSQIESDR
LALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLD
RLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVR
LRTEASS"
BASE COUNT 630 a 682 c 767 g 579 t
ORIGIN
1 aaccctggaa aacagctgtt tgagaagatg gtcagtggca tgtacttggg agagctggtt
61 cgactgatcc tagtcaagat ggccaaggag ggcctcttat ttgaagggcg gatcaccccg
121 gagctgctca cccgagggaa gtttaacacc agtgatgtgt cagccatcga aaagaataag
181 gaaggcctcc acaatgccaa agaaatcctg acccgcctgg gagtggagcc gtccgatgat
241 gactgtgtct cagtccagca cgtttgcacc attgtctcat ttcgctcagc caacttggtg
301 gctgccacac tgggcgccat cttgaaccgc ctgcgtgata acaagggcac acccaggctg
361 cggaccacgg ttggtgtcga cggatctctt tacaagacgc acccacagta ttcccggcgt
421 ttccacaaga ctctaaggcg cttggtgcca gactccgatg tgcgcttcct cctctcggag
481 agtggcagcg gcaagggggc tgccatggtg acggcggtgg cctaccgctt ggccgagcag
541 caccggcaga tagaggagac cctggctcat ttccacctca ccaaagacat gctgctggag
601 gtgaagaaga ggatgcgggc cgagatggag ctggggctga ggaagcagac gcacaacaat
661 gccgtggtta agatgctgcc ctccttcgtc cggagaactc ccgacgggac cgagaatggt
721 gacttcttgg ccctggatct tggaggaacc aatttccgtg tgctgctggt gaaaatccgt
781 agtgggaaaa agagaacggt ggaaatgcac aacaagatct acgccattcc tattgaaatc
841 atgcagggca ctggggaaga gctgtttgat cacattgtct cctgcatctc tgacttcttg
901 gactacatgg ggatcaaagg ccccaggatg cctctgggct tcacgttctc atttccctgc
961 cagcagacga gtctggacgc gggaatcttg atcacgtgga caaagggttt taaggcaaca
1021 gactgcgtgg gccacgatgt agtcacctta ctaagggatg cgataaaaag gagagaggaa
1081 tttgacctgg acgtggtggc tgtggtcaac gacacagtgg gcaccatgat gacctgtgct
1141 tatgaggagc ccacctgtga ggttggactc attgttggga ccggcagcaa tgcctgctac
1201 atggaggaga tgaagaacgt ggagatggtg gagggggacc aggggcagat gtgcatcaac
1261 atggagtggg gggcctttgg ggacaacggg tgtctggatg atatcaggac acactacgac
1321 agactggtga acgaatattc cctaaatgct gggaaacaaa ggtatgagaa gatgatcagt
1381 ggtatgtacc tgggtgaaat cgtccgcaac atcttaatcg acttcaccaa gaagggattc
1441 ctcttccgag ggcagatctc tgagacgatg aagacccggg gcatctttga gaccaagttt
1501 ctctctcaga tcgagagtga ccgattagca ctgctccagg tccgggctat cctccagcag
1561 ctaggtctga atagcacctg cgatgacagt atcctcgtca agacagtgtg cggggtggtg
1621 tccaggaggg ccgcacagct gtgtggcgca ggcatggctg cggttgtgga taagatccgc
1681 gagaacagag gactggaccg tctgaatgtg actgtgggag tggacgggac actctacaag
1741 cttcatccac acttctccag aatcatgcac cagacggtga aggaactgtc accaaaatgt
1801 aacgtgtcct tcctcctgtc tgaggatggc agcggcaagg gggccgccct catcacggcc
1861 gtgggcgtgc ggttacgcac agaggcaagc agctaagagt ccgggatccc cagcctactg
1921 cctctccagc acttctctct tcaagcggcg accccctacc ctcccagcga gttgcgctgg
1981 gagacgctgg cgccagggcc tgccggcgcg ggggaggaaa gcaaaatcca actaatggta
2041 tatattgtag ggtacagaat agagcgtgtg ctgttgataa tatctctcac ccggatcctc
2101 ctcacttgcc ctgccacttt gcatggtttg attttgacct ggtcccccac gtgtgaagtg
2161 tagtggcatc catttctaat gtatgcattc atccaacaga gttatttatt ggctggagat
2221 ggaaaatcac accacctgac aggccttctg ggcctccaaa gcccatcctt ggggttcccc
2281 ctccctgtgt gaaatgtatt atcaccagca gacactgccg ggcctccctc ccgggggcac
2341 tgcctgaagg cgagtgtggg catagcatta gctgcttcct cccctcctgg cacccactgt
2401 ggcctggcat cgcatcgtgg tgtgtcaatg ccacaaaatc gtgtgtccgt ggaaccagtc
2461 ctagccgcgt gtgacagtct tgcattctgt ttgtctcgtg gggggaggtg gacagtcctg
2521 cggaaatgtg tcttgtcttc catttggata aaaggaacca accaacaaac aatgccatca
2581 ctggaatttc ccaccgcttt gtgagccgtg tcgtatgacc tagtaaactt tgtaccaatt
2641 caaaaaaaaa aaaaaaaa
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