LOCUS X65550 12515 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mki67a mRNA (long type) for antigen of monoclonal
antibody Ki-67.
ACCESSION X65550
VERSION X65550.1
KEYWORDS antigen; monoclonal antibody.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 12515)
AUTHORS Gerdes Fors J.
JOURNAL Submitted (11-APR-1992) to the INSDC. J. Gerdes, Forschungsinstitut
Borstel, Div. Molecular Immunology, Parkallee 22, 2061 Borstel, FRG
REMARK sequence revised by author 13-JUL-93 and 08-OCT-93
REFERENCE 2
AUTHORS Schlueter C., Duchrow M., Wholenberg C., Becker M.H.G., Key G.,
Flad HD., Gerdes J.
TITLE The cell proliferation-associated antigen of antibody Ki-67: a very
large, ubiquitous nuclear protein with numerous repeated elements,
representing a new kind of cell cycle-maintaining proteins.
JOURNAL J. Cell Biol. 123(3), 513-522(1993).
PUBMED 8227122
FEATURES Location/Qualifiers
source 1..12515
/db_xref="H-InvDB:HIT000322747"
/organism="Homo sapiens"
/chromosome="10q25-qter"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/cell_line="IM9"
/db_xref="taxon:9606"
exon 1..107
/number=1
exon 108..288
/number=2
CDS 197..9967
/gene="mki67"
/product="antigen of the monoclonal antibody Ki-67"
/db_xref="GOA:P46013"
/db_xref="H-InvDB:HIT000322747.15"
/db_xref="HGNC:HGNC:7107"
/db_xref="InterPro:IPR000253"
/db_xref="InterPro:IPR008984"
/db_xref="InterPro:IPR012568"
/db_xref="InterPro:IPR029334"
/db_xref="PDB:1R21"
/db_xref="PDB:2AFF"
/db_xref="PDB:5J28"
/db_xref="UniProtKB/Swiss-Prot:P46013"
/protein_id="CAA46519.1"
/translation="MWPTRRLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVV
SKQHCKIEIHEQEAILHNFSSTNPTQVNGSVIDEPVRLKHGDVITIIDRSFRYENESL
QNGRKSTEFPRKIREQEPARRVSRSSFSSDPDEKAQDSKAYSKITEGKVSGNPQVHIK
NVKEDSTADDSKDSVAQGTTNVHSSEHAGRNGRNAADPISGDFKEISSVKLVSRYGEL
KSVPTTQCLDNSKKNESPFWKLYESVKKELDVKSQKENVLQYCRKSGLQTDYATEKES
ADGLQGETQLLVSRKSRPKSGGSGHAVAEPASPEQELDQNKGKGRDVESVQTPSKAVG
ASFPLYEPAKMKTPVQYSQQQNSPQKHKNKDLYTTGRRESVNLGKSEGFKAGDKTLTP
RKLSTRNRTPAKVEDAADSATKPENLSSKTRGSIPTDVEVLPTETEIHNEPFLTLWLT
QVERKIQKDSLSKPEKLGTTAGQMCSGLPGLSSVDINNFGDSINESEGIPLKRRRVSF
GGHLRPELFDENLPPNTPLKRGEAPTKRKSLVMHTPPVLKKIIKEQPQPSGKQESGSE
IHVEVKAQSLVISPPAPSPRKTPVASDQRRRSCKTAPASSSKSQTEVPKRGGERVATC
LQKRVSISRSQHDILQMICSKRRSGASEANLIVAKSWADVVKLGAKQTQTKVIKHGPQ
RSMNKRQRRPATPKKPVGEVHSQFSTGHANSPCTIIIGKAHTEKVHVPARPYRVLNNF
ISNQKMDFKEDLSGIAEMFKTPVKEQPQLTSTCHIAISNSENLLGKQFQGTDSGEEPL
LPTSESFGGNVFFSAQNAAKQPSDKCSASPPLRRQCIRENGNVAKTPRNTYKMTSLET
KTSDTETEPSKTVSTVNRSGRSTEFRNIQKLPVESKSEETNTEIVECILKRGQKATLL
QQRREGEMKEIERPFETYKENIELKENDEKMKAMKRSRTWGQKCAPMSDLTDLKSLPD
TELMKDTARGQNLLQTQDHAKAPKSEKGKITKMPCQSLQPEPINTPTHTKQQLKASLG
KVGVKEELLAVGKFTRTSGETTHTHREPAGDGKSIRTFKESPKQILDPAARVTGMKKW
PRTPKEEAQSLEDLAGFKELFQTPGPSEESMTDEKTTKIACKSPPPESVDTPTSTKQW
PKRSLRKADVEEEFLALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLDLAGTL
PGSKRQLQTPKEKAQALEDLAGFKELFQTPGHTEELVAAGKTTKIPCDSPQSDPVDTP
TSTKQRPKRSIRKADVEGELLACRNLMPSAGKAMHTPKPSVGEEKDIIIFVGTPVQKL
DLTENLTGSKRRPQTPKEEAQALEDLTGFKELFQTPGHTEEAVAAGKTTKMPCESSPP
ESADTPTSTRRQPKTPLEKRDVQKELSALKKLTQTSGETTHTDKVPGGEDKSINAFRE
TAKQKLDPAASVTGSKRHPKTKEKAQPLEDLAGWKELFQTPVCTDKPTTHEKTTKIAC
RSQPDPVDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGKAMHTPKPAVSGEKNIY
AFMGTPVQKLDLTENLTGSKRRLQTPKEKAQALEDLAGFKELFQTRGHTEESMTNDKT
AKVACKSSQPDLDKNPASSKRRLKTSLGKVGVKEELLAVGKLTQTSGETTHTHTEPTG
DGKSMKAFMESPKQILDSAASLTGSKRQLRTPKGKSEVPEDLAGFIELFQTPSHTKES
MTNEKTTKVSYRASQPDLVDTPTSSKPQPKRSLRKADTEEEFLAFRKQTPSAGKAMHT
PKPAVGEEKDINTFLGTPVQKLDQPGNLPGSNRRLQTRKEKAQALEELTGFRELFQTP
CTDNPTADEKTTKKILCKSPQSDPADTPTNTKQRPKRSLKKADVEEEFLAFRKLTPSA
GKAMHTPKAAVGEEKDINTFVGTPVEKLDLLGNLPGSKRRPQTPKEKAKALEDLAGFK
ELFQTPGHTEESMTDDKITEVSCKSPQPDPVKTPTSSKQRLKISLGKVGVKEEVLPVG
KLTQTSGKTTQTHRETAGDGKSIKAFKESAKQMLDPANYGTGMERWPRTPKEEAQSLE
DLAGFKELFQTPDHTEESTTDDKTTKIACKSPPPESMDTPTSTRRRPKTPLGKRDIVE
ELSALKQLTQTTHTDKVPGDEDKGINVFRETAKQKLDPAASVTGSKRQPRTPKGKAQP
LEDLAGLKELFQTPVCTDKPTTHEKTTKIACRSPQPDPVGTPTIFKPQSKRSLRKADV
EEESLALRKRTPSVGKAMDTPKPAGGDEKDMKAFMGTPVQKLDLPGNLPGSKRWPQTP
KEKAQALEDLAGFKELFQTPGTDKPTTDEKTTKIACKSPQPDPVDTPASTKQRPKRNL
RKADVEEEFLALRKRTPSAGKAMDTPKPAVSDEKNINTFVETPVQKLDLLGNLPGSKR
QPQTPKEKAEALEDLVGFKELFQTPGHTEESMTDDKITEVSCKSPQPESFKTSRSSKQ
RLKIPLVKVDMKEEPLAVSKLTRTSGETTQTHTEPTGDSKSIKAFKESPKQILDPAAS
VTGSRRQLRTRKEKARALEDLVDFKELFSAPGHTEESMTIDKNTKIPCKSPPPELTDT
ATSTKRCPKTRPRKEVKEELSAVERLTQTSGQSTHTHKEPASGDEGIKVLKQRAKKKP
NPVEEEPSRRRPRAPKEKAQPLEDLAGFTELSETSGHTQESLTAGKATKIPCESPPLE
VVDTTASTKRHLRTRVQKVQVKEEPSAVKFTQTSGETTDADKEPAGEDKGIKALKESA
KQTPAPAASVTGSRRRPRAPRESAQAIEDLAGFKDPAAGHTEESMTDDKTTKIPCKSS
PELEDTATSSKRRPRTRAQKVEVKEELLAVGKLTQTSGETTHTDKEPVGEGKGTKAFK
QPAKRNVDAEDVIGSRRQPRAPKEKAQPLEDLASFQELSQTPGHTEELANGAADSFTS
APKQTPDSGKPLKISRRVLRAPKVEPVGDVVSTRDPVKSQSKSNTSLPPLPFKRGGGK
DGSVTGTKRLRCMPAPEEIVEELPASKKQRVAPRARGKSSEPVVIMKRSLRTSAKRIE
PAEELNSNDMKTNKEEHKLQDSVPENKGISLRSRRQDKTEAEQQITEVFVLAERIEIN
RNEKKPMKTSPEMDIQNPDDGARKPIPRDKVTENKRCLRSARQNESSQPKVAEESGGQ
KSAKVLMQNQKGKGEAGNSDSMCLRSRKTKSQPAASTLESKSVQRVTRSVKRCAENPK
KAEDNVCVKKITTRSHRDSEDI"
exon 289..367
/number=3
exon 368..483
/number=4
exon 484..550
/number=5
exon 561..596
/number=6
exon 597..1676
/number=7
/note="partialy excluded by splicing"
exon 1677..1852
/number=8
exon 1853..2165
/number=9
exon 2166..2284
/number=10
exon 2285..2456
/number=11
exon 2457..2612
/number=12
exon 2613..9457
/number=13
exon 9458..9901
/number=14
exon 9902..12493
/number=15
regulatory 9994..9999
/regulatory_class="polyA_signal_sequence"
regulatory 10529..10534
/regulatory_class="polyA_signal_sequence"
regulatory 11237..11242
/regulatory_class="polyA_signal_sequence"
regulatory 12468..12473
/regulatory_class="polyA_signal_sequence"
polyA_site 12494
BASE COUNT 4166 a 3048 c 2928 g 2373 t
ORIGIN
1 ctaccgggcg gaggtgagcg cggcgccggc tcctcctgcg gcggactttg ggtgcgactt
61 gacgagcggt ggttcgacaa gtggccttgc gggccggatc gtcccagtgg aagagttgta
121 aatttgcttc tggccttccc ctacggatta tacctggcct tcccctacgg attatactca
181 acttactgtt tagaaaatgt ggcccacgag acgcctggtt actatcaaaa ggagcggggt
241 cgacggtccc cactttcccc tgagcctcag cacctgcttg tttggaaggg gtattgaatg
301 tgacatccgt atccagcttc ctgttgtgtc aaaacaacat tgcaaaattg aaatccatga
361 gcaggaggca atattacata atttcagttc cacaaatcca acacaagtaa atgggtctgt
421 tattgatgag cctgtacggc taaaacatgg agatgtaata actattattg atcgttcctt
481 caggtatgaa aatgaaagtc ttcagaatgg aaggaagtca actgaatttc caagaaaaat
541 acgtgaacag gagccagcac gtcgtgtctc aagatctagc ttctcttctg accctgatga
601 gaaagctcaa gattccaagg cctattcaaa aatcactgaa ggaaaagttt caggaaatcc
661 tcaggtacat atcaagaatg tcaaagaaga cagtaccgca gatgactcaa aagacagtgt
721 tgctcaggga acaactaatg ttcattcctc agaacatgct ggacgtaatg gcagaaatgc
781 agctgatccc atttctgggg attttaaaga aatttccagc gttaaattag tgagccgtta
841 tggagaattg aagtctgttc ccactacaca atgtcttgac aatagcaaaa aaaatgaatc
901 tcccttttgg aagctttatg agtcagtgaa gaaagagttg gatgtaaaat cacaaaaaga
961 aaatgtccta cagtattgta gaaaatctgg attacaaact gattacgcaa cagagaaaga
1021 aagtgctgat ggtttacagg gggagaccca actgttggtc tcgcgtaagt caagaccaaa
1081 atctggtggg agcggccacg ctgtggcaga gcctgcttca cctgaacaag agcttgacca
1141 gaacaagggg aagggaagag acgtggagtc tgttcagact cccagcaagg ctgtgggcgc
1201 cagctttcct ctctatgagc cggctaaaat gaagacccct gtacaatatt cacagcaaca
1261 aaattctcca caaaaacata agaacaaaga cctgtatact actggtagaa gagaatctgt
1321 gaatctgggt aaaagtgaag gcttcaaggc tggtgataaa actcttactc ccaggaagct
1381 ttcaactaga aatcgaacac cagctaaagt tgaagatgca gctgactctg ccactaagcc
1441 agaaaatctc tcttccaaaa ccagaggaag tattcctaca gatgtggaag ttctgcctac
1501 ggaaactgaa attcacaatg agccattttt aactctgtgg ctcactcaag ttgagaggaa
1561 gatccaaaag gattccctca gcaagcctga gaaattgggc actacagctg gacagatgtg
1621 ctctgggtta cctggtctta gttcagttga tatcaacaac tttggtgatt ccattaatga
1681 gagtgaggga atacctttga aaagaaggcg tgtgtccttt ggtgggcacc taagacctga
1741 actatttgat gaaaacttgc ctcctaatac gcctctcaaa aggggagaag ccccaaccaa
1801 aagaaagtct ctggtaatgc acactccacc tgtcctgaag aaaatcatca aggaacagcc
1861 tcaaccatca ggaaaacaag agtcaggttc agaaatccat gtggaagtga aggcacaaag
1921 cttggttata agccctccag ctcctagtcc taggaaaact ccagttgcca gtgatcaacg
1981 ccgtaggtcc tgcaaaacag cccctgcttc cagcagcaaa tctcagacag aggttcctaa
2041 gagaggagga gaaagagtgg caacctgcct tcaaaagaga gtgtctatca gccgaagtca
2101 acatgatatt ttacagatga tatgttccaa aagaagaagt ggtgcttcgg aagcaaatct
2161 gattgttgca aaatcatggg cagatgtagt aaaacttggt gcaaaacaaa cacaaactaa
2221 agtcataaaa catggtcctc aaaggtcaat gaacaaaagg caaagaagac ctgctactcc
2281 aaagaagcct gtgggcgaag ttcacagtca atttagtaca ggccacgcaa actctccttg
2341 taccataata atagggaaag ctcatactga aaaagtacat gtgcctgctc gaccctacag
2401 agtgctcaac aacttcattt ccaaccaaaa aatggacttt aaggaagatc tttcaggaat
2461 agctgaaatg ttcaagaccc cagtgaagga gcaaccgcag ttgacaagca catgtcacat
2521 cgctatttca aattcagaga atttgcttgg aaaacagttt caaggaactg attcaggaga
2581 agaacctctg ctccccacct cagagagttt tggaggaaat gtgttcttca gtgcacagaa
2641 tgcagcaaaa cagccatctg ataaatgctc tgcaagccct cccttaagac ggcagtgtat
2701 tagagaaaat ggaaacgtag caaaaacgcc caggaacacc tacaaaatga cttctctgga
2761 gacaaaaact tcagatactg agacagagcc ttcaaaaaca gtatccactg taaacaggtc
2821 aggaaggtct acagagttca ggaatataca gaagctacct gtggaaagta agagtgaaga
2881 aacaaataca gaaattgttg agtgcatcct aaaaagaggt cagaaggcaa cactactaca
2941 acaaaggaga gaaggagaga tgaaggaaat agaaagacct tttgagacat ataaggaaaa
3001 tattgaatta aaagaaaacg atgaaaagat gaaagcaatg aagagatcaa gaacttgggg
3061 gcagaaatgt gcaccaatgt ctgacctgac agacctcaag agcttgcctg atacagaact
3121 catgaaagac acggcacgtg gccagaatct cctccaaacc caagatcatg ccaaggcacc
3181 aaagagtgag aaaggcaaaa tcactaaaat gccctgccag tcattacaac cagaaccaat
3241 aaacacccca acacacacaa aacaacagtt gaaggcatcc ctggggaaag taggtgtgaa
3301 agaagagctc ctagcagtcg gcaagttcac acggacgtca ggggagacca cgcacacgca
3361 cagagagcca gcaggagatg gcaagagcat cagaacgttt aaggagtctc caaagcagat
3421 cctggaccca gcagcccgtg taactggaat gaagaagtgg ccaagaacgc ctaaggaaga
3481 ggcccagtca ctagaagacc tggctggctt caaagagctc ttccagacac caggtccctc
3541 tgaggaatca atgactgatg agaaaactac caaaatagcc tgcaaatctc caccaccaga
3601 atcagtggac actccaacaa gcacaaagca atggcctaag agaagtctca ggaaagcaga
3661 tgtagaggaa gaattcttag cactcaggaa actaacacca tcagcaggga aagccatgct
3721 tacgcccaaa ccagcaggag gtgatgagaa agacattaaa gcatttatgg gaactccagt
3781 gcagaaactg gacctggcag gaactttacc tggcagcaaa agacagctac agactcctaa
3841 ggaaaaggcc caggctctag aagacctggc tggctttaaa gagctcttcc agactcctgg
3901 tcacaccgag gaattagtgg ctgctggtaa aaccactaaa ataccctgcg actctccaca
3961 gtcagaccca gtggacaccc caacaagcac aaagcaacga cccaagagaa gtatcaggaa
4021 agcagatgta gagggagaac tcttagcgtg caggaatcta atgccatcag caggcaaagc
4081 catgcacacg cctaaaccat cagtaggtga agagaaagac atcatcatat ttgtgggaac
4141 tccagtgcag aaactggacc tgacagagaa cttaaccggc agcaagagac ggccacaaac
4201 tcctaaggaa gaggcccagg ctctggaaga cctgactggc tttaaagagc tcttccagac
4261 ccctggtcat actgaagaag cagtggctgc tggcaaaact actaaaatgc cctgcgaatc
4321 ttctccacca gaatcagcag acaccccaac aagcacaaga aggcagccca agacaccttt
4381 ggagaaaagg gacgtacaga aggagctctc agccctgaag aagctcacac agacatcagg
4441 ggaaaccaca cacacagata aagtaccagg aggtgaggat aaaagcatca acgcgtttag
4501 ggaaactgca aaacagaaac tggacccagc agcaagtgta actggtagca agaggcaccc
4561 aaaaactaag gaaaaggccc aacccctaga agacctggct ggctggaaag agctcttcca
4621 gacaccagta tgcactgaca agcccacgac tcacgagaaa actaccaaaa tagcctgcag
4681 atcacaacca gacccagtgg acacaccaac aagctccaag ccacagtcca agagaagtct
4741 caggaaagtg gacgtagaag aagaattctt cgcactcagg aaacgaacac catcagcagg
4801 caaagccatg cacacaccca aaccagcagt aagtggtgag aaaaacatct acgcatttat
4861 gggaactcca gtgcagaaac tggacctgac agagaactta actggcagca agagacggct
4921 acaaactcct aaggaaaagg cccaggctct agaagacctg gctggcttta aagagctctt
4981 ccagacacga ggtcacactg aggaatcaat gactaacgat aaaactgcca aagtagcctg
5041 caaatcttca caaccagacc tagacaaaaa cccagcaagc tccaagcgac ggctcaagac
5101 atccctgggg aaagtgggcg tgaaagaaga gctcctagca gttggcaagc tcacacagac
5161 atcaggagag actacacaca cacacacaga gccaacagga gatggtaaga gcatgaaagc
5221 atttatggag tctccaaagc agatcttaga ctcagcagca agtctaactg gcagcaagag
5281 gcagctgaga actcctaagg gaaagtctga agtccctgaa gacctggccg gcttcatcga
5341 gctcttccag acaccaagtc acactaagga atcaatgact aatgaaaaaa ctaccaaagt
5401 atcctacaga gcttcacagc cagacctagt ggacacccca acaagctcca agccacagcc
5461 caagagaagt ctcaggaaag cagacactga agaagaattt ttagcattta ggaaacaaac
5521 gccatcagca ggcaaagcca tgcacacacc caaaccagca gtaggtgaag agaaagacat
5581 caacacgttt ttgggaactc cagtgcagaa actggaccag ccaggaaatt tacctggcag
5641 caatagacgg ctacaaactc gtaaggaaaa ggcccaggct ctagaagaac tgactggctt
5701 cagagagctt ttccagacac catgcactga taaccccaca gctgatgaga aaactaccaa
5761 aaaaatactc tgcaaatctc cgcaatcaga cccagcggac accccaacaa acacaaagca
5821 acggcccaag agaagcctca agaaagcaga cgtagaggaa gaatttttag cattcaggaa
5881 actaacacca tcagcaggca aagccatgca cacgcctaaa gcagcagtag gtgaagagaa
5941 agacatcaac acatttgtgg ggactccagt ggagaaactg gacctgctag gaaatttacc
6001 tggcagcaag agacggccac aaactcctaa agaaaaggcc aaggctctag aagatctggc
6061 tggcttcaaa gagctcttcc agacaccagg tcacactgag gaatcaatga ccgatgacaa
6121 aatcacagaa gtatcctgca aatctccaca accagaccca gtcaaaaccc caacaagctc
6181 caagcaacga ctcaagatat ccttggggaa agtaggtgtg aaagaagagg tcctaccagt
6241 cggcaagctc acacagacgt cagggaagac cacacagaca cacagagaga cagcaggaga
6301 tggaaagagc atcaaagcgt ttaaggaatc tgcaaagcag atgctggacc cagcaaacta
6361 tggaactggg atggagaggt ggccaagaac acctaaggaa gaggcccaat cactagaaga
6421 cctggccggc ttcaaagagc tcttccagac accagaccac actgaggaat caacaactga
6481 tgacaaaact accaaaatag cctgcaaatc tccaccacca gaatcaatgg acactccaac
6541 aagcacaagg aggcggccca aaacaccttt ggggaaaagg gatatagtgg aagagctctc
6601 agccctgaag cagctcacac agaccacaca cacagacaaa gtaccaggag atgaggataa
6661 aggcatcaac gtgttcaggg aaactgcaaa acagaaactg gacccagcag caagtgtaac
6721 tggtagcaag aggcagccaa gaactcctaa gggaaaagcc caacccctag aagacttggc
6781 tggcttgaaa gagctcttcc agacaccagt atgcactgac aagcccacga ctcacgagaa
6841 aactaccaaa atagcctgca gatctccaca accagaccca gtgggtaccc caacaatctt
6901 caagccacag tccaagagaa gtctcaggaa agcagacgta gaggaagaat ccttagcact
6961 caggaaacga acaccatcag tagggaaagc tatggacaca cccaaaccag caggaggtga
7021 tgagaaagac atgaaagcat ttatgggaac tccagtgcag aaattggacc tgccaggaaa
7081 tttacctggc agcaaaagat ggccacaaac tcctaaggaa aaggcccagg ctctagaaga
7141 cctggctggc ttcaaagagc tcttccagac accaggcact gacaagccca cgactgatga
7201 gaaaactacc aaaatagcct gcaaatctcc acaaccagac ccagtggaca ccccagcaag
7261 cacaaagcaa cggcccaaga gaaacctcag gaaagcagac gtagaggaag aatttttagc
7321 actcaggaaa cgaacaccat cagcaggcaa agccatggac accccaaaac cagcagtaag
7381 tgatgagaaa aatatcaaca catttgtgga aactccagtg cagaaactgg acctgctagg
7441 aaatttacct ggcagcaaga gacagccaca gactcctaag gaaaaggctg aggctctaga
7501 ggacctggtt ggcttcaaag aactcttcca gacaccaggt cacactgagg aatcaatgac
7561 tgatgacaaa atcacagaag tatcctgtaa atctccacag ccagagtcat tcaaaacctc
7621 aagaagctcc aagcaaaggc tcaagatacc cctggtgaaa gtggacatga aagaagagcc
7681 cctagcagtc agcaagctca cacggacatc aggggagact acgcaaacac acacagagcc
7741 aacaggagat agtaagagca tcaaagcgtt taaggagtct ccaaagcaga tcctggaccc
7801 agcagcaagt gtaactggta gcaggaggca gctgagaact cgtaaggaaa aggcccgtgc
7861 tctagaagac ctggttgact tcaaagagct cttctcagca ccaggtcaca ctgaagagtc
7921 aatgactatt gacaaaaaca caaaaattcc ctgcaaatct cccccaccag aactaacaga
7981 cactgccacg agcacaaaga gatgccccaa gacacgtccc aggaaagaag taaaagagga
8041 gctctcagca gttgagaggc tcacgcaaac atcagggcaa agcacacaca cacacaaaga
8101 accagcaagc ggtgatgagg gcatcaaagt attgaagcaa cgtgcaaaga agaaaccaaa
8161 cccagtagaa gaggaaccca gcaggagaag gccaagagca cctaaggaaa aggcccaacc
8221 cctggaagac ctggccggct tcacagagct ctctgaaaca tcaggtcaca ctcaggaatc
8281 actgactgct ggcaaagcca ctaaaatacc ctgcgaatct cccccactag aagtggtaga
8341 caccacagca agcacaaaga ggcatctcag gacacgtgtg cagaaggtac aagtaaaaga
8401 agagccttca gcagtcaagt tcacacaaac atcaggggaa accacggatg cagacaaaga
8461 accagcaggt gaagataaag gcatcaaagc attgaaggaa tctgcaaaac agacaccggc
8521 tccagcagca agtgtaactg gcagcaggag acggccaaga gcacccaggg aaagtgccca
8581 agccatagaa gacctagctg gcttcaaaga cccagcagca ggtcacactg aagaatcaat
8641 gactgatgac aaaaccacta aaataccctg caaatcatca ccagaactag aagacaccgc
8701 aacaagctca aagagacggc ccaggacacg tgcccagaaa gtagaagtga aggaggagct
8761 gttagcagtt ggcaagctca cacaaacctc aggggagacc acgcacaccg acaaagagcc
8821 ggtaggtgag ggcaaaggca cgaaagcatt taagcaacct gcaaagcgga acgtggacgc
8881 agaagatgta attggcagca ggagacagcc aagagcacct aaggaaaagg cccaacccct
8941 ggaagacctg gccagcttcc aagagctctc tcaaacacca ggccacactg aggaactggc
9001 aaatggtgct gctgatagct ttacaagcgc tccaaagcaa acacctgaca gtggaaaacc
9061 tctaaaaata tccagaagag ttcttcgggc ccctaaagta gaacccgtgg gagacgtggt
9121 aagcaccaga gaccctgtaa aatcacaaag caaaagcaac acttccctgc ccccactgcc
9181 cttcaagagg ggaggtggca aagatggaag cgtcacggga accaagaggc tgcgctgcat
9241 gccagcacca gaggaaattg tggaggagct gccagccagc aagaagcaga gggttgctcc
9301 cagggcaaga ggcaaatcat ccgaacccgt ggtcatcatg aagagaagtt tgaggacttc
9361 tgcaaaaaga attgaacctg cggaagagct gaacagcaac gacatgaaaa ccaacaaaga
9421 ggaacacaaa ttacaagact cggtccctga aaataaggga atatccctgc gctccagacg
9481 ccaagataag actgaggcag aacagcaaat aactgaggtc tttgtattag cagaaagaat
9541 agaaataaac agaaatgaaa agaagcccat gaagacctcc ccagagatgg acattcagaa
9601 tccagatgat ggagcccgga aacccatacc tagagacaaa gtcactgaga acaaaaggtg
9661 cttgaggtct gctagacaga atgagagctc ccagcctaag gtggcagagg agagcggagg
9721 gcagaagagt gcgaaggttc tcatgcagaa tcagaaaggg aaaggagaag caggaaattc
9781 agactccatg tgcctgagat caagaaagac aaaaagccag cctgcagcaa gcactttgga
9841 gagcaaatct gtgcagagag taacgcggag tgtcaagagg tgtgcagaaa atccaaagaa
9901 ggctgaggac aatgtgtgtg tcaagaaaat aacaaccaga agtcataggg acagtgaaga
9961 tatttgacag aaaaatcgaa ctgggaaaaa tataataaag ttagttttgt gataagttct
10021 agtgcagttt ttgtcataaa ttacaagtga attctgtaag taaggctgtc agtctgctta
10081 agggaagaaa actttggatt tgctgggtct gaatcggctt cataaactcc actgggagca
10141 ctgctgggct cctggactga gaatagttga acaccggggg ctttgtgaag gagtctgggc
10201 caaggtttgc cctcagcttt gcagaatgaa gccttgaggt ctgtcaccac ccacagccac
10261 cctacagcag ccttaactgt gacacttgcc acactgtgtc gtcgtttgtt tgcctatgtt
10321 ctccagggca cggtggcagg aacaactatc ctcgtctgtc ccaacactga gcaggcactc
10381 ggtaaacacg aatgaatgga taagcgcacg gatgaatgga gcttacaaga tctgtctttc
10441 caatggccgg gggcatttgg tccccaaatt aaggctattg gacatctgca caggacagtc
10501 ctatttttga tgtcctttcc tttctgaaaa taaagttttg tgctttggag aatgactcgt
10561 gagcacatct ttagggacca agagtgactt tctgtaagga gtgactcgtg gcttgccttg
10621 gtctcttggg aatacttttc taactagggt tgctctcacc tgagacattc tccacccgcg
10681 gaatctcagg gtcccaggct gtgggccatc acgacctcaa actggctcct aatctccagc
10741 tttcctgtca ttgaaagctt cggaagttta ctggctctgc tcccgcctgt tttctttctg
10801 actctatctg gcagcccgat gccacccagt acaggaagtg acaccagtac tctgtaaagc
10861 atcatcatcc ttggagagac tgagcactca gcaccttcag ccacgatttc aggatcgctt
10921 ccttgtgagc cgctgcctcc gaaatctcct ttgaagccca gacatctttc tccagcttca
10981 gacttgtaga tataactcgt tcatcttcat ttactttcca ctttgccccc tgtcctctct
11041 gtgttcccca aatcagagaa tagcccgcca tcccccagat cacctgtctg gattcctccc
11101 cattcaccca ccttgccagg tgcaggtgag gatggtgcac cagacagggt agctgtcccc
11161 caaaatgtgc cctgtgcggg cagtgccctg tctccacgtt tgtttcccca gtgtctggcg
11221 gggagccagg tgacatcata aatacttgct gaatgaatgc agaaatcagc ggtactgact
11281 tgtactatat tggctgccat gatagggttc tcacagcgtc atccatgatc gtaagggaga
11341 atgacattct gcttgaggga gggaatagaa aggggcaggg aggggacatc tgagggcttc
11401 acagggctgc aaagggtaca gggattgcac cagggcagaa caggggaggg tgttcaagga
11461 agagtggctc ttagcagagg cactttggaa ggtgtgaggc ataaatgctt ccttctacgt
11521 aggccaacct caaaactttc agtaggaatg ttgctatgat caagttgttc taacacttta
11581 gacttagtag taattatgaa cctcacatag aaaaatttca tccagccata tgcctgtgga
11641 gtggaatatt ctgtttagta gaaaaatcct ttagagttca gctctaacca gaaatcttgc
11701 tgaagtatgt cagcaccttt tctcaccctg gtaagtacag tatttcaaga gcacgctaag
11761 ggtggttttc attttacagg gctgttgatg atgggttaaa aatgttcatt taagggctac
11821 ccccgtgttt aatagatgaa caccacttct acacaaccct ccttggtact gggggaggga
11881 gagatctgac aaatactgcc cattccccta ggctgactgg atttgagaac aaatacccac
11941 ccatttccac catggtatgg taacttctct gagcttcagt ttccaagtga atttccatgt
12001 aataggacat tcccattaaa tacaagctgt ttttactttt tcgcctccca gggcctgtgc
12061 gatctggtcc cccagcctct cttgggcttt cttacactaa ctctgtacct accatctcct
12121 gcctccctta ggcaggcacc tccaaccacc acacactccc tgctgttttc cctgcctgga
12181 actttcccac cagccccacc aagatcattt catccagtcc tgagctcagc ttaagggagg
12241 cttcttgcct gtgggttccc tcacccccat gcctgtcctc caggctgggg caggttctta
12301 gtttgcctgg aattgttctg tacctctttg tagcacgtag tgttgtgaaa ctaagccact
12361 aattgagttt ctggctcccc tcctggggtt gtaagttttg ttcattcatg agggccgact
12421 gtatttcctg gttactgtat cccagtgacc agccacagga gatgtccaat aaagtatgtg
12481 atgaaatggt cttaaaaaaa aaaaaaaaaa aaaaa
//