LOCUS       X64810                  5037 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  H.sapiens encoding PC1/PC3.
ACCESSION   X64810 S88573
VERSION     X64810.1
KEYWORDS    endoprotease; PC1/PC3 protein; subtilisin homologue.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5037)
  AUTHORS   Creemers J.W., Roebroek A.J., de Ven W.J.
  TITLE     Expression in human lung tumor cells of the proprotein processing
            enzyme PC1/PC3. Cloning and primary sequence of a 5 kb cDNA
  JOURNAL   FEBS Lett. 300(1), 82-88(1992).
   PUBMED   1547893
REFERENCE   2  (bases 1 to 5037)
  AUTHORS   Roebroek A.J.M.
  JOURNAL   Submitted (12-JUN-1992) to the INSDC. A.J.M. Roebroek,
            Universitaire Ziekenhuizen, Leuven, Centrum voor Menselijke
            Erfelijkheid, UZ Gasthuisberg, Herestraat 49    3000 Leuven,
            BELGIUM
FEATURES             Location/Qualifiers
     source          1..5037
                     /db_xref="H-InvDB:HIT000322703"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /dev_stage="adult"
                     /tissue_type="human lung cancer: carcinoid tumor"
                     /db_xref="taxon:9606"
     5'UTR           1..189
                     /citation=[1]
     CDS             190..2451
                     /product="PC1/PC3"
                     /function="proprotein processing enzyme"
                     /db_xref="GOA:P29120"
                     /db_xref="H-InvDB:HIT000322703.14"
                     /db_xref="HGNC:HGNC:8743"
                     /db_xref="InterPro:IPR000209"
                     /db_xref="InterPro:IPR002884"
                     /db_xref="InterPro:IPR008979"
                     /db_xref="InterPro:IPR015500"
                     /db_xref="InterPro:IPR022005"
                     /db_xref="InterPro:IPR022398"
                     /db_xref="InterPro:IPR023827"
                     /db_xref="InterPro:IPR023828"
                     /db_xref="InterPro:IPR032815"
                     /db_xref="InterPro:IPR034182"
                     /db_xref="InterPro:IPR036852"
                     /db_xref="InterPro:IPR038466"
                     /db_xref="UniProtKB/Swiss-Prot:P29120"
                     /citation=[1]
                     /protein_id="CAA46031.1"
                     /translation="MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPE
                     AASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQ
                     YEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKG
                     VVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAM
                     QANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKT
                     VEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSA
                     SQQGLSPWYAEKCSSTLATSYSGGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIF
                     ALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALV
                     DLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQ
                     FEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGT
                     WTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMV
                     DPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPK
                     QSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSLYNDYVDVFYNTKPYKHRDDR
                     LLQALVDILNEEN"
     3'UTR           2449..5037
BASE COUNT         1458 a         1061 c         1106 g         1412 t
ORIGIN      
        1 aagcgcttca ctgagcgctc gccgccgccc agcctctcct ctcgcgcctc ctagctcttc
       61 gcagagcaac caggagccag gagtggtcta gagcccgagg gtgggaaggg ggagtctgtc
      121 tggcttttct cctatcttgc ttctttttcc tcttcccttc ccactcttgt tcaagcgagt
      181 gtgtgagcta tggagcgaag agcctggagt ctgcagtgca ctgctttcgt cctcttttgc
      241 gcttggtgtg cactgaacag tgcaaaagcg aaaaggcaat ttgtcaatga atgggcagcg
      301 gagatccccg ggggcccgga agcagcctcg gccatcgccg aggagctggg ctatgacctt
      361 ttgggtcaga ttggttcact tgaaaatcac tacttattca aacataaaaa ccaccccaga
      421 aggtctcgaa ggagtgcctt tcatatcact aagagattat ctgatgatga tcgtgtgata
      481 tgggctgaac aacagtatga aaaagaaaga agtaaacgtt cagctctaag ggactcagca
      541 ctaaatctct tcaatgatcc catgtggaat cagcaatggt acttgcaaga taccaggatg
      601 acggcagccc tgcccaagct ggaccttcat gtgatacctg tttggcaaaa aggcattacg
      661 ggcaaaggag ttgttatcac cgtactggat gatggtttgg agtggaatca cacggacatt
      721 tatgccaact atgatccaga ggctagctat gattttaatg ataatgacca tgatccattt
      781 ccccgatatg atcccacaaa cgagaacaaa cacgggacca gatgtgcagg agaaattgcc
      841 atgcaagcaa ataatcacaa atgcggggtt ggagttgcat acaattccaa agttggaggc
      901 ataagaatgc tggatggcat tgtgacggat gctattgagg ccagttcaat tggattcaat
      961 cctggacacg tggatattta cagtgcaagc tggggcccta atgatgatgg gaaaactgtg
     1021 gaggggcctg gccggctagc ccagaaggct tttgaatatg gtgtcaaaca ggggagacag
     1081 gggaaggggt ccatcttcgt ctgggcttcg ggaaacgggg ggcgtcaggg agataattgt
     1141 gactgtgatg gctacacaga cagcatctac accatctcca tcagcagtgc ctcccagcaa
     1201 ggcctatccc cctggtacgc tgagaagtgc tcctccacac tggccacctc ttacagcggc
     1261 ggagattaca ccgaccagag aatcacgagc gctgacctgc acaatgactg cacggagacg
     1321 cacacaggca cctcggcctc tgcacctctg gctgctggca tcttcgctct ggccctggaa
     1381 gcaaacccaa atctcacctg gcgagatatg cagcacctgg ttgtctggac ctctgagtat
     1441 gacccgctgg ccaataaccc tggatggaaa aagaatggag caggcttgat ggtgaatagt
     1501 cgatttggat ttggcttgct aaatgccaaa gctctggtgg atttagctga ccccaggacc
     1561 tggaggagcg tgcctgagaa gaaagagtgt gttgtaaagg acaatgactt tgagcccaga
     1621 gccctgaaag ctaatggaga agttatcatt gaaattccaa caagagcttg tgaaggacaa
     1681 gaaaatgcta tcaagtccct ggagcatgta caatttgaag caacaattga atattcccga
     1741 agaggagacc ttcatgtcac acttacttct gctgctggaa ctagcactgt gctcttggct
     1801 gaaagagaac gggatacatc tcctaatggc tttaagaact gggacttcat gtctgttcac
     1861 acatggggag agaaccctat aggtacttgg actttgagaa ttacagacat gtctggaaga
     1921 attcaaaatg aaggaagaat tgtgaactgg aagctgattt tgcacgggac ctcttctcag
     1981 ccagagcata tgaagcagcc tcgtgtgtac acgtcctaca acactgttca gaatgacaga
     2041 agaggggtgg agaagatggt ggatccaggg gaggagcagc ccacacaaga gaaccctaag
     2101 gagaacaccc tggtgtccaa aagccccagc agcagcagcg tagggggccg gagggatgag
     2161 ttggaggagg gagccccttc ccaggccatg ctgcgactcc tgcaaagtgc tttcagtaaa
     2221 aactcaccgc caaagcaatc accaaagaag tccccaagtg caaagctcaa catcccttat
     2281 gaaaacttct acgaagccct ggaaaagctg aacaaacctt cccagcttaa agactctgaa
     2341 gacagtctgt ataatgacta tgttgatgtt ttttataaca ctaaacctta caagcacaga
     2401 gacgaccggc tgcttcaagc tctggtggac attctgaatg aggaaaatta aaataagtgt
     2461 gtggtcccaa gttggaaata ttcatgcttc ttccttaccc tgcgattttg cctgtgtctg
     2521 aagtggttgt tttgtcatga attcttatgc ttataatatc ctttgtggca ccttttcttt
     2581 ttctccctaa actgtacatg tgaaggggat gagctcaagc aggaagttca acttccagaa
     2641 ttgatcatag gtatttcaaa acacatcttt cctgtctgca caagtgaagt gttttgttct
     2701 ttctggagtc acagttgaca aaaagctctt acactacatt agaacactgc attagagccc
     2761 atttcaattc tcaaaagaaa aggcaaaacc tgggatatca attaatttga aaacataatc
     2821 tgcaaagaat gagaaggagt cagaaactgt ttctgtagct tgttccctgt cttgtccatg
     2881 tggttcttca aattttgatg ccaagaaagt atttggtagg cctaatgaag gagttcactg
     2941 taagactcat tccctagatc tttctattcc aaagtgccac tcattcctgt agtcaaaatc
     3001 tggtcatgtt ggtcaaaagc tggattattt agatctagaa acagatcttg aaatctgaat
     3061 gctctggttt gagcaatttt cgaacattct ttgcctggtg cactgtgtct gtggtgccag
     3121 aggcgtccgt ggatccagag gtggttatga ctcgtgctgc atgcctggtc tttcctctgt
     3181 ttctccttct gaaagttttc tatacctgtc tcctttctca gccacaaaat aaatgttggg
     3241 agaaatgata tataccactt tcccagaaaa aaaaaaactt acacttggga cttggcaaat
     3301 tcctagtcac aatttttttc agcagtaaca ggaaaccact tatcacatgg agacctaatg
     3361 taataataga aaaatactca taatagggag aaaccaagag aagttttgtt tttgtttttt
     3421 tccaactgtg ttcattagaa cagcgtgttc taagtatttg aaactgaatg tttattcctt
     3481 gatactaaaa gttcttctcc aatcctatca ctgatagtgt ccaaattctc accaaattgc
     3541 tcctaagctt caaatcagaa gcagaaactg gcaggccatg gaccttaatt gtccctcagg
     3601 tagattttgt ttggtatgca gaatgttttt aaaatatgag tggttattga aaatatgatg
     3661 tttcacataa aacctcattc tcggacccat ctttgctcat ggcaacagtt agctggagct
     3721 gagtagcagc tgcctgatta gatgactctc agtccccatg gcaccctgct ccatgttacc
     3781 tagagcaggc acttgattcc ttgctgggca gtatccaata ggcatttgat tttgcccact
     3841 cctacactaa gcgaatgtgt acaaagtgta aatgcattag gaaaaacaaa ctacccgcat
     3901 cttctgttag gcaggatctg tacaataata attatgagtt tgcttatgta atctcacctc
     3961 acctggatga tcactaatac taattcattt attactaacc ttctggcttc cttctctcaa
     4021 tatgcttaca aagtctccag tcacctacaa tgctggcttt ctcccactga gtttgctgtt
     4081 tgcaattttt ccatgaagtt tgaacttcat aaggtaattc atggcattga actggttcat
     4141 gaaaagaaca ctagagtctg tcatttgctt tggcttgaag tatggttggt aacacaaatt
     4201 ttcacctgct cttctaccat ttgaatttgt gtagagggtg tttgcagagc aatgcccgta
     4261 atgcttagag aatgttctcc taaaagactt gcggaatcac tctgtccttg gaagtttcat
     4321 atattgtttg atatgaagtg ttagatagaa tttccaatat tggagcatat caaaaagtat
     4381 taaaactaaa aaggaccaga gaattcttag attggcccgg aaaggccaat aaagagttag
     4441 aatgaaaact cattactttt ccattcccaa tctagtgcta gatgtataaa tctttctttt
     4501 gattcttcct aacaaaatat tttctgggtt aaaaccccag ccaactcatt gggttgtagc
     4561 caaaggttca ctctcaagaa gctttaatat ttaaataaaa tcatattgaa tgtttccaac
     4621 ctggagtata atattcagat ataaaacagt tttgtcagtc tttcttagtg cctgtgtgga
     4681 tttttgtgaa aatgtcaaag agaaaactta tatactattt cccttgaaat tttaaactat
     4741 attttcttta caggtattta taatatacca atgcttttat caaacagaat tttaaagagc
     4801 ataataaatt atattaaaga accaaaagtt ttcctgagaa taagaaagtt tcacccaata
     4861 aaatattttt gaaaggcatg ttcctctgtc aatgaaaaaa agtacatgta tgtgttgtga
     4921 tattaaaagt gacatttgtc taatagccta atacaacatg tagctgagtt taacatgtgt
     4981 ggtcttggta ttcttaaggg aacttccaca ttatacattt gatgtattga ccagaat
//