LOCUS X64330 4297 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for ATP-citrate lyase.
ACCESSION X64330
VERSION X64330.1
KEYWORDS acetyl coA production; ATP citrate-lyase; cholesterol biosynthesis.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4297)
AUTHORS Elshourbagy N.A.
JOURNAL Submitted (31-JAN-1992) to the INSDC. N.A. Elshourbagy, Smithkline
Beecham, P.O.Box 1539, King of Prussia, PA 19406-0939, USA
REFERENCE 2 (bases 1 to 4297)
AUTHORS Elshourbagy N.A., Near J.C., Kmetz P.J., Wells T.N., Groot P.H.,
Saxty B.A., Hughes S.A., Franklin M., Gloger I.S.
TITLE Cloning and expression of a human ATP-citrate lyase cDNA
JOURNAL Eur. J. Biochem. 204(2), 491-499(1992).
PUBMED 1371749
COMMENT Related sequence: J05210
FEATURES Location/Qualifiers
source 1..4297
/db_xref="H-InvDB:HIT000322687"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="adult male"
/clone_lib="lambda zap cDNA library"
/tissue_type="liver"
/db_xref="taxon:9606"
5'UTR 1..84
CDS 85..3402
/gene="ATP-citrate lyase"
/product="ATP-citrate (pro-S-)-lyase"
/EC_number="4.1.3.8"
/db_xref="GOA:P53396"
/db_xref="H-InvDB:HIT000322687.12"
/db_xref="HGNC:HGNC:115"
/db_xref="InterPro:IPR002020"
/db_xref="InterPro:IPR003781"
/db_xref="InterPro:IPR005811"
/db_xref="InterPro:IPR014608"
/db_xref="InterPro:IPR016102"
/db_xref="InterPro:IPR016143"
/db_xref="InterPro:IPR017440"
/db_xref="InterPro:IPR017866"
/db_xref="InterPro:IPR032263"
/db_xref="InterPro:IPR033847"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036969"
/db_xref="PDB:3MWD"
/db_xref="PDB:3MWE"
/db_xref="PDB:3PFF"
/db_xref="PDB:5TDE"
/db_xref="PDB:5TDF"
/db_xref="PDB:5TDM"
/db_xref="PDB:5TDZ"
/db_xref="PDB:5TE1"
/db_xref="PDB:5TEQ"
/db_xref="PDB:5TES"
/db_xref="PDB:5TET"
/db_xref="PDB:6HXH"
/db_xref="PDB:6HXK"
/db_xref="PDB:6HXL"
/db_xref="PDB:6HXM"
/db_xref="PDB:6O0H"
/db_xref="PDB:6QFB"
/db_xref="UniProtKB/Swiss-Prot:P53396"
/protein_id="CAA45614.1"
/translation="MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLL
QDHPWLLSQNLVVKPDQLIKRRGKLGLVGVDLTLDGVKSWLKPRLGQEATVGKATGFL
KNFLIEPFAPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKL
NPEDIKKHLLVHAPDDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLA
AKVDATADYICKVKWGDIEFPPPFGRVAYPEEAYIADLDAKSGASLKLTLLNPKGRIW
TMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPD
GKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMG
EVGKTTGIPIHVFGTETHMTAIVGMAWAPAIPNQPPTAAHTANFLLNAQRETSTPAPS
RTASFYESMVDEVRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGM
QTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRK
HPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTI
IGPATVGGIKPGCFKIGNTGGMLDNILASKLYPQAAVAYVSRSGGMSNELNNIISRTT
DGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKISRGIKEGRL
TKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELG
EIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQEL
IYAGMPITEVFKEEMGIGGALGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNT
IICARTAVELVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGK
LIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVD
GLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLY
RHPWDDISYVLPEHMSM"
3'UTR 3403..4297
BASE COUNT 1048 a 1105 c 1132 g 1012 t
ORIGIN
1 cccggatttt gcggggttcg tcgggcctgt ggaagaagcc ccgccacgga cttcggcaga
61 ggtagagcag gtctctctgc agccatgtcg gccaaggcaa tttcagagca gacgggcaaa
121 gaactccttt acaagttcat ctgtaccacc tcagccatcc agaatcggtt caagtatgct
181 cgggtcactc ctgacacaga ctgggcccgc ttgctgcagg accacccctg gctgctcagc
241 cagaacttgg tagtcaagcc agaccagctg atcaaacgtc gtggaaaact tggtctcgtt
301 ggggtcgacc tcactctgga tggggtcaag tcctggctga agccacggct gggacaggaa
361 gccacagttg gcaaggccac aggcttcctc aagaactttc tgatcgagcc cttcgccccc
421 cacagtcagg ctgaggagtt ctatgtctgc atctatgcca cccgagaagg ggactacgtc
481 ctgttccacc acgagggggg tgtggacgtg ggtgatgtgg acgccaaggc ccagaagctg
541 cttgttggcg tggatgagaa actgaatcct gaggacatca aaaaacacct gttggtccac
601 gcccctgacg acaagaaaga aattctggcc agttttatct ccggcctctt caatttctac
661 gaggacttgt acttcaccta cctcgagatc aatccccttg tagtgaccaa agatggagtc
721 tatgtccttg acttggcggc caaggtggac gccactgccg actacatctg caaagtgaag
781 tggggtgaca tcgagttccc tccccccttc gggcgggtgg catatccaga ggaagcctac
841 attgcagacc tcgatgccaa aagtggggca agcctgaagc tgaccttgct gaaccccaaa
901 gggaggatct ggaccatggt ggccgggggt ggcgcctctg tcgtgtacag cgataccatc
961 tgtgatctag ggggtgtcaa cgagctggca aactatgggg agtactcagg cgcccccagc
1021 gagcagcaga cctatgacta tgccaagact atcctctccc tcatgacccg agagaagcac
1081 ccagatggca agatcctcat cattggaggc agcatcgcaa acttcaccaa cgtggctgcc
1141 acgttcaagg gcatcgtgag agcaattcga gattaccagg gccccctgaa ggagcacgaa
1201 gtcacaatct ttgtccgaag aggtggcccc aactatcagg agggcttacg ggtgatggga
1261 gaagtcggga agaccactgg gatccccatc catgtctttg gcacagagac tcacatgacg
1321 gccattgtgg gcatggcctg ggcaccggcc atccccaacc agccacccac agcggcccac
1381 actgcaaact ttctcctcaa cgcccagcgg gagacatcga ctccagcccc cagcaggaca
1441 gcatcttttt atgagtccat ggtcgatgag gtcagggccg atgaggtggc gcctgcaaag
1501 aaggccaagc ctgccatgcc acaagattca gtcccaagtc caagatccct gcaaggaaag
1561 agcaccaccc tcttcagccg ccacaccaag gccattgtgt ggggcatgca gacccgggcc
1621 gtgcaaggca tgctggactt tgactatgtc tgctcccgag acgagccctc agtggctgcc
1681 atggtctatc ctttcactgg ggaccacaag cagaagtttt actgggggca caaagagatc
1741 ctgatccctg tcttcaagaa catggctgat gccatgagga agcacccgga ggtagatgtg
1801 ctcatcaact ttgcctctct ccgctctgcc tatgacagca ccatggagac catgaactat
1861 gcccagatcc ggaccatcgc catcatagct gaaggcatcc ctgaggccct cacgagaaag
1921 ctgatcaaga aggcggacca gaagggagtg accatcatcg gacctgccac tgttggaggc
1981 atcaagcctg ggtgctttaa gattggcaac acaggtggga tgctggacaa catcctggcc
2041 tccaaactgt acccccaggc agctgtggcc tatgtctcac gttccggagg catgtccaac
2101 gagctcaaca atatcatctc tcggaccacg gatggcgtct atgagggcgt ggccattggt
2161 ggggacaggt acccgggctc cacattcatg gatcatgtgt tacgctatca ggacactcca
2221 ggagtcaaaa tgattgtggt tcttggagag attgggggca ctgaggaata taagatttcc
2281 cggggcatca aggagggccg cctcactaag cccatcgtct gctggtgcat cgggacgtgt
2341 gccaccatgt tctcctctga ggtccagttt ggccatgctg gagcttgtgc caaccaggct
2401 tctgaaactg cagtagccaa gaaccaggct ttgaaggaag caggagtgtt tgtgccccgg
2461 agctttgatg agcttggaga gatcatccag tctgtatacg aagatctcgt ggccaatgga
2521 gtcattgtac ctgcccagga ggtgccgccc ccaaccgtgc ccatggacta ctcctgggcc
2581 agggagcttg gtttgatccg caaacctgcc tcgttcatga ccagcatctg cgatgagcga
2641 ggacaggagc tcatctacgc gggcatgccc atcactgagg tcttcaagga agagatgggc
2701 attggcgggg ccctcggcct cctctggttc cagaaaaggt tgcctaagta ctcttgccag
2761 ttcattgaga tgtgtctgat ggtgacagct gatcacgggc cagccgtctc tggagcccac
2821 aacaccatca tttgtgcgcg caccgcggtg gagctggtct ccagcctcac ctcggggctg
2881 ctcaccatcg gggatcggtt tgggggtgcc ttggatgcag cagccaagat gttcagtaaa
2941 gcctttgaca gtggcattat ccccatggag tttgtgaaca agatgaagaa ggaagggaag
3001 ctgatcatgg gcattggtca ccgagtgaag tcgataaaca acccagacat gcgagtgcag
3061 atcctcaaag attacgtcag gcagcacttc cctgccactc ctctgctcga ttatgcactg
3121 gaagtagaga agattaccac ctcgaagaag ccaaatctta tcctgaatgt agatggtctc
3181 atcggagtcg catttgtaga catgcttaga aactgtgggt cctttactcg ggaggaagct
3241 gatgaatata ttgacattgg agccctcaat ggcatctttg tgctgggaag gagtatgggg
3301 ttcattggac actatcttga tcagaagagg ctgaagcagg ggctgtatcg tcatccgtgg
3361 gatgatattt catatgttct tccggaacac atgagcatgt aacagagcca ggaaccctac
3421 tgcagtaaac tgaagacaag aactcttccc ccaagaaaaa gtgtcagaca gctggcagtg
3481 gagcctgctt tatttagcag gggcctggaa tgtaaacagc cactggggta caggcaccga
3541 agaccaacat ccacaggcta acaccccttc agtccacaca aagaagcttc atattttttt
3601 tataagcata gaaataaaaa ccaagccaat atttgtgact ttgctctgct acctgctgta
3661 tttattatat ggaagcatct aagtactgtc aggatggggt cttcctcatt gtagggcgtt
3721 aggatgttgc tttctttttc cattagttaa acattttttt ctcctttgga ggaagggaat
3781 gaaacattta tggcctcaag atactataca tttaaagcac cccaatgtct ctcttttttt
3841 ttttttttac ttcccttgct tcttccttat ataacatgaa gaacattgta ttaatctgat
3901 ttttaaagac tttttgtatg ttacgtgtta agggcttgtt tggtatccca ctgaaatgtt
3961 ctgtgttgca gaccagagtc tgtttatgtc agggggaggg ggccattgca tccttagcca
4021 ttgtcacaaa atatgtggag tagtaactta atatgtaaag ttgtaacata catacattta
4081 aaatggaaat gcagaaagct gtgaaatgtc ttgtgtctta tgttctctgt atttatgcag
4141 ctgatttgtc tgtctgtaac tgaagtgtgg gtccaaggac tcctaactac tttgcatctg
4201 taatccacaa agattctggg cagctgccac ctcagtctct tctctgtatt atcatagtct
4261 ggtttaaata aactatatag taacaggaat tcctgca
//