LOCUS X64228 6597 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens can mRNA.
ACCESSION X64228 S89710
VERSION X64228.1
KEYWORDS can gene; putative oncogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6597)
AUTHORS von Lindern M.
JOURNAL Submitted (20-JAN-1992) to the INSDC. M. Von Lindern, Dept of Cell
Biology, Erasmus University, P.O. Box 1738, 3000 DR Rotterdam, THE
NETHERLANDS
REFERENCE 2 (bases 1 to 6597)
AUTHORS Lindern M., Fornerod M., Baal S., Jaegle M., Wit T.D., Buijs A.,
Grosveld G.
TITLE The translocation (6;9), associated with a specific subtype of
acute myeloid leukemia, results in the fusion of two genes, dek and
can, and the expression of a chimeric, leukemia-specific dek-can
mRNA
JOURNAL Mol. Cell. Biol. 12(4), 1687-1697(1992).
PUBMED 1549122
COMMENT See also X64229
FEATURES Location/Qualifiers
source 1..6597
/db_xref="H-InvDB:HIT000322670"
/organism="Homo sapiens"
/chromosome="9q34"
/mol_type="mRNA"
/clone_lib="human testes (Clonetech)"
/clone="hXT23, hXT37, hXT54 & hXT65"
/tissue_type="testes"
/germline
/db_xref="taxon:9606"
CDS 95..6367
/gene="can"
/product="putative oncogene"
/db_xref="GOA:P35658"
/db_xref="H-InvDB:HIT000322670.14"
/db_xref="HGNC:HGNC:8064"
/db_xref="InterPro:IPR001680"
/db_xref="InterPro:IPR015943"
/db_xref="InterPro:IPR026054"
/db_xref="InterPro:IPR041553"
/db_xref="PDB:2OIT"
/db_xref="PDB:3FHC"
/db_xref="PDB:3FMO"
/db_xref="PDB:3FMP"
/db_xref="PDB:5DIS"
/db_xref="UniProtKB/Swiss-Prot:P35658"
/protein_id="CAA45535.1"
/translation="MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAV
SNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSC
DNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHKLLKDAAGMVIDMKWNPT
VPSMVAVCLADGSIDVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQ
YLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALL
PKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAASTEVSILARQSD
QINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLL
STDGVLCPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDAS
AAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYSSGSDS
SKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVS
APNIAMKSSFPPSTSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPL
SHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKML
RTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLL
YKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERET
LFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLE
SLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAF
LSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLP
HAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISA
PQQLAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSVPYS
TAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTP
SASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSK
PSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGEL
LFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPP
VLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGK
TSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTE
EATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSG
TAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVE
TSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAP
SATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTF
GQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSF
SFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGF
GSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANK
NPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQG
FGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGT
AAASAGGFGFGSSSNTTSFGTLASQNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFS
FGSNNSSVQGFGGWRS"
misc_feature 4052
/note="translocation breakpoint"
BASE COUNT 1590 a 1870 c 1549 g 1588 t
ORIGIN
1 aggggaggaa gtttgctgtc gagcggcctg ggttccgtgg gcaaggcgtg ggtggcagcg
61 ttggctcgtt cgacgacaca ctgagggcgg cgcgatggga gacgagatgg atgccatgat
121 tcccgagcgg gagatgaagg attttcagtt tagagcgcta aagaaggtga gaatctttga
181 ctcccctgag gaattgccca aggaacgctc gagtctgctt gctgtgtcca acaaatatgg
241 tctggtcttc gctggtggag ccagtggctt gcagattttt cctactaaaa atcttcttat
301 tcaaaataaa cccggagatg atcccaacaa aatagttgat aaagtccaag gcttgctagt
361 tcctatgaaa ttcccaatcc atcacctggc cttgagctgt gataacctca cactctctgc
421 gtgcatgatg tccagtgaat atggttccat tattgctttt tttgatgttc gcacattctc
481 aaatgaggct aaacagcaaa aacgcccatt tgcctatcat aagcttttga aagatgcagc
541 aggcatggtg attgatatga agtggaaccc cactgtcccc tccatggtgg cagtttgtct
601 ggctgatggt agtattgatg tcctgcaagt cacggaaaca gtgaaagtat gtgcaactct
661 tccttccacg gtagcagtaa cctctgtgtg ctggagcccc aaaggaaagc agctggcagt
721 gggaaaacag aatggaactg tggtccagta tcttcctact ttgcaggaaa aaaaagtcat
781 tccttgtcct ccgttttatg agtcagatca tcctgtcaga gttctggatg tgctgtggat
841 tggtacctac gtcttcgcca tagtgtatgc tgctgcagat gggaccctgg aaacgtctcc
901 agatgtggtg atggctctac taccgaaaaa agaagaaaag cacccagaga tatttgtgaa
961 ctttatggag ccctgttatg gcagctgcac ggagagacag catcattact acctcagtta
1021 cattgaggaa tgggatttag tgctggcagc atctgcggct tcaacagaag ttagtatcct
1081 tgctcgacaa agtgatcaga ttaattggga atcttggcta ctggaggatt ctagtcgagc
1141 tgaattgcct gtgacagaca agagtgatga ctccttgccc atgggagttg tcgtagacta
1201 tacaaaccaa gtggaaatca ccatcagtga tgaaaagact cttcctcctg ctccagttct
1261 catgttactt tcaacagatg gtgtgctttg tccattttat atgattaatc aaaatcctgg
1321 ggttaagtct ctcatcaaaa caccagagcg actttcatta gaaggagagc gacagcccaa
1381 gtcaccagga agtactccca ctaccccaac ctcctctcaa gccccacaga aactggatgc
1441 ttctgcagct gcagcccctg cctctctgcc accttcatca cctgctgctc ccattgccac
1501 tttttctttg cttcctgctg gtggagcccc cactgtgttc tcctttggtt cttcatcttt
1561 gaagtcatct gctacggtca ctggggagcc cccttcatat tccagtggct ccgacagctc
1621 caaagcagcc ccaggccctg gcccatcaac cttctctttt gttccccctt ctaaagcctc
1681 cctagccccc acccctgcag cgtctcctgt ggctccatca gctgcttcat tctcctttgg
1741 atcatctggt tttaagccta ccctggaaag cacaccagtg ccaagtgtgt ctgctccaaa
1801 tatagcaatg aagtcctcct tcccaccctc aacctctgct gtcaaagtca accttagtga
1861 aaagtttact gctgcagcta cctctactcc tgttagtagc tcccagagcg cacccccgat
1921 gtcgccattc tcttctgcct ccaagccagc tgcttctgga ccactcagcc accccacgcc
1981 tctctcagca ccacctagtt ccgtgccatt gaagtcctca gtcttgccct caccatcagg
2041 acgatctgct cagggcagtt caagcccagt gccctcaatg gtacagaaat cacccaggat
2101 aacccctcca gcggcaaagc caggctctcc ccaggcaaag tcacttcagc ctgctgttgc
2161 agaaaagcag ggacatcagt ggaaagattc agatcctgta atggctggaa ttggggagga
2221 gattgcacac tttcagaagg agttggaaga gttaaaagcc cgaacttcca aagcctgttt
2281 ccaagtgggc acttctgagg agatgaagat gctgcgaaca gaatcagatg acttgcatac
2341 ctttcttttg gagattaaag agaccacaga gtcgcttcat ggagatataa gtagcctgaa
2401 aacaacttta cttgagggct ttgctggtgt tgaggaagcc agagaacaaa atgaaagaaa
2461 tcgtgactct ggttatctgc atttgcttta taaaagacca ctggatccca agagtgaagc
2521 tcagcttcag gaaattcggc gccttcatca gtatgtgaaa tttgctgtcc aagatgtgaa
2581 tgatgttcta gacttggagt gggatcagca tctggaacaa aagaaaaaac aaaggcacct
2641 gcttgtgcca gagcgagaga cactgtttaa caccctagcc aacaatcggg aaatcatcaa
2701 ccaacagagg aagaggctga atcacctggt ggatagtctt cagcagctcc gcctttacaa
2761 acagacttcc ctgtggagcc tgtcctcggc tgttccttcc cagagcagca ttcacagttt
2821 tgacagtgac ctggaaagcc tgtgcaatgc tttgttgaaa accaccatag aatctcacac
2881 caaatccttg cccaaagtac cagccaaact gtcccccatg aaacaggcac aactgagaaa
2941 cttcttggcc aagaggaaga ccccaccagt gagatccact gctccagcca gcctgtctcg
3001 atcagccttt ctgtctcaga gatattatga agacttggat gaagtcagct caacgtcatc
3061 tgtctcccag tctctggaga gtgaagatgc acggacgtcc tgtaaagatg acgaggcagt
3121 ggttcaggcc cctcggcacg cccccgtggt tcgcactcct tccatccagc ccagtctctt
3181 gccccatgca gcaccttttg ctaaatctca cctggttcat ggttcttcac ctggtgtgat
3241 gggaacttca gtggctacat ctgctagcaa aattattcct caaggggccg atagcacaat
3301 gcttgccacg aaaaccgtga aacatggtgc acctagtcct tcccacccca tctcagcccc
3361 gcagcagctg gccgcagcag cactcaggcg gcagatggcc agtcaggcac cagctgtaaa
3421 cactttgact gaatcaacgt tgaagaatgt ccctcaagtg gtaaatgtgc aggaattgaa
3481 gaataaccct gcaacccctt ctacagccat gggttcttca gtgccctact ccacagccaa
3541 aacacctcac ccagtgttga ccccagtggc tgctaaccaa gccaagcagg ggtctctaat
3601 aaattccctt aagccatctg ggcctacacc agcatccggt cagttatcat ctggtgacaa
3661 agcttcaggg acagccaaga tagaaacagc tgtgacttca accccatctg cttctgggca
3721 gttcagcaag cctttctcat tttctccatc agggactggc tttaattttg ggataatcac
3781 accaacaccg tcttctaatt tcactgctgc acaaggggca acaccctcca ctaaagagtc
3841 aagccagccg gacgcattct catctggtgg gggaagcaaa ccttcttatg aggccattcc
3901 tgaaagctca cctccctcag gaatcacatc cgcatcaaac accaccccag gagaacctgc
3961 cgcatctagc agcagacctg tggcaccttc tggaactgct ctttccacca cctctagtaa
4021 gctggaaacc ccaccgtcca agctgggaga gcttctgttt ccaagttctt tggctggaga
4081 gactctggga agtttttcag gactgcgggt tggccaagca gatgattcta caaaaccaac
4141 caataaggct tcatccacaa gcctaactag tacccagcca accaagacgt caggcgtgcc
4201 ctcagggttt aattttactg cccccccggt gttagggaag cacacggagc cccctgtgac
4261 atcctctgca accaccacct cagtagcacc accagcagcc accagcactt cctcaactgc
4321 cgtttttggc agtctgccag tcaccagtgc aggatcctct ggggtcatca gttttggtgg
4381 gacatctcta agtgctggca agactagttt ttcatttgga agccaacaga ccaatagcac
4441 agtgccccca tctgccccac caccaactac agctgccact ccccttccaa catcattccc
4501 cacattgtca tttggtagcc tcctgagttc agcaactacc ccctccctgc ctatgtccgc
4561 tggcagaagc acagaagagg ccacttcatc agctttgcct gagaagccag gtgacagtga
4621 ggtctcagca tcagcagcct cacttctaga ggagcaacag tcagcccagc ttccccaggc
4681 tcctccgcaa acttctgact ctgttaaaaa agaacctgtt cttgcccagc ctgcagtcag
4741 caactctggc actgcagcat ctagtactag tcttgtagca ctttctgcag aggctacccc
4801 agccaccacg ggggtccctg atgccaggac ggaggcagta ccacctgctt cctccttttc
4861 tgtgcctggg cagactgctg tcacagcagc tgctatctca agtgcaggcc ctgtggccgt
4921 cgaaacatca agtaccccca tagcctccag caccacgtcc attgttgctc ccggcccatc
4981 tgcagaggca gcagcatttg gtaccgtcac ttctggctca tccgtctttg ctcagcctcc
5041 tgctgccagt tctagctcag ctttcaacca gctcaccaac aacacagcca ctgccccctc
5101 tgccacgccc gtgtttgggc aagtggcagc cagcaccgca ccaagtctgt ttgggcagca
5161 gactggtagc acagccagca cagcagctgc cacaccacag gtcagcagct cagggtttag
5221 cagcccagct tttggtacca cagccccagg ggtctttgga cagacaacct tcgggcaggc
5281 ctcagtcttt gggcagtcgg cgagcagtgc tgcaagtgtc ttttccttca gtcagcctgg
5341 gttcagttcc gtgcctgcct tcggtcagcc tgcttcctcc actcccacat ccaccagtgg
5401 aagtgtcttt ggtgccgcct caagtaccag tagctccagt tccttctcat ttggacagtc
5461 ttctcccaac acaggagggg ggctgtttgg ccaaagcaac gctcctgctt ttgggcagag
5521 tcctggcttt ggacagggag gctctgtctt tggtggtacc tcagctgcca ccacaacagc
5581 agcaacctct gggttcagct tttgccaagc ttcaggtttt gggtctagta atactggttc
5641 tgtgtttggt caagcagcca gtactggtgg aatagtcttt ggccagcaat catcctcttc
5701 cagtggtagc gtgtttgggt ctggaaacac tggaagaggg ggaggtttct tcagtggcct
5761 tggaggaaaa cccagtcagg atgcagccaa caaaaaccca ttcagctcgg ccagtggggg
5821 ctttggatcc acagctacct caaatacctc taacctattt ggaaacagtg gggccaagac
5881 atttggtgga tttgccagct cgtcgtttgg agagcagaaa cccactggca ctttcagctc
5941 tggaggagga agtgtggcat cccaaggctt tgggttttcc tctccaaaca aaacaggtgg
6001 cttcggtgct gctccagtgt ttggcagccc tcctactttt gggggatccc ctgggtttgg
6061 aggggtgcca gcattcggtt cagccccagc ctttacaagc cctctgggct cgacgggagg
6121 caaagtgttc ggagagggca ctgcagctgc cagcgcagga ggattcgggt ttgggagcag
6181 cagcaacacc acatccttcg gcacgctcgc gagtcagaat gcccccactt tcggatcact
6241 gtcccaacag acttctggtt ttgggaccca gagtagcgga ttctctggtt ttggatcagg
6301 cacaggaggg ttcagctttg ggtcaaataa ctcgtctgtc cagggttttg gtggctggcg
6361 aagctgaggg cgtgtcagca ggcctttcga tccctgggac caaccgcatc ctcagcttct
6421 tccccgagaa atgctggagc aggctgttca gaccgacgtt gccatcaaaa cacatacacc
6481 cagaaagaaa caacagaaac caaaactcac aaggcgcatg attacttgtt ttatatttca
6541 tgttgggttt tccctcccac tattaaacag tctgtttccg tacaaaaaaa aaaaaaa
//