LOCUS X63692 5434 bp mRNA linear HUM 11-DEC-1996
DEFINITION H.sapiens mRNA for DNA (cytosin-5)-methyltransferase.
ACCESSION X63692
VERSION X63692.1
KEYWORDS DNA methyltransferase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Yen R.
JOURNAL Submitted (31-JAN-1992) to the INSDC. R. Yen, The Oncology Center,
The Johns Hopkins Medical Inst, 424 N Bond Street, Baltimore MD
21213, USA
REMARK Revised by [3]
REFERENCE 2 (bases 1 to 5194)
AUTHORS Yen R.W.C., Vertino P.M., Nelkin B.D., Yu J.J., Deiry W.E.,
Cumaraswamy A., Lennon G.G., Trask B.J., Celano P., Baylin S.B.
TITLE Isolation and characterization of the cDNA encoding human DNA
methyltransferase
JOURNAL Nucleic Acids Res. 20(9), 2287-2291(1992).
PUBMED 1594447
REFERENCE 3 (bases 1 to 5434)
AUTHORS Yen R.
JOURNAL Submitted (23-OCT-1996) to the INSDC. R. Yen, The Oncology Center,
The Johns Hopkins Medical Inst, 424 N Bond Street, Baltimore MD
21213, USA
REFERENCE 5 (bases 1 to 5434)
AUTHORS Bestor T., Laudano A., Mattaliano R., Ingram V.
TITLE Cloning and sequencing of mammalian DNA methyltransferase
JOURNAL J. Mol. Biol. 203(4), 971-983(1988).
PUBMED 3210246
REFERENCE 6 (bases 1 to 5434)
AUTHORS Yoder J.A., Yen R.C., Vertino P.M., Bestor T.H., Baylin S.B.
TITLE New 5' regions of the murine and human genes for DNA
(cytosine-5)-methyltransferase
JOURNAL J Biol Chem 271(49), 31092-31097(1996).
PUBMED 8940105
FEATURES Location/Qualifiers
source 1..5434
/db_xref="H-InvDB:HIT000322624"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="TT cells"
/cell_type="medullary thyroid carcinoma"
/db_xref="taxon:9606"
CDS 238..5088
/product="DNA (cytosine-5-)-methyltransferase"
/EC_number="2.1.1.37"
/db_xref="GOA:P26358"
/db_xref="H-InvDB:HIT000322624.13"
/db_xref="HGNC:HGNC:2976"
/db_xref="InterPro:IPR001025"
/db_xref="InterPro:IPR001525"
/db_xref="InterPro:IPR002857"
/db_xref="InterPro:IPR010506"
/db_xref="InterPro:IPR017198"
/db_xref="InterPro:IPR018117"
/db_xref="InterPro:IPR022702"
/db_xref="InterPro:IPR029063"
/db_xref="InterPro:IPR031303"
/db_xref="PDB:3EPZ"
/db_xref="PDB:3PTA"
/db_xref="PDB:3SWR"
/db_xref="PDB:4WXX"
/db_xref="PDB:4YOC"
/db_xref="PDB:4Z96"
/db_xref="PDB:4Z97"
/db_xref="PDB:5WVO"
/db_xref="PDB:5YDR"
/db_xref="UniProtKB/Swiss-Prot:P26358"
/protein_id="CAA45219.1"
/translation="MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKE
KLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNRE
VNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRK
STRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLP
AEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDE
DGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTE
KKMARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDAN
ESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLE
GGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYI
SKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDE
AGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLV
YQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRS
KQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKT
DGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFC
AGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAMEGGMDPESLLE
GDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRVLEQL
EDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEH
YRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKS
TPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEA
YNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLRTLDVFS
GCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETT
NSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRF
FLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVR
NGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDW
RDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNT
LIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRE
CARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKE
EEAAKD"
regulatory 5388..5393
/regulatory_class="polyA_signal_sequence"
polyA_site 5408
BASE COUNT 1418 a 1488 c 1511 g 1017 t
ORIGIN
1 cgtccgcgtg gggggggtgt gtgcccgcct tgcgcatgcg tgttccctgg gcatggccgg
61 ctccgttcca tccttctgca cagggtatcg cctctctccg tttggtacat cccctcctcc
121 cccacgcccg gactggggtg gtagacgcgc ctccgctcat cgcccctccc catcggtttc
181 cgcgcgaaaa gccggggcgc ctgcgctgcc gccgccgcgt ctgctgaagc ctccgagatg
241 ccggcgcgta ccgccccagc ccgggtgccc acactggccg tcccggccat ctcgctgccc
301 gacgatgtcc gcaggcggct caaagatttg gaaagagaca gcttaacaga aaaggaatgt
361 gtgaaggaga aattgaatct cttgcacgaa tttctgcaaa cagaaataaa gaatcagtta
421 tgtgacttgg aaaccaaatt acgtaaagaa gaattatccg aggagggcta cctggctaaa
481 gtcaaatccc ttttaaataa agatttgtcc ttggagaacg gtgctcatgc ttacaaccgg
541 gaagtgaatg gacgtctaga aaacgggaac caagcaagaa gtgaagcccg tagagtggga
601 atggcagatg ccaacagccc ccccaaaccc ctttccaaac ctcgcacgcc caggaggagc
661 aagtccgatg gagaggctaa gcctgaacct tcacctagcc ccaggattac aaggaaaagc
721 accaggcaaa ccaccatcac atctcatttt gcaaagggcc ctgccaaacg gaaacctcag
781 gaagagtctg aaagagccaa atcggatgag tccatcaagg aagaagacaa agaccaggat
841 gagaagagac gtagagttac atccagagaa cgagttgcta gaccgcttcc tgcagaagaa
901 cctgaaagag caaaatcagg aacgcgcact gaaaaggaag aagaaagaga tgaaaaagaa
961 gaaaagagac tccgaagtca aaccaaagaa ccaacaccca aacagaaact gaaggaggag
1021 ccggacagag aagccagggc aggcgtgcag gctgacgagg acgaagatgg agacgagaaa
1081 gatgagaaga agcacagaag tcaacccaaa gatctagctg ccaaacggag gcccgaagaa
1141 aaagaacctg aaaaagtaaa tccacagatt tctgatgaaa aagacgagga tgaaaaggag
1201 gagaagagac gcaaaacgac ccccaaagaa ccaacggaga aaaaaatggc tcgcgccaaa
1261 acagtcatga actccaagac ccaccctccc aagtgcattc agtgcgggca gtacctggac
1321 gaccctgacc tcaaatatgg gcagcaccca ccagacgcgg tggatgagcc acagatgctg
1381 acaaatgaga agctgtccat ctttgatgcc aacgagtctg gctttgagag ttatgaggcg
1441 cttccccagc acaaactgac ctgcttcagt gtgtactgta agcacggtca cctgtgtccc
1501 atcgacaccg gcctcatcga gaagaatatc gaactcttct tttctggttc agcaaaacca
1561 atctatgatg atgacccgtc tcttgaaggt ggtgttaatg gcaaaaatct tggccccata
1621 aatgaatggt ggatcactgg ctttgatgga ggtgaaaagg ccctcatcgg cttcagcacc
1681 tcatttgccg aatacattct gatggatccc agtcccgagt atgcgcccat atttgggctg
1741 atgcaggaga agatctacat cagcaagatt gtggtggagt tcctgcagag caattccgac
1801 tcgacctatg aggacctgat caacaagatc gagaccacgg ttcctccttc tggcctcaac
1861 ttgaaccgct tcacagagga ctccctcctg cgacacgcgc agtttgtggt ggagcaggtg
1921 gagagttatg acgaggccgg ggacagtgat gagcagccca tcttcctgac gccctgcatg
1981 cgggacctga tcaagctggc tggggtcacg ctgggacaga ggcgagccca ggcgaggcgg
2041 cagaccatca ggcattctac cagggagaag gacaggggac ccacgaaagc caccaccacc
2101 aagctggtct accagatctt cgatactttc ttcgcagagc aaattgaaaa ggatgacaga
2161 gaagacaagg agaacgcctt taagcgccgg cgatgtggcg tctgtgaggt gtgtcagcag
2221 cctgagtgtg ggaaatgtaa agcctgcaag gacatggtta aatttggtgg cagtggacgg
2281 agcaagcagg cttgccaaga gcggaggtgt cccaatatgg ccatgaagga ggcagatgac
2341 gatgaggaag tcgatgataa catcccagag atgccgtcac ccaaaaaaat gcaccagggg
2401 aagaagaaga aacagaacaa gaatcgcatc tcttgggtcg gagaagccgt caagactgat
2461 gggaagaaga gttactataa gaaggtgtgc attgatgcgg aaaccctgga agtgggggac
2521 tgtgtctctg ttattccaga tgattcctca aaaccgctgt atctagcaag ggtcacggcg
2581 ctgtgggagg acagcagcaa cgggcagatg tttcacgccc actggttctg cgctgggaca
2641 gacacagtcc tcggggccac gtcggaccct ctggagctgt tcttggtgga tgaatgtgag
2701 gacatgcagc tttcatatat ccacagcaaa gtgaaagtca tctacaaagc cccctccgaa
2761 aactgggcca tggagggagg catggatccc gagtccctgc tggaggggga cgacgggaag
2821 acctacttct accagctgtg gtatgatcaa gactacgcga gattcgagtc ccctccaaaa
2881 acccagccaa cagaggacaa caagttcaaa ttctgtgtga gctgtgcccg tctggctgag
2941 atgaggcaaa aagaaatccc cagggtcctg gagcagctcg aggacctgga tagccgggtc
3001 ctctactact cagccaccaa gaacggcatc ctgtaccgag ttggtgatgg tgtgtacctg
3061 ccccctgagg ccttcacgtt caacatcaag ctgtccagtc ccgtgaaacg cccacggaag
3121 gagcccgtgg atgaggacct gtacccagag cactaccgga aatactccga ctacatcaaa
3181 ggcagcaacc tggatgcccc tgagccctac cgaattggcc ggatcaaaga gatcttctgt
3241 cccaagaaga gcaacggcag gcccaatgag actgacatca aaatccgggt caacaagttc
3301 tacaggcctg agaacaccca caagtccact ccagcgagct accacgcaga catcaacctg
3361 ctctactgga gcgacgagga ggccgtggtg gacttcaagg ctgtgcaggg ccgctgcacc
3421 gtggagtatg gggaggacct gcccgagtgc gtccaggtgt actccatggg cggccccaac
3481 cgcttctact tcctcgaggc ctataatgca aagagcaaaa gctttgaaga tcctcccaac
3541 catgcccgta gccctggaaa caaagggaag ggcaagggaa aagggaaggg caagcccaag
3601 tcccaagcct gtgagccgag cgagccagag atagagatca agctgcccaa gctgcggacc
3661 ctggatgtgt tttctggctg cggggggttg tcggagggat tccaccaagc aggcatctct
3721 gacacgctgt gggccatcga gatgtgggac cctgcggccc aggcgttccg gctgaacaac
3781 cccggctcca cagtgttcac agaggactgc aacatcctgc tgaagctggt catggctggg
3841 gagaccacca actcccgcgg ccagcggctg ccccagaagg gagacgtgga gatgctgtgc
3901 ggcgggccgc cctgccaggg cttcagcggc atgaaccgct tcaattcgcg cacctactcc
3961 aagttcaaaa actctctggt ggtttccttc ctcagctact gcgactacta ccggccccgg
4021 ttcttcctcc tggagaatgt caggaacttt gtctccttca agcgctccat ggtcctgaag
4081 ctcaccctcc gctgcctggt ccgcatgggc tatcagtgca ccttcggcgt gctgcaggcc
4141 ggtcagtacg gcgtggccca gactaggagg cgggccatca tcctggccgc ggcccctgga
4201 gagaagctcc ctctgttccc ggagccactg cacgtgtttg ctccccgggc ctgccagctg
4261 agcgtggtgg tggatgacaa gaagtttgtg agcaacataa ccaggttgag ctcgggtcct
4321 ttccggacca tcacggtgcg agacacgatg tccgacctgc cggaggtgcg gaatggagcc
4381 tcggcactgg agatctccta caacggggag cctcagtcct ggttccagag gcagctccgg
4441 ggcgcacagt accagcccat cctcagggac cacatctgta aggacatgag tgcattggtg
4501 gctgcccgca tgcggcacat ccccttggcc ccagggtcag actggcgcga tctgcccaac
4561 atcgaggtgc ggctctcaga cggcaccatg gccaggaagc tgcggtatac ccaccatgac
4621 aggaagaacg gccgcagcag ctctggggcc ctccgtgggg tctgctcctg cgtggaagcc
4681 ggcaaagcct gcgaccccgc agccaggcag ttcaacaccc tcatcccctg gtgcctgccc
4741 cacaccggga accggcacaa ccactgggct ggcctctatg gaaggctcga gtgggacggc
4801 ttcttcagca caaccgtcac caaccccgag cccatgggca agcagggccg cgtgctccac
4861 ccagagcagc accgtgtggt gagcgtgcgg gagtgtgccc gctcccaggg cttccctgac
4921 acctaccggc tcttcggcaa catcctggac aagcaccggc aggtgggcaa tgccgtgcca
4981 ccgcccctgg ccaaagccat tggcttggag atcaagcttt gtatgttggc caaagcccga
5041 gagagtgcct cagctaaaat aaaggaggag gaagctgcta aggactagtt ctgccctccc
5101 gtcacccctg tttctggcac caggaatccc caacatgcac tgatgttgtg tttttaacat
5161 gtcaatctgt ccgttcacat gtgtggtaca tggtgtttgt ggccttggct gacatgaagc
5221 tgttgtgtga ggttcgctta tcaactaatg atttagtgat caaattgtgc agtactttgt
5281 gcattctgga ttttaaaagt tttttattat gcattatatc aaatctacca ctgtatgagt
5341 ggaaattaag actttatgta gtttttatat gttgtaatat ttcttcaaat aaatctctcc
5401 tataaaccaa aaaaaaaaaa aaaaaaaaaa aaaa
//