LOCUS X63547 8201 bp mRNA linear HUM 22-DEC-1993
DEFINITION H.sapiens mRNA for tre oncogene (clone 213).
ACCESSION X63547
VERSION X63547.1
KEYWORDS oncogene; transforming capacity; tre gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8201)
AUTHORS Hillova J.
JOURNAL Submitted (16-DEC-1991) to the INSDC. J. Hillova, C.N.R.S. - SDI
I6204, I.C.I.G., Dept of Molecular and Cellular Biology, 14, avenue
Paul-Vaillant Couturier, 94804 Villejuif Cedex, FRANCE
REFERENCE 3 (bases 1 to 8201)
AUTHORS Nakamura T., Hillova J., Mariage-Samson R., Onno M., Huebner K.,
Cannizzaro L.A., Boghosian-Sell L., Croce C.M., Hill M.
TITLE A novel transcriptional unit of the tre oncogene widely expressed
in human cancer cells
JOURNAL Oncogene 7(4), 733-741(1992).
PUBMED 1565468
COMMENT See also X63547, X63596 & X71366-79
The tre-2 genetic element identified in tre-transfectants was
renamed oncRTE17 because of its origin from the repetoire of
hypervariable TRE17 genes (see X63586).
FEATURES Location/Qualifiers
source 1..8201
/db_xref="H-InvDB:HIT000322602"
/organism="Homo sapiens"
/chromosome="17q"
/mol_type="mRNA"
/clone="213"
/cell_line="transfected NIH 3T3 cell"
/tissue_type="Ewings' sarcoma"
/db_xref="taxon:9606"
5'UTR 1..1696
CDS 1697..2827
/gene="tre"
/product="oncogene"
/db_xref="H-InvDB:HIT000322602.13"
/db_xref="HGNC:HGNC:12629"
/db_xref="InterPro:IPR000195"
/db_xref="InterPro:IPR035969"
/db_xref="UniProtKB/TrEMBL:Q15635"
/protein_id="CAA45110.1"
/translation="MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSS
IDRFGILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIP
MNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRD
RYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERH
SLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGI
SLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMN
DDTVLKHLRASTKKLTRKQGDLPPPGPTALGRRCVAGSPQPV"
CDS 2859..6128
/gene="tre"
/product="oncogene"
/db_xref="GOA:P35125"
/db_xref="HGNC:HGNC:12629"
/db_xref="InterPro:IPR000195"
/db_xref="InterPro:IPR001394"
/db_xref="InterPro:IPR018200"
/db_xref="InterPro:IPR028889"
/db_xref="InterPro:IPR035969"
/db_xref="InterPro:IPR038765"
/db_xref="UniProtKB/Swiss-Prot:P35125"
/protein_id="CAA45111.1"
/translation="MPQRLPHARQHTPLPLGSADYRRVVSVRPQGPHRDPKDSRDAAK
REQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGA
VREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFERSC
WVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLS
NLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELW
SGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELK
DSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL
PLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEV
HDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLT
TNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMR
TELYFLSPQENRPSLFGMPLIVPCTVHTQKKDLYDAVWIQVSWLARPLPPQEASIHAQ
DRDNCMGYQYPFTLRVVQKDGISCAWCPQYRFCRGCKIDCGEDRAFIGNAYIAVDWHP
TALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKC
KTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFLVPRDP
ALCQHKPLTPQGDELSKPRILAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPKG
SPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKEN
GAGQICELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACGNGCGDGYSNGQ
LGNHSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCKWYCYNDSS
CEELHPDEIDTDSAYILFYEQQGIDYAQFLPKIDGKKMADTSSTDEDSESDYEKYSML
Q"
3'UTR 6129..8201
polyA_site 8179
BASE COUNT 2258 a 1887 c 2003 g 2053 t
ORIGIN
1 ctaaaaatac cattaagtaa tagtattagc ttttgtattc tgagattcaa cagcagcagt
61 cacttccctc cactcctatg tgtatcccag gaccaccctg ggcggggagg gctgaggtca
121 gggaggtctg aagctggtcc tgggctccgg gggtgacagt gatgaggaac tgggtgcaca
181 catgagtggg gcagccgggc ctggccagag aagcaacaca cacgtgcaca gacatgttta
241 tccacataca catgtgcacg catgtgcaca aacacattgc aggcaggcat gttgacgcct
301 caggcagcgg aggaccctga ctctgggccc tgctgacccg ggcaaggccc attgtgatgc
361 gtgccatgac ctcagaatgt cactggtgct tagcacctat ccgctctcca gactgcgtct
421 gtgttctacg gcagttacac acacgcagtg gtattcacaa gcggttttgt ggactcaaag
481 gttttctccc tgagaggcat aacccaggcc agctgattca tcagaatcag gtgagtgtga
541 cctgctctct tccctccagg ctgacttggg gacagtggct atggtatggg cggtgttggc
601 ctctgggcag ctacagagga gggtcatccc tgagcactca ccgggcgccc gttctacact
661 gcccatgtag acgattttct ctttcgtctt catggtggct tcgtagagtg ggtgctgttc
721 ccaaatgtac ccattcgaca ggtgagccgt ctggggtcag agaggcagta actggcctgg
781 gaatccagac aagaccctgg gttttgctct cagccctgct gtgtgccatg ctagacttca
841 ggcctcaacc ctgagacctc cctgctctag atcccaaatc tgcccagatt tccgatccaa
901 tgggcagagc ctggccctgg cagagacact gggatggatc cactgtgggt ggggaggagg
961 gaagggtcct cagaacacac ctggggccta agctgggtct tgatggtcac tgtgggaccc
1021 actggacaca cacagtccct tgtctgggag tggcatgggg agccttctgc ccttgggcag
1081 ttgtggaaag tgaaggagcc ctggagagct ggctgagggg agactatctt cccttgtgtt
1141 caaaggggtc caggcactgg ggctctcccc aagtatttct tattctgtct ggcctcgctt
1201 tccttttgcc ctgagtattc tcaggaggga cggtccatct agatgtcctc caggagcaag
1261 gacccactgt tcttcatcag tgacccagga aaatgaagcc ccctcctgtg gggacagctc
1321 agaatggtgg agtccacagt ccctccctga gagacatggt ttccatgagc acagtggctg
1381 ctttggagac agtaatcatt ttcatcccca aaaccaaaca cactcctgct caaatggtgt
1441 tattgctaaa gcagcttcac tggttagact gaagggccat ggtagcccaa gtgatgagcg
1501 gggtagaatg gagcagtcag gagagatctt gttccccgta ggaaactggg catctctgtg
1561 gccctgaaca tcccaggagg ccgatcgtac agagacctct ggtgcctgac cgcagttcac
1621 atccacatcc ctggaataga ccatcacagg ctcttcaccc ttggcaggtg gacaccattc
1681 aacctgccgg ggcaggatgg acatggtaga gaatgcagat agtttgcagg cacaggagcg
1741 gaaggacata cttatgaagt atgacaaggg acaccgagct gggctgccag aggacaaggg
1801 gcctgagccc gttggaatca acagcagcat tgatcgtttt ggcattttgc atgagacgga
1861 gctgcctcct gtgactgcac gggaggcgaa gaaaattcgg cgggagatga cacgaacgag
1921 caagtggatg gaaatgctgg gagaatggga gacatataag cacagtagca aactcataga
1981 tcgagtgtac aagggaattc ccatgaacat ccggggcccg gtgtggtcag tcctcctgaa
2041 cattcaggaa atcaagttga aaaaccccgg aagataccag atcatgaagg agaggggcaa
2101 gaggtcatct gaacacatcc accacatcga cctggacgtg aggacgactc tccggaacca
2161 tgtcttcttt agggatcgat atggagccaa gcagagggaa ctattctaca tcctcctggc
2221 ctattcggag tataacccgg aggtgggcta ctgcagggac ctgagccaca tcaccgcctt
2281 gttcctcctt tatctgcctg aggaggacgc attctgggca ctggtgcagc tgctggccag
2341 tgagaggcac tccctgccag gattccacag cccaaatggt gggacagtcc aggggctcca
2401 agaccaacag gagcatgtgg tacccaagtc acaacccaag accatgtggc atcaggacaa
2461 ggaaggtcta tgcgggcagt gtgcctcgtt aggctgcctt ctccggaacc tgattgacgg
2521 gatctctctc gggctcaccc tgcgcctgtg ggacgtgtat ttggtggaag gagaacaggt
2581 gttgatgcca ataaccagca ttgctcttaa ggttcagcag aagcgcctca tgaagacatc
2641 caggtgtggc ctgtgggcac gtctgcggaa ccaattcttc gatacctggg ccatgaacga
2701 tgacaccgtg ctcaagcatc ttagggcctc tacgaagaaa ctaacaagga agcaagggga
2761 cctgccaccc ccaggcccaa cagccctggg acgaaggtgt gtggcaggaa gcccccagcc
2821 agtctgaacc ctgggggcag tcccaggagc cacccaccat gccccaacgg cttccccatg
2881 ccaggcagca cacacccctc cctctgggat cagcagacta caggcgtgtc gtcagtgtca
2941 gaccacaggg gccacacaga gaccccaagg actccagaga tgcagccaaa cgcgagcaag
3001 ggtccttggc acccaggcct gtgccggctt cacgtggtgg gaagaccctc tgcaaggggt
3061 ataggcaggc ccctccaggc ccaccagccc agttccagcg gcccatttgc tcagcttccc
3121 cgccatgggc atctcgtttt tccacgccct gtcctggtgg ggctgtccgg gaagacacgt
3181 accctgtggg cactcagggt gtgcccagcc tggccctggc tcagggagga cctcagggtt
3241 cctggagatt cctggagtgg aagtcaatgc cccggctccc aacggacctg gatatagggg
3301 gcccttggtt cccccattat gattttgaac ggagctgctg ggtccgtgcc atatcccagg
3361 aggaccagct ggccacctgc tggcaggctg aacactgcgg agaggttcac aacaaagata
3421 tgagttggcc tgaggagatg tcttttacag caaatagtag taaaatagat agacaaaagg
3481 ttcccacaga aaagggagcc acaggtctaa gcaacctggg aaacacatgc ttcatgaact
3541 caagcatcca gtgcgttagt aacacacagc cactgacaca gtattttatc tcagggagac
3601 atctttatga actcaacagg acaaatccca ttggtatgaa ggggcatatg gctaaatgct
3661 atggtgattt agtgcaggaa ctctggagtg gaactcagaa gagtgttgcc ccattaaagc
3721 ttcggcggac catagcaaaa tatgctccca agtttgatgg gtttcagcaa caagactccc
3781 aagaacttct ggcttttctc ttggatggtc ttcatgaaga tctcaaccga gtccatgaaa
3841 agccatatgt ggaactgaag gacagtgatg gccgaccaga ctgggaagta gctgcagagg
3901 cctgggacaa ccatctaaga agaaatagat caattattgt ggatttgttc catgggcagc
3961 taagatctca agtcaaatgc aagacatgtg ggcatataag tgtccgattt gaccctttca
4021 attttttgtc tttgccacta ccaatggaca gttacatgga cttagaaata acagtgatta
4081 agttagatgg tactacccct gtacggtatg gactaagact gaatatggat gaaaagtaca
4141 caggtttaaa aaaacagctg agggatctct gtggacttaa ttcagaacaa atcctactag
4201 cagaagtaca tgattccaac ataaagaact ttcctcagga taaccaaaaa gtacaactct
4261 cagtgagcgg atttttgtgt gcatttgaaa ttcctgtccc ttcatctcca atttcagctt
4321 ctagtccaac acaaatagat ttctcctctt caccatctac aaatggaatg ttcaccctaa
4381 ctaccaatgg ggacctaccc aaaccaatat tcatccccaa tggaatgcca aacactgttg
4441 tgccatgtgg aactgagaag aacttcacaa atggaatggt taatggtcac atgccatctc
4501 ttcctgacag cccctttaca ggttacatca ttgcagtcca ccgaaaaatg atgaggacag
4561 aactgtattt cctgtcacct caggagaatc gccccagcct ctttggaatg ccattgattg
4621 ttccatgcac tgtgcatacc cagaagaaag acctatatga tgcggtttgg attcaagtat
4681 cctggttagc aagaccactc ccacctcagg aagctagtat tcatgcccag gatcgtgata
4741 actgtatggg ctatcaatat ccattcactc tacgagttgt gcagaaagat gggatctcct
4801 gtgcttggtg cccacagtat agattttgca gaggctgtaa aattgattgt ggggaagaca
4861 gagctttcat tggaaatgcc tatattgctg tggattggca ccccacagcc cttcaccttc
4921 gctatcaaac atcccaggaa agggttgtag ataagcatga gagtgtggag cagagtcggc
4981 gagcgcaagc cgagcccatc aacctggaca gctgtctccg tgctttcacc agtgaggaag
5041 agctagggga aagtgagatg tactactgtt ccaagtgtaa gacccactgc ttagcaacaa
5101 agaagctgga tctctggagg cttccaccct tcctgattat tcaccttaag cgatttcaat
5161 ttgtaaatga tcagtggata aaatcacaga aaattgtcag atttcttcgg gaaagttttg
5221 atccgagtgc ttttttggta ccacgagacc cggccctctg ccagcataaa ccactcacac
5281 cccaggggga tgagctctcc aagcccagga ttctggcaag agaggtgaag aaagtggatg
5341 cgcagagttc ggctggaaaa gaggacatgc tcctaagcaa aagcccatct tcactcagcg
5401 ctaacatcag cagcagccca aaaggttctc cttcttcatc aagaaaaagt ggaaccagct
5461 gtccctccag caaaaacagc agccctaata gcagcccacg gactttgggg aggagcaaag
5521 ggaggctccg gctgccccag attggcagca aaaataagcc gtcaagtagt aagaagaact
5581 tggatgccag caaagagaat ggggctgggc agatctgtga gctggctgac gccttgagcc
5641 gagggcatat gcgggggggc agccaaccag agctggtcac tcctcaggac catgaggtag
5701 ctttggccaa tggattcctt tatgagcatg aagcatgtgg caatggctgt ggcgatggct
5761 acagcaatgg tcagcttgga aaccacagtg aagaagacag cactgatgac caaagagaag
5821 acactcatat taagcctatt tataatctat atgcaatttc atgccattca ggaattctga
5881 gtgggggcca ttacatcact tatgccaaaa acccaaactg caagtggtac tgttataatg
5941 acagcagctg tgaggaactt caccctgatg aaattgacac cgactctgcc tacattcttt
6001 tctatgagca gcaggggata gactacgcac aatttctgcc aaagattgat ggcaaaaaga
6061 tggcagacac aagcagtacg gatgaagact ctgagtctga ttacgaaaag tactctatgt
6121 tacagtaaag ctaccactct ggctgctaga cagcttggtg gcgagggaga tgactccttg
6181 tagctgatac ttggcaaaag tgtcactgaa agacaagcta aatgtagtta ttttatcctg
6241 ttagaacaaa aattctaatt aaaatagtta acttgaagag tagaaacaat tgtattttga
6301 agtctcatac aagctgtctg atagagaact ttcaggcaga tcccaccatt agcctgtaaa
6361 caaaaggtgt ggcaccagcc acctgggacc aaataagaat tgaattgtgc ttgtccagat
6421 atgaacaaat atgtagtgag tatagagttt accaataatc ataacaaata ttaaagattt
6481 ccttggagtc agaggaaaaa acaaacaatt ataatgttgt ctagggacga catgatacgc
6541 tacctccttt ttcctgaagt tttattccat tatattgaca agatggagaa agcaagatca
6601 tgaaggtgtg caaatgattc ttacggcatg gacaaggatt tttcaattta ttttttaaac
6661 tgtttccata ccctttcttt ttcttgcttt ttgtttttgc cattgtgttt acgtttgaga
6721 cacaaccagt cattggtggc aggggcatag agtggtcagt ctgaaaggga ggctctctta
6781 agagctatgt gccttccaac cagagggaga cccagtagaa agaaaaacat cctgggaaat
6841 ccagctacca gggccctccc agtggaggca tcttacattt aggctacttc aagtatcctc
6901 agaaatgtat tctgcacccc cggccccgcc catgctgagg gaaggggagc agttgccaat
6961 atttgcacca tcttcacatg cacatgttgc aacaagagct tctgggaagg taagcggcat
7021 cggagctaga tcacgtttca caattagtgg ttattctttt ctgtgtttgt tttgcacttt
7081 aaaaaagaga gaacacatgc aaatgaactt gcttgtgtgt atttgatggc tctaagggct
7141 ataaattaca aacaaaacac atcccagaca ttaggagttc ataagtatat ttaatgaaat
7201 tggtggtttt aggaagtcaa ctttagtttt gctttgtttg catgtccact ggttttttta
7261 ttttgatatt tgtctttttt taaattttac agtagtcatt gaaagttatg tttctttgct
7321 tacttcattt tttccctcta attatttaag attggaacaa aagtataaat attatttatt
7381 tgaggtagaa tttttttcat gtagtttctt aatatatact tgaaggaaat gtttcacctt
7441 atttttggtc tttgtttatt catttagacc ctgcaagttg attctcattg ccagattcca
7501 ttaccctttc ttcctcatag gtagtaatta ccaatgtaac taagcatttg tgttctgata
7561 tctgaggcca gtaactatta atatctagtt ctcagagcat ttggaaaggt tatcttaaat
7621 ggctacctaa attgaaatcc ttttcagaaa aaatataatt gcaagtaggt aggagtggcc
7681 taaattgtct aatgtaataa agtcagacaa aatgcacact ttatagtttc aagattttca
7741 gtaaataaaa tctgtccatt cctacctgga catgtcccat taaaaagtgg aagattttaa
7801 ataatttctt tacagatgtt ttatttaaac aggtagcaca atctactaat gttgtgtgat
7861 ttgtgttata ctggttgtaa ttaatttttt taattcatga actagcggaa aatttattaa
7921 attaactatt aactacattc accttgtaaa ttactgtata aaacttgttg acaatgcact
7981 gactttagaa agatgttaat gtacataaat agagtgtaaa taaaatagtg ttgatgtact
8041 gaaatatgaa ctgtatcaaa agtattggta attgtatatg gggtgtacct gtttatctgt
8101 taactattat ccaaacaaat taaatactgt ggttgcctct atgtgctgtt tttcctcata
8161 caagtaaaca cagaaagtca aaaaaaaaaa aaaaaaaaaa a
//