LOCUS X63282 2954 bp mRNA linear HUM 18-APR-2005
DEFINITION H.Sapiens mRNA for alpha2-subunit of soluble guanylyl cyclase.
ACCESSION X63282
VERSION X63282.1
KEYWORDS guanylyl cyclase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Harteneck C., Wedel B., Koesling D., Malkewitz J., Boehme E.,
Schultz G.
TITLE Molecular cloning and expression of a new alpha-subunit of soluble
guanylyl cyclase. Interchangeability of the alpha-subunits of the
enzyme
JOURNAL FEBS Lett. 292(1-2), 217-222(1991).
PUBMED 1683630
REFERENCE 2 (bases 1 to 2954)
AUTHORS Harteneck C.
JOURNAL Submitted (30-MAR-1992) to the INSDC. C. Harteneck, Institut fuer
Pharmakologie, Freie Universitaet Berlin, Thielallee 69-73, 1000
Berlin 33, FRG
FEATURES Location/Qualifiers
source 1..2954
/db_xref="H-InvDB:HIT000322584"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="fetal"
/tissue_type="brain"
/db_xref="taxon:9606"
CDS 391..2589
/product="alpha2-subunit of soluble guanylyl cyclase"
/EC_number="4.6.1.2"
/db_xref="GOA:P33402"
/db_xref="H-InvDB:HIT000322584.12"
/db_xref="HGNC:HGNC:4684"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR011644"
/db_xref="InterPro:IPR011645"
/db_xref="InterPro:IPR018297"
/db_xref="InterPro:IPR024096"
/db_xref="InterPro:IPR029787"
/db_xref="InterPro:IPR038158"
/db_xref="InterPro:IPR042463"
/db_xref="UniProtKB/Swiss-Prot:P33402"
/protein_id="CAA44921.1"
/translation="MSRRKISSESFSSLGSDYLETSPEEEGECPLSRLCWNGSRSPPG
PLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSP
QTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKEEIEDVSGILQCTAN
ILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQA
TLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKL
CSDVSNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFD
PSMSVLQLGEGLRKQLRCDTHKVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKP
EASGSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATR
DVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQ
GQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVE
TIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLA
GVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREEL
PDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL"
BASE COUNT 735 a 779 c 760 g 680 t
ORIGIN
1 tgggccgcag ccctccccgc cccgccgacc gcggtcacac actctcggag cctccccgtg
61 agcgggagcg cggcgcacgg cgatgcgccg aggcgggcgc tgaggcggcg ccgcgcgagc
121 agcagcagag gcggcggcgg cccccagccc agcccggcgc cgccgccgag cccgggcccc
181 aaggtgcggc ggcgccccaa gttcccgcca tgagcagccg gctcgggggg ctccgcggcc
241 ccggggactc ccgccccgcc gggcgcgacc gcagcgcccc gcggccccga cgcgcttaac
301 gttgtcgctt gccggtcccg ccaccgccgc ctccgccgcc gctcgcgtcc tcgccgccac
361 cgcctcggcc gctgcagctc cgccggcagc atgtctcgaa ggaagatttc gtccgagtcc
421 ttcagctccc tgggctccga ctacctggag accagcccgg aggaggaggg ggagtgcccc
481 ctgtctaggc tctgctggaa tggcagccgg agcccgcccg ggccgctgga gcccagcccg
541 gccgcagctg ccgctgccgc cgccccggcc ccgaccccgg ctgcttctgc cgccgccgcc
601 gctgccactg ccggggccag gagggtgcag cgccggaggc gggtcaacct ggactcgctg
661 ggcgagagca tcagccgcct gacggcgccc tcgcctcaga cgatacagca gactctcaag
721 aggacactgc agtattatga acatcaagtt attggttaca gggatgcaga aaagaatttc
781 cacaatatct ctaacagatg ctcctatgca gaccactcca acaaagaaga aattgaagat
841 gtctcaggaa ttcttcagtg tactgctaat atactcggtt tgaagtttga ggaaattcaa
901 aaaagatttg gtgaagagtt ctttaatata tgctttcatg agaatgagag agtccttcga
961 gctgtaggtg gcactttgca ggactttttt aacggctttg atgctttgtt ggaacacatt
1021 agaacttctt ttggaaaaca ggccactctg gagtcaccat ctttcctatg caaagagctc
1081 cctgaaggta ctctcatgct ccactacttc caccctcacc atattgtggg gtttgcaatg
1141 ctggggatga ttaaggctgc aggaaagaag atctatcggc tggatgtgga agtggaacag
1201 gttgcaaatg agaagctatg ctctgatgtt tcaaacccag gcaattgtag ctgtcttact
1261 ttccttatca aagaatgtga aaatactaat atcatgaaga accttccaca gggaacctcc
1321 caagttcctg cggacctcag aattagcatc aacaccttct gtagagcctt ccctttccac
1381 ttgatgtttg atcccagcat gtcagtcctt cagttggggg aaggtctaag gaagcagctt
1441 cgatgtgaca ctcacaaagt gctcaagttt gaggactgct tcgagattgt atctccaaag
1501 gttaatgcca cctttgaaag ggtcctgctg cgactgtcta ccccgtttgt gattagaacc
1561 aagcctgagg cttctggctc tgaaaataaa gacaaggtga tggaagtcaa aggacaaatg
1621 atccatgttc cagaatcaaa ttccatttta tttttgggct ctccatgtgt ggacaagttg
1681 gatgaactca tgggccgagg gctacatctc tcagacatcc ctatccatga tgccacccga
1741 gatgtcattt tggttggtga gcaggcaaag gcccaagatg ggttgaagaa aaggatggat
1801 aaattaaagg caactttaga aagaactcac caggccctgg aagaagagaa aaagaagaca
1861 gtggatcttc tatattctat tttccctggt gatgtagccc agcaattatg gcaagggcag
1921 caagtacagg ccagaaagtt tgatgatgtc accatgctct tttcagacat tgttggcttc
1981 acagccatat gtgcccagtg tactcccatg caagtaatca gcatgctgaa tgaactgtac
2041 accagatttg accaccagtg tggatttttg gatatttata aggtggaaac aataggtgat
2101 gcctactgtg ttgcagcagg gctccacaga aaaagcctct gccatgctaa acccattgct
2161 ctgatggcct tgaagatgat ggaactttca gaagaggtgc tgacacctga tggaagaccg
2221 attcagatga ggataggaat tcactcaggc tccgtgctgg ctggagttgt tggggtgcga
2281 atgccacgtt attgcctgtt tggaaataat gtcacactgg caagcaaatt cgagtcggga
2341 agtcaccctc ggcgcatcaa tgtcagccca accacttacc aattattaaa acgagaagaa
2401 agtttcacat tcattccgcg gtctcgtgaa gagcttccag acaactttcc aaaggaaatt
2461 cctgggatct gctatttcct ggaggtaagg actggtccaa agccaccaaa gccttctctt
2521 tcttcgtcga gaataaaaaa ggtttcctac aacatcggca ccatgttcct ccgggagaca
2581 agcctctgag acctgctaca gatcaaagac tcctccaaaa agcacaagcc cagaacatgg
2641 gtcaccaatg gggggtggaa agagattgtg tctctttcat tgctttgttg agaacaagca
2701 gcaaaatttc tgtattatgt caggcaataa tcctactaaa aggtggaggt gaccgctgtc
2761 aataaaaagc cggaggatga gggaaataag atgtgtccat tcatatgagt ggttttggtc
2821 atatatatac acatatattt taattacaag tgtgggtccc ctttcagaac taaccaataa
2881 atagattcca tgttttcttg tttatcacac atacaagtat ctttccctat atatttgtac
2941 cacttttgag agcc
//