LOCUS X62822 2699 bp mRNA linear HUM 24-FEB-1992 DEFINITION H.sapiens gene encoding beta-galactoside alpha-2,6-sialyltransferase. ACCESSION X62822 VERSION X62822.1 KEYWORDS beta-galactoside alpha 2,6-sialyltransferase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2699) AUTHORS Bast B.J., Zhou L., Freeman G.J., Colley K.J., Ernst T.J., Munro J., Tedder T.F. TITLE The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase JOURNAL J. Cell Biol. 116(2), 423-435(1992). PUBMED 1730763 REFERENCE 2 (bases 1 to 2699) AUTHORS Tedder T.F. JOURNAL Submitted (22-OCT-1991) to the INSDC. T.F. Tedder, Dana-Farber Cancer Institute, Division of Tumor Immunology, 44 Binney Street, Boston MA02115-6084, USA FEATURES Location/Qualifiers source 1..2699 /db_xref="H-InvDB:HIT000322544" /organism="Homo sapiens" /mol_type="mRNA" /dev_stage="Adult" /clone_lib="spleen cDNA library cloned into CDM8 vector" /clone="pHB-6" /cell_type="Lymphocyte" /tissue_type="Spleen" /db_xref="taxon:9606" 5'UTR 1..310 CDS 311..1531 /product="beta-galactoside alpha-2,6-sialyltransferase" /EC_number="2.4.99.1" /db_xref="GOA:P15907" /db_xref="H-InvDB:HIT000322544.12" /db_xref="HGNC:HGNC:10860" /db_xref="InterPro:IPR001675" /db_xref="InterPro:IPR012163" /db_xref="InterPro:IPR038578" /db_xref="PDB:4JS1" /db_xref="PDB:4JS2" /db_xref="UniProtKB/Swiss-Prot:P15907" /protein_id="CAA44634.1" /translation="MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKE FQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSS KNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPF NTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTAN FQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYN FFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTL CDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYL LGKATLPGFRTIHC" mat_peptide 311..1528 /standard_name="sialyltransferase" /product="The protein product is beta-galactoside alpha-2,6-sialyltransferase which occurs as a membrane bound protein with a subcellular location within the Golgi apparatus." /note="This protein also occurs as a soluble form in body fluids which seems to be a proteolytic fragment of the mambrane-bound form." /note="The protein product is only detected within the Golgi apparatus of cells and is not expressed on the cell surface at detectable levels." /note="The protein product is not the CDw75 leukocyte differentiation antigen; the enzymatic activity of the sialyltransferase generates a critical component of the CDw75 antigen." sig_peptide 338..388 /note="Likely transmembrane spanning domain." 3'UTR 1532..2699 BASE COUNT 692 a 708 c 625 g 674 t ORIGIN 1 ctaaaggttc ctgtagggcg gcacaaccag ggagggcgtg gaagctctgc atcccttctc 61 ccataccttg ctctacacat ctcttcatct gtatcctctg cagcatcctt gatgataaac 121 cagtaaatat gagttttgat catcctgaga aaaatgggcc ttggcctgca gacccaataa 181 accttccctc ccatggataa tagtgctaat tcctgaggac ctgaagggcc tgccgcccct 241 gggggattag ccagaagcag gcttgttttc ctgctcagaa caaagtgact tccctgaaca 301 catcttcatt atgattcaca ccaacctgaa gaaaaagttc agctgctgcg tcctggtctt 361 tcttctgttt gcagtcatct gtgtgtggaa ggaaaagaag aaagggagtt actatgattc 421 ctttaaattg caaaccaagg aattccaggt gttaaagagt ctggggaaat tggccatggg 481 gtctgattcc cagtctgtat cctcaagcag cacccaggac ccccacaggg gccgccagac 541 cctcggcagt ctcagaggcc tagccaaggc caaaccagag gcctccttcc aggtgtggaa 601 caaggacagc tcttccaaaa accttatccc taggctgcaa aagatctgga agaattacct 661 aagcatgaac aagtacaaag tgtcctacaa ggggccagga ccaggcatca agttcagtgc 721 agaggccctg cgctgccacc tccgggacca tgtgaatgta tccatggtag aggtcacaga 781 ttttcccttc aatacctctg aatgggaggg ttatctgccc aaggagagca ttaggaccaa 841 ggctgggcct tggggcaggt gtgctgttgt gtcgtcagcg ggatctctga agtcctccca 901 actaggcaga gaaatcgatg atcatgacgc agtcctgagg tttaatgggg cacccacagc 961 caacttccaa caagatgtgg gcacaaaaac taccattcgc ctgatgaact ctcagttggt 1021 taccacagag aagcgcttcc tcaaagacag tttgtacaat gaaggaatcc taattgtatg 1081 ggacccatct gtataccact cagatatccc aaagtggtac cagaatccgg attataattt 1141 ctttaacaac tacaagactt atcgtaagct gcaccccaat cagccctttt acatcctcaa 1201 gccccagatg ccttgggagc tatgggacat tcttcaagaa atctccccag aagagattca 1261 gccaaacccc ccatcctctg ggatgcttgg tatcatcatc atgatgacgc tgtgtgacca 1321 ggtggatatt tatgagttcc tcccatccaa gcgcaagact gacgtgtgct actactacca 1381 gaagttcttc gatagtgcct gcacgatggg tgcctaccac ccgctgctct atgagaagaa 1441 tttggtgaag catctcaacc agggcacaga tgaggacatc tacctgcttg gaaaagccac 1501 actgcctggc ttccggacca ttcactgcta agcacaggct cctcactctt ctccatcagg 1561 cattaaatga atggtctctt ggccacccca gcctgggaag aacattttcc tgaacaattc 1621 cagcctgctc cttttactct aggggcctct gtcagcaaga ccatgggggc ttcaagagcc 1681 tgtggtcagg aaatcaggtc cagccttccc tgtagccaga cagtttatga gcccagagcc 1741 tcctgccaca cacatgcaca catatctagc attctttcca gacagcatcc tccccgcctt 1801 ccaccttggt agatgcaagg tctatctctc ccatcagggc tgccaaagct gggctttgtt 1861 tttcccagca gaatgatgcc attctcacaa accaatgctc tatattgctt gaagtctgca 1921 tctaaatatt gatttcacgt tttaaagaaa ttctcttaaa ttacaattgt gcccaatgca 1981 gggtggctct ggggggcaag taggtggtac aggggattgg aaacatcgtc cgcgcctcca 2041 gagaaaagtt gctcccgagg tccatgcccc tggaacgtgt tcctatcact ctggctggtt 2101 gggctggtcc ttagactggg tgcttatgat taaagggtct tggttagccc actttccctc 2161 tccatgtgga gatggaaggt agagaaggat acagtgtcta tcctcaagtt gctacggttc 2221 agtgagagag gcagacatct gaacaggcag gtaggattca gtgtgctcag tgcactgggg 2281 atttggagag agatgggctt gctctctctg tgcacccagg agggccacgc acttaaaact 2341 gagtttgtgg atcagagaag gctttatagc acaggggcat tcagatgagt cttagaggaa 2401 gagaagaaac atggcaagca gattacatct gagccgtttg aattgtgttt ttctttcttc 2461 ccatgtttat tttctaagat ctacctgaac ttagagactc aagatatttt tttaggaaac 2521 ctcctaccca tgtctgaggt agcaagtgca gcctcacgac agataccagg caatccagag 2581 ccacaaaacg tgattcctcc agctctgcct ggcctgaccc tgtcctgtca gctgggttta 2641 cataccagtc ccattcttcc ttttcaatac ctacccccaa atcttctcct aaccctaga //