LOCUS X60648 3090 bp mRNA linear HUM 18-APR-2005
DEFINITION Human polypyrimidine tract-binding (PTB) mRNA for polypyrimidine
tract-binding protein (pPTB).
ACCESSION X60648
VERSION X60648.1
KEYWORDS polypyrimidine tract binding protein; PTB gene; RNA binding
protein; splicing factor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3090)
AUTHORS Gil A.
JOURNAL Submitted (08-JUL-1991) to the INSDC. A. Gil, Massachusetts
Institute of Technology, Center for Cancer Research E17-528, 77
Massachusetts Avenue, Cambridge, MA 02139, USA
REFERENCE 3 (bases 1 to 3090)
AUTHORS Gil A., Sharp P.A., Jamison S.F., Garcia-Blanco M.A.
TITLE Characterization of cDNAs encoding the polypyrimidine tract-binding
protein
JOURNAL Genes Dev. 5(7), 1224-1236(1991).
PUBMED 1906035
COMMENT At least 3 different isoforms are encoded by the PTB pre-mRNA. The
PTB pre-mRNA is most likely alternatively spliced to generate the
isoforms.
FEATURES Location/Qualifiers
source 1..3090
/db_xref="H-InvDB:HIT000322410"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="PTB, PTB2, PTB3"
/cell_line="HeLa"
/cell_type="epithelial"
/tissue_lib="human placenta cDNA"
/db_xref="taxon:9606"
mRNA 1..3090
/gene="PTB"
CDS 29..1624
/gene="PTB"
/product="polypyrimidine tract-binding protein (pPTB)"
/db_xref="GOA:P26599"
/db_xref="H-InvDB:HIT000322410.13"
/db_xref="HGNC:HGNC:9583"
/db_xref="InterPro:IPR000504"
/db_xref="InterPro:IPR006536"
/db_xref="InterPro:IPR012677"
/db_xref="InterPro:IPR021790"
/db_xref="InterPro:IPR034798"
/db_xref="InterPro:IPR035000"
/db_xref="InterPro:IPR035001"
/db_xref="InterPro:IPR035979"
/db_xref="PDB:1QM9"
/db_xref="PDB:1SJQ"
/db_xref="PDB:1SJR"
/db_xref="PDB:2AD9"
/db_xref="PDB:2ADB"
/db_xref="PDB:2ADC"
/db_xref="PDB:2EVZ"
/db_xref="PDB:2N3O"
/db_xref="PDB:3ZZY"
/db_xref="PDB:3ZZZ"
/db_xref="UniProtKB/Swiss-Prot:P26599"
/protein_id="CAA43056.1"
/translation="MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDS
KKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMN
TEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSG
NLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTK
NNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYT
RPDLPSGDSQPSLDQTMAAAFGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGA
GNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGNQAQLAMS
HLNGHKLHGKPIRITLSKHQNVQLPREGQEDQGLTKDYGNSPLHRFKKPGSKNFQNIF
PPSATLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQAL
IDLHNHDLGENHHLRVSFSKSTI"
misc_feature 29..1624
/note="homology to murine mmp25k"
misc_feature 921
/note="sequence variation between different cDNA isolates
due to alternative splicing of PTB pre-mRNA"
misc_binding 1020..1440
/bound_moiety="RNA"
/note="putative RNA-binding domain"
BASE COUNT 656 a 954 c 819 g 661 t
ORIGIN
1 ccgtcccccg cggtctgctc tgtgtgccat ggacggcatt gtcccagata tagccgttgg
61 tacaaagcgg ggatctgacg agcttttctc tacttgtgtc actaacggac cgtttatcat
121 gagcagcaac tcggcttctg cagcaaacgg aaatgacagc aagaagttca aaggtgacag
181 ccgaagtgca ggcgtcccct ctagagtgat ccacatccgg aagctcccca tcgacgtcac
241 ggagggggaa gtcatctccc tggggctgcc ctttgggaag gtcaccaacc tcctgatgct
301 gaaggggaaa aaccaggcct tcatcgagat gaacacggag gaggctgcca acaccatggt
361 gaactactac acctcggtga cccctgtgct gcgcggccag cccatctaca tccagttctc
421 taaccacaag gagctgaaga ccgacagctc tcccaaccag gcgcgggccc aggcggccct
481 gcaggcggtg aactcggtcc agtcggggaa cctggccttg gctgcctcgg cggcggccgt
541 ggacgcaggg atggcgatgg ccgggcagag ccctgtgctc aggatcatcg tggagaacct
601 cttctaccct gtgaccctgg atgtgctgca ccagattttc tccaagttcg gcacagtgtt
661 gaagatcatc accttcacca agaacaacca gttccaggcc ctgctgcagt atgcggaccc
721 cgtgagcgcc cagcacgcca agctgtcgct ggacgggcag aacatctaca acgcctgctg
781 cacgctgcgc atcgactttt ccaagctcac cagcctcaac gtcaagtaca acaatgacaa
841 gagccgtgac tacacacgcc cagacctgcc ttccggggac agccagccct cgctggacca
901 gaccatggcc gcggccttcg gcctttccgt tccgaacgtc cacggcgccc tggcccccct
961 ggccatcccc tcggcggcgg cggcagctgc ggcggcaggt cggatcgcca tcccgggcct
1021 ggcgggggca ggaaattctg tattgctggt cagcaacctc aacccagaga gagtcacacc
1081 ccaaagcctc tttattcttt tcggcgtcta cggtgacgtg cagcgcgtga agatcctgtt
1141 caataagaag gagaacgccc tagtgcagat ggcggacggc aaccaggccc agctggccat
1201 gagccacctg aacgggcaca agctgcacgg gaagcccatc cgcatcacgc tctcgaagca
1261 ccagaacgtg cagctgcccc gcgagggcca ggaggaccag ggcctgacca aggactacgg
1321 caactcaccc ctgcaccgct tcaagaagcc gggctccaag aacttccaga acatattccc
1381 gccctcggcc actctgcacc tctccaacat cccgccctca gtctccgagg aggatctcaa
1441 ggtcctgttt tccagcaatg ggggcgtcgt caaaggattc aagttcttcc agaaggaccg
1501 caagatggca ctgatccaga tgggctccgt ggaggaggcg gtccaggccc tcattgacct
1561 gcacaaccac gacctcgggg agaaccacca cctgcgggtc tccttctcca agtccaccat
1621 ctaggggcac aggcccacgg ccgggccccc tggcgacaac ttccatcatt ccagagaaaa
1681 gccactttaa aaacagctga agtgacctta gcagaccaga gattttattt ttttaaagag
1741 aaatcagttt acctgttttt aaaaaaatta aatctagttc accttgctca ccctgcggtg
1801 acaggacagc tcaggctctt ggtgactgtg gcagcgggag ttcccggccc tccacacccg
1861 gggccagacc ctcggggcca tgccttggtg gggcctgtgt cgggcgtggg gcctgcaggt
1921 gggcgccccg accacgactt ggcttccttg tgccttaaaa aacctgcctt cctgcagcca
1981 cacacccacc cggggtgtcc tggggaccca aggggtgggg gggtcacacc agagagaggc
2041 agggggcctg gccggctcct gcaggatcat gcagctgggg cgcggcggcc gcgctgcgag
2101 caccccaacc ccagccctct aatcaagtca cgtgattctc ccttcacccc gcccccaggg
2161 ccttcccttc tgccccagcg ggctcccgct gctcagctgc ggagctggtc gacataatct
2221 ctgtattata tactttgcag ttgcagacgt cgtgtcctag caatatttcc agttgaccaa
2281 atattctaat cttttttcat ttatatgcaa aagaaatagt tttaagtaac tttttatagc
2341 aagatgatac aatggtatga gtgtaatcta aacttccttg tggtattacc ttgtatgctg
2401 ttacttttat tttattcctt gtaattaagt cacaggcagg acccagtttc cagagagcag
2461 cggggccgcc cagtgggtca ggcacaggga gccccggtcc tatcttagag cccctgagct
2521 tcagggaagg gcggcgtgtc gccgctctgc atcgcctccg gttgccttac accacgcctt
2581 cacctgcagt cgcctagaaa acttgctctc aaacttcagg gttttttctt ccttcaaatt
2641 ttggaccaaa gtctcatttc tgtgttttgc ctgcctctga tgctgggacc cggaaggcgg
2701 gcgctcctcc tgtctttgtg ctctttctac gcccgcgtcc tgtcccgggg gctctcctag
2761 gatccccttt ccgtaaaagc gtgtaacaag ggtgtaaata tttataattt tttatacctg
2821 ttgtgagacc cgaggggcgg cggcgcggtt ttttatggtg acacaaatgt atattttgct
2881 aacagcaatt ccaggctcag taccgcgacc gagccaggga accccacgca cattccgttg
2941 ccttacccga tggcttgtga cgcggagaga accgattaaa accgtttgag aaactcctcc
3001 cttgtctagc cctgtgttcg ctgtggacgc tgtagaggca ggttggccag tctgtacctg
3061 gacttcgaat aaatcttctg tatcctcaaa
//