LOCUS X59657 3224 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens RNA for MTP.
ACCESSION X59657
VERSION X59657.1
KEYWORDS microsomal triglyceride transfer protein; MTP gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Sharp D., Blinderman L., Combs K.A., Kienzle B., Ricci B.,
Wagersmith K., Gil C.M., Turck C.W., Bouma M.E., Rader D.J.,
Aggerbeck L.P., Gregg R.E., Gordon D.A., Wetterau J.R.
TITLE Cloning and gene defects in microsomal triglyceride transfer
protein associated with abetalipoproteinaemia
JOURNAL Nature 365(6441), 65-69(1993).
PUBMED 8361539
REFERENCE 2 (bases 1 to 3224)
AUTHORS Sharp D.
JOURNAL Submitted (21-MAR-1994) to the INSDC. D. Sharp, Bristol-Myers
Squibb Company, Department of Metabolic Diseases, Princeton New
Jersey, 08543-4000, USA
FEATURES Location/Qualifiers
source 1..3224
/db_xref="H-InvDB:HIT000322331"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="Stratagene human liver cDNA"
/tissue_type="liver"
/db_xref="taxon:9606"
CDS 87..2771
/gene="MTP"
/product="microsomal triglyceride transfer protein"
/db_xref="GOA:P55157"
/db_xref="H-InvDB:HIT000322331.13"
/db_xref="HGNC:HGNC:7467"
/db_xref="InterPro:IPR001747"
/db_xref="InterPro:IPR011030"
/db_xref="InterPro:IPR015816"
/db_xref="InterPro:IPR015819"
/db_xref="InterPro:IPR039988"
/db_xref="UniProtKB/Swiss-Prot:P55157"
/protein_id="CAA42200.1"
/translation="MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLL
DRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIF
KGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQL
SSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVT
TYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAI
IKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQ
HLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQER
FLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAV
VEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTAL
QRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGE
LPQEMNKYMLAIVQDILRLEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERS
PRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEG
EENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQE
LQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVK
AGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQ
KRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF"
variation 300..302
/gene="MTP"
/replace="ct"
variation 1869
/gene="MTP"
/replace="t"
BASE COUNT 984 a 694 c 711 g 835 t
ORIGIN
1 actccctcac tggctgccat tgaaagagtc cacttctcag tgactcctag ctgggcactg
61 gatgcagttg aggattgctg gtcaatatga ttcttcttgc tgtgcttttt ctctgcttca
121 tttcctcata ttcagcttct gttaaaggtc acacaactgg tctctcatta aataatgacc
181 ggctgtacaa gctcacgtac tccactgaag ttcttcttga tcggggcaaa ggaaaactgc
241 aagacagcgt gggctaccgc atttcctcca acgtggatgt ggccttacta tggaggaatc
301 ctgatggtga tgatgaccag ttgatccaaa taacgatgaa ggatgtaaat gttgaaaatg
361 tgaatcagca gagaggagag aagagcatct tcaaaggaaa aagcccatct aaaataatgg
421 gaaaggaaaa cttggaagct ctgcaaagac ctacgctcct tcatctaatc catggaaagg
481 tcaaagagtt ctactcatat caaaatgagg cagtggccat agaaaatatc aagagaggtc
541 tggctagcct atttcagaca cagttaagct ctggaaccac caatgaggta gatatctctg
601 gaaattgtaa agtgacctac caggctcatc aagacaaagt gatcaaaatt aaggccttgg
661 attcatgcaa aatagcgagg tctggattta cgaccccaaa tcaggtcttg ggtgtcagtt
721 caaaagctac atctgtcacc acctataaga tagaagacag ctttgttata gctgtgcttg
781 ctgaagaaac acacaatttt ggactgaatt tcctacaaac cattaagggg aaaatagtat
841 cgaagcagaa attagagctg aagacaaccg aagcaggccc aagattgatg tctggaaagc
901 aggctgcagc cataatcaaa gcagttgatt caaagtacac ggccattccc attgtggggc
961 aggtcttcca gagccactgt aaaggatgtc cttctctctc ggagctctgg cggtccacca
1021 ggaaatacct gcagcctgac aacctttcca aggctgaggc tgtcagaaac ttcctggcct
1081 tcattcagca cctcaggact gcgaagaaag aagagatcct tcaaatacta aagatggaaa
1141 ataaggaagt attacctcag ctggtggatg ctgtcacctc tgctcagacc tcagactcat
1201 tagaagccat tttggacttt ttggatttca aaagtgacag cagcattatc ctccaggaga
1261 ggtttctcta tgcctgtgga tttgcttctc atcccaatga agaactcctg agagccctca
1321 ttagtaagtt caaaggttct attggtagca gtgacatcag agaaactgtt atgatcatca
1381 ctgggacact tgtcagaaag ttgtgtcaga atgaaggctg caaactcaaa gcagtagtgg
1441 aagctaagaa gttaatcctg ggaggacttg aaaaagcaga gaaaaaagag gacaccagga
1501 tgtatctgct ggctttgaag aatgccctgc ttccagaagg catcccaagt cttctgaagt
1561 atgcagaagc aggagaaggg cccatcagcc acctggctac cactgctctc cagagatatg
1621 atctcccttt cataactgat gaggtgaaga agaccttaaa cagaatatac caccaaaacc
1681 gtaaagttca tgaaaagact gtgcgcactg ctgcagctgc tatcatttta aataacaatc
1741 catcctacat ggacgtcaag aacatcctgc tgtctattgg ggagcttccc caagaaatga
1801 ataaatacat gctcgccatt gttcaagaca tcctacgttt ggaaatgcct gcaagcaaaa
1861 ttgtccgtcg agttctgaag gaaatggtcg ctcacaatta tgaccgtttc tccaggagtg
1921 gatcttcttc tgcctacact ggctacatag aacgtagtcc ccgttcggca tctacttaca
1981 gcctagacat tctctactcg ggttctggca ttctaaggag aagtaacctg aacatctttc
2041 agtacattgg gaaggctggt cttcacggta gccaggtggt tattgaagcc caaggactgg
2101 aagccttaat cgcagccacc cctgacgagg gggaggagaa ccttgactcc tatgctggta
2161 tgtcagccat cctctttgat gttcagctca gacctgtcac ctttttcaac ggatacagtg
2221 atttgatgtc caaaatgctg tcagcatctg gcgaccctat cagtgtggtg aaaggactta
2281 ttctgctaat agatcattct caggaacttc agttacaatc tggactaaaa gccaatatag
2341 aggtccaggg tggtctagct attgatattt caggtgcaat ggagtttagc ttgtggtatc
2401 gtgagtctaa aacccgagtg aaaaataggg tgactgtggt aataaccact gacatcacag
2461 tggactcctc ttttgtgaaa gctggcctgg aaaccagtac agaaacagaa gcaggcttgg
2521 agtttatctc cacagtgcag ttttctcagt acccattctt agtttgcatg cagatggaca
2581 aggatgaagc tccattcagg caatttgaga aaaagtacga aaggctgtcc acaggcagag
2641 gttatgtctc tcagaaaaga aaagaaagcg tattagcagg atgtgaattc ccgctccatc
2701 aagagaactc agagatgtgc aaagtggtgt ttgcccctca gccggatagt acttccagcg
2761 gatggttttg aaactgacct gtgatatttt acttgaattt gtctccccga aagggacaca
2821 atgtggcatg actaagtact tgctctctga gagcacagcg tttacatatt tacctgtatt
2881 taagattttt gtaaaaagct acaaaaaact gcagtttgat caaatttggg tatatgcagt
2941 atgctaccca cagcgtcatt ttgaatcatc atgtgacgct ttcaacaacg ttcttagttt
3001 acttatacct ctctcaaatc tcatttggta cagtcagaat agttattctc taagaggaaa
3061 ctagtgtttg ttaaaaacaa aaataaaaac aaaaccacac aaggagaacc caattttgtt
3121 tcaacaattt ttgatcaatg tatatgaagc tcttgatagg acttccttaa gcatgacggg
3181 aaaaccaaac acgttcccta atcaggaaaa aaaaaaaaaa aaaa
//