LOCUS X59617 3083 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens RR1 mRNA for large subunit ribonucleotide reductase.
ACCESSION X59617 S40300
VERSION X59617.1
KEYWORDS DNA synthesis enzyme; holoenzyme; large subunit ribonucleotide
reductase; ribonucleotide reductase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3083)
AUTHORS Mes-Masson A.M.
JOURNAL Submitted (23-APR-1991) to the INSDC. A.M. Mes-Masson,
Biotechnology Research Institute, 6100 Royalmount, Montreal,
Quebec, H4P 2R2, CANADA
REFERENCE 2 (bases 1 to 3083)
AUTHORS Pavloff N., Rivard D., Masson S., Shen S.H., Mes-Masson A.M.
TITLE Sequence analysis of the large and small subunits of human
ribonucleotide reductase
JOURNAL DNA Seq 2(4), 227-234(1992).
PUBMED 1627826
COMMENT See also X59618
FEATURES Location/Qualifiers
source 1..3083
/db_xref="H-InvDB:HIT000322328"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="Clonetech 5'stretch lambda"
/tissue_type="breast carcinoma"
/db_xref="taxon:9606"
CDS 182..2560
/gene="RR1"
/product="large subunit ribonucleotide reductase"
/db_xref="GOA:P23921"
/db_xref="H-InvDB:HIT000322328.13"
/db_xref="HGNC:HGNC:10451"
/db_xref="InterPro:IPR000788"
/db_xref="InterPro:IPR005144"
/db_xref="InterPro:IPR008926"
/db_xref="InterPro:IPR013346"
/db_xref="InterPro:IPR013509"
/db_xref="InterPro:IPR039718"
/db_xref="PDB:2WGH"
/db_xref="PDB:3HNC"
/db_xref="PDB:3HND"
/db_xref="PDB:3HNE"
/db_xref="PDB:3HNF"
/db_xref="PDB:4X3V"
/db_xref="PDB:5D1Y"
/db_xref="PDB:5TUS"
/db_xref="PDB:6AUI"
/db_xref="UniProtKB/Swiss-Prot:P23921"
/protein_id="CAA42180.1"
/translation="MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVI
QGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLY
NYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN
GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSC
FLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML
RVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWI
PDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYA
IIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLA
LNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGL
ADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGIL
QYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNI
YTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKT
VWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLR
TRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS"
regulatory 3027..3032
/regulatory_class="polyA_signal_sequence"
polyA_site 3050
BASE COUNT 944 a 599 c 703 g 837 t
ORIGIN
1 ggggatttgg attgttgcgc ctctgctctg aagaaagtgc tgtctggctg gaactccagt
61 tctttcccct gagcagcgcc tggaacctaa cccttcccac tctgtcacct tctcgatccc
121 gccggcgctt tagagccgca gtccagtctt ggatccttca gagcctcagc cactagctgc
181 gatgcatgtg atcaagcgag atggccgcca agaacgagtc atgtttgaca aaattacatc
241 tcgaatccag aagctttgtt atggactcaa tatggatttt gttgatcctg ctcagatcac
301 catgaaagta atccaaggct tgtacagtgg ggtcaccaca gtggaactag atactttggc
361 tgctgaaaca gctgcaacct tgactactaa gcaccctgac tatgctatcc tggcagccag
421 gatcgctgtc tctaacttgc acaaagaaac aaagaaagtg ttcagtgatg tgatggaaga
481 cctctataac tacataaatc cacataatgg caaacactct cccatggtgg ccaagtcaac
541 attggatatt gttctggcca ataaagatcg cctgaattct gctattatct atgaccgaga
601 tttctcttac aattacttcg gctttaagac gctagagcgg tcttatttgt tgaagatcaa
661 tggaaaagtg gctgaaagac cacaacatat gttgatgaga gtatctgttg ggatccacaa
721 agaagacatt gatgcagcaa ttgaaacata taatcttctt tctgagaggt ggtttactca
781 tgcttcgccc actctcttca atgctggtac caaccgcccg caactttcta gctgttttct
841 tctgagtatg aaagatgaca gcattgaagg catttatgac actctaaagc aatgtgcatt
901 gatttctaag tctgctggag gaattggtgt tgctgtgagt tgtattcggg ctactggcag
961 ctacattgct gggactaatg gcaattccaa tggccttgta ccgatgctga gagtatataa
1021 caacacagct cgatatgtgg atcaaggtgg gaacaagcgt cctggggcat ttgctattta
1081 cctggagcct tggcatttag acatctttga attccttgat ttaaagaaga acacaggaaa
1141 ggaagagcag cgtgccagag atcttttctt tgctctttgg attccggatc tcttcatgaa
1201 acgagtggag actaatcagg actggtcttt gatgtgtcca aatgagtgtc ctggtctgga
1261 tgaggtttgg ggagaggaat ttgagaaact atatgcaagt tatgagaaac aaggtcgtgt
1321 ccgcaaagtt gtaaaagctc agcagctttg gtatgccatc attgagtctc agacggaaac
1381 aggcaccccg tatatgctct acaaagattc ctgtaatcga aagagcaacc agcagaacct
1441 gggaaccatc aaatgcagca acctgtgcac agaaatagtg gagtacacca gcaaagatga
1501 ggttgctgtt tgtaatttgg cttccctggc cctgaatatg tatgtcacat cagaacacac
1561 atacgacttt aagaagttgg ctgaagtcac taaagtcgtt gtccgaaact tgaataaaat
1621 tattgatata aactactatc ctgtaccaga ggcatgccta tcaaataaac gccatcgccc
1681 cattggaatt ggggtacaag gtctggcaga tgcttttatc ctgatgagat acccttttga
1741 gagtgcagaa gcccagttac tgaataagca gatctttgaa actatttatt atggtgctct
1801 ggaagccagc tgtgaccttg ccaaggagca gggcccatac gaaacctatg agggctctcc
1861 agttagcaaa ggaattcttc agtatgatat gtggaatgtt actcctacag acctatggga
1921 ctggaaggtt ctcaaggaga agattgcaaa gtatggtata agaaacagtt tacttattgc
1981 cccgatgcct acagcttcca ctgctcagat cctggggaat aatgagtcca ttgaacctta
2041 caccagcaac atctatactc gcagagtctt gtcaggagaa tttcagattg taaatcctca
2101 cttattgaaa gatcttaccg agcggggcct atggcatgaa gagatgaaaa accagattat
2161 tgcatgcaat ggctctattc agagcatacc agaaattcct gatgacctga agcaacttta
2221 taaaactgtg tgggaaatct ctcagaaaac tgttctcaag atggcagctg agagaggtgc
2281 tttcattgat caaagccaat ctttgaacat ccacattgct gagcctaact atggcaaact
2341 cactagtatg cacttctacg gctggaagca gggtttgaag actgggatgt attatttaag
2401 gacaagacca gcagctaatc caatccagtt cactctaaat aaggagaagc taaaagataa
2461 agaaaaggta tcaaaagagg aagaagagaa ggagaggaac acagcagcca tggtgtgctc
2521 tttggagaat agagatgaat gtctgatgtg tggatcctga ggaaagactt ggaagagacc
2581 agcatgtctt cagtagccaa actacttctt gagcatagat aggtatagtg ggtttgcttg
2641 aggtggtaag gctttgctgg accctgttgc aggcaaaagg agtaattgat ttaaagtact
2701 gttaatgatg ttaatgattt ttttttaaac tcatatattg ggattttcac caaaataatg
2761 cttttgaaaa aaagaaaaaa aaaacggata tattgagaat caaagtagaa gttttaggaa
2821 tgcaaaataa gtcatcttgc atacagggag tggttaagta aggtttcatc acccatttag
2881 catgcttttc tgaagacttc agttttgtta aggagattta gttttactgc tttgactggt
2941 gggtctctag aagcaaaact gagtgataac tcatgagaag tactgatagg acctttatct
3001 ggatatggtc ctataggtta ttctgaaata aagataaaca tttctaagtg aaaaaaaaaa
3061 aaaaaaaaaa aaaaaaaaaa aaa
//