LOCUS X59543 3075 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for M1 subunit of ribonucleotide reductase.
ACCESSION X59543
VERSION X59543.1
KEYWORDS ribonucleotide reductase; ribonucleotide reductase M1 subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3075)
AUTHORS Parker N.J.
JOURNAL Submitted (20-MAY-1991) to the INSDC. N.J. Parker, The Royal
Melbourne Hospital, P.O. Royal Melbourne Hospital, 3050, AUSTRALIA
REFERENCE 2
AUTHORS Parker N.J., Begley C.G., Fox R.M.
TITLE Human M1 subunit of ribonucleotide reductase: cDNA sequence and
expression in stimulated lymphocytes
JOURNAL Nucleic Acids Res. 19(13), 3741-3741(1991).
PUBMED 1840662
FEATURES Location/Qualifiers
source 1..3075
/db_xref="H-InvDB:HIT000322327"
/organism="Homo sapiens"
/chromosome="11"
/mol_type="mRNA"
/tissue_type="bone marrow"
/db_xref="taxon:9606"
mRNA 1..3059
CDS 188..2566
/product="M1 subunit of ribonucleotide reductase"
/db_xref="GOA:P23921"
/db_xref="H-InvDB:HIT000322327.14"
/db_xref="HGNC:HGNC:10451"
/db_xref="InterPro:IPR000788"
/db_xref="InterPro:IPR005144"
/db_xref="InterPro:IPR008926"
/db_xref="InterPro:IPR013346"
/db_xref="InterPro:IPR013509"
/db_xref="InterPro:IPR039718"
/db_xref="PDB:2WGH"
/db_xref="PDB:3HNC"
/db_xref="PDB:3HND"
/db_xref="PDB:3HNE"
/db_xref="PDB:3HNF"
/db_xref="PDB:4X3V"
/db_xref="PDB:5D1Y"
/db_xref="PDB:5TUS"
/db_xref="PDB:6AUI"
/db_xref="UniProtKB/Swiss-Prot:P23921"
/protein_id="CAA42118.1"
/translation="MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVI
QGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLY
NYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN
GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSC
FLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML
RVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWI
PDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYA
IIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLA
LNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGL
ADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGIL
QYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNI
YTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKT
VWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLR
TRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS"
misc_feature 1037
/note="C/A polymorphism"
regulatory 3036..3041
/regulatory_class="polyA_signal_sequence"
polyA_site 3059
BASE COUNT 929 a 603 c 705 g 838 t
ORIGIN
1 ggggaagggg atttggattg ttgcgcctct gctctgaaga aagtgctgtc tggctccaac
61 tccagttctt tcccctgagc aacgcctgga acctaaccct tcccactctg tcaccttctc
121 gatcccgccg gcgctttaga gcggcagtcc agtcttggat ccttcagagc ctcagccact
181 agctgcgatg catgtgatca agcgagatgg ccgccaagaa cgagtcatgt ttgacaaaat
241 tacatctcga atccagaagc tttgttatgg actcaatatg gattttgttg atcctgctca
301 gatcaccatg aaagtaatcc aaggcttgta cagtggggtc accacagtgg aactagatac
361 tttggctgct gaaacagctg caaccttgac tactaagcac cctgactatg ctatcctggc
421 agccaggatc gctgtctcta acttgcacaa agaaacaaag aaagtgttca gtgatgtgat
481 ggaagacctc tataactaca taaatccaca taatggcaaa cactctccca tggtggccaa
541 gtcaacattg gatattgttc tggccaataa agatcgcctg aattctgcta ttatctatga
601 ccgagatttc tcttacaatt acttcggctt taagacgcta gagcggtctt atttgttgaa
661 gatcaatgga aaagtggctg aaagaccaca acatatgttg atgagagtat ctgttgggat
721 ccacaaagaa gacattgatg cagcaattga aacatataat cttctttctg agaggtggtt
781 tactcatgct tcgcccactc tcttcaatgc tggtaccaac cgcccacaac tttctagctg
841 ttttcttctg agtatgaaag atgacagcat tgaaggcatt tatgacactc taaagcaatg
901 tgcattgatt tctaagtctg ctggaggaat tggtgttgct gtgagttgta ttcgggctac
961 tggcagctac attgctggga ctaatggcaa ttccaatggc cttgtaccga tgctgagagt
1021 atataacaac acagctcgat atgtggatca aggtgggaac aagcgtcctg gggcatttgc
1081 tatttacctg gagccttggc atttagacat ctttgaattc cttgatttaa agaagaacac
1141 aggaaaggaa gagcagcgtg ccagagatct tttctttgct ctttggattc cggatctctt
1201 catgaaacga gtggagacta atcaggactg gtctttgatg tgtccaaatg agtgtcctgg
1261 tctggatgag gtttggggag aggaatttga gaaactatat gcaagttatg agaaacaagg
1321 tcgtgtccgc aaagttgtaa aagctcagca gctttggtat gccatcattg agtctcagac
1381 ggaaacaggc accccgtata tgctctacaa agattcctgt aatcgaaaga gcaaccagca
1441 gaacctggga accatcaaat gcagcaacct gtgcacagaa atagtggagt acaccagcaa
1501 agatgaggtt gctgtttgta atttggcttc cctggccctg aatatgtatg tcacatcaga
1561 acacacatac gactttaaga agttggctga agtcactaaa gtcgttgtcc gaaacttgaa
1621 taaaattatt gatataaact actatcctgt accagaggca tgcctatcaa ataaacgcca
1681 tcgccccatt ggaattgggg tacaaggtct ggcagatgct tttatcctga tgagataccc
1741 ttttgagagt gcagaagccc agttactgaa taagcagatc tttgaaacta tttattatgg
1801 tgctctggaa gccagctgtg accttgccaa ggagcagggc ccatacgaaa cctatgaggg
1861 ctctccagtt agcaaaggaa ttcttcagta tgatatgtgg aatgttactc ctacagacct
1921 atgggactgg aaggttctca aggagaagat tgcaaagtat ggtataagaa acagtttact
1981 tattgccccg atgcctacag cttccactgc tcagatcctg gggaataatg agtccattga
2041 accttacacc agcaacatct atactcgcag agtcttgtca ggagaatttc agattgtaaa
2101 tcctcactta ttgaaagatc ttaccgagcg gggcctatgg catgaagaga tgaaaaacca
2161 gattattgca tgcaatggct ctattcagag cataccagaa attcctgatg acctgaagca
2221 actttataaa actgtgtggg aaatctctca gaaaactgtt ctcaagatgg cagctgagag
2281 aggtgctttc attgatcaaa gccaatcttt gaacatccac attgctgagc ctaactatgg
2341 caaactcact agtatgcact tctacggctg gaagcagggt ttgaagactg ggatgtatta
2401 tttaaggacg agaccagcag ctaatccaat ccagttcact ctaaataagg agaagctaaa
2461 agataaagaa aaggtatcaa aagaggaaga agagaaggag aggaacacag cagccatggt
2521 gtgctctttg gagaatagag atgaatgtct gatgtgtgga tcctgaggaa agacttggaa
2581 gagaccagca tgtcttcagt agccaaacta cttcttgagc atagataggt atagtgggtt
2641 tgcttgaggt ggtaaggctt tgctggaccc tgttgcaggc aaaaggagta attgatttaa
2701 agtactgtta atgatgttaa tgattttttt ttaaactcat atattgggat tttcaccaaa
2761 ataatgcttt tgaaaaaaag aaaaaaaaaa cggatatatt gagaatcaaa gtagaagctt
2821 ttaggaatgc aaaataagtc atcttgcata cagggagtgg ttaagtaagg tttcatcacc
2881 catttagcac tgcttttctg aagacttcag ttttgttaag gagatttagt tttactgctt
2941 tgactggtgg gtcctctaga tgcaaaactg agtgataact catgagaagt actgatagga
3001 cctttatctg gatatggtcc tataggttat tctgaaataa agataaacat ttctaagtga
3061 aaaaaaaaaa aaaaa
//