LOCUS X56807 3212 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human DSC2 mRNA for desmocollins type 2a and 2b.
ACCESSION X56807
VERSION X56807.1
KEYWORDS alternative splicing; desmocollin; desmosomal glycoprotein; DSC2
gene; glycoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 3 (bases 1 to 3212)
AUTHORS Buxton R.S.
JOURNAL Submitted (04-DEC-1990) to the INSDC. Buxton R.S., National
Institute for Medical Research, The Ridgeway, Mill Hill, London NW7
1AA, England.
REFERENCE 5 (bases 1 to 3212)
AUTHORS Parker A.E., Wheeler G.N., Arnemann J., Pidsley S.C., Ataliotis P.,
Thomas C.L., Rees D.A., Magee A.I., Buxton R.S.
TITLE Desmosomal glycoproteins II and III. Cadherin-like junctional
molecules generated by alternative splicing
JOURNAL J Biol Chem 266(16), 10438-10445(1991).
PUBMED 2037591
FEATURES Location/Qualifiers
source 1..3212
/db_xref="H-InvDB:HIT000322052"
/organism="Homo sapiens"
/chromosome="18"
/mol_type="mRNA"
/clone_lib="lambda gt11 random primed"
/clone="L5 for DSC3a, L52 for DSC3b"
/cell_type="keratinocyte"
/tissue_type="skin"
/db_xref="taxon:9606"
CDS <1..2584
/codon_start=2
/gene="DSC2"
/product="desmocollin type 2a"
/db_xref="GOA:Q02487"
/db_xref="H-InvDB:HIT000322052.14"
/db_xref="HGNC:HGNC:3036"
/db_xref="InterPro:IPR000233"
/db_xref="InterPro:IPR002126"
/db_xref="InterPro:IPR009122"
/db_xref="InterPro:IPR014868"
/db_xref="InterPro:IPR015919"
/db_xref="InterPro:IPR020894"
/db_xref="InterPro:IPR027397"
/db_xref="PDB:5ERP"
/db_xref="PDB:5J5J"
/db_xref="UniProtKB/Swiss-Prot:Q02487"
/protein_id="CAA40141.1"
/translation="NSRSARDLPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDA
CKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSS
EKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLEN
SLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQ
YESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVG
QVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQL
KIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVE
DKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGV
VNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKA
YDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASD
QGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFS
LESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLC
DCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKV
IPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIE
MVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEESIRGHT
LIKN"
mRNA <1..>2584
/gene="DSC2"
/experiment="experimental evidence, no additional details
recorded"
CDS join(<1..2548,2595..2792)
/codon_start=2
/gene="DSC2"
/product="desmocollin type 2b"
/note="lacking 46 base pair exon"
/db_xref="GOA:Q02487"
/db_xref="HGNC:HGNC:3036"
/db_xref="InterPro:IPR000233"
/db_xref="InterPro:IPR002126"
/db_xref="InterPro:IPR009122"
/db_xref="InterPro:IPR014868"
/db_xref="InterPro:IPR015919"
/db_xref="InterPro:IPR020894"
/db_xref="InterPro:IPR027397"
/db_xref="PDB:5ERP"
/db_xref="PDB:5J5J"
/db_xref="UniProtKB/Swiss-Prot:Q02487"
/protein_id="CAA40142.1"
/translation="NSRSARDLPRALSMEAARPSGSWNGALCRLLLLTLAILIFASDA
CKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSS
EKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLEN
SLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQ
YESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVG
QVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQL
KIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVE
DKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGV
VNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKA
YDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASD
QGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFS
LESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLC
DCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKV
IPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIE
MVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQ
DENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR
"
mRNA join(<2..2548,2595..>2792)
/gene="DSC2"
/experiment="experimental evidence, no additional details
recorded"
sig_peptide 89..121
/gene="DSC2"
mat_peptide 446..2581
/gene="DSC2"
mat_peptide join(446..2548,2595..2789)
/gene="DSC2"
regulatory 3090..3095
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1024 a 643 c 694 g 851 t
ORIGIN
1 gaattcccgc tcggcccgcg acctgccccg agccctctcc atggaggcag cccgcccctc
61 cggctcctgg aacggagccc tctgccggct gctcctgctg accctcgcga tcttaatatt
121 tgccagtgat gcctgcaaaa atgtgacatt acatgttccc tccaaactag atgccgagaa
181 acttgttggt agagttaacc tgaaagagtg ctttacagct gcaaatctaa ttcattcaag
241 tgatcctgac ttccaaattt tggaggatgg ttcagtctat acaacaaata ctattctatt
301 gtcctcggag aagagaagtt ttaccatatt actttccaac actgagaacc aagaaaagaa
361 gaaaatattt gtctttttgg agcatcaaac aaaggtccta aagaaaagac atactaaaga
421 aaaagttcta aggcgcgcca agagaagatg ggctccaatt ccttgttcga tgctagaaaa
481 ctccttgggt ccttttccac ttttccttca acaggttcaa tctgacacgg cccaaaacta
541 taccatatac tattccataa gaggtcctgg agttgaccaa gaacctcgga atttatttta
601 tgtggagaga gacactggaa acttgtattg tactcgtcct gtagatcgtg agcagtatga
661 atcttttgag ataattgcct ttgcaacaac tccagatggg tatactccag aacttccact
721 gcccctaata atcaaaatag aggatgaaaa tgataactac ccaattttta cagaagaaac
781 ttatactttt acaatttttg aaaattgcag agtgggcact actgtgggac aagtgtgtgc
841 tactgacaaa gatgagcctg acacgatgca cacacgcctg aagtactcca tcattgggca
901 ggtgccacca tcacccaccc tattttctat gcatccaact acaggcgtga tcaccacaac
961 atcatctcag ctagacagag agttaattga caagtaccag ttgaaaataa aagtacaaga
1021 catggatggt cagtattttg gtctacagac aacttcaact tgtatcatta acattgatga
1081 tgtaaatgac cacttgccaa catttactcg tacttcttat gtgacatcag tggaagaaaa
1141 tacagttgat gtggaaatct tacgagttac tgttgaggat aaggacttag tgaatactgc
1201 taactggaga gctaattata ccattttaaa gggcaatgaa aatggcaatt ttaaaattgt
1261 aacagatgcc aaaaccaatg aaggagttct ttgtgtagtt aagcctttga attatgaaga
1321 aaagcaacag atgatcttgc aaattggtgt agttaatgaa gctccatttt ccagagaggc
1381 tagtccaaga tcagccatga gcacagcaac agttactgtt aatgtagaag atcaggatga
1441 gggccctgag tgtaaccctc caatacagac tgttcgcatg aaagaaaatg cagaagtggg
1501 aacaacaagc aatggatata aagcatatga cccagaaaca agaagtagca gtggcataag
1561 gtataagaaa ttaactgatc caacagggtg ggtcaccatt gatgaaaata caggatcaat
1621 caaagttttc agaagcctgg atagagaggc agagaccatc aaaaatggca tatataatat
1681 tacagtcctt gcatcagacc aaggagggag aacatgtacg gggacactgg gcattatact
1741 tcaagacgtg aatgataaca gcccattcat acctaaaaag acagtgatca tctgcaaacc
1801 caccatgtca tctgcggaga ttgttgcggt tgatcctgat gagcctatcc atggcccacc
1861 ctttgacttt agtctggaga gttctacttc agaagtacag agaatgtgga gactgaaagc
1921 aattaatgat acagcagcac gtctttccta tcagaatgat cctccatttg gctcatatgt
1981 agtacctata acagtgagag atagacttgg catgtctagt gtcacttcat tggatgttac
2041 actgtgtgac tgcattaccg aaaatgactg cacacatcgt gtagatccaa ggattggcgg
2101 tggaggagta caacttggaa agtgggccat ccttgcaata ttgttgggca tagcattgct
2161 cttttgcatc ctgtttacgc tggtctgtgg ggcttctggg acgtctaaac aaccaaaagt
2221 aattcctgat gatttagccc agcagaacct aattgtatca aacacagaag ctcctggaga
2281 tgacaaagtg tattctgcga atggcttcac aacccaaact gtgggcgctt ctgctcaggg
2341 agtttgtggc accgtgggat caggaatcaa aaacggaggt caggagacca tcgaaatggt
2401 gaaaggagga caccagacct cggaatcctg ccggggggct ggccaccatc acaccctgga
2461 ctcctgcagg ggaggacaca cggaggtgga caactgcaga tacacttact cggagtggca
2521 cagttttact cagccccgtc ttggtgaaga atccattaga ggacacactc tgattaaaaa
2581 ttaaacaatg aaagaaagtg tatctgtgta atcaagatga aaatcacaag catgcccaag
2641 actatgtcct gacatataac tatgaaggaa gaggatcggt ggctgggtct gtaggttgtt
2701 gcagtgaacg acaagaagaa gatgggcttg aatttttgga taatttggag cccaaattta
2761 ggacactagc agaagcatgc atgaagagat gagtgtgttc taataagtct ctgaaagcca
2821 gtggctttat gacttttaaa aaaaattaca aaccaagaat tttttaaagc agaagatgct
2881 atttgtgggg gtttttctct cattatttgg atggaatctc tttggtcaaa tgcacattta
2941 cagagagaca ctataaacaa gtacacaaat ttttcaattt ttacatattt ttaaattact
3001 tatcttctat ccaaggaggt ctacagagaa attaaagtct gccttatttg ttacatttgg
3061 gtataatgac aacagccaat ttatagtgca ataaaatgta attaattcaa gtccttatta
3121 tagactattt gaagcacaac ctaatggaaa attgtagaga ccttgcttta acattatctc
3181 cagttaatta agtgttcatg tggtgggaat tc
//