LOCUS X56654 3750 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human DSG1 mRNA for desmoglein type 1.
ACCESSION X56654
VERSION X56654.1
KEYWORDS desmoglein; desmosomal glycoprotein; DSG1 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3750)
AUTHORS Buxton R.S.
JOURNAL Submitted (22-NOV-1990) to the INSDC. R.S. Buxton, NATIONAL
INSTITUTE FOR MEDICAL RESEARCH, THE RIDGEWAY, MILL HILL, LONDON NW7
1AA, ENGLAND
REFERENCE 4 (bases 147 to 3604)
AUTHORS Wheeler G.N., Parker A.E., Thomas C.L., Ataliotis P., Poynter D.,
Arnemann J., Rutman A.J., Pidsley S.C., Watt F.M., Rees D.A.,
Buxton R.S., Magee A.I.
TITLE Desmosomal glycoprotein DGI, a component of intercellular desmosome
junctions, is related to the cadherin family of cell adhesion
molecules
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88(11), 4796-4800(1991).
PUBMED 1711210
FEATURES Location/Qualifiers
source 1..3750
/db_xref="H-InvDB:HIT000322037"
/organism="Homo sapiens"
/chromosome="18q12.1"
/mol_type="mRNA"
/clone="G4"
/sub_clone="lambda gt11"
/cell_type="keratinocytes"
/db_xref="taxon:9606"
mRNA 1..3750
/gene="DGS1"
/experiment="experimental evidence, no additional details
recorded"
CDS 78..3227
/gene="DGS1"
/product="desmoglein type 1"
/db_xref="GOA:Q02413"
/db_xref="H-InvDB:HIT000322037.13"
/db_xref="HGNC:HGNC:3048"
/db_xref="InterPro:IPR000233"
/db_xref="InterPro:IPR002126"
/db_xref="InterPro:IPR009122"
/db_xref="InterPro:IPR009123"
/db_xref="InterPro:IPR015919"
/db_xref="InterPro:IPR020894"
/db_xref="InterPro:IPR027397"
/db_xref="UniProtKB/Swiss-Prot:Q02413"
/protein_id="CAA39976.1"
/translation="MDWSFFRVVAVLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSI
RRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVI
NQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMA
TFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEI
RTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTI
EIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVV
KPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTY
VVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTK
EQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQE
STSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPF
LMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANII
ECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMR
ECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIG
EDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPP
ISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDN
RPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHP
RESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISG
GIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSA
SPSTARSRITKYSTVQYSK"
sig_peptide 99..134
/gene="DGS1"
/note="hydrophobic core"
mat_peptide 225..3227
/gene="DGS1"
/product="desmoglein type 1"
regulatory 3367..3372
/regulatory_class="polyA_signal_sequence"
regulatory 3671..3676
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1170 a 755 c 840 g 985 t
ORIGIN
1 tgagtgggag aaaggaaaag aacagagaag aacaaacaaa actcccttgg tcttggatgt
61 aagagaatcc agcagagatg gactggagtt tcttcagagt agttgcagtg ctgttcattt
121 ttctggtggt ggtagaagtt aacagtgaat tccgaatcca ggtaagagat tataacacta
181 aaaatggcac catcaaatgg cattcaatcc gaaggcagaa acgtgaatgg atcaagttcg
241 cagcagcctg tcgtgaaggt gaagacaact caaagaggaa cccaatcgcc aaaattcact
301 cagattgtgc tgcaaaccag caagttacat accgcatctc tggagtagga attgatcagc
361 caccatatgg gatctttgtc attaatcaga aaactggtga aattaatata acatccatag
421 ttgatcgaga ggtcactcct ttcttcatta tctactgccg agctctgaac tcaatgggcc
481 aagatttaga gaggcctcta gagctcagag tcagggtttt ggatataaat gacaaccctc
541 cagtgttttc aatggctaca tttgcaggac aaatagaaga aaattctaat gcaaatacac
601 tggtgatgat actcaatgct actgacgcag atgaaccgaa caatttgaac tcaaaaatag
661 ccttcaagat tataagacaa gaaccttcag attcaccaat gtttattatc aacagaaata
721 ctggagaaat tcgaacgatg aataattttc tagacagaga gcaatacggc cagtatgctc
781 ttgctgtaag aggctctgac cgagatggtg gggcagatgg catgtcagcg gaatgtgagt
841 gcaacattaa aatcctcgat gtcaatgata atatccctta catggaacag tcttcatata
901 ccatagaaat tcaagaaaat actctaaatt caaatttgct cgagattaga gtaattgatt
961 tggatgaaga gttctcagct aactggatgg cagtaatttt ctttatctct ggaaatgaag
1021 gaaattggtt tgagatagaa atgaatgaaa gaacaaatgt gggaatttta aaggttgtta
1081 agcccttaga ttatgaagct atgcagagtc tgcaactcag tattggtgtc agaaataaag
1141 ctgaatttca tcattcaatt atgtctcaat ataaactgaa agcatctgca atttctgtga
1201 ctgtgttaaa tgtaattgaa ggcccagtgt ttcgtccagg ttcaaagaca tatgttgtaa
1261 ctggtaatat gggatcaaat gataaagtgg gagactttgt agctactgac ctggacacag
1321 gtagaccttc aacgactgtt aggtatgtaa tgggaaataa tccagctgac ctgctagctg
1381 ttgattcaag aacaggcaaa ctcactttga aaaataaagt taccaaggaa cagtacaata
1441 tgctcggagg aaaataccaa ggaacgattc tctctataga tgataatctt caaagaactt
1501 gcactggtac aattaatatt aacattcaaa gttttggtaa tgacgacagg actaatacag
1561 agccgaacac taaaattact accaatactg gcagacaaga aagtacttct tccactaact
1621 atgataccag cacaacttct actgactcta gccaagtata ttcttctgaa cccggaaacg
1681 gagccaaaga tttgttatca gacaatgtac attttggtcc tgctggcatt ggactcctca
1741 tcatgggatt cttggtctta ggattggtcc catttttgat gatctgttgt gattgtggag
1801 gtgctcctcg tagtgcagct ggctttgagc ctgttcccga atgttcagat ggagcaattc
1861 attcatgggc agtagaagga ccacagcctg aacccaggga tataaccact gtcataccac
1921 aaataccacc tgataacgca aatataattg aatgcattga caactcagga gtttatacaa
1981 atgagtatgg tggcagagaa atgcaagatc tgggaggagg agagagaatg acaggatttg
2041 aactaacaga gggagttaaa acttcaggaa tgcctgagat atgtcaagaa tactctggaa
2101 cattaagaag aaattctatg agggaatgta gagaaggagg tctgaatatg aatttcatgg
2161 aaagctactt ctgtcagaaa gcatatgctt acgcagatga agatgaagga cgcccatcta
2221 atgactgttt gctcatatat gacatcgaag gtgtaggttc ccctgctggc tctgtgggtt
2281 gttgtagctt cattggagaa gacctggatg acagcttctt ggataccctg ggacctaaat
2341 ttaagaagtt ggcagacatc agcctaggaa aagaatcata tccagacctt gatccttctt
2401 ggccaccaca aagcactgaa ccagtttgcc ttcctcagga aacagagccc gttgttagtg
2461 gacacccacc aatctcccca catttcggca ctaccacagt aatttctgag agcacctatc
2521 cctcgggacc tggtgtactg catcctaagc ctattctcga tcctctgggc tatggtaatg
2581 tcactgtgac cgagtcttac accacctctg acactctgaa gccctctgtg cacgttcacg
2641 ataaccgacc agcatcaaac gtggtagtga cagagagagt ggtcggccca atctctggcg
2701 ctgatttgca tggaatgtta gagatgcctg acttgcgaga tgggtcgaat gttatagtga
2761 cagaaagggt aatagcacca agctctagtc tacccacctc tctgactatc catcatccta
2821 gagagtcttc aaatgtggta gtgacagaaa gagtaatcca accaacttcc ggcatgatag
2881 gtagtctgag tatgcacccc gagttagcca atgcccacaa tgtcattgtg acagagaggg
2941 ttgtttctgg tgctggcgta actggaatta gtggcaccac tgggatcagc ggtggcatag
3001 gcagcagtgg cctggttggc accagcatgg gtgctgggag cggtgccctg agtggagctg
3061 gcataagtgg tggtggcatt ggcctgagca gcttgggagg gacagccagc attggccaca
3121 tgaggagttc ctctgaccat cactttaacc aaaccattgg gtccgcctcc cctagcacag
3181 ctcgaagtcg aatcacaaag tatagtaccg tgcaatatag caagtagtca ggaccccagc
3241 tcactttttc atagtcattg tggtttagat ccaattccca ccactaaaaa actaacaatg
3301 tgatttataa cgcacaactt cgtgctcagg tcatctagga gcaaggtgag aaatcacaat
3361 gagaaaaata aatggaaaca ccactgctag gggagagctc tccttagcat tcataaactt
3421 ttctcttata ttaggactaa ggaactaaaa cttgaggcag agtcttcttt gtgcctgagt
3481 ggcctgtagt ccatctccag catgtaactg gccttacgat ggcaattggc atcattctcc
3541 ttgctctgtt ttgcttttcc atatagctcg agcaaaattc aaaaagaact aaatatgcaa
3601 tatatgttca tatctatggg aaaaatctaa aatgtgtgcc agatgccctg ttggtttcac
3661 agataacata aataaaaatt caaccacaga tttatacaag ggttaaccat tttttttaag
3721 tttgactaca tagtcaagtc cacggaattc
//