LOCUS       X54637                  4176 bp    mRNA    linear   HUM 18-APR-2005
DEFINITION  Human tyk2 mRNA for non-receptor protein tyrosine kinase.
ACCESSION   X54637
VERSION     X54637.1
KEYWORDS    protein tyrosine kinase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4176)
  AUTHORS   Krolewski J.J.
  JOURNAL   Submitted (29-AUG-1990) to the INSDC. Krolewski J.J., Columbia
            University, College of Physicians & Surgeons, Dept. of Pathology,
            630 West 168th St., New York, NY 10032, USA.
REFERENCE   2  (bases 1 to 4176)
  AUTHORS   Firmbach-Kraft I., Byers M., Shows T., Dalla-Favera R.,
            Krolewski J.J.
  TITLE     tyk2, prototype of a novel class of non-receptor tyrosine kinase
            genes
  JOURNAL   Oncogene 5(9), 1329-1336(1990).
   PUBMED   2216457
COMMENT     Data kindly reviewed (14-DEC-1990) by Krolewski J.
FEATURES             Location/Qualifiers
     source          1..4176
                     /db_xref="H-InvDB:HIT000321912"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="T-cell lymphoma PEER"
                     /db_xref="taxon:9606"
     CDS             307..3870
                     /note="protein tyrosine kinase"
                     /db_xref="GOA:P29597"
                     /db_xref="H-InvDB:HIT000321912.13"
                     /db_xref="HGNC:HGNC:12440"
                     /db_xref="InterPro:IPR000299"
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR000980"
                     /db_xref="InterPro:IPR001245"
                     /db_xref="InterPro:IPR008266"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR016045"
                     /db_xref="InterPro:IPR016251"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="InterPro:IPR019749"
                     /db_xref="InterPro:IPR020635"
                     /db_xref="InterPro:IPR035963"
                     /db_xref="InterPro:IPR036860"
                     /db_xref="InterPro:IPR041046"
                     /db_xref="InterPro:IPR041155"
                     /db_xref="InterPro:IPR041381"
                     /db_xref="PDB:3LXN"
                     /db_xref="PDB:3LXP"
                     /db_xref="PDB:3NYX"
                     /db_xref="PDB:3NZ0"
                     /db_xref="PDB:3ZON"
                     /db_xref="PDB:4GFO"
                     /db_xref="PDB:4GIH"
                     /db_xref="PDB:4GII"
                     /db_xref="PDB:4GJ2"
                     /db_xref="PDB:4GJ3"
                     /db_xref="PDB:4GVJ"
                     /db_xref="PDB:4OLI"
                     /db_xref="PDB:4PO6"
                     /db_xref="PDB:4PY1"
                     /db_xref="PDB:4WOV"
                     /db_xref="PDB:5C01"
                     /db_xref="PDB:5C03"
                     /db_xref="PDB:5F1Z"
                     /db_xref="PDB:5F20"
                     /db_xref="PDB:5TKD"
                     /db_xref="PDB:5WAL"
                     /db_xref="PDB:6AAM"
                     /db_xref="PDB:6DBK"
                     /db_xref="PDB:6DBM"
                     /db_xref="UniProtKB/Swiss-Prot:P29597"
                     /protein_id="CAA38449.1"
                     /translation="MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWV
                     TFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLY
                     FRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEF
                     VNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRS
                     FRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVP
                     VCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVN
                     KEEGSSGSSGRNPQASLFGKKAKAHKAFGQPADRPREPLWAYFCDFRDITHVVLKEHC
                     VSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDG
                     IHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIE
                     QQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRG
                     ARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDE
                     DPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE
                     NSMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNI
                     LLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKW
                     GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR
                     PSFRTILRDLTRVQPHNLADVLTVNRDSPAVGPTTFHKRYLKKIRDLGEGHFGKVSLY
                     CYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEK
                     SLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAHDYIHRDLAARNVL
                     LDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFG
                     VTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYH
                     LMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC"
BASE COUNT          831 a         1291 c         1269 g          785 t
ORIGIN      
        1 gacgcgggcg cggaaggagc gcggccggag gtcctcagga agaagccgcg gggactggct
       61 gcgcttgaca ggctgcactt ggatgggagc acctggtgcc tcgggactgc tccgatgccc
      121 gggtctgtgc tgaatgtgta atatgcggaa ctatattgaa acattacaac catcttttga
      181 tggcaacacc ctgaggacct cccttttcca gatggggaaa ctgaggccca gaattgctaa
      241 gtggcttgct tgagttgaca cagggagctc caggactcac cctcagctga gccacctgcc
      301 gggagcatgc ctctgcgcca ctgggggatg gccaggggca gtaagcccgt tggggatgga
      361 gcccagccca tggctgccat gggaggcctg aaggtgcttc tgcactgggc tggtccaggc
      421 ggcggggagc cctgggtcac tttcagtgag tcatcgctga cagctgagga agtctgcatc
      481 cacattgcac ataaagttgg tatcactcct ccttgcttca atctctttgc cctcttcgat
      541 gctcaggccc aagtctggtt gcccccaaac cacatcctag agatccccag agatgcaagc
      601 ctgatgctat atttccgcat aaggttttat ttccggaact ggcatggcat gaatcctcgg
      661 gaaccggctg tgtaccgttg tgggccccca ggaaccgagg catcctcaga tcagacagca
      721 caggggatgc aactcctgga cccagcctca tttgagtacc tctttgagca gggcaagcat
      781 gagtttgtga atgacgtggc atcactgtgg gagctgtcga ccgaggagga gatccaccac
      841 tttaagaatg agagcctggg catggccttt ctgcacctct gtcacctcgc tctccgccat
      901 ggcatccccc tggaggaggt ggccaagaag accagcttca aggactgcat cccgcgctcc
      961 ttccgccggc atatccggca gcacagcgcc ctgacccggc tgcgccttcg gaacgtcttc
     1021 cgcaggttcc tgcgggactt ccagccgggc cgactctccc agcagatggt catggtcaaa
     1081 tacctagcca cactcgagcg gctggcaccc cgcttcggca cagagcgtgt gcccgtgtgc
     1141 cacctgaggc tgctggccca ggccgagggg gagccctgct acatccggga cagtggggtg
     1201 gcccctacag accctggccc tgagtctgct gctgggcccc caacccacga ggtgctggtg
     1261 acaggcactg gtggcatcca gtggtggcca gtagaggagg aggtgaacaa ggaggagggt
     1321 tctagtggca gcagtggcag gaacccccaa gccagcctgt ttgggaagaa ggccaaggct
     1381 cacaaggcat tcggccagcc ggcagacagg ccgcgggagc cactgtgggc ctacttctgt
     1441 gacttccggg acatcaccca cgtggtgctg aaagagcact gtgtcagcat ccaccggcag
     1501 gacaacaagt gcctggagct gagcttgcct tcccgggctg cggcgctgtc cttcgtgtcg
     1561 ctggtggacg gctatttccg cctgacggcc gactccagcc actacctgtg ccacgaggtg
     1621 gctcccccac ggctggtgat gagcatccgg gatgggatcc acggacccct gctggagcca
     1681 tttgtgcagg ccaagctgcg gcccgaggac ggcctgtacc tcattcactg gagcaccagc
     1741 cacccctacc gcctgatcct cacagtggcc cagcgtagcc aggcaccaga cggcatgcag
     1801 agcttgcggc tccgaaagtt ccccattgag cagcaggacg gggccttcgt gctggagggc
     1861 tggggccggt ccttccccag cgttcgggaa cttggggctg ccttgcaggg ctgcttgctg
     1921 agggccgggg atgactgctt ctctctgcgt cgctgttgcc tgccccaacc aggagaaacc
     1981 tccaatctca tcatcatgcg gggggctcgg gccagcccca ggacactcaa cctcagccag
     2041 ctcagcttcc accgggttga ccagaaggag atcacccagc tgtcccactt gggccagggc
     2101 acaaggacca acgtgtatga gggccgcctg cgagtggagg gcagcgggga ccctgaggag
     2161 ggcaagatgg atgacgagga ccccctcgtg cctggcaggg accgtgggca ggagctacga
     2221 gtggtgctca aagtgctgga ccctagtcac catgacatcg ccctggcctt ctacgagaca
     2281 gccagcctca tgagccaggt ctcccacacg cacctggcct tcgtgcatgg cgtctgtgtg
     2341 cgcggccctg aaaatagcat ggtgacagag tacgtggagc acggacccct ggatgtgtgg
     2401 ctgcggaggg agcggggcca tgtgcccatg gcttggaaga tggtggtggc ccagcagctg
     2461 gccagcgccc tcagctacct ggagaacaag aacctggttc atggtaatgt gtgtggccgg
     2521 aacatcctgc tggcccggct ggggttggca gagggcacca gccccttcat caagctgagt
     2581 gatcctggcg tgggcctggg cgccctctcc agggaggagc gggtggagag gatcccctgg
     2641 ctggcccccg aatgcctacc aggtggggcc aacagcctaa gcaccgccat ggacaagtgg
     2701 gggtttggcg ccaccctcct ggagatctgc tttgacggag aggcccctct gcagagccgc
     2761 agtccctccg agaaggagca tttctaccag aggcagcacc ggctgcccga gccctcctgc
     2821 ccacagctgg ccacactcac cagccagtgt ctgacctatg agccaaccca gaggccatca
     2881 ttccgcacca tcctgcgtga cctcacccgc gtgcagcccc acaatcttgc tgacgtcttg
     2941 actgtgaacc gggactcacc ggccgtcgga cctactactt tccacaagcg ctatttgaaa
     3001 aagatccgag atctgggcga gggtcacttc ggcaaggtca gcttgtactg ctacgatccg
     3061 accaacgacg gcactggcga gatggtggcg gtgaaagccc tcaaggcaga ctgcggcccc
     3121 cagcaccgct cgggctggaa gcaggagatt gacattctgc gcacgctcta ccacgagcac
     3181 atcatcaagt acaagggctg ctgcgaggac caaggcgaga agtcgctgca gctggtcatg
     3241 gagtacgtgc ccctgggcag cctccgagac tacctgcccc ggcacagcat cgggctggcc
     3301 cagctgctgc tcttcgccca gcagatctgc gagggcatgg cctatctgca cgcgcacgac
     3361 tacatccacc gagacctagc cgcgcgcaac gtgctgctgg acaacgacag gctggtcaag
     3421 atcggggact ttggcctagc caaggccgtg cccgaaggcc acgagtacta ccgcgtgcgc
     3481 gaggatgggg acagccccgt gttctggtat gccccagagt gcctgaagga gtataagttc
     3541 tactatgcgt cagatgtctg gtccttcggg gtgaccctgt atgagctgct gacgcactgt
     3601 gactccagcc agagcccccc cacgaaattc cttgagctca taggcattgc tcagggtcag
     3661 atgacagttc tgagactcac tgagttgctg gaacgagggg agaggctgcc acggcccgac
     3721 aaatgtccct gtgaggtcta tcatctcatg aagaactgct gggagacaga ggcgtccttt
     3781 cgcccaacct tcgagaacct catacccatt ctgaagacag tccatgagaa gtaccaaggc
     3841 caggcccctt cagtgttcag cgtgtgctga ggcacaatgg cagccctgcc tgggaggact
     3901 ggaccaggca gtggctgcag agggagcctc ctgctccctg ctccaggatg aaaccaagag
     3961 ggggatgtca gcctcaccca caccgtgtgc cttactcctg tctagagacc ccacctctgt
     4021 gaacttattt ttctttcttg gccgtgagcc taaccatgat cttgagggac ccaacatttg
     4081 taggggcact aatccagccc ttaaatcccc cagcttccaa acttgaggcc caccatctcc
     4141 accatctggt aataaactca tgttttctct gctggg
//