LOCUS X54486 18687 bp DNA linear HUM 14-NOV-2006
DEFINITION Human gene for C1-inhibitor.
ACCESSION X54486
VERSION X54486.1
KEYWORDS C1 inhibitor; glycoprotein; protease inhibitor; serpin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 18687)
AUTHORS Fothergill J.E.
JOURNAL Submitted (17-AUG-1990) to the INSDC. Fothergill J.E., University
of Aberdeen, Department of Molecular & Cell Biology, Marischal
College, Aberdeen AB9 1AS, Scotland, UK.
REFERENCE 2 (bases 1 to 18687)
AUTHORS Carter P.E., Duponchel C., Tosi M., Fothergill J.E.
TITLE Complete nucleotide sequence of the gene for human C1 inhibitor
with an unusually high density of Alu elements
JOURNAL Eur. J. Biochem. 197(2), 301-308(1991).
PUBMED 2026152
COMMENT inhibits serine proteinases C1r and C1s of the first component of
human complement; belongs to the serpin class of inhibitors;
defects in the gene are associated with 'hereditary angioneurotic
oedema (HANE);
for overlapping sequences see: X07427-33; X07577
FEATURES Location/Qualifiers
source 1..18687
/organism="Homo sapiens"
/mol_type="genomic DNA"
/dev_stage="adult"
/clone_lib="cosmid genomic"
/clone="6d"
/db_xref="taxon:9606"
repeat_region 266..542
/rpt_family="Alu"
regulatory 1080..1083
/regulatory_class="CAAT_signal"
misc_feature 1100..1105
/note="IL-6 element"
regulatory 1122..1125
/regulatory_class="CAAT_signal"
misc_feature 1152..1166
/note="c-myc element (H-DNA)"
mRNA join(1183..1220,1747..1819,3378..3876,5533..5667,
9507..9710,9905..10044,15213..15432,17824..>18341)
/note="C1 inhibitor"
exon 1183..1220
/number=1
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
intron 1221..1746
/number=1
exon 1747..1819
/number=2
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
CDS join(1769..1819,3378..3876,5533..5667,9507..9710,
9905..10044,15213..15432,17824..18077)
/product="C1 inhibitor"
/db_xref="GOA:P05155"
/db_xref="HGNC:HGNC:1228"
/db_xref="InterPro:IPR000215"
/db_xref="InterPro:IPR015553"
/db_xref="InterPro:IPR023795"
/db_xref="InterPro:IPR023796"
/db_xref="InterPro:IPR036186"
/db_xref="InterPro:IPR042178"
/db_xref="InterPro:IPR042185"
/db_xref="PDB:1M6Q"
/db_xref="PDB:2OAY"
/db_xref="PDB:5DU3"
/db_xref="PDB:5DUQ"
/db_xref="UniProtKB/Swiss-Prot:P05155"
/protein_id="CAA38358.1"
/translation="MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGK
VATTVISKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQP
TQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAM
KKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGV
TSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISR
LLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAH
FIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQ
PTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELT
ETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDPRA"
intron 1820..3377
/number=2
misc_feature 2416..2454
/note="putative Z-DNA"
exon 3378..3876
/number=3
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
intron 3877..5532
/number=3
repeat_region 4168..5356
/rpt_family="Alu"
exon 5533..5667
/number=4
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
intron 5668..9506
/number=4
repeat_region 5973..9027
/rpt_family="Alu"
exon 9507..9710
/number=5
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
intron 9711..9904
/number=5
exon 9905..10044
/number=6
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
intron 10045..15212
/number=6
repeat_region 11175..14726
/rpt_family="Alu"
exon 15213..15432
/number=7
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
intron 15433..17823
/number=7
repeat_region 15917..16541
/rpt_family="Alu"
exon 17824..18341
/number=8
/note="C1 inhibitor"
/experiment="experimental evidence, no additional details
recorded"
repeat_region 18394..18669
/rpt_family="Alu"
BASE COUNT 4918 a 4535 c 4335 g 4899 t
ORIGIN
1 gatcctcctg cctcagtctc ctaaaaggct gggattacag gtatgaaccc ccaggcctgc
61 ctacttcgtg tgttttatct ggcaatgctg agaggacagc tagatgtcga ggacagccag
121 atttcgagga cagccagacg tcaaggggga aagcaacttg ctggctcaca cagccagcca
181 ggtctattgt ggagccctag tcgcaaacac atacacccca gctttcaagt ttttaaatat
241 ttatttagtt agttatttgt tttttgagac agtcttgctc tgtcacccag gctggagtgc
301 agtggtgcaa tttcagctca ctgcaacctc tgcctcccag attcaagtga ttgctgcctc
361 agcctcccta gtagctggga ctacatgtgc gcgcctgcac tgcccagcta atttttgtac
421 ttttagcgga aacggggttt ccccatattg gccagagtgg tctcaaactc ctgacctcaa
481 gtgatccacc cacctcggcc tcccaaagtg ctgggattac aggcgtgaga ccgtgcccgg
541 ctagcttttt tttttttttt ttttttaatt aggttgaatg cttgttgagc tgggtgcctc
601 acatccgttg tctgttatac aaagaactac tgattatggg tctctacgag acaaaaatgg
661 cagaacacct acagggcaca ggggagatgg gagcagggat taggcttcag aatacttctc
721 caaatgaggg tgatcagggc ccgacatttc actgctctaa ggctcagtat cttaactatc
781 aaatgggtac aatggggcac aaagggttac tttgaggaat aacggaggtg agcaatttcc
841 aaaaagttca ttcctttaaa aactgcggag cacattttgt gtacatgctg tttttattgt
901 tactcatgaa gacgcggggg aagctttggt tgtgtaaagc tgagaactgc acccaagctt
961 ccccgttcac cccacctacc aggggatttg ggctaaattc ctggcctggc ccacaaagaa
1021 gaccaagcgg tcagtcccat tccgtcccat cctgatttac aggaactcac accagcgatc
1081 aatcttcctt aatttgtaac tgggcagtgt cccgggccag ccaatagcta agactgcccc
1141 ccccgcaccc caccctccct gaccctgggg gactctctac tcagtctgca ctggagctgc
1201 ctggtgacca gaagtttgga gtaggtttgg tgctgggcag gggtggggag tagggtggaa
1261 agcatggagt gaagaggtct agggaggggg tctcctcacc cccgccttcc tgcccgcctt
1321 gatctcgggg gtctctatag gcttgcttcc acctgggact tctgcctcct cctaccccag
1381 cccctcccgc ctcaggcctg ttgtgctcag ccccccagga cctcccctcc cccacgcctc
1441 tggcctcatt gtttggttaa agcaggaccc cctccccctc ccaccacctc ccctccgact
1501 gaacagatgg acagagaccc gggcccacgg ggagaggaag ggccagccgg tgccgggaaa
1561 gggaagcggt ttggggaaaa caaaacagag ggaggagcca gggagaaggt ggccccagga
1621 gggaggagga gggaattcgc taagagggac tggggcctga gacggaatgg gggcgggccc
1681 cgggcggggt gggggcccct gggctcccag ggtgggagct ggctccgagg ctggctggct
1741 ccgcaggtcc gctgacgtcg ccgcccagat ggcctccagg ctgaccctgc tgaccctcct
1801 gctgctgctg ctggctgggg tatgtggtcc cttgtgggat gggggacggg ggtggagacg
1861 ggaggcggga tggtgcgggg tgcgggcggt ggctgaggat taacccttca ggctccgggg
1921 aatgaggaga gctcctcttg ggatcattga gtgtgatcct tgcacacgca ctcgtagatg
1981 gtggaaagag ctcaggactc agacagatgc aagttctaat cttggcgggc catgtaggag
2041 ctgcgcacgt ggtcctgagg acgtcacttt tctcagccta ctcctcctga tttataaaat
2101 gttgaataaa cagatcccac cctgtccacc aagcaggctt ggcaggagga tcacataggg
2161 caaggagatg ggaagcattt tgtgatatca aagcaagagt ttgttgtaga aaagagctgt
2221 ggggaggaga ggtttggctg ctgtgacaca gacggtggtc ccaggctagg gcctgtgaag
2281 acagggaaga atggtagcaa acatacgtgg gtctgggtgg gggtcaatag cagtgagagg
2341 tcccagtggt ctgggaggtc atggactaga aataaggcta agaagtgcag gatcccagga
2401 gaaaggtagg taggggtgtg tgtatgtgcg tgtgtgtgtg tgtgtgcacg cgcaagttgg
2461 tatcacatac tcagcagatg atgtagttat gagcagggag tttggaatca gagaccttgt
2521 tttgacccct agctgtttct cccatttctg tgagaccctg gactagttaa tatgtgtcgg
2581 tatgagtttc tctacctgtg aaatggagct aatgcgtggt ttctcagtgg aggatctgtt
2641 gacattgggg ctggataatt cattgctgag gggctaccct gtgcatttta ggatgttttg
2701 cagtatatct ctagcctcta cgcactagat tccggtagca tcttccctgc tgtctccctg
2761 tgacaaccaa aaatgtctct ggacattgcc aaatatcccc tgggagtcaa aattgtttca
2821 gagccgctgg cctatactac ttctctctcc ctcccttcct gcctcccttc tttcctcctt
2881 ccctttcttc gttcccttcc taatgtgtac tgtttttcca cacccactaa tgggttgcaa
2941 cccacagttt aaaaatttac tgttctaaat caaggagcac aagttcaaat gtctgtacta
3001 gccaagcaag tgagtcaaac aggtagatat ttacaggaaa ttgcaagaac atagataaat
3061 gacaacactc agcttcactg tttggaaaac aacttcctac agggcagtaa ttggtcagag
3121 attacagagt ccctgactat ccctcatctt ctgcagagca cattcctgtg cacccccacc
3181 ctcaccctgt attgcccctt ctctgaggaa ttagtggtgg tggttctaag acagattgct
3241 catctgctgc actgtcagaa attactctct tgtacaggac attttccaca tccacacctt
3301 ctcttcctgc tttgagtatt ttagaggact gtgcctcgta gtaagaaaaa aatgaaactc
3361 agtttcttga accacaggat agagcctcct caaatccaaa tgctaccagc tccagctccc
3421 aggatccaga gagtttgcaa gacagaggcg aagggaaggt cgcaacaaca gttatctcca
3481 agatgctatt cgttgaaccc atcctggagg tttccagctt gccgacaacc aactcaacaa
3541 ccaattcagc caccaaaata acagctaata ccactgatga acccaccaca caacccacca
3601 cagagcccac cacccaaccc accatccaac ccacccaacc aactacccag ctcccaacag
3661 attctcctac ccagcccact actgggtcct tctgcccagg acctgttact ctctgctctg
3721 acttggagag tcattcaaca gaggccgtgt tgggggatgc tttggtagat ttctccctga
3781 agctctacca cgccttctca gcaatgaaga aggtggagac caacatggcc ttttccccat
3841 tcagcatcgc cagcctcctt acccaggtcc tgctcggtaa gaccctgctt gaattctctc
3901 caggtcattt gttggacact cccataagag tcaccaatcc agacacttac aaagccatgc
3961 ctctgggaag aagctgtaaa aatgggctat tatatattgg gggtggggta gagggatgta
4021 tcttttcatt cttgaacatt ccatcatttc acagtgatgt aataggcacg attgcttgta
4081 aaactctgtg actatacaag aacatataaa ataaggtcgc agccactaac catgtttcat
4141 ggcaaggaga ggtgataaga aagatgaaat taggcgcagt ggctcacgcc tgtaatccca
4201 gcactttggg aggccaaggc gggtggatca cctgaggtca ggagttcaag accagcctgg
4261 ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttatcaggga gtggtggtgc
4321 atgcctgtaa tcccagctac ttgggcagct gaggcaggag aatcgcttga acccaggagg
4381 tggaggttgc agtgagccga gaccgcacca ttgcactaca gtctgggtga cagagcgaga
4441 ctctgtctca aaaaaaaaaa aaattatcag agatagacct agagtagatg tggttagtac
4501 tgccttctag ctctgtgacc ttgggcagat cactttaacc tctctgagcc ttgagtcctc
4561 ttgtgtaaaa tagtgatgat gctatctacc tcaaaagatt aagaagcaga aagccaggcc
4621 gggtgcggtg gttcacacct gtaatcccag cattttagga ggccgaggag ggcagatcac
4681 gaggtcagga gttcgagacc agcctgacta acatggtgaa accccgtctc tactaaaaat
4741 aaaaagaaat tagctaggca tggtggtgca cacctgtaac cccagctact caggaggctg
4801 aggcaggaga atcacttgaa cacgggaggc agaggttgca gtgagccgaa atcatgccac
4861 tgcactccag cctgggaaga ctgagcaaga ctctgtctca aaaaaaaaaa aaagaagcag
4921 cctagtgtct gacttagtgg gaggtcaaaa aaatgtaaat cctctgccat cttgagggat
4981 tactgtcaag tcccatttgg taattaccct aggaatggca caaacaaatt actacaagca
5041 gtggggacag agctattact ccccagagag aattctaaaa aggctacaga atctttcttg
5101 gctgggcacg gtgactcaca cctataatcc tggcactttg ggaggccaag gcaggagttc
5161 aagaccagcc tggccaacat gttgaaaccc catctctact aaaaatgcaa aaattagcca
5221 ggcatagtga tgcatgctta ttgtcccagc tacttgggag gcagaggtgg gaggattgct
5281 tgaacctgga gattcaagtg agctgagatt gcaccactgc attccagcct gggccaacaa
5341 agcaagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaga gagagattga gagaacattc
5401 cagctcagat gatctgtgat cccctccaaa gcagggaata ccctccattc cagcctggtc
5461 cccaaccctc attcccaagg aaggcccccg actcatcctg caagtatctt tcatctctgc
5521 cctttgttgc aggggctggg gagaacacca aaacaaacct ggagagcatc ctctcttacc
5581 ccaaggactt cacctgtgtc caccaggccc tgaagggctt cacgaccaaa ggtgtcacct
5641 cagtctctca gatcttccac agcccaggtg agtgcccagg aatgggcagt gtctgcagag
5701 gagggtcctg agaggactct gaagggggac ccagcgctgg ggaaagaaag gacagaggga
5761 atgttggagc tacagtatca gggatggact gcagagcagg tgaagacctt ggcaggagca
5821 ttaggtcact ccaggaacta gactgttctt ctaatgagac cttagacaag tctctggcat
5881 tcatcaactg ctttagaata aaaataaccg ggcaggtaca gtaaaatagt gatgatgcta
5941 tctacctcaa aagattaaga agcagaaagc caggctgggc gtggtggctc acacctgtaa
6001 tcccagcact ttgggaggcc gaggcaggtg gatcacgagg tcaggggttc gagaccagcc
6061 tgaccaacat ggtgaaaccc tgtctctact aaaaatacaa aaattagctg ggcatggtgg
6121 cgggcacctg taatcccagc tattcaggag gctgaggcag gagaattgct tgaacctggg
6181 aggcggaggt tgcagtgagc cgagatgacg ccactgcact ccagcctggg cgacagagca
6241 agactccgtc tcaaaaaaaa aaacaaaaac aaaacaaaaa caaaaaaaaa aaacaaagaa
6301 ggagaaagcc gggccgggca tggtggttct catctgtaag ttcaaggagt tgaaggtatg
6361 ctaggacttt gggaggccaa ggccttcaag accagcctgg gcagcatggc gaaacctgtc
6421 tccattaaaa aaaaaaaagt tgggggtacg gctgggcatg gtggctcaca cctgtaatcc
6481 cagcactttt gggaggctga ggtgggtgga acacctgagg tcaggagttc aagaccagcc
6541 tggccaacat ggcaaaaccc tgtctctatt aaaaacacaa aaattagcct ggcatggtgg
6601 caggcgccta taatcccaac tactcaggag gctgaggcag gagaatcgct tgaacccaag
6661 agagtgaagg ttgcagtgag ctgagatcat gccacttcac tccagcctga gtgaaacagc
6721 aaaactctgt ctcaaaaaaa aaaaaaggaa gaaagaaaaa aggccaggcg cggtgactca
6781 cgcctgtaat cgcaacactt tggcaggccg aggcaggcga ttcacaaggt caggagttcg
6841 agaccagtct ggctaactaa catagtgaaa ctccgtctct actgaaaata caagaaatta
6901 ccctggcatg gtggtgtgca cctgtaatcc cagctactca ggaggctgag gcaggagaat
6961 cgcttgaacc tgggaggcag aggctgcagt gagccgagat cgcgccactg cactccagcc
7021 tggatgacag agcaagactc tgtctcaaaa aaaaaaggcc gggcgcggtg gctcatgcct
7081 gtaatcccag cactttggga ggctgaggcg ggcggaccac gaggtcagaa gatcaagacc
7141 atcctggcta acaagatgaa accctgtctc tgccaaaaaa atacaaaact tagccgggca
7201 tggtggcagg cgcctgtggt cccaactact tgggaggctg aggcaggaga atggcatgaa
7261 cccgggaggc ggagcttgca gtgagccgag attgcgccac tgcactccag cctgggcaac
7321 agagcgagac accatctcaa aaaaaaaaaa aaaaaatggg gcgggcgggc caggcgcggt
7381 gtctcacacc tgtaatccca gcactttggg aggctgaggt gggcggatca cttgaggtca
7441 ggagttcaag accagcctgg ccaacaccag gaaaccctgt ctctgttaaa aatacaaaaa
7501 ttagccaggt gtggtggcac gcgcctgtag tcccagcagg agaataactt caacctggga
7561 gacagaggtt gcagtcagct gagatcgcac cactgcattc cagcctgggt gacagaccga
7621 gactctgtct caaaaaaaaa aaaaaagaag aatacccata tgcattcatt aatatatagg
7681 gctagagggc tagagagcta tagacataaa atagacaaaa aatttttttg ctcatttttg
7741 ggtcaaagga gtcttgggac tctaattctt ttaatttttg tgttatgtga atttgttatc
7801 atttacatgt attatgttat taagtaggta ataatgataa tactaataat aaacttacaa
7861 aacgatccaa tgtagttgtt ttcagacttt gttcctcgga gccctaggac tttgcaaagc
7921 tgtttctgga gtcatggtgg gagtggggtg tggggagcct gagcagtggg gaagggttca
7981 ccacttcctg tgagagggaa acggaccagc tgggctctga gctccccacc cagcctcagc
8041 cagggtccat tttatattgt gggcttcaga catgcctttg tttgaaagca gttctgctgc
8101 tttaaaatgt ttgataacca ttgaactaat ctacccacct ccctttttaa aaaaaaaagg
8161 aaaacttttt tttaagctgt tttttttgtt ttttgttttt ttttaaactg taaaaacaat
8221 acttaggtct ggctcagtgt gcctgtaatt ccaacactga gaggctgagg taggaggatt
8281 gcttgaggct agaatttcga gactagcctc tgggcaacat agacagacct catctctaca
8341 aaaaatttta aaaattatcc gggtgtggta cgtgtctgta gttccagcta tgaaggactg
8401 agacgggagg attgcttgag ccaagaattc gaagttagag tgagctatgt ttatgcctct
8461 gtactctagg ttgggtaaca gagtaggacc ctgtctctaa aaaaaaaaaa atttaattta
8521 aattttaaaa actcacctat caccccatca tctgaaaaac accctctttc agatgtggga
8581 aaaacatggc tcagaggtgt tcaagaaatg ttgcatttat ttattactta caaagctgta
8641 agtcagcttt atccgctgtc ttgctaggtt ggtgaaaaat acgtaacagc attcaatatt
8701 agggcttcta tccccatcta gctgcacact ggagctgtgc caagcaaggt tcttggtctt
8761 atgttgtact taggcatcag caaagcctgg gaaaatatct tttttttttt tttgagacag
8821 aatctcgctc tgtcgcccag gctggaatgc agtggcacca tctcagctca ctgcaacctc
8881 cgtctcccag attcaagtga ttctcctgcc tcagcctccc gaatagctgg gattacaggc
8941 tggtcttgaa ctcctggcct ccagtgatcc acccaccttg gcctcccaaa gtgctgcgat
9001 tacaggtgtg agccaccatg cccagctggg gaaaatatct ttaatctact tagtcctaga
9061 aaaattatct ttcaagtgct tttttttttt ttttttcagt ggactgaagg cttttgcaga
9121 gcaaaagcca ggaagttttg tcacaaactt ccaccaaggc caggaagcag agtctattcc
9181 gtgccaaaat taagggaaga aaagagggaa aatctaggca aatggaattt aatatctcaa
9241 aaagattatc ttgccgagcc atagtcacat agcaagctga ggcagcggag gcttggggct
9301 acttctcttg ttcttggttc tgggtttacc ttctttgggc cttatttgcc acatctgtaa
9361 gaggagtggg ctggaccgcg ctccaccatg ccgtattcac taagtgagca gatagaacca
9421 tagaaagcat gctcactctc aaatcgtgct catggaaaga acgacgtgtt caggactcat
9481 gcctcccttt ctcaacatac ccccagacct ggccataagg gacacctttg tgaatgcctc
9541 tcggaccctg tacagcagca gccccagagt cctaagcaac aacagtgacg ccaacttgga
9601 gctcatcaac acctgggtgg ccaagaacac caacaacaag atcagccggc tgctagacag
9661 tctgccctcc gatacccgcc ttgtcctcct caatgctatc tacctgagtg gtaagggtgc
9721 ccttagccag ttagtcttcc cattctgggt ccttcttccc ctcctggctt caaagcccac
9781 ttaaccccaa gttctacaat cggatctcaa tgtccctgca ctactctttg ctaacaaggc
9841 ttttagctcc tcttcatcct tttcctacct gcattagagc aaccctccca cctcttccct
9901 ctagccaagt ggaagacaac atttgatccc aagaaaacca gaatggaacc ctttcacttc
9961 aaaaactcag ttataaaagt gcccatgatg aatagcaaga agtaccctgt ggcccatttc
10021 attgaccaaa ctttgaaagc caaggtaagt tcttaacctt tccttctcct gtttgaaacc
10081 tacttgagtc tcctgacttt ttttctgctg tagtcccatc attttggggt acatgcttac
10141 aaattcatca cttctactcc ttccatctgt atttccaccc tatcttttct ccttctcctt
10201 tctctagcct tggccaaggc agacattgta tattttaggc tggaaacagg attctcaagt
10261 ttcttcatgc atctctacta tattgaatgg caaaatgtga gtcgtgttcc tattctacac
10321 atctgtttct ttttccagtc aactcatcag aagactctgg tggcttagca agtcctgtgt
10381 gtatgtgggt acctgtgtac agcatacata tacatgtgta gacgtgtata agtatatcct
10441 tgtatatgca tatatgtggt aagtgcatgt gtgcacatga gttaaatggc ttaagtgcat
10501 tagcagaaat tgaacaattt agtttgatga gtagggaggg agagaagaca gaatatggag
10561 cccagaggat cccaactggc aagctatctc atccccagtt accagatatt tccacctttt
10621 taggatggca aaacacagac ctatgagaca gaaaacagta agagacaatg tctcaatacc
10681 tggctgagaa acaaaggctc tgttcttgga acatgctagg cttggttcca cattgggagc
10741 tttccttagc ttttgtttct gcctgtatcc ctcttcactc agatcctcac atagcttgtt
10801 ccttcttgtc atttgggtgt cagctcagag gtcaccttgg tggagaagtc ttctccccat
10861 taaagcagcc tcctcctcac cctgtaatat cactcctgtt ttattatatt cattacactc
10921 atcaccatct gaaattatgt catttatttg cttatttgcc taggacattg tctgtctccc
10981 taagatactg tctctctact tgaatacagg aacctgtctt gtttccttct gtatctgtag
11041 tgcctagaac aatgcctcct atcataggtg ctcattcagt gtttgctgaa taaatgaatg
11101 aatgaaatag agggtgccaa agagagctac tcagtaaaag tggctggaag acttcataga
11161 ggagggtttt tttcgagaca gggtctcact ctgtcactca agctgcagtg cattgacatg
11221 atctcagctc actgcaatct ctgcctcccg agttcaagca gttctcctgc ctcagcctcc
11281 caagtagctg ggactacagg agcccgccac cacacctggc taatttttgt atttttagta
11341 gagacggggt ttcaccatgt tagccaagct ggtctcgaac tcctgacctc aagtgatcca
11401 caccctcagc ctcccaaagg gctgggatta caggcatgag ccacagcgcc cagctgagga
11461 ggttattttt gaccattctt tgctcagtta tttatccact catggactta tccacccatc
11521 tatccatccc tatctaatgt atttgaccat tcatgactca tttagcagaa ccaggacagc
11581 ctgtataagg cacagaagag tgaatatatg tgacaggtcc agagcattgt tcaaattcaa
11641 gatacgttgg gggaggtata aatatgagat ttttttcaaa tcaattggaa tggctattta
11701 atcaaagcca tagatgttag gtggaaagta ggaattaaga acttaacaag ttaggtttaa
11761 atgtaactat tcgaattata agaacaagta tttcctctct aaaaatgttt ttaaagtttc
11821 acacaaaact ctaaaccaaa aatcattgta aaaatccctt ggagtagact gttgaaacca
11881 ttgaggtgag gtgataggtt aaggtgagca ttctggacat ataatatcaa taataaatat
11941 tcaaatacaa agcaggtata atatgaagag taatttctat ctccccaagc caatatgagt
12001 tttgtttgtt tgtttgtttt tcttttgaga taaagtctca ttctgttgcc caggccggag
12061 tgcagtggca caatcccagc tctctgtaac ctctgcctcc caggttcaag cgattctcct
12121 gccttagcct ccctagtagc tgggattata ggtgcctgcc accactccca gctaattttt
12181 gtatttttag tagagatggg gtttcaccat gttggccagg ctggtcatga actcctgacc
12241 tcaagtgctc gtccgtcttc ggcctcctaa agtgctggca ttacaggcgt gagccactgc
12301 acccagcctg agtttttttt ttttttttaa gccaaaggag gaggagtagt tttgtgcaca
12361 aaagccacta tttagagttc cttaggtttt aaacagataa ttaatttaat gtactaacaa
12421 atgcaaaatt aaaattttac ttatgccttt taattttaag ctgaacttgc tacattaaga
12481 gtagggtgat ttggctgggc gcagtggctc atgcctataa tcccagcact ttaggaggct
12541 gaggcaggtg gatcacttga agctaagagt ttgagaccag cctggccaac atggtggaat
12601 tctgtctcta ctaaaaatac aaaaattagc caggcatggt ggcacatgtc tgtaatccca
12661 gctactcagg atgctaaggc acagaatcac ttgaacctgg gaggcagagg ttacagtgag
12721 ccaaaatcgc gccactgcac tccaacctgg gcaacacagc aagactctgt ctcaaaacac
12781 aaaaaaagaa taggctgggt acagtggctc acgcctgtaa tcccagcact ttgggaggcc
12841 gaggcaggtg aatcacctga ggtcaggagt tcgagaccag cttggccaac attgtgaaac
12901 cccatctcca ttaaaaatac aaaaaataag ccgggtgtga tggtgcacgc ctgtaatccc
12961 agatacttgt gaggctggga cagaagaatc gcttgaaccc gggaggcgaa ggttgcagtg
13021 agccgagatc atgccactgc attccagcct gagcgacaga gtgagacctt gtctcagaaa
13081 aaaaaaaata gggtgatttt tatataaaaa cactctcatt tgttcttgaa ttaattgcca
13141 tattgaacag attaaactcc tttaaaccat tttttctatc tacaaacata attagtattc
13201 ccataagcat tttaagctcc ctttaaaaat ttaatatgct cgattttctt ttttctttta
13261 tttatttatg tagttttccc agacagggtc ttactctatc acccagtctg gagtacagtg
13321 acacaatcct cacttactgt aacctcaagc tccttgggat gaagcagtcc tcccacccta
13381 gcctcttaag tagctgagat tccaggcatg agccacctca cccagctgat tttcttttta
13441 aacacatcta atacctgaca ggtcgtaatt acgactgtgc ttggccatat catcctaaca
13501 cctaaagctc acttgtaaac tgaaaattaa atttgaaggg tgaattaact tctagccaac
13561 attccaatat cattctcaca tttaatgaaa ttatcctaca actttgctta aaagcataaa
13621 actagcatgt cagagtctct taaaaattac aatcactatt ttaaataaca aacatacagg
13681 ttaccctgaa cttaacacct ggttttaaca tgatgaagtt ggtttctttt gtcattctta
13741 tactaaattc taaatcttcc tggcacttaa ggatatttac ccaaggaagg gggtgagatt
13801 taccggctca ggtacaccga ggttactggc ttgaaaattc aagaccacag catggtaaat
13861 ttttcttcag agattcaagg ttcatacata ggacttgaag ggcacatgct actcaaatga
13921 gtatatccaa cttgagtgct acatcaacag ggaccccatg tccactcttt tcagtcgaaa
13981 ttggcttact atctacttct tctgggctat tcaggttccg acaattgatt gctttcagtt
14041 aatttcttta ttgcccagtt gaattctgca ttcttctaga ttctttttgt tccttcagcc
14101 tcaatcataa taccatttaa tgacagtctc atatcctatt agactagggt ttctcagcct
14161 tggcactatt gacatattgg gtcagataat tctttgtcct gtgcattgta gaatttagca
14221 tcttccttag cttctactca ctagaagcca gtagcactgt gtgcacatcc tccttgcccc
14281 ctgccagcta tgacaaccaa aatgtctcca gacattacca aatgtccact gagaggcaaa
14341 ttcactccga gttgacaacc cctgtattaa acccaggggc cctgcacttc ttacatactt
14401 ttgtctggtc accagttgaa agtccttctt cttttttttt tctctttttg agatggagtc
14461 tcgctctgtc accaggctgg agtgcagtgg catgatctcg gctcactgca gcctccacct
14521 cccgggttca agcaattctc ctgcctcagc ctcctgagta gctgggatta caggcacgtg
14581 ccaccaccca gctaattttt gtatttttag tagaggtggg gtttcatcat ggtggccagg
14641 atggtctcaa tctcttgacc tcgtgatccg cccacctcgg cctcccaaag tgctgggatt
14701 acaggtgtga gccaccgtgc atgaccaaaa gtccttctaa tagcaaagtg gaaaggtagg
14761 ctgtgaacaa tcttgaatgc catactaaga tttgtactta ttctcatagg cagtgaagag
14821 ccatcaatag tttttacaga ggctgacctg ataactctgg cggttcaatg tgcatgctat
14881 atactatatg cacaacacat taggaaggaa gggaacagcg ctcagagaaa tcaaatcact
14941 tgcccatatt acatagctcg tcagtggtgg agtcagggta taatcagaaa ctcatgctcc
15001 ttcctctacc tctccccagc acagagttgg atcagcactg ttcacccagc tggtatcccc
15061 atttcatggt aaagcctgga agcttaggtc tgactgatgc ttgttgaaat acagactgtg
15121 ggagcagact gcaggacagc attgtgacag agggtggggc caggagagag atgcggtagg
15181 aagactgtta agatgcatct cttattttct aggtggggca gctgcagctc tcccacaatc
15241 tgagtttggt gatcctggta ccccagaacc tgaaacatcg tcttgaagac atggaacagg
15301 ctctcagccc ttctgttttc aaggccatca tggagaaact ggagatgtcc aagttccagc
15361 ccactctcct aacactaccc cgcatcaaag tgacgaccag ccaggatatg ctctcaatca
15421 tggagaaatt gggtgagctc tggcagctta gggttactcc caggccatca gaggagaaag
15481 ggggatccct aagatgtagt tagcattctc tagagtattt tttacatcca taatctcagt
15541 ttgtcctgca accctgcaag ttagaggggt aggtgctatt atcccattgg atcattgtgg
15601 aaatggaggc tcagaagctt tatgtgactt acccagagat tccatgattt acccttgagc
15661 tagtcagagg caaaccagaa caccgaccca ggtctccagc tctcctgagt tttttctatg
15721 gttccttgtg acataggcag tggaacagtg ggacaggtaa ccgaggtgaa ttatggatgc
15781 tccttcccca gacacatttc aaaacagtca gccaccccgt ggaatatgca agaagctatc
15841 tggaagtgca gatctggagg cttctgagtt tacgagaggc aacagagact ccattttctt
15901 tttttttttt ttttttgaga cggagtcttg ctctgtcacc caggacaggc tggagtgcag
15961 tggtgcgatc tctgctcact gcaagatccg cctcccagat tcacgccatg ccattctctc
16021 gcctcagcct cccgagtagc tgggactaca ggtgcccgcc accacgcctg gctaattttg
16081 tttttgtatt tttagtagag acggggtttc actgtgttaa ccaggatggt cacaatctcc
16141 ggaccttgtg atccacctgc ctcggcctcc caaagtgctg ggattacagg catgagtcac
16201 cgcgcccagc ccagagactc cattttctaa cctttgtttt tttgtttgtt tgtttttgag
16261 acggagcctc actctgtcac ccaggctgga gcgcagtggc atgatcttgg gtcactgcaa
16321 cctccgcctc ctgggttcaa gtgattctcc tacctcagcc tcccaagtag ctgggattac
16381 aggcacctac caccacgccc agctaatttt tttgtatttt tagtagagat ggggtttcac
16441 catgttggtg aagctggtct tgaactcctg ggctcaagtg atccacccac ctcggcttcc
16501 caaagtgctg ggattacagg tgtgagccac tgtgcccagc ctcattttct aacctttgat
16561 ctcatgtcca gccctgtcac ttcatttctt gttagagaat ttgaccgcct aacacatgat
16621 tccatttcct tgtatatgtc atctgtatag gaagaaaacc tcttttttat tttcattcaa
16681 cacttctggc caccaaacag gtgtgggagt gttttctaag caattctcca gttatctggg
16741 gacaccaact gggtgtccta caattgaatc caattctaac actctacctg gaaataacat
16801 cagatcccgt gcagtttaag tgctccgccc cagcaaattt ccccccgttt ccaatgtcag
16861 ttacaagact gggttgtcac ctgtgcatca gaccaaccag ctataatttg gagattccca
16921 caactccctg ctagggtttc atcatttgct agaatagctg acaaaactca ggagacactt
16981 acatttactg gtttattatg taaaggatta agtaaaggat acagatgaac agccagttga
17041 agagatacat agggcaaaat ctggaagggt cctgggccca gcagcatcta tcctgtggag
17101 ttctgtttgc taccttcctg acacatgtat gtgttcacca accagaaact ctcagaaccc
17161 tgtactttag gagaagtcat catgtaggca tgattgatta ttacccaatc tccagctcct
17221 ctcttctccc cagaggatgg agagaggggc tggaaagttc caagcttcta atcacacttg
17281 gtctttctgg tgaccagccc caatccagga gccagcagga gtagcctcat tagcacaaaa
17341 ggcattccta tgacccagga aattccaagg gatctagtag ctctgtgtca ggaactggga
17401 tcggagacca aatattagat ggtctaatat ttggagctaa agatgctcct atagcatatt
17461 ttcccattat ttcacagcat catggcattg catataacct cattttttca tatatgacct
17521 atctctgatc tattacctca cttccaaggt cctgggagat aaggaggcaa tgacatcatt
17581 tttcagggtt gttttaggga tgaggggcaa ggcctctcac cttgagagag agtggcagtg
17641 ttgggcccac taatagagga tcccacgaac tgccagaggg tacagtatgt aatctggcaa
17701 acaagggaag aggaagagag cactgggact caggatgaac ccagagaatt caggacaaag
17761 gtctccatca gctgagggta tcatgctggc ttctgactct gtttttctct ggttttgccc
17821 tagaattctt cgatttttct tatgacctta acctgtgtgg gctgacagag gacccagatc
17881 ttcaggtttc tgcgatgcag caccagacag tgctggaact gacagagact ggggtggagg
17941 cggctgcagc ctccgccatc tctgtggccc gcaccctgct ggtctttgaa gtgcagcagc
18001 ccttcctctt cgtgctctgg gaccagcagc acaagttccc tgtcttcatg gggcgagtat
18061 atgaccccag ggcctgagac ctgcaggatc aggttagggc gagcgctacc tctccagcct
18121 cagctctcag ttgcagccct gctgctgcct gcctggactt gcccctgcca cctcctgcct
18181 caggtgtccg ctatccacca aaagggctcc ctgagggtct gggcaaggga cctgcttcta
18241 ttagcccttc tccatggccc tgccatgctc tccaaaccac tttttgcagc tttctctagt
18301 tcaagttcac cagactctat aaataaaacc tgacagacca tgactttctc tgctttgcct
18361 ttgttttttt attttttatt ttttattttt tttaggcagg gtctcaatct gtcacccagg
18421 ctagagtaca gtggtgagat catggttcac tgcagcctta acctcctgag ctcaaacaat
18481 cctcccatct cagcctccta tgtaggtggg accacatggg cttgccacca tgcccagcta
18541 atttttaaat tttttgtaaa gacagggtct tactatgttg cctaggctgg tctccaactc
18601 ctgggctcaa gcaatcatcc taacacagcc tcccgaagtg ctgggattgt aggcacacca
18661 tacctctcct ttgcctttga atatcag
//