LOCUS X54133 4584 bp mRNA linear HUM 18-APR-2005
DEFINITION Human HPTP delta mRNA for protein tyrosine phosphatase delta.
ACCESSION X54133
VERSION X54133.1
KEYWORDS HPTP gene; protein tyrosine phosphatase; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4584)
AUTHORS Saito H.
JOURNAL Submitted (24-JUL-1990) to the INSDC. Saito H., Dana Farber Cancer
Institute , Harvard Medical School, 44 Binney Street, Boston MA
02115, U S A.
REFERENCE 2 (bases 1 to 4584)
AUTHORS Krueger N.X., Streuli M., Saito H.
TITLE Structural diversity and evolution of human receptor-like protein
tyrosine phosphatases
JOURNAL EMBO J. 9(10), 3241-3252(1990).
PUBMED 2170109
REFERENCE 3
AUTHORS Schaapveld R.Q.L., Van den Maagdenberg A.M.J.M., Schepens J.T.G.,
Weghuis D.O., Van Kessel A.G., Wieringa B., Hendriks W.J.A.J.
TITLE The mouse gene Ptprf encoding the leukocyte common antigen-related
molecule LAR: cloning, characterization, and chromosomal
localization
JOURNAL Genomics 27(1), 124-130(1995).
PUBMED 7665159
COMMENT See also X54130-X54135.
FEATURES Location/Qualifiers
source 1..4584
/db_xref="H-InvDB:HIT000321868"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="human placental cDNA"
/clone="HPTP delta 40, 52, 139 & 206"
/tissue_type="placenta"
/db_xref="taxon:9606"
CDS <1..4572
/codon_start=1
/gene="HPTP delta"
/product="protein-tyrosine phosphatase"
/EC_number="3.1.3.48"
/db_xref="GOA:P23468"
/db_xref="H-InvDB:HIT000321868.14"
/db_xref="HGNC:HGNC:9668"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013098"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR016130"
/db_xref="InterPro:IPR029021"
/db_xref="InterPro:IPR036116"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1X5Z"
/db_xref="PDB:2DLH"
/db_xref="PDB:2YD6"
/db_xref="PDB:2YD7"
/db_xref="PDB:4RCA"
/db_xref="PDB:5WY8"
/db_xref="PDB:5XNP"
/db_xref="UniProtKB/Swiss-Prot:P23468"
/protein_id="CAA38068.1"
/translation="EFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT
ILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVK
VLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYEL
VYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS
KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI
PSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAV
NSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTT
EHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTA
LIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA
RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT
LLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT
LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKL
IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLP
EVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVE
LKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSP
YSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS
IPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEY
ESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGY
RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH
GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFL
RRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRN
YMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRL
ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR
QQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQ
YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIG
QVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQR
PAMVQTEDQYQFSYRAALEYLGSFDHYAT"
mRNA 1..4584
/gene="HPTP delta"
misc_feature 2629..2703
/note="transmembrane region"
BASE COUNT 1383 a 1064 c 1058 g 1079 t
ORIGIN
1 gaattcaggg ttgttgctgt caataacatt gggcgggggc ctcccagcga acctgtgcta
61 acacaaacct cagagcaagc accatccagt gccccgaggg atgtccaggc acgaatgttg
121 agttcgacca ccattttggt acagtggaag gaacctgaag agccaaatgg acagatccaa
181 ggatatagag tttattatac aatggatccc actcaacatg tcaacaactg gatgaaacac
241 aatgtagctg acagccaaat cactactatt ggcaacttag tgccccagaa aacatattct
301 gtcaaagtcc tggcttttac ctcaattgga gatggtcccc tttcaagtga catacaagtc
361 atcactcaga caggagtacc agggcagcca ctaaacttca aagcagaacc tgagtctgaa
421 acaagtattt tgctctcttg gacacctcca cgttcagata ccattgccaa ctatgaactg
481 gtctacaaag atggggagca tggagaggag caacgaatta ccattgagcc agggacatca
541 tataggctgc aaggactgaa accaaacagc ttatactatt tccgtctggc tgcacgctcc
601 cctcaaggcc tgggtgcttc tactgcagaa atatcagcta gaaccatgca gtcaaagccg
661 tcagctcctc ctcaagacat tagttgcacc agcccaagtt ccactagtat tttggtaagt
721 tggcaacctc caccagtgga aaaacagaat ggcattatca ctgaatactc catcaagtac
781 actgcagtgg atggggaaga tgacaagcct cacgagattt tgggaattcc ttcggacact
841 accaaatacc ttttggaaca gctggaaaaa tggactgaat accggatcac tgtgacagcc
901 catacagatg tcggccctgg ccctgagagc ttgtccgtgt tgattcgaac caatgaagat
961 gttcctagtg gtcctcctcg caaagtcgag gtagaggctg tcaactcaac atctgttaaa
1021 gtctcatggc gctcacccgt gcccaataaa cagcatggcc agataagagg atatcaggtg
1081 cattatgtga ggatggaaaa tggtgagccc aagggccagc ccatgctgaa agatgtcatg
1141 ctggctgatg cacagtggga atttgatgat actactgaac atgacatgat catttctggg
1201 ctccagcctg aaacttccta ctccctcacc gtcacagcct acacaaccaa aggagatggt
1261 gctcgcagca agcccaaact ggtgtccacc actggggcag ttccagggaa acctcggctt
1321 gtgattaacc acactcagat gaatactgct cttattcagt ggcaccctcc ggtggacaca
1381 tttggacctc ttcagggcta ccgtctaaaa tttggccgca aggatatgga gccacttact
1441 actcttgagt tctctgaaaa agaagatcac tttacagcta cagacatcca caagggagca
1501 tcatacgtct tcaggctctc agccagaaac aaagtgggct ttggggagga gatggtgaag
1561 gagatttcca ttccagaaga agtaccaact ggattccctc aaaaccttca ctcagaaggc
1621 accacttcaa cctccgtcca gttatcttgg caaccacctg tcctggcaga gagaaatggc
1681 attatcacca agtataccct tctttatagg gatatcaaca tcccccttct cccgatggag
1741 cagcttattg ttccagctga caccactatg acactcactg gcttaaaacc agataccaca
1801 tacgatgtaa aagtacgtgc tcatacgagc aaagggcccg ggccatatag tcccagtgtc
1861 cagttcagga cactgcctgt ggatcaagtg tttgcaaaaa attttcatgt caaagcagta
1921 atgaagactt ccgtgttgct gtcttgggag attccagaga attataactc cgccatgcct
1981 ttcaaaattc tttatgatga tgggaaaatg gtagaagaag tggatggccg agccacacag
2041 aagttaattg tcaacctgaa gcctgagaaa tcatattcat ttgtgctgac aaatcgtgga
2101 aacagtgctg gtgggctgca gcacagggtc acggcaaaga ctgcaccaga tgtattacgt
2161 accaagcctg ccttcattgg gaagaccaac ttggatggca tgattactgt gcaactgcct
2221 gaagtacctg caaatgagaa tataaaaggt tactacataa taattgtgcc tttgaagaaa
2281 tctcgcggga aatttatcaa gccatgggag agtccagatg aaatggaatt agatgagctg
2341 cttaaggaga tatctaggaa gcgcagaagc atccgttatg ggagagaagt tgaattaaag
2401 ccatatattg ccgctcactt tgatgtcctt cccactgagt tcaccctggg ggatgacaag
2461 cattatggtg gatttacaaa caagcaactc caaagtggtc aagaatatgt cttctttgtg
2521 ttagcagtaa tggaacatgc agagtctaag atgtatgcaa ccagccctta ctccgacccc
2581 gtggtgtcaa tggatctgga tccgcagcca atcacggatg aagaagaagg cttgatctgg
2641 gttgtaggtc ctgtccttgc agtggtcttt atcatctgca ttgtcattgc tattcttctt
2701 tataaaagga agagggcaga gtccgactct agaaaaagca gcataccgaa caataaggag
2761 atcccttcac accacccaac agaccctgta gaactgaggc gccttaactt tcaaacaccg
2821 ggtatggcta gccatcctcc aatacccatc ttggaacttg cagaccacat tgaaagattg
2881 aaagcaaatg acaacttgaa gttttcccag gaatatgagt caattgaccc tggccagcag
2941 ttcacttggg aacattcaaa cttggaagta aacaaaccaa agaatagata cgcgaatgta
3001 atcgcatatg atcattcccg ggttctccta tcagctatag aagggatccc aggaagtgac
3061 tatgtgaatg ccaactacat agatgggtat aggaagcaaa atgcctatat tgcaacacag
3121 ggatctctcc ccgaaacatt tggggacttt tggagaatga tatgggaaca acggagtgcc
3181 acagttgtca tgatgacaaa actagaagaa agatcaaggg tgaagtgtga ccagtattgg
3241 cctagcagag gcacagaaac ccacggactc gttcaagtaa cgctgcttga tactgtggag
3301 ctggccacat attgtgttcg aacatttgca ctttacaaga atggttcaag tgagaagaga
3361 gaagtgagac aattccagtt caccgcctgg cctgatcatg gtgttccaga acaccctaca
3421 ccttttctag ctttcttacg tagagtcaaa acctgtaacc ctcccgatgc tggtccgatg
3481 gttgtgcact gcagtgcggg agttggccgg actggttgct tcatcgtcat agatgccatg
3541 ttagaaagaa taaagcatga aaaaactgta gatatttatg gccatgtaac tttaatgaga
3601 gcccagagga actatatggt tcaaacagaa gaccaataca tctttatcca tgatgcactg
3661 ttagaagcag tgacttgtgg aaataccgaa gtgccagcta gaaacttgta tgcctacatt
3721 cagaagctga cacaaataga aacgggagag aatgtcacag gaatggagct cgaatttaag
3781 cgtctagcca gctcaaaagc tcacacctca aggtttatca gtgccaatct tccatgtaat
3841 aaattcaaaa atcgccttgt taatattatg ccatatgaat ccacaagggt atgcctgcag
3901 cctatccgtg gagtagaagg atctgattac atcaatgcca gttttattga tggatacaga
3961 caacagaaag cctacatcgc tacccagggg cccttggcag agaccactga agacttctgg
4021 cggatgctct gggaacacaa ttccaccata gttgtgatgc tcaccaagct gcgtgaaatg
4081 ggcagagaga aatgtcacca atactggcca gcagaacggt ctgcaagata ccagtacttt
4141 gttgtagatc ccatggctga gtacaacatg ccacagtata tcctaaggga attcaaggtc
4201 acagatgcca gggacggcca gtcccgaaca gtaaggcagt tccagttcac tgactggcca
4261 gagcaaggag tgccaaagtc cggagaagga tttattgact tcatcggcca agtccataaa
4321 acaaaagaac agtttggcca agatggaccc atttcagtcc attgcagcgc gggcgttgga
4381 agaactggag tcttcataac gctaagcatt gttttggaaa gaatgagata tgaaggagtt
4441 gtagatatct tccagactgt caaaatgtta agaacacaac gaccagctat ggtacagaca
4501 gaggatcaat atcagttttc ctatcgtgcc gcactagagt acctgggcag ctttgaccac
4561 tatgcaacgt agaaacccct gacc
//