LOCUS X54131 6075 bp mRNA linear HUM 18-APR-2005
DEFINITION Human HPTP beta mRNA for protein tyrosine phosphatase beta.
ACCESSION X54131
VERSION X54131.1
KEYWORDS HPTP gene; protein tyrosine phosphatase; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6075)
AUTHORS Saito H.
JOURNAL Submitted (24-JUL-1990) to the INSDC. Saito H., Dana Farber Cancer
Institute , Harvard Medical School, 44 Binney Street, Boston MA
02115, U S A.
REFERENCE 2 (bases 1 to 6075)
AUTHORS Krueger N.X., Streuli M., Saito H.
TITLE Structural diversity and evolution of human receptor-like protein
tyrosine phosphatases
JOURNAL EMBO J. 9(10), 3241-3252(1990).
PUBMED 2170109
COMMENT See also X54130-X54135.
FEATURES Location/Qualifiers
source 1..6075
/db_xref="H-InvDB:HIT000321866"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="human placental cDNA"
/clone="HPTP beta 28, 65, 68, 74, 126 & 132"
/tissue_type="placenta"
/db_xref="taxon:9606"
mRNA 1..6075
/gene="HPTP beta"
sig_peptide 31..96
/note="product is human protein tyrosine phosphatse beta"
CDS 31..6024
/gene="HPTP beta"
/product="protein-tyrosine phosphatase"
/EC_number="3.1.3.48"
/db_xref="GOA:P23467"
/db_xref="H-InvDB:HIT000321866.14"
/db_xref="HGNC:HGNC:9665"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR016130"
/db_xref="InterPro:IPR029021"
/db_xref="InterPro:IPR036116"
/db_xref="PDB:2AHS"
/db_xref="PDB:2H02"
/db_xref="PDB:2H03"
/db_xref="PDB:2H04"
/db_xref="PDB:2HC1"
/db_xref="PDB:2HC2"
/db_xref="PDB:2I3R"
/db_xref="PDB:2I3U"
/db_xref="PDB:2I4E"
/db_xref="PDB:2I4G"
/db_xref="PDB:2I4H"
/db_xref="PDB:2I5X"
/db_xref="UniProtKB/Swiss-Prot:P23467"
/protein_id="CAA38066.1"
/translation="MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQ
WRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFKIISLDEER
TVVLQTDPLPPARFGVSKEKTTSTGLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQ
ESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSL
LISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLSPGYLYNLTVMTEAAG
LQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESR
VLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEANNNGRMR
SLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIV
ESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLL
IHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVANQG
MTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVT
TVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLVAPGDVDNYEVTLSHDG
KVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVS
NSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV
TVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFN
DMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIH
ISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQY
QIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILL
LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAV
TDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQ
GRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFY
ELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPS
PPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY
GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP
DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEV
VEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVRE
ADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEM
ESLGGKRDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPIT
TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVH
LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPE
NRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKD
DFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWT
IREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT
VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQ
CVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH"
mat_peptide 97..6021
/gene="HPTP beta"
/product="protein-tyrosine phosphatase"
/EC_number="3.1.3.48"
misc_feature 4894..4956
/note="transmembrane region"
BASE COUNT 1717 a 1441 c 1447 g 1470 t
ORIGIN
1 gtctcctctg gatcttaact actgagcgca atgctgagcc atggagccgg gttggccttg
61 tggatcacac tgagcctgct gcagactgga ctggcggagc cagagagatg taacttcacc
121 ctggcggagt ccaaggcctc cagccattct gtgtctatcc agtggagaat tttgggctca
181 ccctgtaact ttagcctcat ctatagcagt gacaccctgg gggccgcgtt gtgccctacc
241 tttcggatag acaacaccac atacggatgt aaccttcaag atttacaagc aggaaccatc
301 tataacttca agattatttc tctggatgaa gagagaactg tggtcttgca aacagatcct
361 ttacctcctg ctaggtttgg agtcagtaaa gagaagacga cttcaaccgg cttgcatgtt
421 tggtggactc cttcttccgg aaaagtcacc tcatatgagg tgcaattatt tgatgaaaat
481 aaccaaaaga tacagggggt tcaaattcaa gaaagtactt catggaatga atacactttt
541 ttcaatctca ctgctggtag taaatacaat attgccatca cagctgtttc tggaggaaaa
601 cgttcttttt cagtttatac caatggatca acagtgccat ctccagtgaa agatattggt
661 atttccacaa aagccaattc tctcctgatt tcctggtccc atggttctgg gaatgtggaa
721 cgataccggc tgatgctaat ggataaaggg atcctagttc atggcggtgt tgtggacaaa
781 catgctactt cctatgcttt tcacgggctg tcccctggct acctctacaa cctcactgtt
841 atgactgagg ctgcagggct gcaaaactac aggtggaaac tagtcaggac agcccccatg
901 gaagtctcaa atctgaaggt gacaaatgat ggcagtttga cctctctaaa agtcaaatgg
961 caaagacctc ctggaaatgt ggattcttac aatatcaccc tgtctcacaa agggaccatc
1021 aaggaatcca gagtattagc accttggatt actgaaactc actttaaaga gttagtcccc
1081 ggtcgacttt atcaagttac tgtcagctgt gtctctggtg aactgtctgc tcagaagatg
1141 gcagtgggca gaacatttcc agacaaagtt gcaaacctgg aggcaaacaa taatggcagg
1201 atgaggtctc ttgtagtgag ctggtcgccc cctgctggag actgggagca gtatcggatc
1261 ctactcttca atgattctgt ggtgctgctc aacatcactg tgggaaagga agaaacacag
1321 tatgtcatgg atgacacggg gctcgtaccg ggaagacagt atgaggtgga agtcattgtt
1381 gagagtggaa atttgaagaa ttctgagcgt tgccaaggca ggacagtccc cctggctgtc
1441 ctccagcttc gtgtcaaaca tgccaatgaa acctcactga gtatcatgtg gcagacccct
1501 gtagcagaat gggagaaata catcatttcc ctagctgaca gagacctctt actgatccac
1561 aagtcactct ccaaagatgc caaagaattc acttttactg acctggtgcc tggacgaaaa
1621 tacatggcta cagtcaccag tattagtgga gacttaaaaa attcctcttc agtaaaagga
1681 agaacagtgc ctgcccaagt gactgacttg catgtggcca accaaggaat gaccagtagt
1741 ctgtttacta actggaccca ggcacaagga gacgtagaat tttaccaagt cttactgatc
1801 catgaaaatg tggtcattaa aaatgaaagc atctccagtg agaccagcag atacagcttc
1861 cactctctca agtccggcag cctgtactcc gtggtggtaa caacagtgag tggagggatc
1921 tcttcccgac aagtggttgt ggagggaaga acagtccctt ccagtgtgag tggagtaacg
1981 gtgaacaatt ccggtcgtaa tgactacctc agcgtttcct ggctcgtggc gcccggagat
2041 gtggataact atgaggtaac attgtctcat gacggcaagg tggttcagtc ccttgtcatt
2101 gccaagtctg tcagagaatg ttccttcagc tccctcaccc caggccgcct ctacaccgtg
2161 accataacta caaggagtgg caagtatgaa aatcactcct tcagccaaga gcggacagtg
2221 cctgacaaag tccagggagt cagtgttagc aactcagcca ggagtgacta tttaagggta
2281 tcctgggtgc atgccactgg agactttgat cactatgaag tcaccattaa aaacaaaaac
2341 aacttcattc aaactaaaag cattcccaag tcagaaaacg aatgtgtatt tgttcagcta
2401 gtccctggac ggttgtacag tgtcactgtt actacaaaaa gtggacaata tgaagccaat
2461 gaacaaggga atgggagaac aattccagag cctgttaagg atctaacatt gcgcaacagg
2521 agcactgagg acttgcatgt gacttggtca ggagctaatg gggatgtcga ccaatatgag
2581 atccagctgc tcttcaatga catgaaagta tttcctcctt ttcaccttgt aaataccgca
2641 accgagtatc gatttacttc cctaacacca ggccgccaat acaaaattct tgtcttgacg
2701 attagcgggg atgtacagca gtcagccttc attgagggct tcacagttcc tagtgctgtc
2761 aaaaatattc acatttctcc caatggagca acagatagcc tgacggtgaa ctggactcct
2821 ggtgggggag acgttgattc ctacacggtg tcggcattca ggcacagtca aaaggttgac
2881 tctcagacta ttcccaagca cgtctttgag cacacgttcc acagactgga ggccggggag
2941 cagtaccaga tcatgattgc ctcagtcagc gggtccctga agaatcagat aaatgtggtt
3001 gggcggacag ttccagcatc tgtccaagga gtaattgcag acaatgcata cagcagttat
3061 tccttaatag taagttggca aaaagctgct ggtgtggcag aaagatatga tatcctgctt
3121 ctaactgaaa atggaatcct tctgcgcaac acatcagagc cagccaccac taagcaacac
3181 aaatttgaag atctaacacc aggcaagaaa tacaagatac agatcctaac tgtcagtgga
3241 ggcctcttta gcaaggaagc ccagactgaa ggccgaacag tcccagcagc tgtcaccgac
3301 ctgaggatca cagagaactc caccaggcac ctgtccttcc gctggaccgc ctcagagggg
3361 gagctcagct ggtacaacat ctttttgtac aacccagatg ggaatctcca ggagagagct
3421 caagttgacc cactagtcca gagcttctct ttccagaact tgctacaagg cagaatgtac
3481 aagatggtga ttgtaactca cagtggggag ctgtctaatg agtctttcat atttggtaga
3541 acagtcccag cctctgtgag tcatctcagg gggtccaatc ggaacacgac agacagcctt
3601 tggttcaact ggagtccagc ctctggggac tttgactttt atgagctgat tctctataat
3661 cccaatggca caaagaagga aaactggaaa gacaaggacc tgacggagtg gcggtttcaa
3721 ggccttgttc ctggaaggaa gtacgtgctg tgggtggtaa ctcacagtgg agatctcagc
3781 aataaagtca cagcggagag cagaacagct ccaagtcctc ccagtcttat gtcatttgct
3841 gacattgcaa acacatcctt ggccatcacg tggaaagggc ccccagactg gacagactac
3901 aacgactttg agctgcagtg gttgcccaga gatgcactta ctgtcttcaa cccctacaac
3961 aacagaaaat cagaaggacg cattgtgtat ggtcttcgtc cagggagatc ctatcaattc
4021 aacgtcaaga ctgtcagtgg tgattcctgg aaaacttaca gcaaaccaat ttttggatct
4081 gtgaggacaa agcctgacaa gatacaaaac ctgcattgcc ggcctcagaa ctccacggcc
4141 attgcctgtt cttggatccc tcctgattct gactttgatg gttatagtat tgaatgccgg
4201 aaaatggaca cccaagaagt tgagttttcc agaaagctgg agaaagaaaa atctctgctc
4261 aacatcatga tgctagtgcc ccataagagg tacctggtgt ccatcaaagt gcagtcggcc
4321 ggcatgacca gcgaggtggt tgaagacagc actatcacaa tgatagaccg cccccctcct
4381 ccacccccac acattcgtgt gaatgaaaag gatgtgctaa ttagcaagtc ttccatcaac
4441 tttactgtca actgcagctg gttcagcgac accaatggag ctgtgaaata cttcacagtg
4501 gtggtgagag aggctgatgg cagtgatgag ctgaagccag aacagcagca ccctctccct
4561 tcctacctgg agtacaggca caatgcctcc attcgggtgt atcagactaa ttattttgcc
4621 agcaaatgtg ccgaaaatcc taacagcaac tccaagagtt ttaacattaa gcttggagca
4681 gagatggaga gcttaggtgg aaaacgcgat cccactcagc aaaaattctg tgatggacca
4741 ctgaagccac acactgccta cagaatcagc attcgagctt ttacacagct ctttgatgag
4801 gacctgaagg aattcacaaa gccactctat tcagacacat ttttttcttt acccatcact
4861 actgaatcag agcccttgtt tggagctatt gaaggtgtga gtgctggtct gtttttaatt
4921 ggcatgctag tggctgttgt tgccttattg atctgcagac agaaagtgag ccatggtcga
4981 gaaagaccct ctgcccgtct gagcattcgt agggatcgac cattatctgt ccacttaaac
5041 ctgggccaga aaggtaaccg gaaaacttct tgtccaataa aaataaatca gtttgaaggg
5101 catttcatga agctacaggc tgactccaac taccttctat ccaaggaata cgaggagtta
5161 aaagacgtgg gccgaaacca gtcatgtgac attgcactct tgccggagaa tagagggaaa
5221 aatcgataca acaatatatt gccctatgat gccacgcgag tgaagctctc caatgtagat
5281 gatgatcctt gctctgacta catcaatgcc agctacatcc ctggcaacaa cttcagaaga
5341 gaatacattg tcactcaggg accgcttcct ggcaccaagg atgacttctg gaaaatggtg
5401 tgggaacaaa acgttcacaa catcgtcatg gtgacccagt gtgttgagaa gggccgagta
5461 aagtgtgacc attactggcc agcggaccag gattccctct actatgggga cctcatcctg
5521 cagatgctct cagagtccgt cctgcctgag tggaccatcc gggagtttaa gatatgcggt
5581 gaggaacagc ttgatgcaca cagactcatc cgccactttc actatacggt gtggccagac
5641 catggagtcc cagaaaccac ccagtctctg atccagtttg tgagaactgt cagggactac
5701 atcaacagaa gcccgggtgc tgggcccact gtggtgcact gcagtgctgg tgtgggtagg
5761 actggaacct ttattgcatt ggaccgaatc ctccagcagt tagactccaa agactctgtg
5821 gacatttatg gagcagtgca cgacctaaga cttcacaggg ttcacatggt ccagactgag
5881 tgtcagtatg tctacctaca tcagtgtgta agagatgtcc tcagagcaag aaagctacgg
5941 agtgaacaag aaaacccctt gtttccaatc tatgaaaatg tgaatccaga gtatcacaga
6001 gatccagtct attcaaggca ttgagaatgt acctgaagag ctcctggata aaaattattc
6061 actgtgtgat ttgtt
//