LOCUS X54130 2430 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human HPTP alpha mRNA for protein tyrosine phosphatase alpha.
ACCESSION X54130
VERSION X54130.1
KEYWORDS HPTP gene; protein tyrosine phosphatase; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2430)
AUTHORS Saito H.
JOURNAL Submitted (24-JUL-1990) to the INSDC. Saito H., Dana Farber Cancer
Institute , Harvard Medical School, 44 Binney Street, Boston MA
02115, U S A.
REFERENCE 2 (bases 1 to 2430)
AUTHORS Krueger N.X., Streuli M., Saito H.
TITLE Structural diversity and evolution of human receptor-like protein
tyrosine phosphatases
JOURNAL EMBO J. 9(10), 3241-3252(1990).
PUBMED 2170109
COMMENT See also X54130-X54135.
FEATURES Location/Qualifiers
source 1..2430
/db_xref="H-InvDB:HIT000321865"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="human placental cDNA"
/tissue_type="placenta"
/db_xref="taxon:9606"
mRNA 1..2430
/gene="HPTP alpha"
sig_peptide 31..87
/note="product is human protein tyrosine phosphatase
alpha"
CDS 31..2412
/gene="HPTP alpha"
/product="protein-tyrosine phosphatase"
/EC_number="3.1.3.48"
/db_xref="GOA:P18433"
/db_xref="H-InvDB:HIT000321865.13"
/db_xref="HGNC:HGNC:9664"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR016130"
/db_xref="InterPro:IPR016336"
/db_xref="InterPro:IPR027262"
/db_xref="InterPro:IPR029021"
/db_xref="UniProtKB/Swiss-Prot:P18433"
/protein_id="CAA38065.1"
/translation="MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVK
EEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITIS
PNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFII
IVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLE
EEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT
PVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLK
ERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLIT
QFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML
DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH
LQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRV
IIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT
ELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQ
FHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVL
ERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK"
mat_peptide 88..2409
/gene="HPTP alpha"
/product="protein-tyrosine phosphatase"
/EC_number="3.1.3.48"
misc_feature 457..528
/note="transmembrane region"
BASE COUNT 697 a 599 c 602 g 532 t
ORIGIN
1 taattaactt tttaaaagaa gctaataagc atggattcct ggttcattct tgttctgctc
61 ggcagtggtc tgatatgtgt cagtgccaac aatgctacca cagttgcacc ttctgtagga
121 attacaagat taattaactc atcaacggca gaaccagtta aagaagaggc caaaacttca
181 aatccaactt cttcactaac ttctctttct gtggcaccaa cattcagccc aaatataact
241 ctgggaccca cctatttaac cactgtcaat tcttcagact ctgacaatgg gaccacaaga
301 acagcaagca ccaattctat aggcattaca atttcaccaa atggaacgtg gcttccagat
361 aaccagttca cggatgccag aacagaaccc tgggagggga attccagcac cgcagcaacc
421 actccagaaa ctttccctcc ttcagatgag acaccaatta ttgcggtgat ggtggccctg
481 tcctctctgc tagtgatcgt gtttattatc atagttttgt acatgttaag gtttaagaaa
541 tacaagcaag ctgggagcca ttccaattct ttccgcttat ccaacggccg cactgaggat
601 gtggagcccc agagtgtgcc acttctggcc agatccccaa gcaccaacag gaaataccca
661 cccctgcccg tggacaagct ggaagaggaa attaaccgga gaatggcaga cgacaataag
721 ctcttcaggg aggaattcaa cgctctccct gcatgtccta tccaggccac ctgtgaggct
781 gcttccaagg aggaaaacaa ggaaaaaaat cgatatgtaa acatcttgcc ttatgaccac
841 tctagagtcc acctgacacc ggttgaaggg gttccagatt ctgattacat caatgcttca
901 ttcatcaacg gttaccaaga aaagaacaaa ttcattgctg cacaaggacc aaaagaagaa
961 acggtgaatg atttctggcg gatgatctgg gaacaaaaca cagccaccat cgtcatggtt
1021 accaacctga aggagagaaa ggagtgcaag tgcgcccagt actggccaga ccaaggctgc
1081 tggacctatg ggaatattcg ggtgtctgta gaggatgtga ctgtcctggt ggactacaca
1141 gtacggaagt tctgcatcca gcaggtgggc gacatgacca acagaaagcc acagcgcctc
1201 atcactcagt tccactttac cagctggcca gactttgggg tgccttttac cccgatcggc
1261 atgctcaagt tcctcaagaa ggtgaaggcc tgtaaccctc agtatgcagg ggccatcgtg
1321 gtccactgca gtgcaggtgt agggcgtaca ggtacctttg tcgtcattga tgccatgctg
1381 gacatgatgc atacagaacg gaaggtggac gtgtatggct ttgtgagccg gatccgggca
1441 cagcgctgcc agatggtgca aaccgatatg cagtatgtct tcatatacca agcccttctg
1501 gagcattatc tctatggaga tacagaactg gaagtgacct ctctagaaac ccacctgcag
1561 aaaatttaca acaaaatccc agggaccagc aacaatggat tagaggagga gtttaagaag
1621 ttaacatcaa tcaaaatcca gaatgacaag atgcggactg gaaaccttcc agccaacatg
1681 aagaagaacc gtgttttaca gatcattcca tatgaattca acagagtgat cattccagtt
1741 aagcggggcg aagagaatac agactatgtg aacgcatcct ttattgatgg ctaccggcag
1801 aaggactcct atatcgccag ccagggccct cttctccaca caattgagga cttctggcga
1861 atgatctggg agtggaaatc ctgctctatc gtgatgctaa cagaactgga ggagagaggc
1921 caggagaagt gtgcccagta ctggccatct gatggactgg tgtcctatgg agatattaca
1981 gtggaactga agaaggagga ggaatgtgag agctacaccg tccgagacct cctggtcacc
2041 aacaccaggg agaataagag ccggcagatc cggcagttcc acttccatgg ctggcctgaa
2101 gtgggcatcc ccagtgacgg aaagggcatg atcagcatca tcgccgccgt gcagaagcag
2161 cagcagcagt cagggaacca ccccatcacc gtgcactgca gcgccggggc aggaaggacg
2221 gggaccttct gtgccctgag caccgtcctg gagcgtgtga aagcagaggg gattttggat
2281 gtcttccaga ctgtcaagag cctgcggcta cagaggccac acatggtcca gacactggaa
2341 cagtatgagt tctgctacaa ggtggtgcag gagtatattg atgcattctc agattatgcc
2401 aacttcaagt aagcggcaac aagggtccgt
//