LOCUS       X53961                  2619 bp    mRNA    linear   HUM 31-MAR-1995
DEFINITION  Human mRNA for lactoferrin.
ACCESSION   X53961
VERSION     X53961.1
KEYWORDS    lactoferrin; lactotransferrin; secreted protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Rey M.W.
  JOURNAL   Submitted (16-JUL-1990) to the INSDC. Rey M.W., Genencor
            International, 180 Kimball Way, South San Francisco, CA 94080, USA.
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Rey M.W., Woldshuk S.L., de Boer H.A., Pieper F.R.
  TITLE     Complete nucleotide sequence of human mammary gland lactoferrin
  JOURNAL   Nucleic Acids Res. 18(17), 5288-5288(1990).
   PUBMED   2402455
COMMENT     sequence is both genomic and cDNA
            see <M18642> for conflicting sequence
FEATURES             Location/Qualifiers
     source          1..2619
                     /db_xref="H-InvDB:HIT000321862"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="lambda gt11"
                     /clone="HLF-1"
                     /cell_type="epithelial"
                     /tissue_type="mammary gland"
                     /db_xref="taxon:9606"
     regulatory      227..232
                     /note="pot. TATA box"
                     /regulatory_class="promoter"
     CDS             295..2430
                     /product="precursor (AA -19 to 692)"
                     /db_xref="GOA:P02788"
                     /db_xref="H-InvDB:HIT000321862.14"
                     /db_xref="HGNC:HGNC:6720"
                     /db_xref="InterPro:IPR001156"
                     /db_xref="InterPro:IPR016357"
                     /db_xref="InterPro:IPR018195"
                     /db_xref="InterPro:IPR030684"
                     /db_xref="PDB:1B0L"
                     /db_xref="PDB:1BKA"
                     /db_xref="PDB:1CB6"
                     /db_xref="PDB:1DSN"
                     /db_xref="PDB:1EH3"
                     /db_xref="PDB:1FCK"
                     /db_xref="PDB:1H43"
                     /db_xref="PDB:1H44"
                     /db_xref="PDB:1H45"
                     /db_xref="PDB:1HSE"
                     /db_xref="PDB:1L5T"
                     /db_xref="PDB:1LCF"
                     /db_xref="PDB:1LCT"
                     /db_xref="PDB:1LFG"
                     /db_xref="PDB:1LFH"
                     /db_xref="PDB:1LFI"
                     /db_xref="PDB:1LGB"
                     /db_xref="PDB:1N76"
                     /db_xref="PDB:1SQY"
                     /db_xref="PDB:1U62"
                     /db_xref="PDB:1VFD"
                     /db_xref="PDB:1VFE"
                     /db_xref="PDB:1XV4"
                     /db_xref="PDB:1XV7"
                     /db_xref="PDB:1Z6V"
                     /db_xref="PDB:1Z6W"
                     /db_xref="PDB:2BJJ"
                     /db_xref="PDB:2DP4"
                     /db_xref="PDB:2GMC"
                     /db_xref="PDB:2GMD"
                     /db_xref="PDB:2HD4"
                     /db_xref="PDB:2PMS"
                     /db_xref="UniProtKB/Swiss-Prot:P02788"
                     /protein_id="CAA37914.1"
                     /translation="MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQR
                     NMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVY
                     GTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPTGTLRPFLNWTG
                     PPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKC
                     LRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVV
                     ARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRI
                     DSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCS
                     SASTTEDCIALVLKGEADAMSLDGGYVYTACKCGLVPVLAENYKSQQSSDPDPNCVDR
                     PVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEY
                     FSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVK
                     DVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMD
                     KVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKY
                     LGPQYVAGITNLKKCSTSPLLEACEFLRK"
     sig_peptide     295..351
                     /note="signal peptide (AA -19 to -1)"
     mat_peptide     352..2427
                     /note="lactoferrin (AA 1-692)"
BASE COUNT          626 a          661 c          767 g          565 t
ORIGIN      
        1 gactcctagg ggcttgcaga cctagtggga gagaaagaac atcgcagcag ccaggcagaa
       61 ccaggacagg tgaggtgcag gctggctttc ctctcgcagc gcggtgtgga gtcctgtcct
      121 gcctcagggc ttttcggagc ctggatcctc aaggaacaag tagacctggc cgcggggagt
      181 ggggagggaa ggggtgtcta ttgggcaaca gggcggcaaa gccctgaata aaggggcgca
      241 gggcaggcgc aagtgcagag ccttcgtttg ccaagtcgcc tccagaccgc agacatgaaa
      301 cttgtcttcc tcgtcctgct gttcctcggg gccctcggac tgtgtctggc tggccgtagg
      361 agaaggagtg ttcagtggtg cgccgtatcc caacccgagg ccacaaaatg cttccaatgg
      421 caaaggaata tgagaaaagt gcgtggccct cctgtcagct gcataaagag agactccccc
      481 atccagtgta tccaggccat tgcggaaaac agggccgatg ctgtgaccct tgatggtggt
      541 ttcatatacg aggcaggcct ggccccctac aaactgcgac ctgtagcggc ggaagtctac
      601 gggaccgaaa gacagccacg aactcactat tatgccgtgg ctgtggtgaa gaagggcggc
      661 agctttcagc tgaacgaact gcaaggtctg aagtcctgcc acacaggcct tcgcaggacc
      721 gctggatgga atgtccctac agggacactt cgtccattct tgaattggac gggtccacct
      781 gagcccattg aggcagctgt ggccaggttc ttctcagcca gctgtgttcc cggtgcagat
      841 aaaggacagt tccccaacct gtgtcgcctg tgtgcgggga caggggaaaa caaatgtgcc
      901 ttctcctccc aggaaccgta cttcagctac tctggtgcct tcaagtgtct gagagacggg
      961 gctggagacg tggcttttat cagagagagc acagtgtttg aggacctgtc agacgaggct
     1021 gaaagggacg agtatgagtt actctgccca gacaacactc ggaagccagt ggacaagttc
     1081 aaagactgcc atctggcccg ggtcccttct catgccgttg tggcacgaag tgtgaatggc
     1141 aaggaggatg ccatctggaa tcttctccgc caggcacagg aaaagtttgg aaaggacaag
     1201 tcaccgaaat tccagctctt tggctcccct agtgggcaga aagatctgct gttcaaggac
     1261 tctgccattg ggttttcgag ggtgcccccg aggatagatt ctgggctgta ccttggctcc
     1321 ggctacttca ctgccatcca gaacttgagg aaaagtgagg aggaagtggc tgcccggcgt
     1381 gcgcgggtcg tgtggtgtgc ggtgggcgag caggagctgc gcaagtgtaa ccagtggagt
     1441 ggcttgagcg aaggcagcgt gacctgctcc tcggcctcca ccacagagga ctgcatcgcc
     1501 ctggtgctga aaggagaagc tgatgccatg agtttggatg gaggatatgt gtacactgca
     1561 tgcaaatgtg gtttggtgcc tgtcctggca gagaactaca aatcccaaca aagcagtgac
     1621 cctgatccta actgtgtgga tagacctgtg gaaggatatc ttgctgtggc ggtggttagg
     1681 agatcagaca ctagccttac ctggaactct gtgaaaggca agaagtcctg ccacaccgcc
     1741 gtggacagga ctgcaggctg gaatatcccc atgggcctgc tcttcaacca gacgggctcc
     1801 tgcaaatttg atgaatattt cagtcaaagc tgtgcccctg ggtctgaccc gagatctaat
     1861 ctctgtgctc tgtgtattgg cgacgagcag ggtgagaata agtgcgtgcc caacagcaac
     1921 gagagatact acggctacac tggggctttc cggtgcctgg ctgagaatgc tggagacgtt
     1981 gcatttgtga aagatgtcac tgtcttgcag aacactgatg gaaataacaa tgaggcatgg
     2041 gctaaggatt tgaagctggc agactttgcg ctgctgtgcc tcgatggcaa acggaagcct
     2101 gtgactgagg ctagaagctg ccatcttgcc atggccccga atcatgccgt ggtgtctcgg
     2161 atggataagg tggaacgcct gaaacaggtg ctgctccacc aacaggctaa atttgggaga
     2221 aatggatctg actgcccgga caagttttgc ttattccagt ctgaaaccaa aaaccttctg
     2281 ttcaatgaca acactgagtg tctggccaga ctccatggca aaacaacata tgaaaaatat
     2341 ttgggaccac agtatgtcgc aggcattact aatctgaaaa agtgctcaac ctcccccctc
     2401 ctggaagcct gtgaattcct caggaagtaa aaccgaagaa gatggcccag ctccccaaga
     2461 aagcctcagc cattcactgc ccccagctct tctccccagg tgtgttgggg ccttggctcc
     2521 cctgctgaag gtggggattg cccatccatc tgcttacaat tccctgctgt cgtcttagca
     2581 agaagtaaaa tgagaaattt tgttgatatt caaaaaaaa
//