LOCUS X53682 2488 bp DNA linear HUM 14-NOV-2006
DEFINITION Human LAG-1 gene.
ACCESSION X53682
VERSION X53682.2
KEYWORDS LAG-1 gene; secreted protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2488)
AUTHORS Triebel F.
JOURNAL Submitted (03-JUL-1990) to the INSDC. Triebel F., Laboratoire
d'Immunologie Cellulaire U333, Institut Gustav Roussy, 94805
Villejuif, France.
REFERENCE 2 (bases 1 to 2488)
AUTHORS Baixeras E., Roman-Roman S., Jitsukawa S., Genevee C., Mechiche S.,
Viegas-Pequignot E., Hercend T., Triebel F.
TITLE Cloning and expression of a lymphocyte activation gene (LAG-1)
JOURNAL Mol. Immunol. 27(11), 1091-1102(1990).
PUBMED 2247088
FEATURES Location/Qualifiers
source 1..2488
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
regulatory 562..571
/note="GM-CSF decanucleotide-like sequence"
/regulatory_class="other"
regulatory 616..620
/regulatory_class="TATA_box"
mRNA join(656..797,1356..1470,2043..2443)
/gene="LAG-1"
exon 656..797
/number=1
prim_transcript 656..2488
/gene="LAG-1"
CDS join(722..797,1356..1470,2043..2130)
/gene="LAG-1"
/db_xref="GOA:P13236"
/db_xref="HGNC:HGNC:10630"
/db_xref="InterPro:IPR000827"
/db_xref="InterPro:IPR001811"
/db_xref="InterPro:IPR036048"
/db_xref="InterPro:IPR039809"
/db_xref="PDB:1HUM"
/db_xref="PDB:1HUN"
/db_xref="PDB:1JE4"
/db_xref="PDB:2FFK"
/db_xref="PDB:2FIN"
/db_xref="PDB:2X6L"
/db_xref="PDB:3TN2"
/db_xref="PDB:4RAL"
/db_xref="UniProtKB/Swiss-Prot:P13236"
/protein_id="CAA37722.2"
/translation="MKLCVTVLSLLVLVAAFCSLALSAPMGSDPPTACCFSYTARKLP
RNFVVDYYETSSLCSQPAVVFQTKRGKQVCADPSESWVQEYVYDLELN"
sig_peptide 722..790
mat_peptide join(791..797,1356..1470,2043..2127)
/gene="LAG-1"
intron 798..1355
/number=1
exon 1356..1470
/number=2
intron 1471..2042
/number=2
exon 2043..2443
/number=3
BASE COUNT 606 a 620 c 600 g 662 t
ORIGIN
1 cccctgctca aggttatggt aggatatata taatatgtgt aacacagctt tcccagtgcc
61 tggtacaacc taagtgtcca ataagaactt acaaatgttc ctgagccacc ctactgggtc
121 cctccgcaca tccaatgctg gactcttcat gcccaaggaa acatataggg cacaaaagtc
181 agtggcactg agctcagcag aagaaggcac aggaagggga tgggggagtc ctggttcccg
241 ctttgttttt ggggccagga ctgtggccag cctggaaaga ctggcatgaa ccctccagca
301 tctgggggtg ccaaccacca agagcagcac agttcttgtc tacagccact tgtagcaggt
361 gtgaacattt catcttttcc tctggggttt gcaactctct ccccagtctc ggtcactgct
421 tttggctgta ccacttccct tttcttctcg cctgcacctc cctcatcttt cctctatgat
481 gacatcgccc tggggaagag aagctgagag gaactcctca ctcagctagc ttcaggagcc
541 atgactacga tctctaccat ggaaattcca ctcactctcc tgtgccccca catttgtcct
601 aggcctcaga gtccctataa gagagattcc caactcagta tcagcacagg acacagctag
661 gttctgaagc ttctgagttc tgcagcctca cctctgagaa aacctctttg ccaccaatac
721 catgaagctc tgcgtgactg tcctgtctct cctcgtgcta gtagctgcct tctgctctct
781 agcactctca gcaccaagta agtctacttt tgcagctgct atttcgagtc aaggtctagg
841 cagagtcttt tttctattca tggctggcaa acagtgggat ctggggatgg gacaaaaggc
901 agctaggaag attgccatgt agtctgctgc taaatgtaga gtctagtaga tattcagtaa
961 cattcaagtt cctattttct taagaattag caaccagcag aggaaaacga tgggctggaa
1021 gtcagactgt tgaattggct ctgcctttaa ttgatttgtt caagcaagcc cctgtccctc
1081 tctgtgcctt ggtttcccca tctgtcatat gaagggagtg cgatgtgttc tgagactgaa
1141 tccagttcca atcttctaga tttctttctc gttcttctct gaagatccac tattcagaat
1201 aagactcctg ctcatgttag gtgggaatgg atacaaggga ccatatttgg ggttctggta
1261 gctccacagg gatgctcaat gaagatgcaa aattagaagt caaaataaac agctcccatg
1321 ggcagtgttg atctcaccct ggcctttcct ttcagtgggc tcagaccctc ccaccgcctg
1381 ctgcttttct tacaccgcga ggaagcttcc tcgcaacttt gtggtagatt actatgagac
1441 cagcagcctc tgctcccagc cagctgtggt agtatcaacc ctgctgccct ggagcaaggg
1501 tgagggctga ttttaagggg cctgttttgg ggagggggtg atgagcgttg gggagggagc
1561 tctcaggctg aagccttccc tgacagcagt gaggtcacag gtcatgactc acttttcaag
1621 tgctgaaggc ggctggtggc agccgagaca gaagggggat tcctggagga agttattcag
1681 aggacaggga cgaggggaag gcagacaggt cccgtgagat atggaccaat tccttaaacc
1741 atgctagaaa aacatgtgga aaagtcacta ccaggctggc agggaatggg gcaatctatt
1801 catactgatt gcaatgccca ctggttccta atctgggcaa cccctggggc ccacagctaa
1861 atccagtgag tgaagttaca gggagtctgc ttccagtgct gctccggaag gatccatcca
1921 ccagagctgc cccacatgga ccatggtcag gcagaggaag atgcctacca caggcaaggg
1981 ataaagccag atgacctcaa aggtcccatg ggattctaat ctgtctagcc cttgttctac
2041 agattccaaa ccaaaagagg caagcaagtc tgtgctgacc ccagtgagtc ctgggtccag
2101 gagtacgtgt atgacctgga actgaactga gctgctcaga gacaggaagt cttcagggaa
2161 ggtcacctga gcctggatgc ttctccatga gccgcatctc cctccatact cagactcctc
2221 tccgcagttc ctgtctcttc tcttaatgta atctctttta tgtgctgtat tattgtatta
2281 ggtgttattt ccattattta tattagttta gccaaaggat aagtgtccct atggggatgg
2341 tccactctca ctctttctct gctgttgcaa atacatggat aacaccatta attccatgtg
2401 ttttcataat aaaactttaa aataaaatgc aaacagtttc tttgtgtgat ttaatttgat
2461 ttgggggtaa aaggaattgc ctggtacc
//