LOCUS X53364 2565 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens HePTP mRNA for tyrosine phosphatase.
ACCESSION X53364
VERSION X53364.1
KEYWORDS tyrosine phosphatase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2565)
AUTHORS Jirik F.R.
JOURNAL Submitted (05-JUN-1990) to the INSDC. Jirik F.R., Biomedical
Research Centre, 2222 Health Sciences Mall, University of British
Columbia Campus, Vancouver, B.C. V6T 1W5, Canada.
REFERENCE 3 (bases 1 to 2565)
AUTHORS Jirik F.R., Janzen N.M., Melhado I.G., Harder K.W.
TITLE Cloning and chromosomal assignment of a widely expressed human
receptor-like protein-tyrosine phosphatase
JOURNAL FEBS Lett. 273(1-2), 239-242(1990).
PUBMED 2172030
FEATURES Location/Qualifiers
source 1..2565
/db_xref="H-InvDB:HIT000321830"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="cDNA; HepG2"
/cell_line="HePTP"
/db_xref="taxon:9606"
misc_feature 179..235
/note="leader sequence"
misc_feature 179..598
/note="extracellular domain"
CDS 179..2560
/product="tyrosine phosphatase precursor"
/db_xref="GOA:P18433"
/db_xref="H-InvDB:HIT000321830.13"
/db_xref="HGNC:HGNC:9664"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR016130"
/db_xref="InterPro:IPR016336"
/db_xref="InterPro:IPR027262"
/db_xref="InterPro:IPR029021"
/db_xref="UniProtKB/Swiss-Prot:P18433"
/protein_id="CAA37447.1"
/translation="MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVK
EEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITIS
PNGTWLPDNQFTDARTEPWPGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFII
IVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLE
EEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT
PVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLK
ERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLIT
QFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML
DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH
LQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRV
IIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT
ELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQ
FHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVL
ERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK"
mat_peptide 236..2557
/product="tyrosine phosphatase"
misc_feature 599..676
/note="transmembrane domain"
misc_feature 944..1681
/note="catalitic domain 1"
misc_feature 1823..2551
/note="catalitic domain 2"
BASE COUNT 729 a 637 c 626 g 573 t
ORIGIN
1 aattccgtgg taatggatga tgcagttcaa ataactaagg acacatgttc aaagagcata
61 attaactttt taaaagaagc tagacttctt cagaagcttg ccagtttttc aagctgattt
121 ctctcactgg caactcttca gagtgctgtt cctactccac cctcccctgg tgataagcat
181 ggattcctgg ttcattcttg ttctgctcgg cagtggtctg atatgtgtca gtgccaacaa
241 tgctaccaca gttgcacctt ctgtaggaat cacaagatta attaactcat caacggcaga
301 accagttaaa gaagaggcca aaacttcaaa tccaacttct tcactaactt ctctttctgt
361 ggcaccaaca ttcagcccaa atataactct gggacccacc tatttaacca ctgtcaattc
421 ttcagactct gacaatggga ccacaagaac agcaagcacc aattctatag gcattacaat
481 ttcaccaaat ggaacgtggc ttccagataa ccagttcacg gatgccagaa cagaaccctg
541 gccggggaat tccagcaccg cagcaaccac tccagaaact ttccctcctt cagatgagac
601 accaattatt gcggtgatgg tggccctgtc ctctctgcta gtgatcgtgt ttattatcat
661 agttttgtac atgttaaggt ttaagaaata caagcaagct gggagccatt ccaattcttt
721 ccgcttatcc aacggccgca ctgaggatgt ggagccccag agtgtgccac ttctggccag
781 atccccaagc accaacagga aatacccacc cctgcccgtg gacaagctgg aagaggaaat
841 taaccggaga atggcagacg acaataagct cttcagggag gaattcaacg ctctccctgc
901 atgtcctatc caggccacct gtgaggctgc ttccaaggag gaaaacaagg aaaaaaatcg
961 atatgtaaac atcttgcctt atgaccactc tagagtccac ctgacaccgg ttgaaggggt
1021 tccagattct gattacatca atgcttcatt catcaacggt taccaagaaa agaacaaatt
1081 cattgctgca caaggaccaa aagaagaaac ggtgaatgat ttctggcgga tgatctggga
1141 acaaaacaca gccaccatcg tcatggttac caacctgaag gagagaaagg agtgcaagtg
1201 cgcccagtac tggccagacc aaggctgctg gacctatggg aatattcggg tgtctgtaga
1261 ggatgtgact gtcctggtgg actacacagt acggaagttc tgcatccagc aggtgggcga
1321 catgaccaac agaaagccac agcgcctcat cactcagttc cactttacca gctggccaga
1381 ctttggggtg ccttttaccc cgatcggcat gctcaagttc ctcaagaagg tgaaggcctg
1441 taaccctcag tatgcagggg ccatcgtggt ccactgcagt gcaggtgtag ggcgtacagg
1501 tacctttgtc gtcattgatg ccatgctgga catgatgcat acagaacgga aggtggacgt
1561 gtatggcttt gtgagccgga tccgggcaca gcgctgccag atggtgcaaa ccgatatgca
1621 gtatgtcttc atataccaag cccttctgga gcattatctc tatggagata cagaactgga
1681 agtgacctct ctagaaaccc acctgcagaa aatttacaac aaaatcccag ggaccagcaa
1741 caatggatta gaggaggagt ttaagaagtt aacatcaatc aaaatccaga atgacaagat
1801 gcggactgga aaccttccag ccaacatgaa gaagaaccgt gttttacaga tcattccata
1861 tgaattcaac agagtgatca ttccagttaa gcggggcgaa gagaatacag actatgtgaa
1921 cgcatccttt attgatggct accggcagaa ggactcctat atcgccagcc agggccctct
1981 tctccacaca attgaggact tctggcgaat gatctgggag tggaaatcct gctctatcgt
2041 gatgctaaca gaactggagg agagaggcca ggagaagtgt gcccagtact ggccatctga
2101 tggactggtg tcctatggag atattacagt ggaactgaag aaggaggagg aatgtgagag
2161 ctacaccgtc cgagacctcc tggtcaccaa caccagggag aataagagcc ggcagatccg
2221 gcagttccac ttccatggct ggcctgaagt gggcatcccc agtgacggaa agggcatgat
2281 cagcatcatc gccgccgtgc agaagcagca gcagcagtca gggaaccacc ccatcaccgt
2341 gcactgcagc gccggggcag gaaggacggg gaccttctgt gccctgagca ccgtcctgga
2401 gcgtgtgaaa gcagagggga ttttggatgt cttccagact gtcaagagcc tgcggctaca
2461 gaggccacac atggtccaga cactggaaca gtatgagttc tgctacaagg tggtgcagga
2521 gtatattgat gcattctcag attatgccaa cttcaagtaa gcggc
//