LOCUS X53051 2220 bp mRNA linear HUM 31-MAR-1995
DEFINITION Human mRNA for vascular cell adhesion molecule 1 (VCAM-1).
ACCESSION X53051
VERSION X53051.1
KEYWORDS cell adhesion molecule; vascular cell adhesion molecule; vascular
cell adhesion molecule 1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2220)
AUTHORS Polte T.R.
JOURNAL Submitted (21-MAY-1990) to the INSDC. Polte T.R., Otsuka America
Pharmaceutical, Inc.,, 9900 Medical Center Drive, Rockville, MD
20850, USA.
REFERENCE 2 (bases 1 to 929;1204 to 2220)
AUTHORS Polte T., Newman W., Gopal T.V.
TITLE Full length vascular cell adhesion molecule 1 (VCAM-1)
JOURNAL Nucleic Acids Res. 18(19), 5901-5901(1990).
PUBMED 1699207
COMMENT See M30257 for related sequence.
FEATURES Location/Qualifiers
source 1..2220
/db_xref="H-InvDB:HIT000321817"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="endothelial"
/tissue_type="umbilical vein"
/db_xref="taxon:9606"
CDS 1..2220
/product="precursor peptide"
/db_xref="GOA:P19320"
/db_xref="H-InvDB:HIT000321817.13"
/db_xref="HGNC:HGNC:12663"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR003987"
/db_xref="InterPro:IPR003989"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR008424"
/db_xref="InterPro:IPR013098"
/db_xref="InterPro:IPR013106"
/db_xref="InterPro:IPR013151"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1IJ9"
/db_xref="PDB:1VCA"
/db_xref="PDB:1VSC"
/db_xref="UniProtKB/Swiss-Prot:P19320"
/protein_id="CAA37218.1"
/translation="MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVS
LTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESR
KLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMK
SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ
VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL
TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLT
CSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKL
EKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENI
EFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN
VAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTL
ISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCT
CGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLT
LDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV"
sig_peptide 1..24
/note="signal peptide"
mat_peptide 25..2217
/note="vascular cell adhesion molecule 1"
repeat_region 109..927
/note="internal repeat 1"
repeat_region 973..1791
/note="internal repeat 2"
BASE COUNT 671 a 442 c 529 g 578 t
ORIGIN
1 atgcctggga agatggtcgt gatccttgga gcctcaaata tactttggat aatgtttgca
61 gcttctcaag cttttaaaat cgagaccacc ccagaatcta gatatcttgc tcagattggt
121 gactccgtct cattgacttg cagcaccaca ggctgtgagt ccccattttt ctcttggaga
181 acccagatag atagtccact gaatgggaag gtgacgaatg aggggaccac atctacgctg
241 acaatgaatc ctgttagttt tgggaacgaa cactcttacc tgtgcacagc aacttgtgaa
301 tctaggaaat tggaaaaagg aatccaggtg gagatctact cttttcctaa ggatccagag
361 attcatttga gtggccctct ggaggctggg aagccgatca cagtcaagtg ttcagttgct
421 gatgtatacc catttgacag gctggagata gacttactga aaggagatca tctcatgaag
481 agtcaggaat ttctggagga tgcagacagg aagtccctgg aaaccaagag tttggaagta
541 acctttactc ctgtcattga ggatattgga aaagttcttg tttgccgagc taaattacac
601 attgatgaaa tggattctgt gcccacagta aggcaggctg taaaagaatt gcaagtctac
661 atatcaccca agaatacagt tatttctgtg aatccatcca caaagctgca agaaggtggc
721 tctgtgacca tgacctgttc cagcgagggt ctaccagctc cagagatttt ctggagtaag
781 aaattagata atgggaatct acagcacctt tctggaaatg caactctcac cttaattgct
841 atgaggatgg aagattctgg aatttatgtg tgtgaaggag ttaatttgat tgggaaaaac
901 agaaaagagg tggaattaat tgttcaagag aaaccattta ctgttgagat ctcccctgga
961 ccccggattg ctgctcagat tggagactca gtcatgttga catgtagtgt catgggctgt
1021 gaatccccat ctttctcctg gagaacccag atagacagcc ctctgagcgg gaaggtgagg
1081 agtgagggga ccaattccac gctgaccctg agccctgtga gttttgagaa cgaacactct
1141 tatctgtgca cagtgacttg tggacataag aaactggaaa agggaatcca ggtggagctc
1201 tactcattcc ctagagatcc agaaatcgag atgagtggtg gcctcgtgaa tgggagctct
1261 gtcactgtaa gctgcaaggt tcctagcgtg tacccccttg accggctgga gattgaatta
1321 cttaaggggg agactattct ggagaatata gagtttttgg aggatacgga tatgaaatct
1381 ctagagaaca aaagtttgga aatgaccttc atccctacca ttgaagatac tggaaaagct
1441 cttgtttgtc aggctaagtt acatattgat gacatggaat tcgaacccaa acaaaggcag
1501 agtacgcaaa cactttatgt caatgttgcc cccagagata caaccgtctt ggtcagccct
1561 tcctccatcc tggaggaagg cagttctgtg aatatgacat gcttgagcca gggctttcct
1621 gctccgaaaa tcctgtggag caggcagctc cctaacgggg agctacagcc tctttctgag
1681 aatgcaactc tcaccttaat ttctacaaaa atggaagatt ctggggttta tttatgtgaa
1741 ggaattaacc aggctggaag aagcagaaag gaagtggaat taattatcca agttactcca
1801 aaagacataa aacttacagc ttttccttct gagagtgtca aagaaggaga cactgtcatc
1861 atctcttgta catgtggaaa tgttccagaa acatggataa tcctgaagaa aaaagcggag
1921 acaggagaca cagtactaaa atctatagat ggcgcctata ccatccgaaa ggcccagttg
1981 aaggatgcgg gagtatatga atgtgaatct aaaaacaaag ttggctcaca attaagaagt
2041 ttaacacttg atgttcaagg aagagaaaac aacaaagact atttttctcc tgagcttctc
2101 gtgctctatt ttgcatcctc cttaataata cctgccattg gaatgataat ttactttgca
2161 agaaaagcca acatgaaggg gtcatatagt cttgtagaag cacagaaatc aaaagtgtag
//