LOCUS X52941 2311 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human LTF mRNA for lactoferrin (lactotransferrin).
ACCESSION X52941
VERSION X52941.1
KEYWORDS lactoferrin; lactotransferrin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2311)
AUTHORS Powell M.J.
JOURNAL Submitted (01-MAY-1990) to the INSDC. Powell M.J., Delta
Biotechnology Limited, Castle Court, Castle Boulevard, Nottingham.
NG7 1FD, GREAT BRITAIN.
REFERENCE 2 (bases 1 to 2311)
AUTHORS Powell M.J., Ogden J.E.
TITLE Nucleotide sequence of human lactoferrin cDNA
JOURNAL Nucleic Acids Res. 18(13), 4013-4013(1990).
PUBMED 2374734
COMMENT See also <M18642> for overlapping sequence.
Data kindly reviewed (27-JUL-1990) by Powell M.J.
FEATURES Location/Qualifiers
source 1..2311
/db_xref="H-InvDB:HIT000321807"
/organism="Homo sapiens"
/chromosome="3"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/clone="lambda L15, lambda L16"
/tissue_type="mammary gland"
/db_xref="taxon:9606"
CDS <1..2130
/codon_start=1
/note="precursor lactoferrin (709 AA)"
/db_xref="GOA:P02788"
/db_xref="H-InvDB:HIT000321807.14"
/db_xref="HGNC:HGNC:6720"
/db_xref="InterPro:IPR001156"
/db_xref="InterPro:IPR016357"
/db_xref="InterPro:IPR018195"
/db_xref="InterPro:IPR030684"
/db_xref="PDB:1B0L"
/db_xref="PDB:1BKA"
/db_xref="PDB:1CB6"
/db_xref="PDB:1DSN"
/db_xref="PDB:1EH3"
/db_xref="PDB:1FCK"
/db_xref="PDB:1H43"
/db_xref="PDB:1H44"
/db_xref="PDB:1H45"
/db_xref="PDB:1HSE"
/db_xref="PDB:1L5T"
/db_xref="PDB:1LCF"
/db_xref="PDB:1LCT"
/db_xref="PDB:1LFG"
/db_xref="PDB:1LFH"
/db_xref="PDB:1LFI"
/db_xref="PDB:1LGB"
/db_xref="PDB:1N76"
/db_xref="PDB:1SQY"
/db_xref="PDB:1U62"
/db_xref="PDB:1VFD"
/db_xref="PDB:1VFE"
/db_xref="PDB:1XV4"
/db_xref="PDB:1XV7"
/db_xref="PDB:1Z6V"
/db_xref="PDB:1Z6W"
/db_xref="PDB:2BJJ"
/db_xref="PDB:2DP4"
/db_xref="PDB:2GMC"
/db_xref="PDB:2GMD"
/db_xref="PDB:2HD4"
/db_xref="PDB:2PMS"
/db_xref="UniProtKB/Swiss-Prot:P02788"
/protein_id="CAA37116.1"
/translation="LVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNM
RKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGT
ERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPP
EPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLR
DGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVAR
SVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDS
GLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSA
STTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPV
EGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFS
QSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDV
TVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKV
ERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLG
PQYVAGITNLKKCSTSPLLEACEFLRK"
sig_peptide <1..51
/note="signal peptide (partial) (17 AA)"
mat_peptide 52..2127
/note="mature lactoferrin (AA 1-692)"
misc_feature 1456..1459
/note="ggct was gcgt in <M18642>"
misc_feature 1619..1621
/note="acg was atg in <M18642>"
misc_feature 1890..1892
/note="gtt was gct in <M18642>"
polyA_site 2311..2311
/note="polyA site"
BASE COUNT 549 a 584 c 660 g 518 t
ORIGIN
1 cttgtcttcc tcgtcctgct gttcctcggg gccctcggac tgtgtctggc tggccgtagg
61 agaaggagtg ttcagtggtg cgccgtatcc caacccgagg ccacaaaatg cttccaatgg
121 caaaggaata tgagaaaagt gcgtggccct cctgtcagct gcataaagag agactccccc
181 atccagtgta tccaggccat tgcggaaaac agggccgatg ctgtgaccct tgatggtggt
241 ttcatatacg aggcaggcct ggccccctac aaactgcgac ctgtagcggc ggaagtctac
301 gggaccgaaa gacagccacg aactcactat tatgccgtgg ctgtggtgaa gaagggcggc
361 agctttcagc tgaacgaact gcaaggtctg aagtcctgcc acacaggcct tcgcaggacc
421 gctggatgga atgtccctat agggacactt cgtccattct tgaattggac gggtccacct
481 gagcccattg aggcagctgt ggccaggttc ttctcagcca gctgtgttcc cggtgcagat
541 aaaggacagt tccccaacct gtgtcgcctg tgtgcgggga caggggaaaa caaatgtgcc
601 ttctcctccc aggaaccgta cttcagctac tctggtgcct tcaagtgtct gagagacggg
661 gctggagacg tggcttttat cagagagagc acagtgtttg aggacctgtc agacgaggct
721 gaaagggacg agtatgagtt actctgccca gacaacactc ggaagccagt ggacaagttc
781 aaagactgcc atctggcccg ggtcccttct catgccgttg tggcacgaag tgtgaatggc
841 aaggaggatg ccatctggaa tcttctccgc caggcacagg aaaagtttgg aaaggacaag
901 tcaccgaaat tccagctctt tggctcccct agtgggcaga aagatctgct gttcaaggac
961 tctgccattg ggttttcgag ggtgcccccg aggatagatt ctgggctgta ccttggctcc
1021 ggctacttca ctgccatcca gaacttgagg aaaagtgagg aggaagtggc tgcccggcgt
1081 gcgcgggtcg tgtggtgtgc ggtgggcgag caggagctgc gcaagtgtaa ccagtggagt
1141 ggcttgagcg aaggcagcgt gacctgctcc tcggcctcca ccacagagga ctgcatcgcc
1201 ctggtgctga aaggagaagc tgatgccatg agtttggatg gaggatatgt gtacactgca
1261 ggcaaatgtg gtttggtgcc tgtcctggca gagaactaca aatcccaaca aagcagtgac
1321 cctgatccta actgtgtgga tagacctgtg gaaggatatc ttgctgtggc ggtggttagg
1381 agatcagaca ctagccttac ctggaactct gtgaaaggca agaagtcctg ccacaccgcc
1441 gtggacagga ctgcaggctg gaatatcccc atgggcctgc tcttcaacca gacgggctcc
1501 tgcaaatttg atgaatattt cagtcaaagc tgtgcccctg ggtctgaccc gagatctaat
1561 ctctgtgctc tgtgtattgg cgacgagcag ggtgagaata agtgcgtgcc caacagcaac
1621 gagagatact acggctacac tggggctttc cggtgcctgg ctgagaatgc tggagacgtt
1681 gcatttgtga aagatgtcac tgtcttgcag aacactgatg gaaataacaa tgaggcatgg
1741 gctaaggatt tgaagctggc agactttgcg ctgctgtgcc tcgatggcaa acggaagcct
1801 gtgactgagg ctagaagctg ccatcttgcc atggccccga atcatgccgt ggtgtctcgg
1861 atggataagg tggaacgcct gaaacaggtg ttgctccacc aacaggctaa atttgggaga
1921 aatggatctg actgcccgga caagttttgc ttattccagt ctgaaaccaa aaaccttctg
1981 ttcaatgaca acactgagtg tctggccaga ctccatggca aaacaacata tgaaaaatat
2041 ttgggaccac agtatgtcgc aggcattact aatctgaaaa agtgctcaac ctcccccctc
2101 ctggaagcct gtgaattcct caggaagtaa aaccgaagaa gatggcccag ctccccaaga
2161 aagcctcagc cattcactgc ccccagctct tctccccagg tgtgttgggg ccttggctcc
2221 cctgctgaag gtggggattg cccatccatc tgcttacaat tccctgctgt cgtcttagca
2281 agaagtaaaa tgagaaattt tgttgatatt c
//