LOCUS X52851 6711 bp DNA linear HUM 14-NOV-2006
DEFINITION Human cyclophilin gene for cyclophilin (EC 5.2.1.8).
ACCESSION X52851
VERSION X52851.1
KEYWORDS Alu repeat; cyclophilin; cyclosporin A-binding protein;
peptidylprolyl isomerase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6711)
AUTHORS Hofer E.
JOURNAL Submitted (23-APR-1990) to the INSDC. Hofer E., Sandoz Ltd,
Preclinical Research, 386/625, 4002 Basle , Switzerland.
REFERENCE 2
AUTHORS Haendler B., Hofer E.
TITLE Characterization of the human cyclophilin gene and of related
processed pseudogenes
JOURNAL Eur. J. Biochem. 190(3), 477-482(1990).
PUBMED 2197089
COMMENT See also <Y00052> for cDNA sequence and <X52852-8> for related
processed pseudogenic sequences.
FEATURES Location/Qualifiers
source 1..6711
/organism="Homo sapiens"
/mol_type="genomic DNA"
/clone_lib="Lambda EMBL3"
/clone="CPH-70"
/cell_type="leucocyte"
/db_xref="taxon:9606"
misc_feature 71..360
/note="Alu repeat"
misc_feature 361..562
/note="Alu repeat"
protein_bind 781..790
/bound_moiety="Sp1"
/note="SP1 binding domain"
protein_bind 1371..1380
/bound_moiety="Sp1"
/note="SP1 binding domain"
regulatory 1585..1591
/regulatory_class="TATA_box"
mRNA join(1616..1728,4173..4203,4318..4406,4628..4800,
6215..6561)
exon 1616..1728
/number=1
CDS join(1660..1728,4173..4203,4318..4406,4628..4800,
6215..6350)
/product="peptidylprolyl isomerase"
/EC_number="5.2.1.8"
/db_xref="GOA:P62937"
/db_xref="HGNC:HGNC:9253"
/db_xref="InterPro:IPR002130"
/db_xref="InterPro:IPR020892"
/db_xref="InterPro:IPR024936"
/db_xref="InterPro:IPR029000"
/db_xref="PDB:1AK4"
/db_xref="PDB:1AWQ"
/db_xref="PDB:1AWR"
/db_xref="PDB:1AWS"
/db_xref="PDB:1AWT"
/db_xref="PDB:1AWU"
/db_xref="PDB:1AWV"
/db_xref="PDB:1BCK"
/db_xref="PDB:1CWA"
/db_xref="PDB:1CWB"
/db_xref="PDB:1CWC"
/db_xref="PDB:1CWF"
/db_xref="PDB:1CWH"
/db_xref="PDB:1CWI"
/db_xref="PDB:1CWJ"
/db_xref="PDB:1CWK"
/db_xref="PDB:1CWL"
/db_xref="PDB:1CWM"
/db_xref="PDB:1CWO"
/db_xref="PDB:1FGL"
/db_xref="PDB:1M63"
/db_xref="PDB:1M9C"
/db_xref="PDB:1M9D"
/db_xref="PDB:1M9E"
/db_xref="PDB:1M9F"
/db_xref="PDB:1M9X"
/db_xref="PDB:1M9Y"
/db_xref="PDB:1MF8"
/db_xref="PDB:1MIK"
/db_xref="PDB:1NMK"
/db_xref="PDB:1OCA"
/db_xref="PDB:1RMH"
/db_xref="PDB:1VBS"
/db_xref="PDB:1VBT"
/db_xref="PDB:1W8L"
/db_xref="PDB:1W8M"
/db_xref="PDB:1W8V"
/db_xref="PDB:1YND"
/db_xref="PDB:1ZKF"
/db_xref="PDB:2ALF"
/db_xref="PDB:2CPL"
/db_xref="PDB:2CYH"
/db_xref="PDB:2MS4"
/db_xref="PDB:2MZU"
/db_xref="PDB:2N0T"
/db_xref="PDB:2RMA"
/db_xref="PDB:2RMB"
/db_xref="PDB:2X25"
/db_xref="PDB:2X2A"
/db_xref="PDB:2X2C"
/db_xref="PDB:2X2D"
/db_xref="PDB:2XGY"
/db_xref="PDB:3CYH"
/db_xref="PDB:3CYS"
/db_xref="PDB:3K0M"
/db_xref="PDB:3K0N"
/db_xref="PDB:3K0O"
/db_xref="PDB:3K0P"
/db_xref="PDB:3K0Q"
/db_xref="PDB:3K0R"
/db_xref="PDB:3ODI"
/db_xref="PDB:3ODL"
/db_xref="PDB:3RDD"
/db_xref="PDB:4CYH"
/db_xref="PDB:4IPZ"
/db_xref="PDB:4N1M"
/db_xref="PDB:4N1N"
/db_xref="PDB:4N1O"
/db_xref="PDB:4N1P"
/db_xref="PDB:4N1Q"
/db_xref="PDB:4N1R"
/db_xref="PDB:4N1S"
/db_xref="PDB:4YUG"
/db_xref="PDB:4YUH"
/db_xref="PDB:4YUI"
/db_xref="PDB:4YUJ"
/db_xref="PDB:4YUK"
/db_xref="PDB:4YUL"
/db_xref="PDB:4YUM"
/db_xref="PDB:4YUN"
/db_xref="PDB:4YUO"
/db_xref="PDB:4YUP"
/db_xref="PDB:5CYH"
/db_xref="PDB:5F66"
/db_xref="PDB:5FJB"
/db_xref="PDB:5KUL"
/db_xref="PDB:5KUN"
/db_xref="PDB:5KUO"
/db_xref="PDB:5KUQ"
/db_xref="PDB:5KUR"
/db_xref="PDB:5KUS"
/db_xref="PDB:5KUU"
/db_xref="PDB:5KUV"
/db_xref="PDB:5KUW"
/db_xref="PDB:5KUZ"
/db_xref="PDB:5KV0"
/db_xref="PDB:5KV1"
/db_xref="PDB:5KV2"
/db_xref="PDB:5KV3"
/db_xref="PDB:5KV4"
/db_xref="PDB:5KV5"
/db_xref="PDB:5KV6"
/db_xref="PDB:5KV7"
/db_xref="PDB:5LUD"
/db_xref="PDB:5NOQ"
/db_xref="PDB:5NOR"
/db_xref="PDB:5NOS"
/db_xref="PDB:5NOT"
/db_xref="PDB:5NOU"
/db_xref="PDB:5NOV"
/db_xref="PDB:5NOW"
/db_xref="PDB:5NOX"
/db_xref="PDB:5NOY"
/db_xref="PDB:5NOZ"
/db_xref="PDB:5T9U"
/db_xref="PDB:5T9W"
/db_xref="PDB:5T9Z"
/db_xref="PDB:5TA2"
/db_xref="PDB:5TA4"
/db_xref="PDB:5WC7"
/db_xref="PDB:6BTA"
/db_xref="PDB:6GJI"
/db_xref="PDB:6GJJ"
/db_xref="PDB:6GJL"
/db_xref="PDB:6GJM"
/db_xref="PDB:6GJN"
/db_xref="PDB:6GJP"
/db_xref="PDB:6GJR"
/db_xref="PDB:6GJY"
/db_xref="PDB:6GS6"
/db_xref="UniProtKB/Swiss-Prot:P62937"
/protein_id="CAA37039.1"
/translation="MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEK
GFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMAN
AGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIAD
CGQLE"
intron 1729..4172
/number=1
misc_feature 2054..2063
/note="general enhancer core"
protein_bind 2522..2537
/bound_moiety="NP1"
/note="NP1 binding domain"
misc_feature 3207..3445
/note="Alu repeat"
protein_bind 4094..4100
/bound_moiety="AP1"
/note="AP1 binding domain"
exon 4173..4203
/number=2
intron 4204..4317
/number=2
exon 4318..4406
/number=3
intron 4407..4627
/number=3
exon 4628..4800
/number=4
intron 4801..6214
/number=4
misc_feature 5026..5314
/note="Alu repeat"
misc_feature 5340..5626
/note="Alu repeat"
misc_feature 5755..6043
/note="Alu repeat"
exon 6215..6561
/number=5
regulatory 6538..6543
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1552 a 1625 c 1717 g 1817 t
ORIGIN
1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat
61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc
121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc
181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt
241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga
301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc
361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc
421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag
481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc
541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc
601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag
661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg
721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc
781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa
841 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc
901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag
961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc
1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc
1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc
1141 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac
1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg
1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc
1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc
1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt
1441 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag
1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg
1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt
1621 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc
1681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg
1741 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc
1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca
1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg
1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg
1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag
2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc
2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat
2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag
2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag
2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg
2341 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg
2401 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg
2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga
2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt
2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt
2641 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac
2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag
2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg
2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact
2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag
2941 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag
3001 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca
3061 atgagggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg
3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata
3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg
3241 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg
3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga
3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac
3421 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat
3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag
3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa
3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt
3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa
3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg
3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta
3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt
3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt
3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct
4021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga
4081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc
4141 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag
4201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt
4261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa
4321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca
4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt
4441 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac
4501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga
4561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg
4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga
4681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc
4741 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg
4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa
4861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata
4921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac
4981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg
5041 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct
5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg
5161 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg
5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg
5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt
5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca
5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct
5461 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat
5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac
5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct
5641 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt
5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt
5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac
5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg
5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt
5941 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct
6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt
6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa
6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg
6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg
6241 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg
6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg
6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc
6421 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg
6481 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat
6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag
6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt
6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t
//