LOCUS       X52425                  3597 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human IL-4-R mRNA for the interleukin 4 receptor.
ACCESSION   X52425
VERSION     X52425.1
KEYWORDS    B cell growth factor; IL-4-R gene; interleukin; interleukin 4
            receptor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Idzerda R.L., March C.J., Mosley B., Lyman S.D., Bos T.V.,
            Gimpel S.D., Din W.S., Grabstein K.H., Widmer M.B., Park L.S.,
            Cosman D., Beckmann M.P.
  TITLE     Human interleukin 4 receptor confers biological responsiveness and
            defines a novel receptor superfamily
  JOURNAL   J. Exp. Med. 171(3), 861-873(1990).
   PUBMED   2307934
COMMENT     Data kindly reviewed (11-MAR-1991) by Beckmann M.P.
FEATURES             Location/Qualifiers
     source          1..3597
                     /db_xref="H-InvDB:HIT000321777"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_type="T cell, tissue=peripheral blood, clone=T22-8"
                     /db_xref="taxon:9606"
     mRNA            <1..3597
                     /gene="IL-4-R gene"
     sig_peptide     176..250
                     /product="interleukin 4 receptor"
     CDS             176..2653
                     /gene="IL-4-R gene"
                     /product="interleukin 4 receptor"
                     /db_xref="GOA:P24394"
                     /db_xref="H-InvDB:HIT000321777.14"
                     /db_xref="HGNC:HGNC:6015"
                     /db_xref="InterPro:IPR003531"
                     /db_xref="InterPro:IPR003961"
                     /db_xref="InterPro:IPR013783"
                     /db_xref="InterPro:IPR015319"
                     /db_xref="InterPro:IPR036116"
                     /db_xref="PDB:1IAR"
                     /db_xref="PDB:1IRS"
                     /db_xref="PDB:1ITE"
                     /db_xref="PDB:3BPL"
                     /db_xref="PDB:3BPN"
                     /db_xref="PDB:3BPO"
                     /db_xref="PDB:5E4E"
                     /db_xref="UniProtKB/Swiss-Prot:P24394"
                     /protein_id="CAA36672.1"
                     /translation="MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTC
                     EWKMNGPTNCSTELRLLYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLD
                     LWAGQQLLWKGSFKPSEHVKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYA
                     VNIWSENDPADFRIYNVTYLEPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPS
                     TKWHNSYREPFEQHLLLGVSVSCIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVA
                     IIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQ
                     GSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSR
                     DDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPS
                     AGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSP
                     CPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAA
                     PVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGA
                     SSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEP
                     GEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMA
                     SPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPA
                     PGNAQSSSQTPKIVNFVSVGPTYMRVS"
     mat_peptide     251..2650
                     /gene="IL-4-R gene"
                     /product="interleukin 4 receptor"
     misc_feature    872..943
                     /product="interleukin 4 receptor"
                     /note="putative transmembrane region"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT          794 a         1034 c         1039 g          730 t
ORIGIN      
        1 ggcgaatgga gcaggggcgc gcagataatt aaagatttac acacagctgg aagaaatcat
       61 agagaagccg ggcgtggtgg ctcatgccta taatcccagc acttttggag gctgaggcgg
      121 gcagatcact tgagatcagg agttcgagac cagcctggtg ccttggcatc tcccaatggg
      181 gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc aggtggcaag
      241 ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca tgagcatctc
      301 tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc gcctgttgta
      361 ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca acggaggcgc
      421 ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact atacactgga
      481 cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg agcatgtgaa
      541 acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc tgctgctgac
      601 ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct atgcagtcaa
      661 catttggagt gaaaacgacc cggcagattt cagaatctat aacgtgacct acctagaacc
      721 ctccctccgc atcgcagcca gcaccctgaa gtctgggatt tcctacaggg cacgggtgag
      781 ggcctgggct cagtgctata acaccacctg gagtgagtgg agccccagca ccaagtggca
      841 caactcctac agggagccct tcgagcagca cctcctgctg ggcgtcagcg tttcctgcat
      901 tgtcatcctg gccgtctgcc tgttgtgcta tgtcagcatc accaagatta agaaagaatg
      961 gtgggatcag attcccaacc cagcccgcag ccgcctcgtg gctataataa tccaggatgc
     1021 tcaggggtca cagtgggaga agcggtcccg aggccaggaa ccagccaagt gcccacactg
     1081 gaagaattgt cttaccaagc tcttgccctg ttttctggag cacaacatga aaagggatga
     1141 agatcctcac aaggctgcca aagagatgcc tttccagggc tctggaaaat cagcatggtg
     1201 cccagtggag atcagcaaga cagtcctctg gccagagagc atcagcgtgg tgcgatgtgt
     1261 ggagttgttt gaggccccgg tggagtgtga ggaggaggag gaggtagagg aagaaaaagg
     1321 gagcttctgt gcatcgcctg agagcagcag ggatgacttc caggagggaa gggagggcat
     1381 tgtggcccgg ctaacagaga gcctgttcct ggacctgctc ggagaggaga atgggggctt
     1441 ttgccagcag gacatggggg agtcatgcct tcttccacct tcgggaagta cgagtgctca
     1501 catgccctgg gatgagttcc caagtgcagg gcccaaggag gcacctccct ggggcaagga
     1561 gcagcctctc cacctggagc caagtcctcc tgccagcccg acccagagtc cagacaacct
     1621 gacttgcaca gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca gcttcagcaa
     1681 ctccctgagc cagtcaccgt gtcccagaga gctgggtcca gacccactgc tggccagaca
     1741 cctggaggaa gtagaacccg agatgccctg tgtcccccag ctctctgagc caaccactgt
     1801 gccccaacct gagccagaaa cctgggagca gatcctccgc cgaaatgtcc tccagcatgg
     1861 ggcagctgca gcccccgtct cggcccccac cagtggctat caggagtttg tacatgcggt
     1921 ggagcagggt ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag gagaggctgg
     1981 ttacaaggcc ttctcaagcc tgcttgccag cagtgctgtg tccccagaga aatgtgggtt
     2041 tggggctagc agtggggaag aggggtataa gcctttccaa gacctcattc ctggctgccc
     2101 tggggaccct gccccagtcc ctgtcccctt gttcaccttt ggactggaca gggagccacc
     2161 tcgcagtccg cagagctcac atctcccaag cagctcccca gagcacctgg gtctggagcc
     2221 gggggaaaag gtagaggaca tgccaaagcc cccacttccc caggagcagg ccacagaccc
     2281 ccttgtggac agcctgggca gtggcattgt ctactcagcc cttacctgcc acctgtgcgg
     2341 ccacctgaaa cagtgtcatg gccaggagga tggtggccag acccctgtca tggccagtcc
     2401 ttgctgtggc tgctgctgtg gagacaggtc ctcgccccct acaacccccc tgagggcccc
     2461 agacccctct ccaggtgggg ttccactgga ggccagtctg tgtccggcct ccctggcacc
     2521 ctcgggcatc tcagagaaga gtaaatcctc atcatccttc catcctgccc ctggcaatgc
     2581 tcagagctca agccagaccc ccaaaatcgt gaactttgtc tccgtgggac ccacatacat
     2641 gagggtctct taggtgcatg tcctcttgtt gctgagtctg cagatgagga ctagggctta
     2701 tccatgcctg ggaaatgcca cctcctggaa ggcagccagg ctggcagatt tccaaaagac
     2761 ttgaagaacc atggtatgaa ggtgattggc cccactgacg ttggcctaac actgggctgc
     2821 agagactgga ccccgcccag cattgggctg ggctcgccac atcccatgag agtagagggc
     2881 actgggtcgc cgtgccccac ggcaggcccc tgcaggaaaa ctgaggccct tgggcacctc
     2941 gacttgtgaa cgagttgttg gctgctccct ccacagcttc tgcagcagac tgtccctgtt
     3001 gtaactgccc aaggcatgtt ttgcccacca gatcatggcc cacgtggagg cccacctgcc
     3061 tctgtctcac tgaactagaa gccgagccta gaaactaaca cagccatcaa gggaatgact
     3121 tgggcggcct tgggaaatcg atgagaaatt gaacttcagg gagggtggtc attgcctaga
     3181 ggtgctcatt catttaacag agcttcctta ggttgatgct ggaggcagaa tcccggctgt
     3241 caaggggtgt tcagttaagg ggagcaacag aggacatgaa aaattgctat gactaaagca
     3301 gggacaattt gctgccaaac acccatgccc agctgtatgg ctgggggctc ctcgtatgca
     3361 tggaaccccc agaataaata tgctcagcca ccctgtgggc cgggcaatcc agacagcagg
     3421 cataaggcac cagttaccct gcatgttggc ccagacctca ggtgctaggg aaggcgggaa
     3481 ccttgggttg agtaatgctc gtctgtgtgt tttagtttca tcacctgtta tctgtgtttg
     3541 ctgaggagag tggaacagaa ggggtggagt tttgtataaa taaagtttct ttgtctc
//