LOCUS X52229 1721 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for transmembrane epithelial tumour mucin antigen.
ACCESSION X52229
VERSION X52229.1
KEYWORDS transmembrane protein; tumor antigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1721)
AUTHORS Wreschner D.H.
JOURNAL Submitted (16-MAR-1990) to the INSDC. Wreschner D.H., Tel Aviv
University, Dept of Microbiology, Faculty of Life Sciences, Tel
Aviv 69978, Israel.
REFERENCE 2 (bases 1 to 1721)
AUTHORS Wreschener D.H., Hareuveni M., Tsarfaty I., Smorodinsky N.,
Horov J., Zaretsky J., Kotkes P., Weiss M., Lathe R., Dion A.S.,
Keydar I.
TITLE Human epithelial tumor antigen cDNA sequences. Differential
splicing may generate multiple protein forms
JOURNAL Eur. J. Biochem. 189(3), 463-473(1990).
PUBMED 2351132
REFERENCE 3
AUTHORS Hareuveni M., Tsarfaty I., Zaretsky J., Kotkes P., Horev J.,
Zrihan S., Weiss M., Green S., Lathe R., Keydar I., Wreschner D.H.
TITLE A transcribed gene, containing a variable number of tandem repeats,
codes for a human epithelial tumor antigen. cDNA cloning,
expression of the transfected gene and over-expression in breast
cancer tissue
JOURNAL Eur. J. Biochem. 189(3), 475-486(1990).
PUBMED 2112460
COMMENT See <X52228> for secreted tumour antigen.
FEATURES Location/Qualifiers
source 1..1721
/db_xref="H-InvDB:HIT000321741"
/organism="Homo sapiens"
/chromosome="1q21-24"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/cell_line="T47D breast tumour"
/db_xref="taxon:9606"
CDS 58..1605
/product="precursor polypeptide (AA -21 to 494)"
/db_xref="GOA:P15941"
/db_xref="H-InvDB:HIT000321741.12"
/db_xref="HGNC:HGNC:7508"
/db_xref="InterPro:IPR000082"
/db_xref="InterPro:IPR036364"
/db_xref="PDB:1SM3"
/db_xref="PDB:2ACM"
/db_xref="PDB:2FO4"
/db_xref="PDB:5T6P"
/db_xref="PDB:5T78"
/db_xref="PDB:6FZQ"
/db_xref="PDB:6FZR"
/db_xref="UniProtKB/Swiss-Prot:P15941"
/protein_id="CAA36478.1"
/translation="MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSS
VPSSTEKNAVSMTSSVLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVP
VTRPALGSTTPPAHDVTSAPDNKPAPGSTAPPAHGVTSAPDTRPPPGSTAPPAHGVTS
APDTRPPPGSTAPAAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALASTAPPVHNV
TSASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASS
THHSTVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDIS
EMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRY
NLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKN
YGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAV
AATSANL"
sig_peptide 58..120
/note="signal peptide (AA -21 to -1)"
mat_peptide 121..1602
/note="transmembrane tumor mucin antigen (AA 1 to 494)"
BASE COUNT 339 a 634 c 395 g 353 t
ORIGIN
1 gaattccctg gctgcttgaa tctgttctgc cccctcccca cccatttcac caccaccatg
61 acaccgggca cccagtctcc tttcttcctg ctgctgctcc tcacagtgct tacagttgtt
121 acaggttctg gtcatgcaag ctctacccca ggtggagaaa aggagacttc ggctacccag
181 agaagttcag tgcccagctc tactgagaag aatgctgtga gtatgaccag cagcgtactc
241 tccagccaca gccccggttc aggctcctcc accactcagg gacaggatgt cactctggcc
301 ccggccacgg aaccagcttc aggttcagct gccacctggg gacaggatgt cacctcggtc
361 ccagtcacca ggccagccct gggctccacc accccgccag cccacgatgt cacctcagcc
421 ccggacaaca agccagcccc gggctccacc gcccccccag cccacggtgt cacctcggcc
481 ccggacacca ggccgccccc gggctccacc gcccccccag cccacggtgt cacctcggcc
541 ccggacacca ggccgccccc gggctccacc gcgcccgcag cccacggtgt cacctcggcc
601 ccggacacca ggccggcccc gggctccacc gcccccccag cccatggtgt cacctcggcc
661 ccggacaaca ggcccgcctt ggcgtccacc gcccctccag tccacaatgt cacctcggcc
721 tcaggctctg catcaggctc agcttctact ctggtgcaca acggcacctc tgccagggct
781 accacaaccc cagccagcaa gagcactcca ttctcaattc ccagccacca ctctgatact
841 cctaccaccc ttgccagcca tagcaccaag actgatgcca gtagcactca ccatagcacg
901 gtacctcctc tcacctcctc caatcacagc acttctcccc agttgtctac tggggtctct
961 ttctttttcc tgtcttttca catttcaaac ctccagttta attcctctct ggaagatccc
1021 agcaccgact actaccaaga gctgcagaga gacatttctg aaatgttttt gcagatttat
1081 aaacaagggg gttttctggg cctctccaat attaagttca ggccaggatc tgtggtggta
1141 caattgactc tggccttccg agaaggtacc atcaatgtcc acgacgtgga gacacagttc
1201 aatcagtata aaacggaagc agcctctcga tataacctga cgatctcaga cgtcagcgtg
1261 agtgatgtgc catttccttt ctctgcccag tctggggctg gggtgccagg ctggggcatc
1321 gcgctgctgg tgctggtctg tgttctggtt gcgctggcca ttgtctatct cattgccttg
1381 gctgtctgtc agtgccgccg aaagaactac gggcagctgg acatctttcc agcccgggat
1441 acctaccatc ctatgagcga gtaccccacc taccacaccc atgggcgcta tgtgccccct
1501 agcagtaccg atcgtagccc ctatgagaag gtttctgcag gtaatggtgg cagcagcctc
1561 tcttacacaa acccagcagt ggcagccact tctgccaact tgtaggggca cgtcgccctc
1621 tgagctgagt ggccagccag tgccattcca ctccactcag ggctctctgg gccagtcctc
1681 ctgggagccc ccaccacaac acttcccagg catggaattc c
//