LOCUS X51602 7680 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human flt mRNA for receptor-related tyrosine kinase.
ACCESSION X51602
VERSION X51602.1
KEYWORDS flt gene; fms-related tyrosine kinase gene; tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7680)
AUTHORS Shibuya M.
JOURNAL Submitted (02-JAN-1989) to the INSDC. Shibuya M., Institute of
Medical Science, University of Tokyo, 4-6-1 Shirokane-dai,
Minato-ku, Tokyo 108, Japan.
REFERENCE 2 (bases 1 to 7680)
AUTHORS Shibuya M., Yamaguchi S., Yamane A., Ikeda T., Tojo A.,
Matsushime H., Sato M.
TITLE Nucleotide sequence and expression of a novel human receptor-type
tyrosine kinase gene (flt) closely related to the fms family
JOURNAL Oncogene 5(4), 519-524(1990).
PUBMED 2158038
REFERENCE 3 (bases 1 to 7680)
AUTHORS Han H.J., Fujiwara T., Shin S., Nakamura Y.
TITLE Dinucleotide repeat polymorphism in the 3' non-coding region of the
FLTI gene
JOURNAL Hum. Mol. Genet. 2(12), 2204-2204(1993).
PUBMED 8111406
COMMENT Data kindly reviewed (20-JUL-1990) by Shibuya M.
FEATURES Location/Qualifiers
source 1..7680
/db_xref="H-InvDB:HIT000321669_03"
/organism="Homo sapiens"
/chromosome="13"
/map="13q12"
/mol_type="mRNA"
/clone="3-7, 3-5"
/tissue_type="placenta"
/db_xref="taxon:9606"
CDS 250..4266
/note="flt gene product (AA 1-1338)"
/db_xref="GOA:P17948"
/db_xref="H-InvDB:HIT000321669_03.4"
/db_xref="HGNC:HGNC:3763"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR001824"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR008266"
/db_xref="InterPro:IPR009135"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR013098"
/db_xref="InterPro:IPR013106"
/db_xref="InterPro:IPR013151"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR020635"
/db_xref="InterPro:IPR036179"
/db_xref="InterPro:IPR041348"
/db_xref="PDB:1FLT"
/db_xref="PDB:1QSV"
/db_xref="PDB:1QSZ"
/db_xref="PDB:1QTY"
/db_xref="PDB:1RV6"
/db_xref="PDB:2XAC"
/db_xref="PDB:3HNG"
/db_xref="PDB:4CKV"
/db_xref="PDB:4CL7"
/db_xref="PDB:5ABD"
/db_xref="PDB:5EX3"
/db_xref="PDB:5T89"
/db_xref="UniProtKB/Swiss-Prot:P17948"
/protein_id="CAA35946.1"
/translation="MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQ
AGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHT
GFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV
TSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT
NYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRA
SVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFI
TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLII
KDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ
ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR
MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM
PTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIM
NVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDC
HANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSV
ESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLLIRKMKRSSSEIKTDYLSII
MDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR
TVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKY
GNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQ
EDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL
SENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVL
LWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPR
FAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFN
SGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTWTD
SKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIAC
CSPPPDYNSVVLYSTPPI"
BASE COUNT 2279 a 1661 c 1739 g 2001 t
ORIGIN
1 gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgg gctccggggc
61 tcgggtgcag cggccagcgg gcctggcggc gaggattacc cggggaagtg gttgtctcct
121 ggctggagcc gcgagacggg cgctcagggc gcggggccgg cggcggcgaa cgagaggacg
181 gactctggcg gccgggtcgt tggccggggg agcgcgggca ccgggcgagc aggccgcgtc
241 gcgctcacca tggtcagcta ctgggacacc ggggtcctgc tgtgcgcgct gctcagctgt
301 ctgcttctca caggatctag ttcaggttca aaattaaaag atcctgaact gagtttaaaa
361 ggcacccagc acatcatgca agcaggccag acactgcatc tccaatgcag gggggaagca
421 gcccataaat ggtctttgcc tgaaatggtg agtaaggaaa gcgaaaggct gagcataact
481 aaatctgcct gtggaagaaa tggcaaacaa ttctgcagta ctttaacctt gaacacagct
541 caagcaaacc acactggctt ctacagctgc aaatatctag ctgtacctac ttcaaagaag
601 aaggaaacag aatctgcaat ctatatattt attagtgata caggtagacc tttcgtagag
661 atgtacagtg aaatccccga aattatacac atgactgaag gaagggagct cgtcattccc
721 tgccgggtta cgtcacctaa catcactgtt actttaaaaa agtttccact tgacactttg
781 atccctgatg gaaaacgcat aatctgggac agtagaaagg gcttcatcat atcaaatgca
841 acgtacaaag aaatagggct tctgacctgt gaagcaacag tcaatgggca tttgtataag
901 acaaactatc tcacacatcg acaaaccaat acaatcatag atgtccaaat aagcacacca
961 cgcccagtca aattacttag aggccatact cttgtcctca attgtactgc taccactccc
1021 ttgaacacga gagttcaaat gacctggagt taccctgatg aaaaaaataa gagagcttcc
1081 gtaaggcgac gaattgacca aagcaattcc catgccaaca tattctacag tgttcttact
1141 attgacaaaa tgcagaacaa agacaaagga ctttatactt gtcgtgtaag gagtggacca
1201 tcattcaaat ctgttaacac ctcagtgcat atatatgata aagcattcat cactgtgaaa
1261 catcgaaaac agcaggtgct tgaaaccgta gctggcaagc ggtcttaccg gctctctatg
1321 aaagtgaagg catttccctc gccggaagtt gtatggttaa aagatgggtt acctgcgact
1381 gagaaatctg ctcgctattt gactcgtggc tactcgttaa ttatcaagga cgtaactgaa
1441 gaggatgcag ggaattatac aatcttgctg agcataaaac agtcaaatgt gtttaaaaac
1501 ctcactgcca ctctaattgt caatgtgaaa ccccagattt acgaaaaggc cgtgtcatcg
1561 tttccagacc cggctctcta cccactgggc agcagacaaa tcctgacttg taccgcatat
1621 ggtatccctc aacctacaat caagtggttc tggcacccct gtaaccataa tcattccgaa
1681 gcaaggtgtg acttttgttc caataatgaa gagtccttta tcctggatgc tgacagcaac
1741 atgggaaaca gaattgagag catcactcag cgcatggcaa taatagaagg aaagaataag
1801 atggctagca ccttggttgt ggctgactct agaatttctg gaatctacat ttgcatagct
1861 tccaataaag ttgggactgt gggaagaaac ataagctttt atatcacaga tgtgccaaat
1921 gggtttcatg ttaacttgga aaaaatgccg acggaaggag aggacctgaa actgtcttgc
1981 acagttaaca agttcttata cagagacgtt acttggattt tactgcggac agttaataac
2041 agaacaatgc actacagtat tagcaagcaa aaaatggcca tcactaagga gcactccatc
2101 actcttaatc ttaccatcat gaatgtttcc ctgcaagatt caggcaccta tgcctgcaga
2161 gccaggaatg tatacacagg ggaagaaatc ctccagaaga aagaaattac aatcagagat
2221 caggaagcac catacctcct gcgaaacctc agtgatcaca cagtggccat cagcagttcc
2281 accactttag actgtcatgc taatggtgtc cccgagcctc agatcacttg gtttaaaaac
2341 aaccacaaaa tacaacaaga gcctggaatt attttaggac caggaagcag cacgctgttt
2401 attgaaagag tcacagaaga ggatgaaggt gtctatcact gcaaagccac caaccagaag
2461 ggctctgtgg aaagttcagc atacctcact gttcaaggaa cctcggacaa gtctaatctg
2521 gagctgatca ctctaacatg cacctgtgtg gctgcgactc tcttctggct cctattaacc
2581 ctccttatcc gaaaaatgaa aaggtcttct tctgaaataa agactgacta cctatcaatt
2641 ataatggacc cagatgaagt tcctttggat gagcagtgtg agcggctccc ttatgatgcc
2701 agcaagtggg agtttgcccg ggagagactt aaactgggca aatcacttgg aagaggggct
2761 tttggaaaag tggttcaagc atcagcattt ggcattaaga aatcacctac gtgccggact
2821 gtggctgtga aaatgctgaa agagggggcc acggccagcg agtacaaagc tctgatgact
2881 gagctaaaaa tcttgaccca cattggccac catctgaacg tggttaacct gctgggagcc
2941 tgcaccaagc aaggagggcc tctgatggtg attgttgaat actgcaaata tggaaatctc
3001 tccaactacc tcaagagcaa acgtgactta ttttttctca acaaggatgc agcactacac
3061 atggagccta agaaagaaaa aatggagcca ggcctggaac aaggcaagaa accaagacta
3121 gatagcgtca ccagcagcga aagctttgcg agctccggct ttcaggaaga taaaagtctg
3181 agtgatgttg aggaagagga ggattctgac ggtttctaca aggagcccat cactatggaa
3241 gatctgattt cttacagttt tcaagtggcc agaggcatgg agttcctgtc ttccagaaag
3301 tgcattcatc gggacctggc agcgagaaac attcttttat ctgagaacaa cgtggtgaag
3361 atttgtgatt ttggccttgc ccgggatatt tataagaacc ccgattatgt gagaaaagga
3421 gatactcgac ttcctctgaa atggatggct cccgaatcta tctttgacaa aatctacagc
3481 accaagagcg acgtgtggtc ttacggagta ttgctgtggg aaatcttctc cttaggtggg
3541 tctccatacc caggagtaca aatggatgag gacttttgca gtcgcctgag ggaaggcatg
3601 aggatgagag ctcctgagta ctctactcct gaaatctatc agatcatgct ggactgctgg
3661 cacagagacc caaaagaaag gccaagattt gcagaacttg tggaaaaact aggtgatttg
3721 cttcaagcaa atgtacaaca ggatggtaaa gactacatcc caatcaatgc catactgaca
3781 ggaaatagtg ggtttacata ctcaactcct gccttctctg aggacttctt caaggaaagt
3841 atttcagctc cgaagtttaa ttcaggaagc tctgatgatg tcagatatgt aaatgctttc
3901 aagttcatga gcctggaaag aatcaaaacc tttgaagaac ttttaccgaa tgccacctcc
3961 atgtttgatg actaccaggg cgacagcagc actctgttgg cctctcccat gctgaagcgc
4021 ttcacctgga ctgacagcaa acccaaggcc tcgctcaaga ttgacttgag agtaaccagt
4081 aaaagtaagg agtcggggct gtctgatgtc agcaggccca gtttctgcca ttccagctgt
4141 gggcacgtca gcgaaggcaa gcgcaggttc acctacgacc acgctgagct ggaaaggaaa
4201 atcgcgtgct gctccccgcc cccagactac aactcggtgg tcctgtactc caccccaccc
4261 atctagagtt tgacacgaag ccttatttct agaagcacat gtgtatttat acccccagga
4321 aactagcttt tgccagtatt atgcatatat aagtttacac ctttatcttt ccatgggagc
4381 cagctgcttt ttgtgatttt tttaatagtg cttttttttt ttgactaaca agaatgtaac
4441 tccagataga gaaatagtga caagtgaaga acactactgc taaatcctca tgttactcag
4501 tgttagagaa atccttccta aacccaatga cttccctgct ccaacccccg ccacctcagg
4561 gcacgcagga ccagtttgat tgaggagctg cactgatcac ccaatgcatc acgtacccca
4621 ctgggccagc cctgcagccc aaaacccagg gcaacaagcc cgttagcccc aggggatcac
4681 tggctggcct gagcaacatc tcgggagtcc tctagcaggc ctaagacatg tgaggaggaa
4741 aaggaaaaaa agcaaaaagc aagggagaaa agagaaaccg ggagaaggca tgagaaagaa
4801 tttgagacgc accatgtggg cacggagggg gacggggctc agcaatgcca tttcagtggc
4861 ttcccagctc tgacccttct acatttgagg gcccagccag gagcagatgg acagcgatga
4921 ggggacattt tctggattct gggaggcaag aaaaggacaa atatcttttt tggaactaaa
4981 gcaaatttta gacctttacc tatggaagtg gttctatgtc cattctcatt cgtggcatgt
5041 tttgatttgt agcactgagg gtggcactca actctgagcc catacttttg gctcctctag
5101 taagatgcac tgaaaactta gccagagtta ggttgtctcc aggccatgat ggccttacac
5161 tgaaaatgtc acattctatt ttgggtatta atatatagtc cagacactta actcaatttc
5221 ttggtattat tctgttttgc acagttagtt gtgaaagaaa gctgagaaga atgaaaatgc
5281 agtcctgagg agagttttct ccatatcaaa acgagggctg atggaggaaa aaggtcaata
5341 aggtcaaggg aagaccccgt ctctatacca accaaaccaa ttcaccaaca cagttgggac
5401 ccaaaacaca ggaagtcagt cacgtttcct tttcatttaa tggggattcc actatctcac
5461 actaatctga aaggatgtgg aagagcatta gctggcgcat attaagcact ttaagctcct
5521 tgagtaaaaa ggtggtatgt aatttatgca aggtatttct ccagttggga ctcaggatat
5581 tagttaatga gccatcacta gaagaaaagc ccattttcaa ctgctttgaa acttgcctgg
5641 ggtctgagca tgatgggaat agggagacag ggtaggaaag ggcgcctact cttcagggtc
5701 taaagatcaa gtgggccttg gatcgctaag ctggctctgt ttgatgctat ttatgcaagt
5761 tagggtctat gtatttagga tgcgcctact cttcagggtc taaagatcaa gtgggccttg
5821 gatcgctaag ctggctctgt ttgatgctat ttatgcaagt tagggtctat gtatttagga
5881 tgtctgcacc ttctgcagcc agtcagaagc tggagaggca acagtggatt gctgcttctt
5941 ggggagaaga gtatgcttcc ttttatccat gtaatttaac tgtagaacct gagctctaag
6001 taaccgaaga atgtatgcct ctgttcttat gtgccacatc cttgtttaaa ggctctctgt
6061 atgaagagat gggaccgtca tcagcacatt ccctagtgag cctactggct cctggcagcg
6121 gcttttgtgg aagactcact agccagaaga gaggagtggg acagtcctct ccaccaagat
6181 ctaaatccaa acaaaagcag gctagagcca gaagagagga caaatctttg ttgttcctct
6241 tctttacaca tacgcaaacc acctgtgaca gctggcaatt ttataaatca ggtaactgga
6301 aggaggttaa actcagaaaa aagaagacct cagtcaattc tctacttttt tttttttttt
6361 tccaaatcag ataatagccc agcaaatagt gataacaaat aaaaccttag ctgttcatgt
6421 cttgatttca ataattaatt cttaatcatt aagagaccat aataaatact ccttttcaag
6481 agaaaagcaa aaccattaga attgttactc agctccttca aactcaggtt tgtagcatac
6541 atgagtccat ccatcagtca aagaatggtt ccatctggag tcttaatgta gaaagaaaaa
6601 tggagacttg taataatgag ctagttacaa agtgcttgtt cattaaaata gcactgaaaa
6661 ttgaaacatg aattaactga taatattcca atcatttgcc atttatgaca aaaatggttg
6721 gcactaacaa agaacgagca cttcctttca gagtttctga gataatgtac gtggaacagt
6781 ctgggtggaa tggggctgaa accatgtgca agtctgtgtc ttgtcagtcc aagaagtgac
6841 accgagatgt taattttagg gacccgtgcc ttgtttccta gcccacaaga atgcaaacat
6901 caaacagata ctcgctagcc tcatttaaat tgattaaagg aggagtgcat ctttggccga
6961 cagtggtgta actgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgggtgtg
7021 ggtgtatgtg tgttttgtgc ataactattt aaggaaactg gaattttaaa gttactttta
7081 tacaaaccaa gaatatatgc tacagatata agacagacat ggtttggtcc tatatttcta
7141 gtcatgatga atgtattttg tataccatct tcatataata tacttaaaaa tatttcttaa
7201 ttgggatttg taatcgtacc aacttaattg ataaacttgg caactgcttt tatgttctgt
7261 ctccttccat aaatttttca aaatactaat tcaacaaaga aaaagctctt ttttttccta
7321 aaataaactc aaatttatcc ttgtttagag cagagaaaaa ttaagaaaaa ctttgaaatg
7381 gtctcaaaaa attgctaaat attttcaatg gaaaactaaa tgttagttta gctgattgta
7441 tggggttttc gaacctttca ctttttgttt gttttaccta tttcacaact gtgtaaattg
7501 ccaataattc ctgtccatga aaatgcaaat tatccagtgt agatatattt gaccatcacc
7561 ctatggatat tggctagttt tgcctttatt aagcaaattc atttcagcct gaatgtctgc
7621 ctatatattc tctgctcttt gtattctcct ttgaacccgt taaaacatcc tgtggcactc
//