LOCUS X51405 2443 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for carboxypeptidase E (EC 3.4.17.10).
ACCESSION X51405
VERSION X51405.1
KEYWORDS carboxypeptidase E; carboxypeptidase H; enkephalin convertase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2443)
AUTHORS Hall C.
JOURNAL Submitted (19-JAN-1990) to the INSDC. Hall C., Institute of
Neurology, Department of Neurochemistry, 1 Wakefield Street, London
WC1 N1PJ, UK.
REFERENCE 2 (bases 1 to 2443)
AUTHORS Manser E., Fernandez D., Loo L., Goh P.Y., Monfries C., Hall C.,
Lim L.
TITLE Human carboxypeptidase E. Isolation and characterization of the
cDNA, sequence conservation, expression and processing in vitro
JOURNAL Biochem. J. 267(2), 517-525(1990).
PUBMED 2334405
COMMENT For Rat cDNA for carboxypetidase E see <X51406>.
FEATURES Location/Qualifiers
source 1..2443
/db_xref="H-InvDB:HIT000321643"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="human retina cDNA"
/clone="P1622"
/tissue_type="brain"
/db_xref="taxon:9606"
CDS 291..1721
/note="pre-pro polypeptide (AA -25 to 451)"
/db_xref="GOA:P16870"
/db_xref="H-InvDB:HIT000321643.14"
/db_xref="HGNC:HGNC:2303"
/db_xref="InterPro:IPR000834"
/db_xref="InterPro:IPR008969"
/db_xref="InterPro:IPR034232"
/db_xref="UniProtKB/Swiss-Prot:P16870"
/protein_id="CAA35767.1"
/translation="MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQ
QEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEP
GEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPD
GFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKI
VDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDA
IFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSS
NCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANAT
ISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELE
SFSERKEEEKEELMEWWKMMSETLNF"
sig_peptide 291..365
/note="signal peptide (AA -25 to -1)"
misc_feature 366..1718
/note="pro-peptide (AA 1-451)"
mat_peptide 414..1718
/note="mature carboxypeptidase E (AA 17-451)"
BASE COUNT 658 a 538 c 618 g 629 t
ORIGIN
1 aaatggcgtg cccgtctctc cgccggcccc ctgcctcgca gtggtttctc ctgcagctcc
61 cctgggctcc gcggccagta gtgcagcccg tggagccgcg gctttgcccg tctcctctgg
121 gtggccccag tgcgcgggct gacactcatt cagccgggga aggtgaggcg agtagaggct
181 ggtgcggaac ttgccgcccc cagcagcgcc ggcgggctaa gcccagggcc gggcagacaa
241 aagaggccgc ccgcgtagga aggcacggcc ggcggcggcg gagcgcagcg atggccgggc
301 gagggggcag cgcgctgctg gctctgtgcg gggcactggc tgcctgcggg tggctcctgg
361 gcgccgaagc ccaggagccc ggggcgcccg cggcgggcat gaggcggcgc cggcggctgc
421 agcaagagga cggcatctcc ttcgagtacc accgctaccc cgagctgcgc gaggcgctcg
481 tgtccgtgtg gctgcagtgc accgccatca gcaggattta cacggtgggg cgcagcttcg
541 agggccggga gctcctggtc atcgagctgt ccgacaaccc tggcgtccat gagcctggtg
601 agcctgaatt taaatacatt gggaatatgc atgggaatga ggctgttgga cgagaactgc
661 tcattttctt ggcccagtac ctatgcaacg aataccagaa ggggaacgag acaattgtca
721 acctgatcca cagtacccgc attcacatca tgccttccct gaacccagat ggctttgaga
781 aggcagcgtc tcagcctggt gaactcaagg actggtttgt gggtcgaagc aatgcccagg
841 gaatagatct gaaccggaac tttccagacc tggataggat agtgtacgtg aatgagaaag
901 aaggtggtcc aaataatcat ctgttgaaaa atatgaagaa aattgtggat caaaacacaa
961 agcttgctcc tgagaccaag gctgtcattc attggattat ggatattcct tttgtgcttt
1021 ctgccaatct ccatggagga gaccttgtgg ccaattatcc atatgatgag acgcggagtg
1081 gtagtgctca cgaatacagc tcctccccag atgacgccat tttccaaagc ttggcccggg
1141 catactcttc tttcaacccg gccatgtctg accccaatcg gccaccatgt cgcaagaatg
1201 atgatgacag cagctttgta gatggaacca ccaacggtgg tgcttggtac agcgtacctg
1261 gagggatgca agacttcaat taccttagca gcaactgttt tgagatcacc gtggagctta
1321 gctgtgagaa gttcccacct gaagagactc tgaagaccta ctgggaggat aacaaaaact
1381 ccctcattag ctaccttgag cagatacacc gaggagttaa aggatttgtc cgagaccttc
1441 aaggtaaccc aattgcgaat gccaccatct ccgtggaagg aatagaccac gatgttacat
1501 ccgcaaagga tggtgattac tggagattgc ttatacctgg aaactataaa cttacagcct
1561 cagctccagg ctatctggca ataacaaaga aagtggcagt tccttacagc cctgctgctg
1621 gggttgattt tgaactggag tcattttctg aaaggaaaga agaggagaag gaagaattga
1681 tggaatggtg gaaaatgatg tcagaaactt taaattttta aaaaggcttc tagttagctg
1741 ctttaaatct atctatataa tgtagtatga tgtaatgtgg tctttttttt agattttgtg
1801 cagttaatac ttaacattga tttatttttt aatcatttaa atattaatca actttcctta
1861 aaataaatag cctcttaggt aaaaatataa gaacttgata tatttcattc tcttatatag
1921 tattcatttt cctacctata ttacacaaaa aagtatagaa aagatttaag taattttgcc
1981 atcctaggct taaatgcaat attcctggta ttatttacaa tgcagaattt tttgagtaat
2041 tctagctttc aaaaattagt gaagttcttt tactgtaatt ggtgacaatg tcacataatg
2101 aatgctattg aaaaggttaa cagatacagc tcggagttgt gagcactcta ctgcaagact
2161 taaatagttc agtataaatt gtcgtttttt tcttgtgctg actaactata agcatgatct
2221 tgttaatgca tttttgatgg gaagaaaagg tacatgttta caaagaggtt ttatgaaaag
2281 aataaaaatt gacttcttgc ttgtacatat aggagcaata ctattatatt atgtagtccg
2341 ttaacactac ttaaaagttt agggttttct cttggttgta gagtggccca gaattgcatt
2401 ctgaatgaat aaaggttaaa aaaaaatccc cagtgaaaaa aaa
//