LOCUS X17648 1807 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for granulocyte-macrophage colony-stimulating factor
receptor (hGM-CSF-R).
ACCESSION X17648
VERSION X17648.1
KEYWORDS differation factor receptor; granulocyte-macrophage colony
stimulating factor receptor; growth factor receptor; transmembrane
glycoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1807)
AUTHORS Gearing D.P., King J.A., Gough N.M., Nicola N.A.
TITLE Expression cloning of a receptor for human granulocyte-macrophage
colony-stimulating factor
JOURNAL EMBO J. 8(12), 3667-3676(1989).
PUBMED 2555171
COMMENT Data kindly reviewed (20-FEB-1990) by Gearing D.P.
FEATURES Location/Qualifiers
source 1..1807
/db_xref="H-InvDB:HIT000321625_03"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="pi H3M"
/clone="pGMR138 and pGMR29"
/tissue_type="placenta"
/db_xref="taxon:9606"
CDS 25..93
/note="unidentified ORF (22 AA)"
/db_xref="H-InvDB:HIT000321625_02.6"
/db_xref="UniProtKB/TrEMBL:A2NV12"
/protein_id="CAA35637.1"
/translation="MPWGLQQENPWRQQIREAAMFA"
CDS 150..1352
/note="precursor protein (AA -22 to 378)"
/db_xref="GOA:P15509"
/db_xref="HGNC:HGNC:2435"
/db_xref="InterPro:IPR003532"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR015321"
/db_xref="InterPro:IPR036116"
/db_xref="InterPro:IPR040907"
/db_xref="PDB:4NKQ"
/db_xref="PDB:4RS1"
/db_xref="UniProtKB/Swiss-Prot:P15509"
/protein_id="CAA35638.1"
/translation="MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRT
MNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQ
RGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRR
REIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERF
NPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGD
LENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVG
TLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREE
VLTVKEIT"
sig_peptide 150..215
/note="signal peptide (AA -22 to -1)"
mat_peptide 216..1349
/note="mature granulocyte-macrophage colony-stimulating
factor receptor (AA 1-378)"
misc_feature 1776..1781
/note="pot. polyadenylation signal"
misc_feature 1783..1788
/note="pot. polyadenylation signal"
polyA_site 1807..1807
/note="polyadenylation site"
BASE COUNT 499 a 437 c 453 g 418 t
ORIGIN
1 agcaggtgga aggagaggaa gcggatgccg tggggtttac agcaggaaaa tccgtggaga
61 cagcagatcc gagaagcggc gatgtttgcg tagaaccctg tacgtgcttc cttcggcctg
121 tcgctcttcc cttctctctg accagcacca tgcttctcct ggtgacaagc cttctgctct
181 gtgagttacc acacccagca ttcctcctga tcccagagaa atcggatctg cgaacagtgg
241 caccagcctc tagtctcaat gtgaggtttg actccaggac gatgaattta agctgggact
301 gccaagaaaa cacaaccttc agcaagtgtt tcttaactga caagaagaac agagtcgtgg
361 aacccaggct cagtaacaac gaatgttcgt gcacatttcg tgaaatttgt ctgcatgaag
421 gagtcacatt tgaggttcac gtgaatacta gtcaaagagg atttcaacag aaactgcttt
481 atccaaattc aggaagggag ggtaccgctg ctcagaattt ctcctgtttc atctacaatg
541 cggatttaat gaactgtacc tgggcgaggg gtccgacggc cccccgtgac gtccagtatt
601 ttttgtacat acgaaactca aagagaagga gggagatccg gtgtccttat tacatacaag
661 actcaggaac ccatgtggga tgtcacctgg ataacctgtc aggattaacg tctcgcaatt
721 actttctggt taacggaacc agccgagaaa ttggcatcca attctttgat tcacttttgg
781 acacaaagaa aatagaacga ttcaaccctc ccagcaatgt caccgtacgt tgcaacacga
841 cgcactgcct cgtacggtgg aaacagccca ggacctatca gaagctgtcg tacctggact
901 ttcagtacca gctggacgtc cacagaaaga atacccagcc tggcacggaa aacctactga
961 ttaatgtttc tggtgatttg gaaaatagat acaactttcc aagctctgag cccagagcaa
1021 aacacagtgt gaagatcaga gctgcagacg tccgcatctt gaattggagc tcctggagtg
1081 aagccattga atttggttct gacgacggga acctcggctc tgtgtacatt tatgtgctcc
1141 taatcgtggg aacccttgtc tgtggcatcg tcctcggctt cctctttaaa aggttcctta
1201 ggatacagcg gctgttcccg ccagttccac agatcaaaga caaactgaat gataaccatg
1261 aggtggaaga cgagatcatc tgggaggaat tcaccccaga ggaagggaaa ggctaccgcg
1321 aagaggtctt gaccgtgaag gaaattacct gagacccaga gggtgtagga atggcatgga
1381 catctccgcc tccgcgacac gggggaactg ttttcttgat gatgctgtga acctttatat
1441 cattttctat gtttttattt aaaaacatga catttggggc caggcgcggt ggctcacgcc
1501 tgtaatccca gcactttggg aggccaaggc aggcggatca cctgaggtca ggagttcaag
1561 accagcctgc ccaacatggt gaaaccccat ctggactaaa aatgcagaaa tttacccagg
1621 cacggcggcg gacgcccatc atcccagcta cttgggaggc tgaggcagga gaattgcttg
1681 aacccgtgag gcggaggttg tagtgagcca agatcgcacc attgcacacc aacctgcgtg
1741 acagagcaag attgcatctc aaaacaaaca ataataataa ataataaaaa cctgatattt
1801 ggctggg
//