LOCUS X17094 4180 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human fur mRNA for furin.
ACCESSION X17094
VERSION X17094.1
KEYWORDS fur gene; furin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4180)
AUTHORS Van den Ouweland A.M.W.
JOURNAL Submitted (07-NOV-1989) to the INSDC. Van den Ouweland A.M.W.,
University of Nijmegeen, Molecular Oncology Section, Department of
Biochemistry, St. Adelbertusplein 1, 6500 HB Nijmegen, The
Netherlands.
REFERENCE 2 (bases 1 to 4180)
AUTHORS Van den Ouweland A.M.W., Van Duijnhoven H.L.P., Keizer G.D.,
Dorssers L.C.J., Van de Ven W.J.M.
TITLE Structural homology between the human fur gene product and the
subtilisin-like protease encoded by yeast KEX2
JOURNAL Nucleic Acids Res. 18(3), 664-664(1990).
PUBMED 2408021
COMMENT See <X15723> for furin gene;
See also <X04329> for furin C' terminus mRNA.
Data kindly reviewed (22-MAR-1990) by Ouweland A.v.d.
FEATURES Location/Qualifiers
source 1..4180
/db_xref="H-InvDB:HIT000321598"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/cell_line="KG-1, ML-1, MCF-7"
/cell_type="blood cell"
/db_xref="taxon:9606"
CDS 217..2601
/note="furin (AA 1-794)"
/db_xref="GOA:P09958"
/db_xref="H-InvDB:HIT000321598.14"
/db_xref="HGNC:HGNC:8568"
/db_xref="InterPro:IPR000209"
/db_xref="InterPro:IPR002884"
/db_xref="InterPro:IPR006212"
/db_xref="InterPro:IPR008979"
/db_xref="InterPro:IPR009030"
/db_xref="InterPro:IPR015500"
/db_xref="InterPro:IPR022398"
/db_xref="InterPro:IPR023827"
/db_xref="InterPro:IPR023828"
/db_xref="InterPro:IPR032815"
/db_xref="InterPro:IPR034182"
/db_xref="InterPro:IPR036852"
/db_xref="InterPro:IPR038466"
/db_xref="PDB:4OMC"
/db_xref="PDB:4OMD"
/db_xref="PDB:4RYD"
/db_xref="PDB:4Z2A"
/db_xref="PDB:5JMO"
/db_xref="PDB:5JXG"
/db_xref="PDB:5JXH"
/db_xref="PDB:5JXI"
/db_xref="PDB:5JXJ"
/db_xref="PDB:5MIM"
/db_xref="PDB:6A8Y"
/db_xref="PDB:6EQV"
/db_xref="PDB:6EQW"
/db_xref="PDB:6EQX"
/db_xref="PDB:6HLB"
/db_xref="PDB:6HLD"
/db_xref="PDB:6HLE"
/db_xref="PDB:6HZA"
/db_xref="PDB:6HZB"
/db_xref="PDB:6HZC"
/db_xref="PDB:6HZD"
/db_xref="UniProtKB/Swiss-Prot:P09958"
/protein_id="CAA34948.1"
/translation="MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAV
ANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAK
RRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNH
PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYN
ARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFR
GVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACS
STLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRD
MQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC
IIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKF
TLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLD
THYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSS
RESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRS
GFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL"
BASE COUNT 794 a 1335 c 1255 g 796 t
ORIGIN
1 gcggggaagc agcagcggcc aggatgaatc ccaggtgctc tggagctgga tggtgaaggt
61 cggcactctt caccctcccg agccctgccc gtctcggccc catgccccca ccagtcagcc
121 ccgggccaca ggcagtgagc aggcacctgg gagccgaggc cctatgacca ggccaaggag
181 acgggcgctc cagggtccca gccacctgtc ccccccatgg agctgaggcc ctggttgcta
241 tgggtggtag cagcaacagg aaccttggtc ctgctagcag ctgatgctca gggccagaag
301 gtcttcacca acacgtgggc tgtgcgcatc cctggaggcc cagcggtggc caacagtgtg
361 gcacggaagc atgggttcct caacctgggc cagatcttcg gggactatta ccacttctgg
421 catcgaggag tgacgaagcg gtccctgtcg cctcaccgcc cgcggcacag ccggctgcag
481 agggagcctc aagtacagtg gctggaacag caggtggcaa agcgacggac taaacgggac
541 gtgtaccagg agcccacaga ccccaagttt cctcagcagt ggtacctgtc tggtgtcact
601 cagcgggacc tgaatgtgaa ggcggcctgg gcgcagggct acacagggca cggcattgtg
661 gtctccattc tggacgatgg catcgagaag aaccacccgg acttggcagg caattatgat
721 cctggggcca gttttgatgt caatgaccag gaccctgacc cccagcctcg gtacacacag
781 atgaatgaca acaggcacgg cacacggtgt gcgggggaag tggctgcggt ggccaacaac
841 ggtgtctgtg gtgtaggtgt ggcctacaac gcccgcattg gaggggtgcg catgctggat
901 ggcgaggtga cagatgcagt ggaggcacgc tcgctgggcc tgaaccccaa ccacatccac
961 atctacagtg ccagctgggg ccccgaggat gacggcaaga cagtggatgg gccagcccgc
1021 ctcgccgagg aggccttctt ccgtggggtt agccagggcc gaggggggct gggctccatc
1081 tttgtctggg cctcggggaa cgggggccgg gaacatgaca gctgcaactg cgacggctac
1141 accaacagta tctacacgct gtccatcagc agcgccacgc agtttggcaa cgtgccgtgg
1201 tacagcgagg cctgctcgtc cacactggcc acgacctaca gcagtggcaa ccagaatgag
1261 aagcagatcg tgacgactga cttgcggcag aagtgcacgg agtctcacac gggcacctca
1321 gcctctgccc ccttagcagc cggcatcatt gctctcaccc tggaggccaa taagaacctc
1381 acatggcggg acatgcaaca cctggtggta cagacctcga agccagccca cctcaatgcc
1441 aacgactggg ccaccaatgg tgtgggccgg aaagtgagcc actcatatgg ctacgggctt
1501 ttggacgcag gcgccatggt ggccctggcc cagaattgga ccacagtggc cccccagcgg
1561 aagtgcatca tcgacatcct caccgagccc aaagacatcg ggaaacggct cgaggtgcgg
1621 aagaccgtga ccgcgtgcct gggcgagccc aaccacatca ctcggctgga gcacgctcag
1681 gcgcggctca ccctgtccta taatcgccgt ggcgacctgg ccatccacct ggtcagcccc
1741 atgggcaccc gctccaccct gctggcagcc aggccacatg actactccgc agatgggttt
1801 aatgactggg ccttcatgac aactcattcc tgggatgagg atccctctgg cgagtgggtc
1861 ctagagattg aaaacaccag cgaagccaac aactatggga cgctgaccaa gttcaccctc
1921 gtactctatg gcaccgcccc tgaggggctg cccgtacctc cagaaagcag tggctgcaag
1981 accctcacgt ccagtcaggc ctgtgtggtg tgcgaggaag gcttctccct gcaccagaag
2041 agctgtgtcc agcactgccc tccaggcttc gccccccaag tcctcgatac gcactatagc
2101 accgagaatg acgtggagac catccgggcc agcgtctgcg ccccctgcca cgcctcatgt
2161 gccacatgcc aggggccggc cctgacagac tgcctcagct gccccagcca cgcctccttg
2221 gaccctgtgg agcagacttg ctcccggcaa agccagagca gccgagagtc cccgccacag
2281 cagcagccac ctcggctgcc cccggaggtg gaggcggggc aacggctgcg ggcagggctg
2341 ctgccctcac acctgcctga ggtggtggcc ggcctcagct gcgccttcat cgtgctggtc
2401 ttcgtcactg tcttcctggt cctgcagctg cgctctggct ttagttttcg gggggtgaag
2461 gtgtacacca tggaccgtgg cctcatctcc tacaaggggc tgccccctga agcctggcag
2521 gaggagtgcc cgtctgactc agaagaggac gagggccggg gcgagaggac cgcctttatc
2581 aaagaccaga gcgccctctg atgagcccac tgcccacccc ctcaagccaa tcccctcctt
2641 gggcactttt taattcacca aagtattttt ttatcttggg actgggtttg gaccccagct
2701 gggaggcaag aggggtggag actgtttccc atcctaccct cgggcccacc tggccacctg
2761 aggtgggccc aggaccagct ggggcgtggg gagggccgta ccccaccctc agcacccctt
2821 ccatgtggag aaaggagtga aacctttagg gcagcttgcc ccggccccgg ccccagccag
2881 agttcctgcg gagtgaagag gggcagccct tgcttgttgg gattcctgac ccaggccgca
2941 gctcttgccc ttccctgtcc ctctaaagca ataatggtcc catccaggca gtcgggggct
3001 ggcctaggag atatctgagg gaggaggcca cctctccaag ggcttctgca ccctccaccc
3061 tgtcccccag ctctggtgag tcttggcggc agcagccatc ataggaaggg accaaggcaa
3121 ggcaggtgcc tccaggtgtg cacgtggcat gtggcctgtg gcctgtgtcc catgacccac
3181 ccctgtgctc cgtgcctcca ccaccactgg ccaccaggct ggcgcagcca aggccgaagc
3241 tctggctgaa ccctgtgctg gtgtcctgac caccctcccc tctcttgcac ccgcctctcc
3301 cgtcagggcc caagtccctg ttttctgagc ccgggctgcc tgggctgttg gcactcacag
3361 acctggagcc cctgggtggg tggtggggag gggcgctggc ccagccggcc tctctggcct
3421 cccacccgat gctgctttcc cctgtgggga tctcaggggc tgtttgagga tatattttca
3481 ctttgtgatt atttcacttt agatgctgat gatttgtttt tgtattttta atgggggtag
3541 cagctggact acccacgttc tcacacccac cgtccgccct gctcctccct ggctgccctg
3601 gccctgaggt gtgggggctg cagcatgttg ctgaggagtg aggaatagtt gagccccaag
3661 tcctgaagag gcgggccagc caggcgggct caaggaaagg gggtcccagt gggaggggca
3721 ggctgacatc tgtgtttcaa gtggggctcg ccatgccggg ggttcatagg tcactggctc
3781 tccaagtgcc agaggtgggc aggtggtggc actgagcccc cccaacactg tgccctggtg
3841 gagaaagcac tgacctgtca tgcccccctc aaacctcctc ttctgacgtg ccttttgcac
3901 ccctcccatt aggacaatca gtcccctccc atctgggagt ccccttttct tttctaccct
3961 agccattcct ggtacccagc catctgccca ggggtgcccc ctcctctccc atccccctgc
4021 cctcgtggcc agcccggctg gttttgtaag atactgggtt ggtgcacagt gatttttttc
4081 ttgtaattta aacaggccca gcattgctgg ttctatttaa tggacatgag ataatgttag
4141 aggttttaaa gtgattaaac gtgcagacta tgcaaaccag
//