LOCUS X17033 5373 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human mRNA for integrin alpha-2 subunit.
ACCESSION X17033 M28249
VERSION X17033.1
KEYWORDS collagen receptor; integrin; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5373)
AUTHORS Takada Y., Hemler M.E.
JOURNAL Submitted (22-SEP-1989) to the INSDC. Takada Y., Hemler M.E.,
Hemler M.E., Dana-Farber Cancer Institute, Mayer 613, 44 Binney,
Street, Boston, MA 02115, USA.
REFERENCE 2 (bases 1 to 5373)
AUTHORS Takada Y., Hemler M.E.
TITLE The primary structure of the VLA-2/collagen receptor alpha 2
subunit (platelet GPIa): homology to other integrins and the
presence of a possible collagen-binding domain
JOURNAL J. Cell Biol. 109(1), 397-407(1989).
PUBMED 2545729
FEATURES Location/Qualifiers
source 1..5373
/db_xref="H-InvDB:HIT000321595"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="2.72"
/cell_type="endothelial cell"
/db_xref="taxon:9606"
CDS 49..3594
/note="integrin alpha-2 preprotein (AA -29 to 1152)"
/db_xref="GOA:P17301"
/db_xref="H-InvDB:HIT000321595.15"
/db_xref="HGNC:HGNC:6137"
/db_xref="InterPro:IPR000413"
/db_xref="InterPro:IPR002035"
/db_xref="InterPro:IPR013517"
/db_xref="InterPro:IPR013519"
/db_xref="InterPro:IPR013649"
/db_xref="InterPro:IPR018184"
/db_xref="InterPro:IPR028994"
/db_xref="InterPro:IPR032695"
/db_xref="InterPro:IPR036465"
/db_xref="PDB:1AOX"
/db_xref="PDB:1DZI"
/db_xref="PDB:1PQB"
/db_xref="PDB:1V7P"
/db_xref="PDB:4BJ3"
/db_xref="PDB:5HJ2"
/db_xref="PDB:5THP"
/db_xref="PDB:6ND8"
/db_xref="PDB:6ND9"
/db_xref="PDB:6NDA"
/db_xref="PDB:6NDB"
/db_xref="PDB:6NDC"
/db_xref="PDB:6NDD"
/db_xref="PDB:6NDE"
/db_xref="PDB:6NDF"
/db_xref="PDB:6NDG"
/db_xref="PDB:6NDH"
/db_xref="UniProtKB/Swiss-Prot:P17301"
/protein_id="CAA34894.1"
/translation="MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPS
SEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTS
IPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSA
SFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYAN
NPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATK
VMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIAS
IPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQND
ILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGEST
HFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDV
LLVGAPMYMSDLKKEEGRVYLFTIKKGILGQHQFLEGPEGIENTRFGSAIAALSDINM
DGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDG
YGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFS
AKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEH
IIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISD
LVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSL
PVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALS
ESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFI
FSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQ
TSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASST
FQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLL
LALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS"
sig_peptide 49..135
/note="signal peptide (AA -29 to -1)"
mat_peptide 136..3591
/note="mature integrin alpha-2 (AA 1-1152)"
BASE COUNT 1635 a 1088 c 1134 g 1516 t
ORIGIN
1 gaattcctgc aaacccagcg caactacggt cccccggtca gacccaggat ggggccagaa
61 cggacagggg ccgcgccgct gccgctgctg ctggtgttag cgctcagtca aggcatttta
121 aattgttgtt tggcctacaa tgttggtctc ccagaagcaa aaatattttc cggtccttca
181 agtgaacagt ttgggtatgc agtgcagcag tttataaatc caaaaggcaa ctggttactg
241 gttggttcac cctggagtgg ctttcctgag aaccgaatgg gagatgtgta taaatgtcct
301 gttgacctat ccactgccac atgtgaaaaa ctaaatttgc aaacttcaac aagcattcca
361 aatgttactg agatgaaaac caacatgagc ctcggcttga tcctcaccag gaacatggga
421 actggaggtt ttctcacatg tggtcctctg tgggcacagc aatgtgggaa tcagtattac
481 acaacgggtg tgtgttctga catcagtcct gattttcagc tctcagccag cttctcacct
541 gcaactcagc cctgcccttc cctcatagat gttgtggttg tgtgtgatga atcaaatagt
601 atttatcctt gggatgcagt aaagaatttt ttggaaaaat ttgtacaagg ccttgatata
661 ggccccacaa agacacaggt ggggttaatt cagtatgcca ataatccaag agttgtgttt
721 aacttgaaca catataaaac caaagaagaa atgattgtag caacatccca gacatcccaa
781 tatggtgggg acctcacaaa cacattcgga gcaattcaat atgcaagaaa atatgcctat
841 tcagcagctt ctggtgggcg acgaagtgct acgaaagtaa tggtagttgt aactgacggt
901 gaatcacatg atggttcaat gttgaaagct gtgattgatc aatgcaacca tgacaatata
961 ctgaggtttg gcatagcagt tcttgggtac ttaaacagaa acgcccttga tactaaaaat
1021 ttaataaaag aaataaaagc gatcgctagt attccaacag aaagatactt tttcaatgtg
1081 tctgatgaag cagctctact agaaaaggct gggacattag gagaacaaat tttcagcatt
1141 gaaggtactg ttcaaggagg agacaacttt cagatggaaa tgtcacaagt gggattcagt
1201 gcagattact cttctcaaaa tgatattctg atgctgggtg cagtgggagc ttttggctgg
1261 agtgggacca ttgtccagaa gacatctcat ggccatttga tctttcctaa acaagccttt
1321 gaccaaattc tgcaggacag aaatcacagt tcatatttag gttactctgt ggctgcaatt
1381 tctactggag aaagcactca ctttgttgct ggtgctcctc gggcaaatta taccggccag
1441 atagtgctat atagtgtgaa tgagaatggc aatatcacgg ttattcaggc tcaccgaggt
1501 gaccagattg gctcctattt tggtagtgtg ctgtgttcag ttgatgtgga taaagacacc
1561 attacagacg tgctcttggt aggtgcacca atgtacatga gtgacctaaa gaaagaggaa
1621 ggaagagtct acctgtttac tatcaaaaag ggcattttgg gtcagcacca atttcttgaa
1681 ggccccgagg gcattgaaaa cactcgattt ggttcagcaa ttgcagctct ttcagacatc
1741 aacatggatg gctttaatga tgtgattgtt ggttcaccac tagaaaatca gaattctgga
1801 gctgtataca tttacaatgg tcatcagggc actatccgca caaagtattc ccagaaaatc
1861 ttgggatccg atggagcctt taggagccat ctccagtact ttgggaggtc cttggatggc
1921 tatggagatt taaatgggga ttccatcacc gatgtgtcta ttggtgcctt tggacaagtg
1981 gttcaactct ggtcacaaag tattgctgat gtagctatag aagcttcatt cacaccagaa
2041 aaaatcactt tggtcaacaa gaatgctcag ataattctca aactctgctt cagtgcaaag
2101 ttcagaccta ctaagcaaaa caatcaagtg gccattgtat ataacatcac acttgatgca
2161 gatggatttt catccagagt aacctccagg gggttattta aagaaaacaa tgaaaggtgc
2221 ctgcagaaga atatggtagt aaatcaagca cagagttgcc ccgagcacat catttatata
2281 caggagccct ctgatgttgt caactctttg gatttgcgtg tggacatcag tctggaaaac
2341 cctggcacta gccctgccct tgaagcctat tctgagactg ccaaggtctt cagtattcct
2401 ttccacaaag actgtggtga ggatggactt tgcatttctg atctagtcct agatgtccga
2461 caaataccag ctgctcaaga acaacccttt attgtcagca accaaaacaa aaggttaaca
2521 ttttcagtaa cactgaaaaa taaaagggaa agtgcataca acactggaat tgttgttgat
2581 ttttcagaaa acttgttttt tgcatcattc tccctaccgg ttgatgggac agaagtaaca
2641 tgccaggtgg ctgcatctca gaagtctgtt gcctgcgatg taggctaccc tgctttaaag
2701 agagaacaac aggtgacttt tactattaac tttgacttca atcttcaaaa ccttcagaat
2761 caggcgtctc tcagtttcca agccttaagt gaaagccaag aagaaaacaa ggctgataat
2821 ttggtcaacc tcaaaattcc tctcctgtat gatgctgaaa ttcacttaac aagatctacc
2881 aacataaatt tttatgaaat ctcttcggat gggaatgttc cttcaatcgt gcacagtttt
2941 gaagatgttg gtccaaaatt catcttctcc ctgaaggtaa caacaggaag tgttccagta
3001 agcatggcaa ctgtaatcat ccacatccct cagtatacca aagaaaagaa cccactgatg
3061 tacctaactg gggtgcaaac agacaaggct ggtgacatca gttgtaatgc agatatcaat
3121 ccactgaaaa taggacaaac atcttcttct gtatctttca aaagtgaaaa tttcaggcac
3181 accaaagaat tgaactgcag aactgcttcc tgtagtaatg ttacctgctg gttgaaagac
3241 gttcacatga aaggagaata ctttgttaat gtgactacca gaatttggaa cgggactttc
3301 gcatcatcaa cgttccagac agtacagcta acggcagctg cagaaatcaa cacctataac
3361 cctgagatat atgtgattga agataacact gttacgattc ccctgatgat aatgaaacct
3421 gatgagaaag ccgaagtacc aacaggagtt ataataggaa gtataattgc tggaatcctt
3481 ttgctgttag ctctggttgc aattttatgg aagctcggct tcttcaaaag aaaatatgaa
3541 aagatgacca aaaatccaga tgagattgat gagaccacag agctcagtag ctgaaccagc
3601 agacctacct gcagtgggaa ccggcagcat cccagccagg gtttgctgtt tgcgtgcatg
3661 gatttctttt taaatcccat atttttttta tcatgtcgta ggtaaactaa cctggtattt
3721 taagagaaaa ctgcaggtca gtttggatga agaaattgtg gggggtgggg gaggtgcggg
3781 gggcaggtag ggaaataata gggaaaatac ctattttata tgatggggga aaaaaagtaa
3841 tctttaaact ggctggccca gagtttacat tctaatttgc attgtgtcag aaacatgaaa
3901 tgcttccaag catgacaact tttaaagaaa aatatgatac tctcagattt taagggggaa
3961 aactgttctc tttaaaatat ttgtctttaa acagcaacta cagaagtgga agtgcttgat
4021 atgtaagtac ttccacttgt gtatatttta atgaatattg atgttaacaa gaggggaaaa
4081 caaaacacag gttttttcaa tttatgctgc tcatccaaag ttgccacaga tgatacttcc
4141 aagtgataat tttatttata aactaggtaa aatttgttgt tggttccttt tataccacgg
4201 ctgccccttc cacaccccat cttgctctaa tgatcaaaac atgcttgaat aactgagctt
4261 agagtatacc tcctatatgt ccatttaagt taggagaggg ggcgatatag agactaaggc
4321 acaaaatttt gtttaaaact cagaatataa catttatgta aaatcccatc tgctagaagc
4381 ccatcctgtg ccagaggaag gaaaaggagg aaatttcctt tctcttttag gaggcacaac
4441 agttctcttc taggatttgt ttggctgact ggcagtaacc tagtgaattt ttgaaagatg
4501 agtaatttct ttggcaacct tcctcctccc ttactgaacc actctcccac ctcctggtgg
4561 taccattatt atagaagccc tctacagcct gactttctct ccagcggtcc aaagttatcc
4621 cctcctttac ccctcatcca aagttcccac tccttcagga cagctgctgt gcattagata
4681 ttagggggga aagtcatctg tttaatttac acacttgcat gaattactgt atataaactc
4741 cttaacttca gggagctatt ttcatttagt gctaaacaag taagaaaaat aagctagagt
4801 gaatttctaa atgttggaat gttatgggat gtaaacaatg taaagtaaaa cactctcagg
4861 atttcaccag aagttacaga tgaggcactg gaaaccacca ccaaattagc aggtgcacct
4921 tctgtggctg tcttgtttct gaagtacttt ttcttccaca agagtgaatt tgacctaggc
4981 aagtttgttc aaaaggtaga tcctgagatg atttggtcag attgggataa ggcccagcaa
5041 tctgcatttt aacaagcacc ccagtcacta ggatgcagat ggaccacact ttgagaaaca
5101 ccacccattt ctactttttg caccttattt tctctgttcc tgagccccca cattctctag
5161 gagaaactta gattaaaatt cacagacact acatatctaa agctttgaca agtccttgac
5221 ctctataaac ttcagagtcc tcattataaa atgggaagac tgagctggag ttcagcagtg
5281 atgcttttta gttttaaaag tctatgatct gatctggact tcctataata caaatacaca
5341 atcctccaag aatttgactt ggaaaaggaa ttc
//