LOCUS X16416 5527 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human c-abl mRNA encoding p150 protein.
ACCESSION X16416
VERSION X16416.1
KEYWORDS oncogene; p150 protein; protein kinase; tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5527)
AUTHORS Fainstein E.
JOURNAL Submitted (05-SEP-1989) to the INSDC. Fainstein E., The Weizmann
Institute of Science, Department of Chemical Immunology, Rehovot,
Israel.
REFERENCE 2 (bases 1 to 5527)
AUTHORS Fainstein E., Einat M., Gokkel E., Marcelle C., Croce C.M.,
Gale R.P., Canaani E.
TITLE Nucleotide sequence analysis of human abl and bcr-abl cDNAs
JOURNAL Oncogene 4(12), 1477-1481(1989).
PUBMED 2687768
COMMENT the sequence X16416 contains exon 1a
see <M14752> for overlapping sequence
FEATURES Location/Qualifiers
source 1..5527
/db_xref="H-InvDB:HIT000321556"
/organism="Homo sapiens"
/chromosome="9q34"
/mol_type="mRNA"
/clone="p18, p15"
/cell_line="SV80"
/cell_type="fibroblasts"
/db_xref="taxon:9606"
CDS 148..3540
/note="p150 protein (AA 1-1130)"
/db_xref="GOA:P00519"
/db_xref="H-InvDB:HIT000321556.15"
/db_xref="HGNC:HGNC:76"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR000980"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR001452"
/db_xref="InterPro:IPR008266"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR015015"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR020635"
/db_xref="InterPro:IPR033221"
/db_xref="InterPro:IPR035837"
/db_xref="InterPro:IPR036028"
/db_xref="InterPro:IPR036860"
/db_xref="PDB:1AB2"
/db_xref="PDB:1ABL"
/db_xref="PDB:1AWO"
/db_xref="PDB:1BBZ"
/db_xref="PDB:1JU5"
/db_xref="PDB:1OPL"
/db_xref="PDB:1ZZP"
/db_xref="PDB:2ABL"
/db_xref="PDB:2E2B"
/db_xref="PDB:2F4J"
/db_xref="PDB:2FO0"
/db_xref="PDB:2G1T"
/db_xref="PDB:2G2F"
/db_xref="PDB:2G2H"
/db_xref="PDB:2G2I"
/db_xref="PDB:2GQG"
/db_xref="PDB:2HIW"
/db_xref="PDB:2HYY"
/db_xref="PDB:2HZ0"
/db_xref="PDB:2HZ4"
/db_xref="PDB:2HZI"
/db_xref="PDB:2O88"
/db_xref="PDB:2V7A"
/db_xref="PDB:3CS9"
/db_xref="PDB:3EG0"
/db_xref="PDB:3EG1"
/db_xref="PDB:3EG2"
/db_xref="PDB:3EG3"
/db_xref="PDB:3EGU"
/db_xref="PDB:3K2M"
/db_xref="PDB:3PYY"
/db_xref="PDB:3QRI"
/db_xref="PDB:3QRJ"
/db_xref="PDB:3QRK"
/db_xref="PDB:3T04"
/db_xref="PDB:3UE4"
/db_xref="PDB:3UYO"
/db_xref="PDB:4J9B"
/db_xref="PDB:4J9C"
/db_xref="PDB:4J9D"
/db_xref="PDB:4J9E"
/db_xref="PDB:4J9F"
/db_xref="PDB:4J9G"
/db_xref="PDB:4J9H"
/db_xref="PDB:4J9I"
/db_xref="PDB:4JJB"
/db_xref="PDB:4JJC"
/db_xref="PDB:4JJD"
/db_xref="PDB:4TWP"
/db_xref="PDB:4WA9"
/db_xref="PDB:4XEY"
/db_xref="PDB:4YC8"
/db_xref="PDB:4ZOG"
/db_xref="PDB:5DC0"
/db_xref="PDB:5DC4"
/db_xref="PDB:5DC9"
/db_xref="PDB:5HU9"
/db_xref="PDB:5MO4"
/db_xref="PDB:5NP2"
/db_xref="PDB:5OAZ"
/db_xref="PDB:6AMV"
/db_xref="PDB:6AMW"
/db_xref="PDB:6BL8"
/db_xref="PDB:6NPE"
/db_xref="PDB:6NPU"
/db_xref="PDB:6NPV"
/db_xref="UniProtKB/Swiss-Prot:P00519"
/protein_id="CAA34438.1"
/translation="MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSE
AARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEA
QTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQ
RSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP
KRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED
TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE
VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT
YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE
LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEK
ELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEP
AVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREM
DGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFR
SPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDL
QSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVF
KDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAEKGSALGTPAAAEPVTPTSK
AGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKP
SQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPS
GTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKG
VVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAIN
KLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR"
BASE COUNT 1196 a 1672 c 1594 g 1065 t
ORIGIN
1 cgcggccgcc ctgggcgggc gcgggcggcg ggcggcggtg agggcggcct gcggggcggc
61 gcccgggggc cgggccgagc cgggcctgag ccgggcccgg accgagctgg gagaggggct
121 ccggcccgat cgttcgcttg gcgcaaaatg ttggagatct gcctgaagct ggtgggctgc
181 aaatccaaga aggggctgtc ctcgtcctcc agctgttatc tggaagaagc ccttcagcgg
241 ccagtagcat ctgactttga gcctcagggt ctgagtgaag ccgctcgttg gaactccaag
301 gaaaaccttc tcgctggacc cagtgaaaat gaccccaacc ttttcgttgc actgtatgat
361 tttgtggcca gtggagataa cactctaagc ataactaaag gtgaaaagct ccgggtctta
421 ggctataatc acaatgggga atggtgtgaa gcccaaacca aaaatggcca aggctgggtc
481 ccaagcaact acatcacgcc agtcaacagt ctggagaaac actcctggta ccatgggcct
541 gtgtcccgca atgccgctga gtatctgctg agcagcggga tcaatggcag cttcttggtg
601 cgtgagagtg agagcagtcc tggccagagg tccatctcgc tgagatacga agggagggtg
661 taccattaca ggatcaacac tgcttctgat ggcaagctct acgtctcctc cgagagccgc
721 ttcaacaccc tggccgagtt ggttcatcat cattcaacgg tggccgacgg gctcatcacc
781 acgctccatt atccagcccc aaagcgcaac aagcccactg tctatggtgt gtcccccaac
841 tacgacaagt gggagatgga acgcacggac atcaccatga agcacaagct gggcgggggc
901 cagtacgggg aggtgtacga gggcgtgtgg aagaaataca gcctgacggt ggccgtgaag
961 accttgaagg aggacaccat ggaggtggaa gagttcttga aagaagctgc agtcatgaaa
1021 gagatcaaac accctaacct ggtgcagctc cttggggtct gcacccggga gcccccgttc
1081 tatatcatca ctgagttcat gacctacggg aacctcctgg actacctgag ggagtgcaac
1141 cggcaggagg tgaacgccgt ggtgctgctg tacatggcca ctcagatctc gtcagccatg
1201 gagtacctgg agaagaaaaa cttcatccac agagatcttg ctgcccgaaa ctgcctggta
1261 ggggagaacc acttggtgaa ggtagctgat tttggcctga gcaggttgat gacaggggac
1321 acctacacag cccatgctgg agccaagttc cccatcaaat ggactgcacc cgagagcctg
1381 gcctacaaca agttctccat caagtccgac gtctgggcat ttggagtatt gctttgggaa
1441 attgctacct atggcatgtc cccttacccg ggaattgacc tgtcccaggt gtatgagctg
1501 ctagagaagg actaccgcat ggagcgccca gaaggctgcc cagagaaggt ctatgaactc
1561 atgcgagcat gttggcagtg gaatccctct gaccggccct cctttgctga aatccaccaa
1621 gcctttgaaa caatgttcca ggaatccagt atctcagacg aagtggaaaa ggagctgggg
1681 aaacaaggcg tccgtggggc tgtgagtacc ttgctgcagg ccccagagct gcccaccaag
1741 acgaggacct ccaggagagc tgcagagcac agagacacca ctgacgtgcc tgagatgcct
1801 cactccaagg gccagggaga gagcgatcct ctggaccatg agcctgccgt gtctccattg
1861 ctccctcgaa aagagcgagg tcccccggag ggcggcctga atgaagatga gcgccttctc
1921 cccaaagaca aaaagaccaa cttgttcagc gccttgatca agaagaagaa gaagacagcc
1981 ccaacccctc ccaaacgcag cagctccttc cgggagatgg acggccagcc ggagcgcaga
2041 ggggccggcg aggaagaggg ccgagacatc agcaacgggg cactggcttt cacccccttg
2101 gacacagctg acccagccaa gtccccaaag cccagcaatg gggctggggt ccccaatgga
2161 gccctccggg agtccggggg ctcaggcttc cggtctcccc acctgtggaa gaagtccagc
2221 acgctgacca gcagccgcct agccaccggc gaggaggagg gcggtggcag ctccagcaag
2281 cgcttcctgc gctcttgctc cgcctcctgc gttccccatg gggccaagga cacggagtgg
2341 aggtcagtca cgctgcctcg ggacttgcag tccacgggaa gacagtttga ctcgtccaca
2401 tttggagggc acaaaagtga gaagccggct ctgcctcgga agagggcagg ggagaacagg
2461 tctgaccagg tgacccgagg cacagtaacg cctcccccca ggctggtgaa aaagaatgag
2521 gaagctgctg atgaggtctt caaagacatc atggagtcca gcccgggctc cagcccgccc
2581 aacctgactc caaaacccct ccggcggcag gtcaccgtgg cccctgcctc gggcctcccc
2641 cacaaggaag aagctgaaaa gggcagtgcc ttagggaccc ctgctgcagc tgagccagtg
2701 acccccacca gcaaagcagg ctcaggtgca ccagggggca ccagcaaggg ccccgccgag
2761 gagtccagag tgaggaggca caagcactcc tctgagtcgc cagggaggga caaggggaaa
2821 ttgtccaggc tcaaacctgc cccgccgccc ccaccagcag cctctgcagg gaaggctgga
2881 ggaaagccct cgcagagccc gagccaggag gcggccgggg aggcagtcct gggcgcaaag
2941 acaaaagcca cgagtctggt tgatgctgtg aacagtgacg ctgccaagcc cagccagccg
3001 ggagagggcc tcaaaaagcc cgtgctcccg gccactccaa agccacagtc cgccaagccg
3061 tcggggaccc ccatcagccc agcccccgtt ccctccacgt tgccatcagc atcctcggcc
3121 ctggcagggg accagccgtc ttccactgcc ttcatccctc tcatatcaac ccgagtgtct
3181 cttcggaaaa cccgccagcc tccagagcgg atcgccagcg gcgccatcac caagggcgtg
3241 gtcctggaca gcaccgaggc gctgtgcctc gccatctcta ggaactccga gcagatggcc
3301 agccacagcg cagtgctgga ggccggcaaa aacctctaca cgttctgcgt gagctatgtg
3361 gattccatcc agcaaatgag gaacaagttt gccttccgag aggccatcaa caaactggag
3421 aataatctcc gggagcttca gatctgcccg gcgacagcag gcagtggtcc ggcggccact
3481 caggacttca gcaagctcct cagttcggtg aaggaaatca gtgacatagt gcagaggtag
3541 cagcagtcag gggtcaggtg tcaggcccgt cggagctgcc tgcagcacat gcgggctcgc
3601 ccatacccat gacagtggct gacaagggac tagtgagtca gcaccttggc ccaggagctc
3661 tgcgccaggc agagctgagg gccctgtgga gtccagctct actacctacg tttgcaccgc
3721 ctgccctccc gcaccttcct cctccccgct ccgtctctgt cctcgaattt tatctgtgga
3781 gttcctgctc cgtggactgc agtcggcatg ccaggacccg ccagccccgc tcccacctag
3841 tgccccagac tgagctctcc aggccaggtg ggaacggctg atgtggactg tctttttcat
3901 ttttttctct ctggagcccc tcctcccccg gctgggcctc cttcttccac ttctccaaga
3961 atggaagcct gaactgaggc cttgtgtgtc aggccctctg cctgcactcc ctggccttgc
4021 ccgtcgtgtg ctgaagacat gtttcaagaa ccgccatttc gggaagggca tgcacgggcc
4081 atgcacacgg ctggtcactc tgccctctgc tgctgcccgg ggtggggtgc actcgccatt
4141 tcctcacgtg caggacagct cttgatttgg gtggaaaaca gggtgctaaa gccaaccagc
4201 ctttgggtcc tgggcaggtg ggagctgaaa aggatcgagg catggggcat gtcctttcca
4261 tctgtccaca tccccagagc ccagctcttg ctctcttgtg acgtgcactg tgaatcctgg
4321 caagaaagct tgagtctcaa gggtggcagg tcactgtcac tgccgacatc cctcccccag
4381 cagaatggag gcaggggaca agggaggcag tggctagtgg ggtgaacagc tggtgccaaa
4441 tagccccaga ctgggcccag gcaggtctgc aagggcccag agtgaaccgt cctttcacac
4501 atctgggtgc cctgaagggc ccttcccctc ccccactcct ctaagacaaa gtagattctt
4561 acaaggccct ttcctttgga acaagacagc cttcactttt ctgagttctt gaagcatttc
4621 aaagccctgc ctctgtgtag ccgccctgag agagaataga gctgccactg ggcacctcgc
4681 gacaggtggg aggaaagggc ctgcgcagtc ctggtcctgg ctgcactctt gaactgggcg
4741 aatgtcttat ttaattaccg tgagtgacat agcctcatgt tctgtggggg tcatcaggga
4801 gggttaggaa aaccacaaac ggagcccctg aaagcctcac gtatttcaca gagcacgcct
4861 gccatcttct ccccgaggct gccccaggcc ggagcccaga taccggcggg ctgtgactct
4921 gggcagggac ccggggtctc ctggaccttg acagagcagc taactccgag agcagtgggc
4981 aggtggccgc ccctgaggct tcacgccgga gaagccacct tcccgcccct tcataccgcc
5041 tcgtgccagc agcctcgcac aggccctagc tttacgctca tcacctaaac ttgtacttta
5101 tttttctgat agaaatggtt tcctctggat cgttttatgc ggttcttaca gcacatcacc
5161 tctttccccc cgacggctgt gacgcagcgg agaggcacta gtcaccgaca gcggccttga
5221 agacagagca aagcccccac ccaggtcccc cgactgcctg tctccatgag gtactggtcc
5281 cttccttttg ttaacgtgat gtgccactat attttacacg tatctcttgg tatgcatctt
5341 ttatagacgc tcttttctaa gtggcgtgtg catagcgtcc tgccctgccc tcgggggcct
5401 gtggtggctc cccctctgct tctcggggtc cagtgcattt tgtttctgta tatgattctc
5461 tgtggttttt tttgaatcca aatctgtcct ctgtagtatt ttttaaataa atcagtgttt
5521 acattag
//