LOCUS X15262 989 bp mRNA linear HUM 18-APR-2005 DEFINITION Human mRNA for ret proto-oncogene 5'-end. ACCESSION X15262 VERSION X15262.1 KEYWORDS glycoprotein; proto-oncogene; receptor; ret cellular oncogene; ret oncogene; ret proto-oncogene; transmembrane protein; tyrosine kinase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 989) AUTHORS Takahashi M. JOURNAL Submitted (16-MAY-1989) to the INSDC. Takahashi M., Aichi Cancer Center Research Institute, , Lab. of Exp. Pathology, Chikusa-ku, Nagoya 464, Japan. REFERENCE 2 (bases 1 to 989) AUTHORS Takahashi M. TITLE Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence JOURNAL Oncogene 4(6), 805-806(1989). PUBMED 2660074 COMMENT See also M16029 and X12949 for proto-ret cDNA seq. X15262 proto-ret cDNA seq revises formerly reported seq, see x12949. The 5' terminal 112 nucleotides in X12949 are thought to represent a cloning artefact. Data kindly reviewed (25-aug-1989) by Takahashi M. FEATURES Location/Qualifiers source 1..989 /db_xref="H-InvDB:HIT000321497" /organism="Homo sapiens" /mol_type="mRNA" /clone="lambda ret-G2." /cell_line="THP-1" /cell_type="monocytic leukemia cells" /db_xref="taxon:9606" CDS 150..>989 /product="ret preprotein (AA -28 to 252)" /db_xref="GOA:P07949" /db_xref="H-InvDB:HIT000321497.13" /db_xref="HGNC:HGNC:9967" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR001245" /db_xref="InterPro:IPR002126" /db_xref="InterPro:IPR008266" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR015919" /db_xref="InterPro:IPR016249" /db_xref="InterPro:IPR017441" /db_xref="InterPro:IPR020635" /db_xref="InterPro:IPR040667" /db_xref="InterPro:IPR041163" /db_xref="InterPro:IPR041317" /db_xref="PDB:1XPD" /db_xref="PDB:2IVS" /db_xref="PDB:2IVT" /db_xref="PDB:2IVU" /db_xref="PDB:2IVV" /db_xref="PDB:2X2K" /db_xref="PDB:2X2L" /db_xref="PDB:2X2M" /db_xref="PDB:2X2U" /db_xref="PDB:4CKI" /db_xref="PDB:4CKJ" /db_xref="PDB:4UX8" /db_xref="PDB:5AMN" /db_xref="PDB:5FM2" /db_xref="PDB:5FM3" /db_xref="PDB:6FEK" /db_xref="PDB:6NE7" /db_xref="PDB:6NEC" /db_xref="PDB:6NJA" /db_xref="UniProtKB/Swiss-Prot:P07949" /protein_id="CAA33333.1" /translation="MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQ AAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLD HSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSL KPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAP DSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGV DTAS" sig_peptide 150..233 /note="signal peptide (AA -28 to -1)" mat_peptide 234..>989 /note="ret protein (AA 1 - 252)" misc_feature 441..449 /note="pot. N-linked glycosylation site" misc_feature 600..608 /note="pot. N-linked glycosylation site" misc_feature 744..752 /note="pot. N-linked glycosylation site" BASE COUNT 146 a 364 c 308 g 171 t ORIGIN 1 cccggaacgt gcgtcgcgcc cccagtgtcc gtcgcgtccg ccgcgccccg ggcggggatg 61 gggcggccag actgagcgcc gcacccgcca tccagacccg ccggccctag ccgcagtccc 121 tccagccgtg gccccagcgc gcacgggcga tggcgaaggc gacgtccggt gccgcggggc 181 tgcgtctgct gttgctgctg ctgctgccgc tgctaggcaa agtggcattg ggcctctact 241 tctcgaggga tgcttactgg gagaagctgt atgtggacca ggcggccggc acgcccttgc 301 tgtacgtcca tgccctgcgg gacgcccctg aggaggtgcc cagcttccgc ctgggccagc 361 atctctacgg cacgtaccgc acacggctgc atgagaacaa ctggatctgc atccaggagg 421 acaccggcct cctctacctt aaccggagcc tggaccatag ctcctgggag aagctcagtg 481 tccgcaaccg cggctttccc ctgctcaccg tctacctcaa ggtcttcctg tcacccacat 541 cccttcgtga gggcgagtgc cagtggccag gctgtgcccg cgtatacttc tccttcttca 601 acacctcctt tccagcctgc agctccctca agccccggga gctctgcttc ccagagacaa 661 ggccctcctt ccgcattcgg gagaaccgac ccccaggcac cttccaccag ttccgcctgc 721 tgcctgtgca gttcttgtgc cccaacatca gcgtggccta caggctcctg gagggtgagg 781 gtctgccctt ccgctgcgcc ccggacagcc tggaggtgag cacgcgctgg gccctggacc 841 gcgagcagcg ggagaagtac gagctggtgg ccgtgtgcac cgtgcacgcc ggcgcgcgcg 901 aggaggtggt gatggtgccc ttcccggtga ccgtgtacga cgaggacgac tcggcgccca 961 ccttccccgc gggcgtcgac accgccagc //