LOCUS       X15262                   989 bp    mRNA    linear   HUM 18-APR-2005
DEFINITION  Human mRNA for ret proto-oncogene 5'-end.
ACCESSION   X15262
VERSION     X15262.1
KEYWORDS    glycoprotein; proto-oncogene; receptor; ret cellular oncogene; ret
            oncogene; ret proto-oncogene; transmembrane protein; tyrosine
            kinase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 989)
  AUTHORS   Takahashi M.
  JOURNAL   Submitted (16-MAY-1989) to the INSDC. Takahashi M., Aichi Cancer
            Center Research Institute, , Lab. of Exp. Pathology, Chikusa-ku,
            Nagoya 464, Japan.
REFERENCE   2  (bases 1 to 989)
  AUTHORS   Takahashi M.
  TITLE     Isolation of ret proto-oncogene cDNA with an amino-terminal signal
            sequence
  JOURNAL   Oncogene 4(6), 805-806(1989).
   PUBMED   2660074
COMMENT     See also M16029 and X12949 for proto-ret cDNA seq.
            X15262 proto-ret cDNA seq revises formerly reported seq, see
            x12949. The 5' terminal 112 nucleotides in X12949 are thought to
            represent a cloning artefact.
            
            Data kindly reviewed (25-aug-1989) by Takahashi M.
FEATURES             Location/Qualifiers
     source          1..989
                     /db_xref="H-InvDB:HIT000321497"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone="lambda ret-G2."
                     /cell_line="THP-1"
                     /cell_type="monocytic leukemia cells"
                     /db_xref="taxon:9606"
     CDS             150..>989
                     /product="ret preprotein (AA -28 to 252)"
                     /db_xref="GOA:P07949"
                     /db_xref="H-InvDB:HIT000321497.13"
                     /db_xref="HGNC:HGNC:9967"
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR001245"
                     /db_xref="InterPro:IPR002126"
                     /db_xref="InterPro:IPR008266"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR015919"
                     /db_xref="InterPro:IPR016249"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="InterPro:IPR020635"
                     /db_xref="InterPro:IPR040667"
                     /db_xref="InterPro:IPR041163"
                     /db_xref="InterPro:IPR041317"
                     /db_xref="PDB:1XPD"
                     /db_xref="PDB:2IVS"
                     /db_xref="PDB:2IVT"
                     /db_xref="PDB:2IVU"
                     /db_xref="PDB:2IVV"
                     /db_xref="PDB:2X2K"
                     /db_xref="PDB:2X2L"
                     /db_xref="PDB:2X2M"
                     /db_xref="PDB:2X2U"
                     /db_xref="PDB:4CKI"
                     /db_xref="PDB:4CKJ"
                     /db_xref="PDB:4UX8"
                     /db_xref="PDB:5AMN"
                     /db_xref="PDB:5FM2"
                     /db_xref="PDB:5FM3"
                     /db_xref="PDB:6FEK"
                     /db_xref="PDB:6NE7"
                     /db_xref="PDB:6NEC"
                     /db_xref="PDB:6NJA"
                     /db_xref="UniProtKB/Swiss-Prot:P07949"
                     /protein_id="CAA33333.1"
                     /translation="MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQ
                     AAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLD
                     HSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSL
                     KPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAP
                     DSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGV
                     DTAS"
     sig_peptide     150..233
                     /note="signal peptide (AA -28 to -1)"
     mat_peptide     234..>989
                     /note="ret protein (AA 1 - 252)"
     misc_feature    441..449
                     /note="pot. N-linked glycosylation site"
     misc_feature    600..608
                     /note="pot. N-linked glycosylation site"
     misc_feature    744..752
                     /note="pot. N-linked glycosylation site"
BASE COUNT          146 a          364 c          308 g          171 t
ORIGIN      
        1 cccggaacgt gcgtcgcgcc cccagtgtcc gtcgcgtccg ccgcgccccg ggcggggatg
       61 gggcggccag actgagcgcc gcacccgcca tccagacccg ccggccctag ccgcagtccc
      121 tccagccgtg gccccagcgc gcacgggcga tggcgaaggc gacgtccggt gccgcggggc
      181 tgcgtctgct gttgctgctg ctgctgccgc tgctaggcaa agtggcattg ggcctctact
      241 tctcgaggga tgcttactgg gagaagctgt atgtggacca ggcggccggc acgcccttgc
      301 tgtacgtcca tgccctgcgg gacgcccctg aggaggtgcc cagcttccgc ctgggccagc
      361 atctctacgg cacgtaccgc acacggctgc atgagaacaa ctggatctgc atccaggagg
      421 acaccggcct cctctacctt aaccggagcc tggaccatag ctcctgggag aagctcagtg
      481 tccgcaaccg cggctttccc ctgctcaccg tctacctcaa ggtcttcctg tcacccacat
      541 cccttcgtga gggcgagtgc cagtggccag gctgtgcccg cgtatacttc tccttcttca
      601 acacctcctt tccagcctgc agctccctca agccccggga gctctgcttc ccagagacaa
      661 ggccctcctt ccgcattcgg gagaaccgac ccccaggcac cttccaccag ttccgcctgc
      721 tgcctgtgca gttcttgtgc cccaacatca gcgtggccta caggctcctg gagggtgagg
      781 gtctgccctt ccgctgcgcc ccggacagcc tggaggtgag cacgcgctgg gccctggacc
      841 gcgagcagcg ggagaagtac gagctggtgg ccgtgtgcac cgtgcacgcc ggcgcgcgcg
      901 aggaggtggt gatggtgccc ttcccggtga ccgtgtacga cgaggacgac tcggcgccca
      961 ccttccccgc gggcgtcgac accgccagc
//