LOCUS X14940 2378 bp DNA linear HUM 09-SEP-2004
DEFINITION Human C mu gene for IgM heavy chain exons CH1-4, secretory.
ACCESSION X14940
VERSION X14940.1
KEYWORDS alternative splicing; constant region; Ig heavy chain; IgM;
immunoglobulin; rearranged DNA.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2378)
AUTHORS Dorai H.
JOURNAL Submitted (03-APR-1989) to the INSDC. Dorai H., Damon-Biotech, 119
Fourth Avenue, Needham Heights, MA 02194, U S A.
REFERENCE 2 (bases 1 to 2378)
AUTHORS Dorai H., Gillies S.D.
TITLE The complete nucleotide sequence of a human immunoglobulin genomic
C mu gene
JOURNAL Nucleic Acids Res. 17(15), 6412-6412(1989).
PUBMED 2505237
COMMENT see X14939 for M1 and M2 membrane exons, located approximately
1.9kb downstream from CH4;
FEATURES Location/Qualifiers
source 1..2378
/organism="Homo sapiens"
/chromosome="14"
/map="q32"
/mol_type="genomic DNA"
/clone_lib="lambda phage EMBL 3"
/clone="2"
/cell_line="HeLa"
/cell_type="fibroblast"
/tissue_type="muscle"
/db_xref="taxon:9606"
precursor_RNA <1..>2209
/note="mu heavy chain transcript"
CDS <233..>544
/codon_start=3
/note="IgM hv, C mu (104 AA) (233 is 2nd base in codon)
(544 is 1st base in codon)"
/db_xref="GOA:P01871"
/db_xref="HGNC:HGNC:5541"
/db_xref="InterPro:IPR003006"
/db_xref="InterPro:IPR003597"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1HEZ"
/db_xref="PDB:2AGJ"
/db_xref="PDB:2RCJ"
/db_xref="UniProtKB/Swiss-Prot:P01871"
/protein_id="CAE82013.1"
/translation="SASAPTLFPLVSCENSPSDTSSVAVGCLAQDFLPDSITLSWKYK
NNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTDEHVVCKVQHPNGNKEKNVPL
P"
mRNA 233..544
/note="exon CH1"
intron 545..630
/note="intron I"
CDS <631..>966
/codon_start=3
/note="IgM hv, C mu (112 AA) (631 is 2nd base in codon)
(966 is 1st base in codon)"
/db_xref="GOA:P01871"
/db_xref="HGNC:HGNC:5541"
/db_xref="InterPro:IPR003006"
/db_xref="InterPro:IPR003597"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1HEZ"
/db_xref="PDB:2AGJ"
/db_xref="PDB:2RCJ"
/db_xref="UniProtKB/Swiss-Prot:P01871"
/protein_id="CAE82014.1"
/translation="IAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWL
REGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQ
QNASSMCVP"
mRNA 631..966
/note="exon CH2"
intron 967..1211
/note="intron II"
CDS <1212..>1531
/codon_start=3
/note="IgM hv, C mu (107 AA) (1212 is 2nd base in codon)"
/db_xref="GOA:P01871"
/db_xref="HGNC:HGNC:5541"
/db_xref="InterPro:IPR003006"
/db_xref="InterPro:IPR003597"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1HEZ"
/db_xref="PDB:2AGJ"
/db_xref="PDB:2RCJ"
/db_xref="UniProtKB/Swiss-Prot:P01871"
/protein_id="CAA33069.1"
/translation="QDTAIRVFAIPPSFASIFLTKSTKLTCLVTDLTTYDSVTISWTR
QNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDLPSPLKQTIS
RPKG"
mRNA 1212..1531
/note="exon CH3"
intron 1532..1709
/note="intron III"
CDS <1710..>2096
/note="IgM hv, C mu secreted form (129 AA)"
/db_xref="GOA:P01871"
/db_xref="HGNC:HGNC:5541"
/db_xref="InterPro:IPR003006"
/db_xref="InterPro:IPR003597"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1HEZ"
/db_xref="PDB:2AGJ"
/db_xref="PDB:2RCJ"
/db_xref="UniProtKB/Swiss-Prot:P01871"
/protein_id="CAA33070.1"
/translation="VALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQ
RGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTE
RTVDKSTGKPTLYNVSLVMSDTAGTCY"
mRNA 1710..2096
/note="exon CH4"
CDS <1710..>2036
/note="IgM hv, C mu membrane form (109 AA)"
/db_xref="GOA:P01871"
/db_xref="HGNC:HGNC:5541"
/db_xref="InterPro:IPR003006"
/db_xref="InterPro:IPR003597"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1HEZ"
/db_xref="PDB:2AGJ"
/db_xref="PDB:2RCJ"
/db_xref="UniProtKB/Swiss-Prot:P01871"
/protein_id="CAA33071.1"
/translation="VALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQ
RGQPLSPEKYVTSAPMPEPQAPGRYFAHSILTVSEEEWNTGETYTCVAHEALPNRVTE
RTVDKST"
mRNA 1710..2036
/note="alternative exon 4,"
misc_feature 2036..2037
/note="alternative splice site for membrane exon"
misc_feature 2202..2209
/note="polyA signal"
BASE COUNT 473 a 840 c 653 g 412 t
ORIGIN
1 cccagcagcc cagcagcctt ggacaaagac ctgaggcctc accacgcccc gccacccctg
61 atagccatga cagtctgggc tttggaggcc tgcaggtggg ctcggccttg gtggggcagc
121 cacagcggga cgcaagtagt gagggcactc agaacgccac tcagccccga caggcagggc
181 acgaggaggc agctcctcac cctccctttc tcttttgtct gcgggtcctc agggagtgca
241 tccgccccaa cccttttccc cctcgtctcc tgtgagaatt ccccgtcgga tacgagcagc
301 gtggccgttg gctgcctcgc acaggacttc cttcccgact ccatcacttt gtcctggaaa
361 tacaagaaca actctgacat cagcagtacc cggggcttcc catcagtcct gagagggggc
421 aagtacgcag ccacctcaca ggtgctgctg ccttccaagg acgtcatgca gggcacagac
481 gaacacgtgg tgtgcaaagt ccagcacccc aacggcaaca aagaaaagaa cgtgcctctt
541 ccaggtgagg gccgggcagc caccgggaca gagagggagc cgaaggggcg ggagtggcgg
601 gcaccgggct gacacgtgtc ctcactgcag tgattgccga gctgcctccc aaagtgagcg
661 tcttcgtccc accccgcgac ggcttcttcg gcaacccccg caagtccaag ctcatctgcc
721 aggccacggg tttcagtccc cggcagattc aggtgtcctg gctgcgcgag gggaagcagg
781 tggggtctgg cgtcaccacg gaccaggtgc aggctgaggc caaagagtct gggcccacga
841 cctacaaggt gaccagcaca ctgaccatca aagagagcga ctggctcggc cagagcatgt
901 tcacctgccg cgtggatcac aggggcctga ccttccagca gaatgcgtcc tccatgtgtg
961 tccccggtga gtgacctgtc cctcaggggc agcacccacc gacacacagg ggtccactcg
1021 ggtctcgatt cgccaccccg gatgcagcca tctactccct gagccttggc ttcccagagc
1081 ggccaagggc aggggctcgg gcggcaggac ccctgggctc ggcagaggca gttgctactc
1141 tttgggtggg aaccatgcct ccgcccacat ccacacctgc cccacctctg actcccttct
1201 cttgactcca gatcaagaca cagccatccg ggtcttcgcc atccccccat cctttgccag
1261 catcttcctc accaagtcca ccaagttgac ctgcctggtc acagacctga ccacctatga
1321 cagcgtgacc atctcctgga cccgccagaa tggcgaagct gtgaaaaccc acaccaacat
1381 ctccgagagc caccccaatg ccactttcag cgccgtgggt gaggccagca tctgcgagga
1441 tgactggaat tccggggaga ggttcacgtg caccgtgacc cacacagacc tgccctcgcc
1501 actgaagcag accatctccc ggcccaaggg taggccccac tcttgcccct cttcctgcac
1561 tccctgggac ctcccttggc ctctggggca tggtggaaag cacccctcac tcccccgttg
1621 tctgggcaac tggggaaaag gggactcaac cccagcccac aggctgtccc cccactgccc
1681 cgccctcacc accatctctg ttcacagggg tggccctgca caggcccgat gtctacttgc
1741 tgccaccagc ccgggagcag ctgaacctgc gggagtcggc caccatcacg tgcctggtga
1801 cgggcttctc tcccgcggac gtcttcgtgc agtggatgca gagggggcag cccttgtccc
1861 cggagaagta tgtgaccagc gccccaatgc ctgagcccca ggccccaggc cggtacttcg
1921 cccacagcat cctgaccgtg tccgaagagg aatggaacac gggggagacc tacacctgcg
1981 tggcccatga ggccctgccc aacagggtca ccgagaggac cgtggacaag tccaccggta
2041 aacccaccct gtacaacgtg tccctggtca tgtccgacac agctggcacc tgctactgac
2101 cctgctggcc tgcccacagg ctcggggcgg ctggccgctc tgtgtgtgca tgcaaactaa
2161 cccgtgtcaa cggggtgaga tgttgcatct tataaaatta gaaataaaaa gatccattca
2221 aaagatactg gtcctgagtg cacgatgctc tggcctactg gggcggcggc tgtgctgcac
2281 ccaccctgcg cctcccctgc agaacacctt cctccacagc ccccacccct gcctcaccca
2341 cctgcgtgcc tcagtggctt ctagaaaccc ctgaattc
//