LOCUS       X14905                   705 bp    mRNA    linear   HUM 14-JUL-1995
DEFINITION  Human IAPP mRNA 5' region for islet amyloid polypeptide precursor
            (IAP-c2).
ACCESSION   X14905 Y07495
VERSION     X14905.1
KEYWORDS    IAPP gene; islet amyloid polypeptide.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 705)
  AUTHORS   Mosselman S.
  JOURNAL   Submitted (31-MAR-1989) to the INSDC. Mosselman S., Institute of
            Molecular Biology and Medical Biotechnology, University of Utrecht,
            Padualaan 8, 3584 CH Utrecht, The Netherlands.
REFERENCE   2  (bases 1 to 705)
  AUTHORS   Mosselman S., Hoeppener J.W.M., Lips C.J.M., Jansz H.S.
  TITLE     The complete islet amyloid polypeptide precursor is encoded by two
            exons
  JOURNAL   FEBS Lett. 247(1), 154-158(1989).
   PUBMED   2651160
REFERENCE   3  (bases 1 to 705)
  AUTHORS   Mosselman S.
  JOURNAL   Submitted (26-APR-1989) to the INSDC.
COMMENT     The sequence overlaps with that reported by Sanke et. al. in
            J. Biol. Chem. 263:17243-17246(1988) J04422 and by Mosselman
            et. al. in FEBS letters 239:227-232(1988).
FEATURES             Location/Qualifiers
     source          1..705
                     /db_xref="H-InvDB:HIT000321472"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="lambda gt10"
                     /clone="lambda hIAP-c2"
                     /tissue_type="insulinoma"
                     /db_xref="taxon:9606"
     CDS             <1..58
                     /codon_start=2
                     /product="IAPP precursor"
                     /db_xref="GOA:P10997"
                     /db_xref="H-InvDB:HIT000321472.13"
                     /db_xref="HGNC:HGNC:5329"
                     /db_xref="InterPro:IPR000443"
                     /db_xref="InterPro:IPR001693"
                     /db_xref="InterPro:IPR018360"
                     /db_xref="InterPro:IPR021116"
                     /db_xref="InterPro:IPR021117"
                     /db_xref="PDB:1KUW"
                     /db_xref="PDB:2G48"
                     /db_xref="PDB:2KB8"
                     /db_xref="PDB:2L86"
                     /db_xref="PDB:3DG1"
                     /db_xref="PDB:3FPO"
                     /db_xref="PDB:3FR1"
                     /db_xref="PDB:3FTH"
                     /db_xref="PDB:3FTK"
                     /db_xref="PDB:3FTL"
                     /db_xref="PDB:3FTR"
                     /db_xref="PDB:3G7V"
                     /db_xref="PDB:3G7W"
                     /db_xref="PDB:3HGZ"
                     /db_xref="PDB:5K5G"
                     /db_xref="PDB:5KNZ"
                     /db_xref="PDB:5KO0"
                     /db_xref="PDB:5MGQ"
                     /db_xref="UniProtKB/Swiss-Prot:P10997"
                     /protein_id="CAA33033.1"
                     /translation="KRNAVEVLKREPLNYLPL"
     regulatory      232..237
                     /note="pot. polyA signal"
                     /regulatory_class="polyA_signal_sequence"
     old_sequence    705..705
                     /note="polyA removed [2]"
                     /citation=[2]
BASE COUNT          210 a          128 c          168 g          199 t
ORIGIN      
        1 caagaggaat gcagtagagg ttttaaagag agagccactg aattacttgc ccctttagag
       61 gacaatgtaa ctctatagtt attgttttat gttctagtga tttcctgtat aatttaacag
      121 tgcccttttc atctccagtg tgaatatatg gtctgtgtgt ctgatgtttg ttgctaggac
      181 atataccttc tcaaaagatt gttttatatg tagtactaac taaggtccca taataaaaag
      241 atagtatctt ttaaaatgaa atgtttttgc tatagatttg tattttaaaa cataagaacg
      301 tcattttggg acctatatct cagtggcaca ggtttaagaa cgaaggagaa aaaggtagtt
      361 tgaaccttgg taaattgtaa acagctaata atgaagttat tcttgacatg agaaaatcag
      421 taattggacc aggcgcggtg gctcttgcct gtaatcccag cactttggga ggccgaggca
      481 ggcagatcac aaggtcagga gttcgagacc agcctgacca acatggtgaa accctgtctc
      541 tactaaaaat acaaaaatta gccgggggtg gtgacatgtg cctgtaatcc cagctactca
      601 ggaggctaag gcaggagaat cgcttaaacc caggaggcgg aggttgcagt gagccgagat
      661 tgcaccactg cactccagcc tgggtggcag agtgagactc gtctc
//