LOCUS X14810 5873 bp DNA linear HUM 14-NOV-2006
DEFINITION Human DNA for prostate specific antigen (PSA).
ACCESSION X14810
VERSION X14810.1
KEYWORDS Alu repetitive sequence; prostate specific antigen; serine
protease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5873)
AUTHORS Klobeck H.G., Combriato G., Schulz P., Arbusow V., Fittler F.
TITLE Genomic sequence of human prostate specific antigen (PSA)
JOURNAL Nucleic Acids Res. 17(10), 3981-3981(1989).
PUBMED 2471958
COMMENT See also acc# x05332 and x07730.
Data kindly reviewed (19th June 1989) by Klobeck H.-G.
FEATURES Location/Qualifiers
source 1..5873
/organism="Homo sapiens"
/mol_type="genomic DNA"
/cell_type="lymphoid cell line GM 607"
/db_xref="taxon:9606"
regulatory 332..338
/regulatory_class="TATA_box"
misc_feature 355..365
/note="transcriptional start region"
mRNA join(<401..446,1688..1847,3477..3763,3907..4043,
5413..>5568)
CDS join(401..446,1688..1847,3477..3763,3907..4043,5413..5568)
/product="prostate specific antigen (PSA)"
/db_xref="GOA:P07288"
/db_xref="HGNC:HGNC:6364"
/db_xref="InterPro:IPR001254"
/db_xref="InterPro:IPR001314"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR018114"
/db_xref="InterPro:IPR033116"
/db_xref="PDB:1PFA"
/db_xref="PDB:2PSA"
/db_xref="PDB:2ZCH"
/db_xref="PDB:2ZCK"
/db_xref="PDB:2ZCL"
/db_xref="PDB:3QUM"
/db_xref="UniProtKB/Swiss-Prot:P07288"
/protein_id="CAA32915.1"
/translation="MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVAS
RGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYD
MSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSI
EPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLV
CNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDTIVANP"
sig_peptide join(401..446,1688..1713)
exon <401..446
/number=1
intron 447..1687
/number=1
exon 1688..1847
/number=2
mat_peptide join(1714..1847,3477..3763,3907..4043,5413..5565)
/product="prostate specific antigen (PSA)"
intron 1848..3476
/number=2
misc_feature 2311..2663
/note="Alu repetitive sequence"
exon 3477..3763
/number=3
intron 3764..3906
/number=3
exon 3907..4043
/number=4
intron 4044..5412
/number=4
exon 5413..>5568
/number=5
BASE COUNT 1186 a 1778 c 1503 g 1406 t
ORIGIN
1 ggtgtcttag gcacactggt cttggagtgc aaaggatcta ggcacgtgag gctttgtatg
61 aagaatcggg gatcgtaccc accccctgtt tctgtttcat cctgggcatg tctcctctgc
121 ctttgtcccc tagatgaagt ctccatgagc tacaagggcc tggtgcatcc agggtgatct
181 agtaattgca gaacagcaag tgctagctct ccctcccctt ccacagctct gggtgtggga
241 gggggttgtc cagcctccag cagcatgggg agggccttgg tcagcctctg ggtgccagca
301 gggcaggggc ggagtcctgg ggaatgaagg ttttataggg ctcctggggg aggctcccca
361 gccccaagct taccacctgc acccggagag ctgtgtcacc atgtgggtcc cggttgtctt
421 cctcaccctg tccgtgacgt ggattggtga gaggggccat ggttgggggg atgcaggaga
481 gggagccagc cctgactgtc aagctgaggc tctttccccc ccaacccagc accccagccc
541 agacagggag ctgggctctt ttctgtctct cccagcccca cttcaagccc atacccccag
601 tcccctccat attgcaacag tcctcactcc cacaccaggt ccccgctccc tcccacttac
661 cccagaactt tcttcccatt tgcccagcca gctccctgct cccagctgct ttactaaagg
721 ggaagttcct gggcatctcc gtgtttctct ttgtggggct caaaacctcc aaggacctct
781 ctcaatgcca ttggttcctt ggaccgtatc actggtccat ctcctgagcc cctcaatcct
841 atcacagtct actgactttt cccattcagc tgtgagtgtc caaccctatc ccagagacct
901 tgatgcttgg cctcccaatc ttgccctagg atacccagat gccaaccaga cacctccttc
961 tttcctagcc aggctatctg gcctgagaca acaaatgggt ccctcagtct ggcaatggga
1021 ctctgagaac tcctcattcc ctgactctta gccccagact cttcattcag tggcccacat
1081 tttccttagg aaaaacatga gcatccccag ccacaactgc cagctctctg agtccccaaa
1141 tctgcatcct tttcaaaacc taaaaacaaa aagaaaaaca aataaaacaa aaccaactca
1201 gaccagaact gttttctcaa cctgggactt cctaaacttt ccaaaacctt cctcttccag
1261 caactgaacc tcgccataag gcacttatcc ctggttccta gcacccctta tcccctcaga
1321 atccacaact tgtaccaagt ttcccttctc ccagtccaag accccaaatc accacaaagg
1381 acccaatccc cagactcaag atatggtctg ggcgctgtct tgtgtctcct accctgatcc
1441 ctgggttcaa ctctgctccc agagcatgaa gcctctccac cagcaccagc caccaacctg
1501 caaacctagg gaagattgac agaattccca gcctttccca gctccccctg cccatgtccc
1561 aggactccca gccttggttc tctgcccccg tgtcttttca aacccacatc ctaaatccat
1621 ctcctatccg agtcccccag ttccccctgt caaccctgat tcccctgatc tagcaccccc
1681 tctgcaggcg ctgcgcccct catcctgtct cggattgtgg gaggctggga gtgcgagaag
1741 cattcccaac cctggcaggt gcttgtggcc tctcgtggca gggcagtctg cggcggtgtt
1801 ctggtgcacc cccagtgggt cctcacagct gcccactgca tcaggaagtg agtaggggcc
1861 tggggtctgg ggagcaggtg tctgtgtccc agaggaataa cagctgggca ttttccccag
1921 gataacctct aaggccagcc ttgggactgg gggagagagg gaaagttctg gttcaggtca
1981 catggggagg cagggttggg gctggaccac cctccccatg gctgcctggg tctccatctg
2041 tgtccctcta tgtctctttg tgtcgctttc attatgtctc ttggtaactg gcttcggttg
2101 tgtctctccg tgtgactatt ttgttctctc tctccctctc ttctctgtct tcagtctcca
2161 tatctccccc tctctctgtc cttctctggt ccctctctag ccagtgtgtc tcaccctgta
2221 tctctctgcc aggctctgtc tctcggtctc tgtctcacct gtgccttctc cctactgaac
2281 acacgcacgg gatgggcctg ggggaccctg agaaaaggaa gggctttggc tgggcgcggt
2341 ggctcacacc tgtaatccca gcactttggg aggccaaggc aggtagatca cctgaggtca
2401 ggagttcgag accagcctgg ccaactggtg aaaccccatc tctactaaaa atacaaaaaa
2461 ttagccaggc gtggtggcgc atgcctgtag tcccagctac tcaggagctg agggaggaga
2521 attgcattga acctggaggt tgaggttgca gtgagccgag accgtgccac tgcactccag
2581 cctgggtgac agagtgagac tccgcctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaga
2641 aaagaaaaga aaagaaaagg aagtgtttta tccctgatgt gtgtgggtat gagggtatga
2701 gagggcccct ctcactccat tccttctcca ggacatccct ccactcttgg gagacacaga
2761 gaagggctgg ttccagctgg agctgggagg ggcaattgag ggaggaggaa ggagaagggg
2821 gaaggaaaac agggtatggg ggaaaggacc ctggggagcg aagtggagga tacaaccttg
2881 ggcctgcagg caggctacct acccacttgg aaacccacgc caaagccgca tctacagctg
2941 agccactctg aggcctcccc tccccggcgg tccccactca gctccaaagt ctctctccct
3001 tttctctccc acactttatc atcccccgga ttcctctcta cttggttctc attcttcctt
3061 tgacttcctg cttccctttc tcattcatct gtttctcact ttctgcctgg ttttgttctt
3121 ctctctctct ttctctggcc catgtctgtt tctctatgtt tctgtctttt ctttctcatc
3181 ctgtgtattt tcggctcacc ttgtttgtca ctgttctccc ctctgccctt tcattctctc
3241 tgccctttta ccctcttcct tttcccttgg ttctctcagt tctgtatctg cccttcaccc
3301 tctcacactg ctgtttccca actcgttgtc tgtattttgg cctgaactgt gtcttcccaa
3361 ccctgtgttt tctcactgtt tctttttctc ttttggagcc tcctccttgc tcctctgtcc
3421 cttctctctt tccttatcat cctcgctcct cattcctgcg tctgcttcct ccccagcaaa
3481 agcgtgatct tgctgggtcg gcacagcctg tttcatcctg aagacacagg ccaggtattt
3541 caggtcagcc acagcttccc acacccgctc tacgatatga gcctcctgaa gaatcgattc
3601 ctcaggccag gtgatgactc cagccacgac ctcatgctgc tccgcctgtc agagcctgcc
3661 gagctcacgg atgctgtgaa ggtcatggac ctgcccaccc aggagccagc actggggacc
3721 acctgctacg cctcaggctg gggcagcatt gaaccagagg agtgtacgcc tgggccagat
3781 ggtgcagccg ggagcccaga tgcctgggtc tgagggagga ggggacagga ctcctgggtc
3841 tgagggagga gggccaagga accaggtggg gtccagccca caacagtgtt tttgcctggc
3901 ccgtagtctt gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg
3961 tgtgtgcgca agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga
4021 cagggggcaa aagcacctgc tcggtgagtc atccctactc ccaagatctt gagggaaagg
4081 tgagtgggac cttaattctg ggctggggtc tagaagccaa caaggcgtct gcctcccctg
4141 ctccccagct gtagccatgc cacctccccg tgtctcatct cattccctcc ttccctcttc
4201 tttgactccc tcaaggcaat aggttattct tacagcacaa ctcatctgtt cctgcgttca
4261 gcacacggtt actaggcacc tgctatgcac ccagcactgc cctagagcct gggacatagc
4321 agtgaacaga cagagagcag cccctccctt ctgtagcccc caagccagtg aggggcacag
4381 gcaggaacag ggaccacaac acagaaaagc tggagggtgt caggaggtga tcaggctctc
4441 ggggagggag aaggggtggg gagtgtgact gggaggagac atcctgcaga aggtgggagt
4501 gagcaaacac ctgcgcaggg gaggggaggg cctgcggcac ctgggggagc agagggaaca
4561 gcatctggcc aggcctggga ggaggggcct agagggcgtc aggagcagag aggaggttgc
4621 ctggctggag tgaaggatcg gggcagggtg cgagagggaa caaaggaccc ctcctgcagg
4681 gcctcacctg ggccacagga ggacactgct tttcctctga ggagtcagga actgtggatg
4741 gtgctggaca gaagcaggac agggcctggc tcaggtgtcc agaggctgcg ctggcctcct
4801 atgggatcag actgcaggga gggagggcag cagggatgtg gagggagtga tgatggggct
4861 gacctggggg tggctccagg cattgtcccc acctgggccc ttacccagcc tccctcacag
4921 gctcctggcc ctcagtctct cccctccact ccattctcca cctacccaca gtgggtcatt
4981 ctgatcaccg aactgaccat gccagccctg ccgatggtcc tccatggctc cctagtgccc
5041 tggagaggag gtgtctagtc agagagtagt cctggaaggt ggcctctgtg aggagccacg
5101 gggacagcat cctgcagatg gtcctggccc ttgtcccacc gacctgtcta caaggactgt
5161 cctcgtggac cctcccctct gcacaggagc tggaccctga agtcccttcc taccggccag
5221 gactggagcc cctacccctc tgttggaatc cctgcccacc ttcttctgga agtcggctct
5281 ggagacattt ctctcttctt ccaaagctgg gaactgctat ctgttatctg cctgtccagg
5341 tctgaaagat aggattgccc aggcagaaac tgggactgac ctatctcact ctctccctgc
5401 ttttaccctt agggtgattc tgggggccca cttgtctgta atggtgtgct tcaaggtatc
5461 acgtcatggg gcagtgaacc atgtgccctg cccgaaaggc cttccctgta caccaaggtg
5521 gtgcattacc ggaagtggat caaggacacc atcgtggcca acccctgagc acccctatca
5581 agtccctatt gtagtaaact tggaaccttg gaaatgacca ggccaagact caagcctccc
5641 cagttctact gacctttgtc cttaggtgtg aggtccaggg ttgctaggaa aagaaatcag
5701 cagacacagg tgtagaccag agtgtttctt aaatggtgta attttgtcct ctctgtgtcc
5761 tggggaatac tggccatgcc tggagacata tcactcaatt tctctgagga cacagttagg
5821 atggggtgtc tgtgttattt gtgggataca gagatgaaag aggggtggga tcc
//