LOCUS X14787 5722 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human mRNA for thrombospondin.
ACCESSION X14787
VERSION X14787.1
KEYWORDS calcium binding protein; glycoprotein; thrombospondin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5722)
AUTHORS Hennessy S.W., Frazier B.A., Kim D.D., Deckwerth T.L.,
Baumgartel D.M., Rotwein P., Frazier W.A.
TITLE Complete thrombospondin mRNA sequence includes potential regulatory
sites in the 3' untranslated region
JOURNAL J. Cell Biol. 108(2), 729-736(1989).
PUBMED 2918029
FEATURES Location/Qualifiers
source 1..5722
/db_xref="H-InvDB:HIT000321462"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt11 and pUC19"
/clone="6A,S10,TXE"
/cell_type="fibroblast and epithelial"
/db_xref="taxon:9606"
CDS 112..3624
/product="precursor polypeptide (AA -31 to 1139)"
/db_xref="GOA:P07996"
/db_xref="H-InvDB:HIT000321462.14"
/db_xref="HGNC:HGNC:11785"
/db_xref="InterPro:IPR000742"
/db_xref="InterPro:IPR000884"
/db_xref="InterPro:IPR001007"
/db_xref="InterPro:IPR001791"
/db_xref="InterPro:IPR001881"
/db_xref="InterPro:IPR003367"
/db_xref="InterPro:IPR008859"
/db_xref="InterPro:IPR013032"
/db_xref="InterPro:IPR013320"
/db_xref="InterPro:IPR017897"
/db_xref="InterPro:IPR028499"
/db_xref="InterPro:IPR028974"
/db_xref="InterPro:IPR036383"
/db_xref="PDB:1LSL"
/db_xref="PDB:1UX6"
/db_xref="PDB:1Z78"
/db_xref="PDB:1ZA4"
/db_xref="PDB:2ERF"
/db_xref="PDB:2ES3"
/db_xref="PDB:2OUH"
/db_xref="PDB:2OUJ"
/db_xref="PDB:3R6B"
/db_xref="PDB:5FOE"
/db_xref="UniProtKB/Swiss-Prot:P07996"
/protein_id="CAA32889.1"
/translation="MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGS
GRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRG
TLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFV
QEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFV
FGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDE
LSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVD
SCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCS
TSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVT
CGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTC
GGGVQKRSRLCNNPAPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYP
DGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRF
TGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGY
AGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDD
DDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACA
ADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTC
DNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVP
NPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQ
NDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQ
SSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPG
QVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGG
RLGLFVFSQEMVFFSDLKYECRDP"
sig_peptide 112..204
/note="signal peptide (AA -31 to -1)"
mat_peptide 205..3621
/note="thrombospondin (AA 1 to 1139)"
misc_feature 5518..5559
/note="polyU stretch"
misc_feature 5697..5702
/note="polyA signal"
polyA_site 5722..5722
/note="polyA site"
BASE COUNT 1514 a 1388 c 1387 g 1433 t
ORIGIN
1 ggacgcacag gcattccccg cgcccctcca gccctcgccg ccctcgccac cgctcccggc
61 cgccgcgctc cggtacacac aggatccctg ctgggcacca acagctccac catggggctg
121 gcctggggac taggcgtcct gttcctgatg catgtgtgtg gcaccaaccg cattccagag
181 tctggcggag acaacagcgt gtttgacatc tttgaactca ccggggccgc ccgcaagggg
241 tctgggcgcc gactggtgaa gggccccgac ccttccagcc cagctttccg catcgaggat
301 gccaacctga tcccccctgt gcctgatgac aagttccaag acctggtgga tgctgtgcgg
361 gcagaaaagg gtttcctcct tctggcatcc ctgaggcaga tgaagaagac ccggggcacg
421 ctgctggccc tggagcggaa agaccactct ggccaggtct tcagcgtggt gtccaatggc
481 aaggcgggca ccctggacct cagcctgacc gtccaaggaa agcagcacgt ggtgtctgtg
541 gaagaagctc tcctggcaac cggccagtgg aagagcatca ccctgtttgt gcaggaagac
601 agggcccagc tgtacatcga ctgtgaaaag atggagaatg ctgagttgga cgtccccatc
661 caaagcgtct tcaccagaga cctggccagc atcgccagac tccgcatcgc aaaggggggc
721 gtcaatgaca atttccaggg ggtgctgcag aatgtgaggt ttgtctttgg aaccacacca
781 gaagacatcc tcaggaacaa aggctgctcc agctctacca gtgtcctcct cacccttgac
841 aacaacgtgg tgaatggttc cagccctgcc atccgcacta actacattgg ccacaagaca
901 aaggacttgc aagccatctg cggcatctcc tgtgatgagc tgtccagcat ggtcctggaa
961 ctcaggggcc tgcgcaccat tgtgaccacg ctgcaggaca gcatccgcaa agtgactgaa
1021 gagaacaaag agttggccaa tgagctgagg cggcctcccc tatgctatca caacggagtt
1081 cagtacagaa ataacgagga atggactgtt gatagctgca ctgagtgtca ctgtcagaac
1141 tcagttacca tctgcaaaaa ggtgtcctgc cccatcatgc cctgctccaa tgccacagtt
1201 cctgatggag aatgctgtcc tcgctgttgg cccagcgact ctgcggacga tggctggtct
1261 ccatggtccg agtggacctc ctgttctacg agctgtggca atggaattca gcagcgcggc
1321 cgctcctgcg atagcctcaa caaccgatgt gagggctcct cggtccagac acggacctgc
1381 cacattcagg agtgtgacaa aagatttaaa caggatggtg gctggagcca ctggtccccg
1441 tggtcatctt gttctgtgac atgtggtgat ggtgtgatca caaggatccg gctctgcaac
1501 tctcccagcc cccagatgaa tgggaaaccc tgtgaaggcg aagcgcggga gaccaaagcc
1561 tgcaagaaag acgcctgccc catcaatgga ggctggggtc cttggtcacc atgggacatc
1621 tgttctgtca cctgtggagg aggggtacag aaacgtagtc gtctctgcaa caaccccgca
1681 ccccagtttg gaggcaagga ctgcgttggt gatgtaacag aaaaccagat ctgcaacaag
1741 caggactgtc caattgatgg atgcctgtcc aatccctgct ttgccggcgt gaagtgtact
1801 agctaccctg atggcagctg gaaatgtggt gcttgtcccc ctggttacag tggaaatggc
1861 atccagtgca cagatgttga tgagtgcaaa gaagtgcctg atgcctgctt caaccacaat
1921 ggagagcacc ggtgtgagaa cacggacccc ggctacaact gcctgccctg ccccccacgc
1981 ttcaccggct cacagccctt cggccagggt gtcgaacatg ccacggccaa caaacaggtg
2041 tgcaagcccc gtaacccctg cacggatggg acccacgact gcaacaagaa cgccaagtgc
2101 aactacctgg gccactatag cgaccccatg taccgctgcg agtgcaagcc tggctacgct
2161 ggcaatggca tcatctgcgg ggaggacaca gacctggatg gctggcccaa tgagaacctg
2221 gtgtgcgtgg ccaatgcgac ttaccactgc aaaaaggata attgccccaa ccttcccaac
2281 tcagggcagg aagactatga caaggatgga attggtgatg cctgtgatga tgacgatgac
2341 aatgataaaa ttccagatga cagggacaac tgtccattcc attacaaccc agctcagtat
2401 gactatgaca gagatgatgt gggagaccgc tgtgacaact gtccctacaa ccacaaccca
2461 gatcaggcag acacagacaa caatggggaa ggagacgcct gtgctgcaga cattgatgga
2521 gacggtatcc tcaatgaacg ggacaactgc cagtacgtct acaatgtgga ccagagagac
2581 actgatatgg atggggttgg agatcagtgt gacaattgcc ccttggaaca caatccggat
2641 cagctggact ctgactcaga ccgcattgga gatacctgtg acaacaatca ggatattgat
2701 gaagatggcc accagaacaa tctggacaac tgtccctatg tgcccaatgc caaccaggct
2761 gaccatgaca aagatggcaa gggagatgcc tgtgaccacg atgatgacaa cgatggcatt
2821 cctgatgaca aggacaactg cagactcgtg cccaatcccg accagaagga ctctgacggc
2881 gatggtcgag gtgatgcctg caaagatgat tttgaccatg acagtgtgcc agacatcgat
2941 gacatctgtc ctgagaatgt tgacatcagt gagaccgatt tccgccgatt ccagatgatt
3001 cctctggacc ccaaagggac atcccaaaat gaccctaact gggttgtacg ccatcagggt
3061 aaagaactcg tccagactgt caactgtgat cctggactcg ctgtaggtta tgatgagttt
3121 aatgctgtgg acttcagtgg caccttcttc atcaacaccg aaagggacga tgactatgct
3181 ggatttgtct ttggctacca gtccagcagc cgcttttatg ttgtgatgtg gaagcaagtc
3241 acccagtcct actgggacac caaccccacg agggctcagg gatactcggg cctttctgtg
3301 aaagttgtaa actccaccac agggcctggc gagcacctgc ggaacgccct gtggcacaca
3361 ggaaacaccc ctggccaggt gcgcaccctg tggcatgacc ctcgtcacat aggctggaaa
3421 gatttcaccg cctacagatg gcgtctcagc cacaggccaa agacgggttt cattagagtg
3481 gtgatgtatg aagggaagaa aatcatggct gactcaggac ccatctatga taaaacctat
3541 gctggtggta gactagggtt gtttgtcttc tctcaagaaa tggtgttctt ctctgacctg
3601 aaatacgaat gtagagatcc ctaatcatca aattgttgat tgaaagactg atcataaacc
3661 aatgctggta ttgcaccttc tggaactatg ggcttgagaa aacccccagg atcacttctc
3721 cttggcttcc ttcttttctg tgcttgcatc agtgtggact cctagaacgt gcgacctgcc
3781 tcaagaaaat gcagttttca aaaacagact catcagcatt cagcctccaa tgaataagac
3841 atcttccaag catataaaca attgctttgg tttccttttg aaaaagcatc tacttgcttc
3901 agttgggaag gtgcccattc cactctgcct ttgtcacaga gcagggtgct attgtgaggc
3961 catctctgag cagtggactc aaaagcattt tcaggcatgt cagagaaggg aggactcact
4021 agaattagca aacaaaacca ccctgacatc ctccttcagg aacacgggga gcagaggcca
4081 aagcactaag gggagggcgc atacccgaga cgattgtatg aagaaaatat ggaggaactg
4141 ttacatgttc ggtactaagt cattttcagg ggattgaaag actattgctg gatttcatga
4201 tgctgactgg cgttagctga ttaacccatg taaataggca cttaaataga agcaggaaag
4261 ggagacaaag actggcttct ggacttcctc cctgatcccc acccttactc atcaccttgc
4321 agtggccaga attagggaat cagaatcaaa ccagtgtaag gcagtgctgg ctgccattgc
4381 ctggtcacat tgaaattggt ggcttcattc tagatgtagc ttgtgcagat gtagcaggaa
4441 aataggaaaa cctaccatct cagtgagcac cagctgcctc ccaaaggagg ggcagccgtg
4501 cttatatttt tatggttaca atggcacaaa attattatca acctaactaa aacattcctt
4561 ttctcttttt tccgtaatta ctaggtagtt ttctaattct ctcttttgga agtatgattt
4621 ttttaaagtc tttacgatgt aaaatattta ttttttactt attctggaag atctggctga
4681 aggattattc atggaacagg aagaagcgta aagactatcc atgtcatctt tgttgagagt
4741 cttcgtgact gtaagattgt aaatacagat tatttattaa ctctgttctg cctggaaatt
4801 taggcttcat acggaaagtg tttgagagca agtagttgac atttatcagc aaatctcttg
4861 caagaacagc acaaggaaaa tcagtctaat aagctgctct gccccttgtg ctcagagtgg
4921 atgttatggg attccttttt tctctgtttt atcttttcaa gtggaattag ttggttatcc
4981 atttgcaaat gttttaaatt gcaaagaaag ccatgaggtc ttcaatactg ttttacccca
5041 tcccttgtgc atatttccag ggagaaggaa agcatataca cttttttctt tcatttttcc
5101 aaaagagaaa aaaatgacaa aaggtgaaac ttacatacaa atattacctc atttgttgtg
5161 tgactgagta aagaattttt ggatcaagcg gaaagagttt aagtgtctaa caaacttaaa
5221 gctactgtag tacctaaaaa gtcagtgttg tacatagcat aaaaactctg cagagaagta
5281 ttcccaataa ggaaatagca ttgaaatgtt aaatacaatt tctgaaagtt atgttttttt
5341 tctatcatct ggtataccat tgctttattt ttataaatta ttttctcatt gccattggaa
5401 tagaatattc agattgtgta gatatgctat ttaaataatt tatcaggaaa tactgcctgt
5461 agagttagta tttctatttt tatataatgt ttgcacactg aattgaagaa ttgttggttt
5521 tttctttttt ttgttttttt tttttttttt tttttttttg cttttgacct cccattttta
5581 ctatttgcca ataccttttt ctaggaatgt gctttttttt gtacacattt ttatccattt
5641 tacattctaa agcagtgtaa gttgtatatt actgtttctt atgtacaagg aacaacaata
5701 aatcatatgg aaatttatat tt
//